PTPRM (protein tyrosine phosphatase receptor type M)

Gene

• Entrez ID: 5797
• Gene name: Protein tyrosine phosphatase receptor type M
• Gene symbol: PTPRM
• Synonyms (NCBI Gene): PTPRL1, R-PTP-MU, RPTPM, RPTPU, hR-PTPu
• Chromosome: 18
• Chromosome location: 18p11.23
• Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018602	hsa-miR-335-5p	Microarray	18185580
MIRT054104	hsa-miR-205-5p	Immunohistochemistry, Luciferase reporter assay, Microarray, QRTPCR	23497265
MIRT654619	hsa-miR-1264	HITS-CLIP	23824327
MIRT654618	hsa-miR-4461	HITS-CLIP	23824327
MIRT654617	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT654615	hsa-miR-1253	HITS-CLIP	23824327
MIRT654614	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT654613	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT654612	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT654611	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT654610	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT654609	hsa-miR-507	HITS-CLIP	23824327
MIRT654608	hsa-miR-557	HITS-CLIP	23824327
MIRT654619	hsa-miR-1264	HITS-CLIP	23824327
MIRT654618	hsa-miR-4461	HITS-CLIP	23824327
MIRT654616	hsa-miR-1279	HITS-CLIP	23824327
MIRT654617	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT654615	hsa-miR-1253	HITS-CLIP	23824327
MIRT654614	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT654613	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT654612	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT654611	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT654610	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT654609	hsa-miR-507	HITS-CLIP	23824327
MIRT654608	hsa-miR-557	HITS-CLIP	23824327
MIRT654607	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT654619	hsa-miR-1264	HITS-CLIP	23824327
MIRT654618	hsa-miR-4461	HITS-CLIP	23824327
MIRT654617	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT654615	hsa-miR-1253	HITS-CLIP	23824327
MIRT654614	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT654613	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT654612	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT654611	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT654610	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT654609	hsa-miR-507	HITS-CLIP	23824327
MIRT654608	hsa-miR-557	HITS-CLIP	23824327
MIRT654619	hsa-miR-1264	HITS-CLIP	23824327
MIRT654618	hsa-miR-4461	HITS-CLIP	23824327
MIRT654616	hsa-miR-1279	HITS-CLIP	23824327
MIRT654617	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT654615	hsa-miR-1253	HITS-CLIP	23824327
MIRT654614	hsa-miR-6770-5p	HITS-CLIP	23824327
MIRT654613	hsa-miR-452-3p	HITS-CLIP	23824327
MIRT654612	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT654611	hsa-miR-580-3p	HITS-CLIP	23824327
MIRT654610	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT654609	hsa-miR-507	HITS-CLIP	23824327
MIRT654608	hsa-miR-557	HITS-CLIP	23824327
MIRT654607	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT2081294	hsa-miR-103a	CLIP-seq
MIRT2081295	hsa-miR-107	CLIP-seq
MIRT2081296	hsa-miR-15a	CLIP-seq
MIRT2081297	hsa-miR-15b	CLIP-seq
MIRT2081298	hsa-miR-16	CLIP-seq
MIRT2081299	hsa-miR-195	CLIP-seq
MIRT2081300	hsa-miR-424	CLIP-seq
MIRT2081301	hsa-miR-4310	CLIP-seq
MIRT2081302	hsa-miR-497	CLIP-seq
MIRT2604709	hsa-miR-1206	CLIP-seq
MIRT2604710	hsa-miR-221	CLIP-seq
MIRT2604711	hsa-miR-222	CLIP-seq
MIRT2604712	hsa-miR-365	CLIP-seq
MIRT2604713	hsa-miR-3690	CLIP-seq
MIRT2604714	hsa-miR-375	CLIP-seq
MIRT2604715	hsa-miR-3941	CLIP-seq
MIRT2604716	hsa-miR-3978	CLIP-seq
MIRT2604717	hsa-miR-4254	CLIP-seq
MIRT2604718	hsa-miR-4540	CLIP-seq
MIRT2604719	hsa-miR-4643	CLIP-seq
MIRT2604720	hsa-miR-466	CLIP-seq
MIRT2604721	hsa-miR-4672	CLIP-seq
MIRT2604722	hsa-miR-4729	CLIP-seq
MIRT2604723	hsa-miR-4789-3p	CLIP-seq
MIRT2604724	hsa-miR-485-3p	CLIP-seq
MIRT2604725	hsa-miR-491-3p	CLIP-seq
MIRT2604726	hsa-miR-548a-5p	CLIP-seq
MIRT2604727	hsa-miR-548ab	CLIP-seq
MIRT2604728	hsa-miR-548ak	CLIP-seq
MIRT2604729	hsa-miR-548b-5p	CLIP-seq
MIRT2604730	hsa-miR-548c-5p	CLIP-seq
MIRT2604731	hsa-miR-548d-5p	CLIP-seq
MIRT2604732	hsa-miR-548h	CLIP-seq
MIRT2604733	hsa-miR-548i	CLIP-seq
MIRT2604734	hsa-miR-548j	CLIP-seq
MIRT2604735	hsa-miR-548k	CLIP-seq
MIRT2604736	hsa-miR-548l	CLIP-seq
MIRT2604737	hsa-miR-548w	CLIP-seq
MIRT2604738	hsa-miR-548y	CLIP-seq
MIRT2604739	hsa-miR-556-3p	CLIP-seq
MIRT2604740	hsa-miR-559	CLIP-seq
MIRT2604741	hsa-miR-656	CLIP-seq
MIRT2604742	hsa-miR-875-3p	CLIP-seq
MIRT2604709	hsa-miR-1206	CLIP-seq
MIRT2604713	hsa-miR-3690	CLIP-seq
MIRT2604714	hsa-miR-375	CLIP-seq
MIRT2604715	hsa-miR-3941	CLIP-seq
MIRT2604717	hsa-miR-4254	CLIP-seq
MIRT2604718	hsa-miR-4540	CLIP-seq
MIRT2604719	hsa-miR-4643	CLIP-seq
MIRT2604720	hsa-miR-466	CLIP-seq
MIRT2604721	hsa-miR-4672	CLIP-seq
MIRT2604722	hsa-miR-4729	CLIP-seq
MIRT2604723	hsa-miR-4789-3p	CLIP-seq
MIRT2604724	hsa-miR-485-3p	CLIP-seq
MIRT2604742	hsa-miR-875-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001937	Process	Negative regulation of endothelial cell proliferation	IMP	18566238
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA
GO:0004725	Function	Protein tyrosine phosphatase activity	IDA	8393854, 17965016, 18566238
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	IDA	10809770
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	9531566, 11278757, 16380380
GO:0005737	Component	Cytoplasm	IDA	16380380
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	1655529
GO:0005911	Component	Cell-cell junction	IDA	10753936
GO:0005911	Component	Cell-cell junction	IDA	15491993, 16380380
GO:0005912	Component	Adherens junction	IDA	17965016
GO:0007155	Process	Cell adhesion	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IDA	8393854
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0007165	Process	Signal transduction	IBA
GO:0007165	Process	Signal transduction	IDA	15080886
GO:0009410	Process	Response to xenobiotic stimulus	IDA	18566238
GO:0010596	Process	Negative regulation of endothelial cell migration	IMP	18566238
GO:0010828	Process	Positive regulation of D-glucose transmembrane transport	IDA	10753936
GO:0010829	Process	Negative regulation of D-glucose transmembrane transport	IDA	21998202
GO:0010842	Process	Retina layer formation	IMP	14623235
GO:0016020	Component	Membrane	IEA
GO:0016525	Process	Negative regulation of angiogenesis	IMP	18566238
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IDA	10753936
GO:0030027	Component	Lamellipodium	IDA	15706045
GO:0030336	Process	Negative regulation of cell migration	IEA
GO:0031175	Process	Neuron projection development	IBA
GO:0031175	Process	Neuron projection development	IDA	16380380
GO:0031175	Process	Neuron projection development	IMP	17276081
GO:0031290	Process	Retinal ganglion cell axon guidance	IDA	15080886
GO:0042802	Function	Identical protein binding	IPI	10809770
GO:0045296	Function	Cadherin binding	IDA	9531566
GO:0045296	Function	Cadherin binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	15491993
GO:1904659	Process	D-glucose transmembrane transport	TAS	12556481

Other IDs

• MIM: 176888
• HGNC: 9675
• e!Ensembl: ENSG00000173482

Protein

• UniProt ID: P28827
• Protein name: Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48)
• Protein function: Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation (PubMed:10753936, PubMed:17761881). Promotes CTNND1 dephosp
• PDB: 1RPM, 2C9A, 2V5Y, 8A16, 8A17
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00629	MAM	27 → 183	MAM domain, meprin/A5/mu	Domain
  PF00047	ig	189 → 274	Immunoglobulin domain	Domain
  PF00041	fn3	283 → 366	Fibronectin type III domain	Domain
  PF00041	fn3	488 → 575	Fibronectin type III domain	Domain
  PF18861	PTP_tm	611 → 768	Transmembrane domain of protein tyrosine phosphatase, receptor type J	Family
  PF00102	Y_phosphatase	923 → 1153	Protein-tyrosine phosphatase	Domain
  PF00102	Y_phosphatase	1213 → 1447	Protein-tyrosine phosphatase	Domain

• Sequence:

  MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSD
  PWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKV
  NNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGH
  PCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRR
  FIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI
  QLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGE
  GGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYC
  YQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDED
  LPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVS
  KLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQT
  DNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYY
  FAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVA
  TKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSST
  RQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY
  YPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGF
  KEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYID
  GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYK
  DIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQV
  KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQT
  EEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTL
  RVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVT
  QHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLE
  EDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNG
  GEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKF
  CYEVALEYLNSG

• Sequence length: 1452

Pathways

KEGG:

Cell adhesion molecules
Adherens junction

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HUNTINGTON DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LYMPHATIC SYSTEM DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PTPRM-related disorder	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ROLANDIC EPILEPSY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Adenocarcinoma	Associate	26683690	★☆☆☆☆ Found in Text Mining only
Astrocytoma	Associate	27586084	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Inhibit	23185569	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Associate	22968929, 25910225	★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Inhibit	37403117	★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Inhibit	25910225	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	22968929, 25910225	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Associate	27586084, 34225581	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Associate	27784745	★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Associate	30685201	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Stimulate	32826853	★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Associate	32056145	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	23185569, 32826853, 37403117	★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	25910225, 34397405	★☆☆☆☆ Found in Text Mining only
Oral Submucous Fibrosis	Associate	36966276	★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Inhibit	37403117	★☆☆☆☆ Found in Text Mining only
Pancreatic Intraductal Neoplasms	Associate	22355676	★☆☆☆☆ Found in Text Mining only
Polyposis Syndrome Hereditary Mixed 1	Associate	25910225	★☆☆☆☆ Found in Text Mining only
Sex Chromosome Aberrations	Associate	28771244	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Associate	36966276	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Stimulate	32826853	★☆☆☆☆ Found in Text Mining only