Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5793
Gene name Gene Name - the full gene name approved by the HGNC.	Protein tyrosine phosphatase receptor type G
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PTPRG
Synonyms (NCBI Gene) Gene synonyms aliases	HPTPG, PTPG, R-PTP-GAMMA, RPTPG
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p14.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020238	hsa-miR-130b-3p	Sequencing	20371350
MIRT031199	hsa-miR-19b-3p	Sequencing	20371350
MIRT047641	hsa-miR-10a-5p	CLASH	23622248
MIRT041395	hsa-miR-193b-3p	CLASH	23622248
MIRT039600	hsa-miR-624-5p	CLASH	23622248
MIRT038215	hsa-miR-342-5p	CLASH	23622248
MIRT031199	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT092487	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT020238	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT092488	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT092496	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT092492	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT092498	hsa-miR-3666	PAR-CLIP	21572407
MIRT092497	hsa-miR-4295	PAR-CLIP	21572407
MIRT092494	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT555127	hsa-miR-4282	PAR-CLIP	21572407
MIRT092500	hsa-miR-7844-5p	PAR-CLIP	21572407
MIRT555126	hsa-miR-6854-3p	PAR-CLIP	21572407
MIRT092499	hsa-miR-4671-3p	PAR-CLIP	21572407
MIRT444469	hsa-miR-548ac	PAR-CLIP	22100165
MIRT444468	hsa-miR-548bb-3p	PAR-CLIP	22100165
MIRT444467	hsa-miR-548d-3p	PAR-CLIP	22100165
MIRT444466	hsa-miR-548h-3p	PAR-CLIP	22100165
MIRT444465	hsa-miR-548z	PAR-CLIP	22100165
MIRT444464	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT444463	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT444462	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT444461	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT444460	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT444459	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT444458	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT444457	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT444456	hsa-miR-6892-3p	PAR-CLIP	22100165
MIRT444455	hsa-miR-2276-5p	PAR-CLIP	22100165
MIRT444454	hsa-miR-4469	PAR-CLIP	22100165
MIRT444453	hsa-miR-7113-3p	PAR-CLIP	22100165
MIRT444452	hsa-miR-4287	PAR-CLIP	22100165
MIRT444450	hsa-miR-4685-3p	PAR-CLIP	22100165
MIRT444451	hsa-miR-642a-5p	PAR-CLIP	22100165
MIRT444449	hsa-miR-6867-3p	PAR-CLIP	22100165
MIRT439862	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439862	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT031199	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT092487	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT020238	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT092488	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT092496	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT092492	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT092498	hsa-miR-3666	PAR-CLIP	21572407
MIRT092497	hsa-miR-4295	PAR-CLIP	21572407
MIRT092494	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT555127	hsa-miR-4282	PAR-CLIP	21572407
MIRT092500	hsa-miR-7844-5p	PAR-CLIP	21572407
MIRT555126	hsa-miR-6854-3p	PAR-CLIP	21572407
MIRT092499	hsa-miR-4671-3p	PAR-CLIP	21572407
MIRT444469	hsa-miR-548ac	PAR-CLIP	22100165
MIRT444468	hsa-miR-548bb-3p	PAR-CLIP	22100165
MIRT444467	hsa-miR-548d-3p	PAR-CLIP	22100165
MIRT444466	hsa-miR-548h-3p	PAR-CLIP	22100165
MIRT444465	hsa-miR-548z	PAR-CLIP	22100165
MIRT444464	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT444463	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT444462	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT444461	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT444460	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT444459	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT444458	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT444457	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT444456	hsa-miR-6892-3p	PAR-CLIP	22100165
MIRT444455	hsa-miR-2276-5p	PAR-CLIP	22100165
MIRT444454	hsa-miR-4469	PAR-CLIP	22100165
MIRT444453	hsa-miR-7113-3p	PAR-CLIP	22100165
MIRT444452	hsa-miR-4287	PAR-CLIP	22100165
MIRT444450	hsa-miR-4685-3p	PAR-CLIP	22100165
MIRT444451	hsa-miR-642a-5p	PAR-CLIP	22100165
MIRT444449	hsa-miR-6867-3p	PAR-CLIP	22100165
MIRT1276123	hsa-let-7a	CLIP-seq
MIRT1276124	hsa-let-7b	CLIP-seq
MIRT1276125	hsa-let-7c	CLIP-seq
MIRT1276126	hsa-let-7d	CLIP-seq
MIRT1276127	hsa-let-7e	CLIP-seq
MIRT1276128	hsa-let-7f	CLIP-seq
MIRT1276129	hsa-let-7g	CLIP-seq
MIRT1276130	hsa-let-7i	CLIP-seq
MIRT1276131	hsa-miR-1	CLIP-seq
MIRT1276132	hsa-miR-1208	CLIP-seq
MIRT1276133	hsa-miR-1265	CLIP-seq
MIRT1276134	hsa-miR-129-3p	CLIP-seq
MIRT1276135	hsa-miR-1294	CLIP-seq
MIRT1276136	hsa-miR-1298	CLIP-seq
MIRT1276137	hsa-miR-1303	CLIP-seq
MIRT1276138	hsa-miR-130a	CLIP-seq
MIRT1276139	hsa-miR-130b	CLIP-seq
MIRT1276140	hsa-miR-141	CLIP-seq
MIRT1276141	hsa-miR-147	CLIP-seq
MIRT1276142	hsa-miR-19a	CLIP-seq
MIRT1276143	hsa-miR-19b	CLIP-seq
MIRT1276144	hsa-miR-200a	CLIP-seq
MIRT1276145	hsa-miR-202	CLIP-seq
MIRT1276146	hsa-miR-203	CLIP-seq
MIRT1276147	hsa-miR-2053	CLIP-seq
MIRT1276148	hsa-miR-206	CLIP-seq
MIRT1276149	hsa-miR-2392	CLIP-seq
MIRT1276150	hsa-miR-2682	CLIP-seq
MIRT1276151	hsa-miR-297	CLIP-seq
MIRT1276152	hsa-miR-301a	CLIP-seq
MIRT1276153	hsa-miR-301b	CLIP-seq
MIRT1276154	hsa-miR-320a	CLIP-seq
MIRT1276155	hsa-miR-320b	CLIP-seq
MIRT1276156	hsa-miR-320c	CLIP-seq
MIRT1276157	hsa-miR-320d	CLIP-seq
MIRT1276158	hsa-miR-3613-5p	CLIP-seq
MIRT1276159	hsa-miR-3646	CLIP-seq
MIRT1276160	hsa-miR-3651	CLIP-seq
MIRT1276161	hsa-miR-3673	CLIP-seq
MIRT1276162	hsa-miR-3688-3p	CLIP-seq
MIRT1276163	hsa-miR-380	CLIP-seq
MIRT1276164	hsa-miR-3911	CLIP-seq
MIRT1276165	hsa-miR-4316	CLIP-seq
MIRT1276166	hsa-miR-4318	CLIP-seq
MIRT1276167	hsa-miR-4420	CLIP-seq
MIRT1276168	hsa-miR-4429	CLIP-seq
MIRT1276169	hsa-miR-4458	CLIP-seq
MIRT1276170	hsa-miR-4495	CLIP-seq
MIRT1276171	hsa-miR-449c	CLIP-seq
MIRT1276172	hsa-miR-4500	CLIP-seq
MIRT1276173	hsa-miR-454	CLIP-seq
MIRT1276174	hsa-miR-4648	CLIP-seq
MIRT1276175	hsa-miR-4654	CLIP-seq
MIRT1276176	hsa-miR-4659a-3p	CLIP-seq
MIRT1276177	hsa-miR-4659b-3p	CLIP-seq
MIRT1276178	hsa-miR-4662a-3p	CLIP-seq
MIRT1276179	hsa-miR-4677-3p	CLIP-seq
MIRT1276180	hsa-miR-4687-5p	CLIP-seq
MIRT1276181	hsa-miR-4693-5p	CLIP-seq
MIRT1276182	hsa-miR-4694-3p	CLIP-seq
MIRT1276183	hsa-miR-4698	CLIP-seq
MIRT1276184	hsa-miR-4769-5p	CLIP-seq
MIRT1276185	hsa-miR-520d-5p	CLIP-seq
MIRT1276186	hsa-miR-524-5p	CLIP-seq
MIRT1276187	hsa-miR-562	CLIP-seq
MIRT1276188	hsa-miR-567	CLIP-seq
MIRT1276189	hsa-miR-568	CLIP-seq
MIRT1276190	hsa-miR-613	CLIP-seq
MIRT1276191	hsa-miR-644	CLIP-seq
MIRT1276192	hsa-miR-651	CLIP-seq
MIRT1276193	hsa-miR-802	CLIP-seq
MIRT1276194	hsa-miR-892a	CLIP-seq
MIRT1276195	hsa-miR-940	CLIP-seq
MIRT1276196	hsa-miR-98	CLIP-seq
MIRT2081189	hsa-miR-101	CLIP-seq
MIRT1276132	hsa-miR-1208	CLIP-seq
MIRT2081190	hsa-miR-144	CLIP-seq
MIRT2081191	hsa-miR-196a	CLIP-seq
MIRT2081192	hsa-miR-196b	CLIP-seq
MIRT2081193	hsa-miR-21	CLIP-seq
MIRT1276150	hsa-miR-2682	CLIP-seq
MIRT1276151	hsa-miR-297	CLIP-seq
MIRT1276158	hsa-miR-3613-5p	CLIP-seq
MIRT2081194	hsa-miR-3617	CLIP-seq
MIRT2081195	hsa-miR-3668	CLIP-seq
MIRT2081196	hsa-miR-3682-3p	CLIP-seq
MIRT2081197	hsa-miR-3910	CLIP-seq
MIRT2081198	hsa-miR-3927	CLIP-seq
MIRT2081199	hsa-miR-4264	CLIP-seq
MIRT2081200	hsa-miR-4277	CLIP-seq
MIRT2081201	hsa-miR-4299	CLIP-seq
MIRT1276167	hsa-miR-4420	CLIP-seq
MIRT2081202	hsa-miR-4456	CLIP-seq
MIRT1276171	hsa-miR-449c	CLIP-seq
MIRT2081203	hsa-miR-4695-3p	CLIP-seq
MIRT2081204	hsa-miR-4724-5p	CLIP-seq
MIRT2081205	hsa-miR-4760-5p	CLIP-seq
MIRT2081206	hsa-miR-4797-3p	CLIP-seq
MIRT2081207	hsa-miR-513a-3p	CLIP-seq
MIRT1276185	hsa-miR-520d-5p	CLIP-seq
MIRT1276186	hsa-miR-524-5p	CLIP-seq
MIRT2081208	hsa-miR-548ae	CLIP-seq
MIRT2081209	hsa-miR-548aj	CLIP-seq
MIRT2081210	hsa-miR-548am	CLIP-seq
MIRT2081211	hsa-miR-548n	CLIP-seq
MIRT2081212	hsa-miR-548q	CLIP-seq
MIRT2081213	hsa-miR-548x	CLIP-seq
MIRT1276187	hsa-miR-562	CLIP-seq
MIRT1276188	hsa-miR-567	CLIP-seq
MIRT1276189	hsa-miR-568	CLIP-seq
MIRT2081214	hsa-miR-570	CLIP-seq
MIRT2081215	hsa-miR-590-5p	CLIP-seq
MIRT2081216	hsa-miR-622	CLIP-seq
MIRT2081217	hsa-miR-641	CLIP-seq
MIRT1276194	hsa-miR-892a	CLIP-seq
MIRT1276195	hsa-miR-940	CLIP-seq
MIRT1276131	hsa-miR-1	CLIP-seq
MIRT2307108	hsa-miR-1204	CLIP-seq
MIRT1276132	hsa-miR-1208	CLIP-seq
MIRT1276138	hsa-miR-130a	CLIP-seq
MIRT1276139	hsa-miR-130b	CLIP-seq
MIRT1276140	hsa-miR-141	CLIP-seq
MIRT2307109	hsa-miR-155	CLIP-seq
MIRT1276142	hsa-miR-19a	CLIP-seq
MIRT1276143	hsa-miR-19b	CLIP-seq
MIRT1276144	hsa-miR-200a	CLIP-seq
MIRT1276148	hsa-miR-206	CLIP-seq
MIRT2307110	hsa-miR-2277-3p	CLIP-seq
MIRT1276150	hsa-miR-2682	CLIP-seq
MIRT1276151	hsa-miR-297	CLIP-seq
MIRT1276152	hsa-miR-301a	CLIP-seq
MIRT1276153	hsa-miR-301b	CLIP-seq
MIRT2307111	hsa-miR-338-3p	CLIP-seq
MIRT1276158	hsa-miR-3613-5p	CLIP-seq
MIRT2307112	hsa-miR-3616-5p	CLIP-seq
MIRT2307113	hsa-miR-3647-5p	CLIP-seq
MIRT1276161	hsa-miR-3673	CLIP-seq
MIRT1276167	hsa-miR-4420	CLIP-seq
MIRT2307114	hsa-miR-4422	CLIP-seq
MIRT1276171	hsa-miR-449c	CLIP-seq
MIRT2307115	hsa-miR-452	CLIP-seq
MIRT1276173	hsa-miR-454	CLIP-seq
MIRT2307116	hsa-miR-4670-3p	CLIP-seq
MIRT2307117	hsa-miR-4676-3p	CLIP-seq
MIRT1276182	hsa-miR-4694-3p	CLIP-seq
MIRT2307118	hsa-miR-4731-3p	CLIP-seq
MIRT2081206	hsa-miR-4797-3p	CLIP-seq
MIRT2307119	hsa-miR-4801	CLIP-seq
MIRT2307120	hsa-miR-490-5p	CLIP-seq
MIRT1276185	hsa-miR-520d-5p	CLIP-seq
MIRT2307121	hsa-miR-522	CLIP-seq
MIRT1276186	hsa-miR-524-5p	CLIP-seq
MIRT1276188	hsa-miR-567	CLIP-seq
MIRT1276189	hsa-miR-568	CLIP-seq
MIRT2307122	hsa-miR-573	CLIP-seq
MIRT1276190	hsa-miR-613	CLIP-seq
MIRT2307123	hsa-miR-634	CLIP-seq
MIRT2307124	hsa-miR-653	CLIP-seq
MIRT1276193	hsa-miR-802	CLIP-seq
MIRT1276194	hsa-miR-892a	CLIP-seq
MIRT1276195	hsa-miR-940	CLIP-seq
MIRT2081189	hsa-miR-101	CLIP-seq
MIRT2081190	hsa-miR-144	CLIP-seq
MIRT2081197	hsa-miR-3910	CLIP-seq
MIRT1276158	hsa-miR-3613-5p	CLIP-seq
MIRT1276189	hsa-miR-568	CLIP-seq
MIRT1276158	hsa-miR-3613-5p	CLIP-seq
MIRT1276189	hsa-miR-568	CLIP-seq
MIRT2457469	hsa-miR-1252	CLIP-seq
MIRT2457470	hsa-miR-1271	CLIP-seq
MIRT2457471	hsa-miR-182	CLIP-seq
MIRT1276162	hsa-miR-3688-3p	CLIP-seq
MIRT2457472	hsa-miR-4470	CLIP-seq
MIRT1276182	hsa-miR-4694-3p	CLIP-seq
MIRT1276183	hsa-miR-4698	CLIP-seq
MIRT2457473	hsa-miR-96	CLIP-seq
MIRT1276132	hsa-miR-1208	CLIP-seq
MIRT2604642	hsa-miR-1257	CLIP-seq
MIRT1276138	hsa-miR-130a	CLIP-seq
MIRT1276139	hsa-miR-130b	CLIP-seq
MIRT1276140	hsa-miR-141	CLIP-seq
MIRT1276142	hsa-miR-19a	CLIP-seq
MIRT1276143	hsa-miR-19b	CLIP-seq
MIRT1276144	hsa-miR-200a	CLIP-seq
MIRT1276146	hsa-miR-203	CLIP-seq
MIRT2604643	hsa-miR-2116	CLIP-seq
MIRT2604644	hsa-miR-23a	CLIP-seq
MIRT2604645	hsa-miR-23b	CLIP-seq
MIRT2604646	hsa-miR-23c	CLIP-seq
MIRT1276150	hsa-miR-2682	CLIP-seq
MIRT1276152	hsa-miR-301a	CLIP-seq
MIRT1276153	hsa-miR-301b	CLIP-seq
MIRT2604647	hsa-miR-3129-3p	CLIP-seq
MIRT2604648	hsa-miR-3607-3p	CLIP-seq
MIRT1276158	hsa-miR-3613-5p	CLIP-seq
MIRT2604649	hsa-miR-3614-3p	CLIP-seq
MIRT1276159	hsa-miR-3646	CLIP-seq
MIRT2604650	hsa-miR-3686	CLIP-seq
MIRT2604651	hsa-miR-410	CLIP-seq
MIRT2081200	hsa-miR-4277	CLIP-seq
MIRT2604652	hsa-miR-4293	CLIP-seq
MIRT1276167	hsa-miR-4420	CLIP-seq
MIRT2604653	hsa-miR-4475	CLIP-seq
MIRT1276171	hsa-miR-449c	CLIP-seq
MIRT1276173	hsa-miR-454	CLIP-seq
MIRT2604654	hsa-miR-4717-3p	CLIP-seq
MIRT2604655	hsa-miR-548a-3p	CLIP-seq
MIRT2081208	hsa-miR-548ae	CLIP-seq
MIRT2081209	hsa-miR-548aj	CLIP-seq
MIRT2081210	hsa-miR-548am	CLIP-seq
MIRT2604656	hsa-miR-548e	CLIP-seq
MIRT2604657	hsa-miR-548f	CLIP-seq
MIRT2604658	hsa-miR-548g	CLIP-seq
MIRT2081213	hsa-miR-548x	CLIP-seq
MIRT1276189	hsa-miR-568	CLIP-seq
MIRT2081214	hsa-miR-570	CLIP-seq
MIRT2604659	hsa-miR-596	CLIP-seq
MIRT2604660	hsa-miR-642b	CLIP-seq
MIRT1276193	hsa-miR-802	CLIP-seq
MIRT1276194	hsa-miR-892a	CLIP-seq
MIRT1276195	hsa-miR-940	CLIP-seq
MIRT2689099	hsa-miR-105	CLIP-seq
MIRT1276132	hsa-miR-1208	CLIP-seq
MIRT1276138	hsa-miR-130a	CLIP-seq
MIRT1276139	hsa-miR-130b	CLIP-seq
MIRT1276140	hsa-miR-141	CLIP-seq
MIRT2689100	hsa-miR-199a-3p	CLIP-seq
MIRT2689101	hsa-miR-199b-3p	CLIP-seq
MIRT1276142	hsa-miR-19a	CLIP-seq
MIRT1276143	hsa-miR-19b	CLIP-seq
MIRT1276144	hsa-miR-200a	CLIP-seq
MIRT1276146	hsa-miR-203	CLIP-seq
MIRT1276150	hsa-miR-2682	CLIP-seq
MIRT1276152	hsa-miR-301a	CLIP-seq
MIRT1276153	hsa-miR-301b	CLIP-seq
MIRT2689102	hsa-miR-3129-5p	CLIP-seq
MIRT1276158	hsa-miR-3613-5p	CLIP-seq
MIRT1276159	hsa-miR-3646	CLIP-seq
MIRT2689103	hsa-miR-4257	CLIP-seq
MIRT2604652	hsa-miR-4293	CLIP-seq
MIRT1276167	hsa-miR-4420	CLIP-seq
MIRT1276171	hsa-miR-449c	CLIP-seq
MIRT1276173	hsa-miR-454	CLIP-seq
MIRT2081206	hsa-miR-4797-3p	CLIP-seq
MIRT1276189	hsa-miR-568	CLIP-seq
MIRT2604659	hsa-miR-596	CLIP-seq
MIRT1276193	hsa-miR-802	CLIP-seq
MIRT1276194	hsa-miR-892a	CLIP-seq
MIRT2689104	hsa-miR-936	CLIP-seq
MIRT1276195	hsa-miR-940	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
CTCF	Unknown	21150880

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA
GO:0004725	Function	Protein tyrosine phosphatase activity	IDA	19167335
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	IEA
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	TAS	8382771
GO:0005515	Function	Protein binding	IPI	19167335, 21112398, 25970784, 31980649
GO:0005615	Component	Extracellular space	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8382771
GO:0007165	Process	Signal transduction	IBA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	TAS	8382771
GO:0010633	Process	Negative regulation of epithelial cell migration	IMP	21724833
GO:0010977	Process	Negative regulation of neuron projection development	IEA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031175	Process	Neuron projection development	IBA
GO:0042802	Function	Identical protein binding	IPI	19167335
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:1903385	Process	Regulation of homophilic cell adhesion	IMP	21724833

MIM	HGNC	e!Ensembl
176886	9671	ENSG00000144724

Protein

UniProt ID

P23470

Protein name

Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48)

Protein function

Possesses tyrosine phosphatase activity.

PDB

2H4V , 2HY3 , 2NLK , 2PBN , 3JXH , 3QCB , 3QCC , 3QCD , 3QCE , 3QCF , 3QCG , 3QCH , 3QCI , 3QCJ , 3QCK , 3QCL , 3QCM , 3QCN , 5E5R , 8XQD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00194	Carb_anhydrase	59 → 320	Eukaryotic-type carbonic anhydrase	Domain
PF00041	fn3	348 → 436	Fibronectin type III domain	Domain
PF00102	Y_phosphatase	874 → 1118	Protein-tyrosine phosphatase	Domain
PF00102	Y_phosphatase	1175 → 1409	Protein-tyrosine phosphatase	Domain

Tissue specificity

TISSUE SPECIFICITY: Found in a variety of tissues.

Sequence

MRRLLEPCWWILFLKITSSVLHYVVCFPALTEGYVGALHENRHGSAVQIRRRKASGDPYW
AYSGAYGPEHWVTSSVSCGGRHQSPIDILDQYARVGEEYQELQLDGFDNESSNKTWMKNT
GKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSAGSEHSINGRRFPVEMQIFFYN
PDDFDSFQTAISENRIIGAMAIFFQVSPRDNSALDPIIHGLKGVVHHEKETFLDPFVLRD
LLPASLGSYYRYTGSLTTPPCSEIVEWIVFRRPVPISYHQLEAFYSIFTTEQQDHVKSVE
YLRNNFRPQQRLHDRVVSKSAVRDSWNHDMTDFLENPLGTEASKVCSSPPIHMKVQPLNQ
TALQVSWSQPETIYHPPIMNYMISYSWTKNEDEKEKTFTKDSDKDLKATISHVSPDSLYL
FRVQAVCRNDMRSDFSQTMLFQANTTRIFQGTRIVKTGVPTASPASSADMAPISSGSSTW
TSSGIPFSFVSMATGMGPSSSGSQATVASVVTSTLLAGLGFGGGGISSFPSTVWPTRLPT
AASASKQAARPVLATTEALASPGPDGDSSPTKDGEGTEEGEKDEKSESEDGEREHEEDGE
KDSEKKEKSGVTHAAEERNQTEPSPTPSSPNRTAEGGHQTIPGHEQDHTAVPTDQTGGRR
DAGPGLDPDMVTSTQVPPTATEEQYAGSDPKRPEMPSKKPMSRGDRFSEDSRFITVNPAE
KNTSGMISRPAPGRMEWIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREV
PSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGEL
YSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKD
SKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRK
CDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQ
YHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQI
KDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSIL
IPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGM
KGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEF
VYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWP
NPDAPISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVF
QVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNGAVLIADESDPAES
MESLV

Sequence length

1445

Interactions

View interactions

Show/Hide Unknown Diseases (9)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Dementia	Dementia	N/A	N/A	GWAS
Dermatitis	Atopic dermatitis	N/A	N/A	GWAS
Ischemic Stroke	Ischemic stroke	N/A	N/A	GWAS
Mental Depression	Major depressive disorder	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Neuroticism	Neuroticism	N/A	N/A	GWAS
Ovarian cancer	Epithelial ovarian cancer	N/A	N/A	GWAS
Psoriasis	Psoriasis	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (23)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenoma	Associate	21150880
Breast Neoplasms	Associate	16475675, 26409453
Breast Neoplasms	Inhibit	27602768
Carcinogenesis	Associate	16475675, 24496747, 27602768
Carcinoma Renal Cell	Associate	36405010
Colorectal Neoplasms	Associate	21150880
COVID 19	Associate	36460583
Diabetes Gestational	Associate	34530062
Fuchs' Endothelial Dystrophy	Associate	20825314, 22234156
Hereditary Breast and Ovarian Cancer Syndrome	Associate	27602768
Kidney Neoplasms	Associate	16475675
Leukemia Myelogenous Chronic BCR ABL Positive	Inhibit	32225105, 32700424, 33893334, 36382578
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	34906644, 36077295
Memory Disorders	Associate	27211562
Multiple Myeloma	Associate	37019174
Multiple Sclerosis	Associate	33603109
Neoplasms	Inhibit	16475675, 27602768, 30145116, 32225105, 33893334, 34906644, 36077295, 36382578, 36405010
Neoplasms	Associate	21150880, 26409453
Osteosarcoma	Associate	29371290
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	24496747
Psychotic Disorders	Associate	19567891, 27211562
Stomach Neoplasms	Associate	17963294
Triple Negative Breast Neoplasms	Associate	34326372

PTPRG (protein tyrosine phosphatase receptor type G)