Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5787
Gene name	Protein tyrosine phosphatase receptor type B
Gene symbol	PTPRB
Synonyms (NCBI Gene)	HPTP-BETAHPTPBPTPBR-PTP-BETAVEPTP
Chromosome	12
Chromosome location	12q15
Summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022308	hsa-miR-124-3p	Microarray	18668037
MIRT053404	hsa-miR-629-5p	Microarray	23807165
MIRT641056	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT641054	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT641055	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT641053	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT641052	hsa-miR-651-3p	HITS-CLIP	23824327
MIRT641051	hsa-miR-513b-3p	HITS-CLIP	23824327
MIRT641050	hsa-miR-6830-5p	HITS-CLIP	23824327
MIRT641049	hsa-miR-5009-3p	HITS-CLIP	23824327
MIRT641048	hsa-miR-561-5p	HITS-CLIP	23824327
MIRT641047	hsa-miR-4279	HITS-CLIP	23824327
MIRT641046	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT457972	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT457970	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT457969	hsa-miR-455-5p	PAR-CLIP	23592263
MIRT457968	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT457967	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT457966	hsa-miR-924	PAR-CLIP	23592263
MIRT457965	hsa-miR-19a-3p	PAR-CLIP	23592263
MIRT457964	hsa-miR-19b-3p	PAR-CLIP	23592263
MIRT457963	hsa-miR-627-5p	PAR-CLIP	23592263
MIRT736704	hsa-miR-624-5p	Luciferase reporter assayWestern blottingImmunohistochemistry (IHC)ImmunofluorescenceqRT-PCR	31829261
MIRT641056	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT641054	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT641055	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT641053	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT641052	hsa-miR-651-3p	HITS-CLIP	23824327
MIRT641051	hsa-miR-513b-3p	HITS-CLIP	23824327
MIRT641050	hsa-miR-6830-5p	HITS-CLIP	23824327
MIRT641049	hsa-miR-5009-3p	HITS-CLIP	23824327
MIRT641048	hsa-miR-561-5p	HITS-CLIP	23824327
MIRT641047	hsa-miR-4279	HITS-CLIP	23824327
MIRT641046	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT457972	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT457970	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT457969	hsa-miR-455-5p	PAR-CLIP	23592263
MIRT457968	hsa-miR-4726-3p	PAR-CLIP	23592263
MIRT457967	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT457966	hsa-miR-924	PAR-CLIP	23592263
MIRT457965	hsa-miR-19a-3p	PAR-CLIP	23592263
MIRT457964	hsa-miR-19b-3p	PAR-CLIP	23592263
MIRT457963	hsa-miR-627-5p	PAR-CLIP	23592263
MIRT1275880	hsa-miR-1227	CLIP-seq
MIRT1275881	hsa-miR-1285	CLIP-seq
MIRT1275882	hsa-miR-129-5p	CLIP-seq
MIRT1275883	hsa-miR-3140-3p	CLIP-seq
MIRT1275884	hsa-miR-3187-5p	CLIP-seq
MIRT1275885	hsa-miR-3614-5p	CLIP-seq
MIRT1275886	hsa-miR-4252	CLIP-seq
MIRT1275887	hsa-miR-450b-5p	CLIP-seq
MIRT1275888	hsa-miR-4793-3p	CLIP-seq
MIRT1275889	hsa-miR-507	CLIP-seq
MIRT1275890	hsa-miR-508-5p	CLIP-seq
MIRT1275891	hsa-miR-557	CLIP-seq
MIRT1275892	hsa-miR-612	CLIP-seq
MIRT1275893	hsa-miR-661	CLIP-seq
MIRT1275894	hsa-miR-766	CLIP-seq
MIRT1275895	hsa-miR-1207-5p	CLIP-seq
MIRT1275896	hsa-miR-1264	CLIP-seq
MIRT1275881	hsa-miR-1285	CLIP-seq
MIRT1275897	hsa-miR-137	CLIP-seq
MIRT1275898	hsa-miR-142-3p	CLIP-seq
MIRT1275899	hsa-miR-1587	CLIP-seq
MIRT1275900	hsa-miR-1915	CLIP-seq
MIRT1275901	hsa-miR-2054	CLIP-seq
MIRT1275902	hsa-miR-219-2-3p	CLIP-seq
MIRT1275903	hsa-miR-2355-3p	CLIP-seq
MIRT1275904	hsa-miR-23a	CLIP-seq
MIRT1275905	hsa-miR-23b	CLIP-seq
MIRT1275906	hsa-miR-23c	CLIP-seq
MIRT1275907	hsa-miR-24	CLIP-seq
MIRT1275908	hsa-miR-25	CLIP-seq
MIRT1275909	hsa-miR-28-5p	CLIP-seq
MIRT1275910	hsa-miR-2964a-3p	CLIP-seq
MIRT1275911	hsa-miR-3064-3p	CLIP-seq
MIRT1275912	hsa-miR-3120-5p	CLIP-seq
MIRT1275913	hsa-miR-3122	CLIP-seq
MIRT1275914	hsa-miR-3129-3p	CLIP-seq
MIRT1275915	hsa-miR-3139	CLIP-seq
MIRT1275916	hsa-miR-3160-5p	CLIP-seq
MIRT1275917	hsa-miR-3174	CLIP-seq
MIRT1275918	hsa-miR-3187-3p	CLIP-seq
MIRT1275884	hsa-miR-3187-5p	CLIP-seq
MIRT1275919	hsa-miR-3192	CLIP-seq
MIRT1275920	hsa-miR-32	CLIP-seq
MIRT1275921	hsa-miR-3609	CLIP-seq
MIRT1275922	hsa-miR-3613-3p	CLIP-seq
MIRT1275923	hsa-miR-3616-5p	CLIP-seq
MIRT1275924	hsa-miR-363	CLIP-seq
MIRT1275925	hsa-miR-3647-5p	CLIP-seq
MIRT1275926	hsa-miR-3662	CLIP-seq
MIRT1275927	hsa-miR-3664-5p	CLIP-seq
MIRT1275928	hsa-miR-367	CLIP-seq
MIRT1275929	hsa-miR-3682-3p	CLIP-seq
MIRT1275930	hsa-miR-3689a-3p	CLIP-seq
MIRT1275931	hsa-miR-3689c	CLIP-seq
MIRT1275932	hsa-miR-371b-5p	CLIP-seq
MIRT1275933	hsa-miR-3913-5p	CLIP-seq
MIRT1275886	hsa-miR-4252	CLIP-seq
MIRT1275934	hsa-miR-4269	CLIP-seq
MIRT1275935	hsa-miR-4284	CLIP-seq
MIRT1275936	hsa-miR-431	CLIP-seq
MIRT1275937	hsa-miR-432	CLIP-seq
MIRT1275938	hsa-miR-4433	CLIP-seq
MIRT1275939	hsa-miR-4435	CLIP-seq
MIRT1275940	hsa-miR-4443	CLIP-seq
MIRT1275941	hsa-miR-4466	CLIP-seq
MIRT1275942	hsa-miR-451b	CLIP-seq
MIRT1275943	hsa-miR-4639-3p	CLIP-seq
MIRT1275944	hsa-miR-4646-3p	CLIP-seq
MIRT1275945	hsa-miR-4659a-3p	CLIP-seq
MIRT1275946	hsa-miR-4659b-3p	CLIP-seq
MIRT1275947	hsa-miR-4662a-5p	CLIP-seq
MIRT1275948	hsa-miR-4674	CLIP-seq
MIRT1275949	hsa-miR-4676-5p	CLIP-seq
MIRT1275950	hsa-miR-4696	CLIP-seq
MIRT1275951	hsa-miR-4701-5p	CLIP-seq
MIRT1275952	hsa-miR-4715-3p	CLIP-seq
MIRT1275953	hsa-miR-4717-3p	CLIP-seq
MIRT1275954	hsa-miR-4728-5p	CLIP-seq
MIRT1275955	hsa-miR-4736	CLIP-seq
MIRT1275956	hsa-miR-4746-3p	CLIP-seq
MIRT1275957	hsa-miR-4753-3p	CLIP-seq
MIRT1275958	hsa-miR-4763-3p	CLIP-seq
MIRT1275959	hsa-miR-490-3p	CLIP-seq
MIRT1275960	hsa-miR-500a	CLIP-seq
MIRT1275961	hsa-miR-518a-5p	CLIP-seq
MIRT1275962	hsa-miR-527	CLIP-seq
MIRT1275963	hsa-miR-548ae	CLIP-seq
MIRT1275964	hsa-miR-548ag	CLIP-seq
MIRT1275965	hsa-miR-548ah	CLIP-seq
MIRT1275966	hsa-miR-548ai	CLIP-seq
MIRT1275967	hsa-miR-548aj	CLIP-seq
MIRT1275968	hsa-miR-548am	CLIP-seq
MIRT1275969	hsa-miR-548m	CLIP-seq
MIRT1275970	hsa-miR-548t	CLIP-seq
MIRT1275971	hsa-miR-548x	CLIP-seq
MIRT1275972	hsa-miR-573	CLIP-seq
MIRT1275973	hsa-miR-575	CLIP-seq
MIRT1275974	hsa-miR-579	CLIP-seq
MIRT1275975	hsa-miR-584	CLIP-seq
MIRT1275976	hsa-miR-588	CLIP-seq
MIRT1275977	hsa-miR-607	CLIP-seq
MIRT1275892	hsa-miR-612	CLIP-seq
MIRT1275978	hsa-miR-616	CLIP-seq
MIRT1275979	hsa-miR-643	CLIP-seq
MIRT1275980	hsa-miR-658	CLIP-seq
MIRT1275893	hsa-miR-661	CLIP-seq
MIRT1275981	hsa-miR-665	CLIP-seq
MIRT1275982	hsa-miR-675	CLIP-seq
MIRT1275983	hsa-miR-676	CLIP-seq
MIRT1275984	hsa-miR-708	CLIP-seq
MIRT1275985	hsa-miR-764	CLIP-seq
MIRT1275986	hsa-miR-765	CLIP-seq
MIRT1275987	hsa-miR-890	CLIP-seq
MIRT1275988	hsa-miR-891b	CLIP-seq
MIRT1275989	hsa-miR-921	CLIP-seq
MIRT1275990	hsa-miR-92a	CLIP-seq
MIRT1275991	hsa-miR-92b	CLIP-seq
MIRT1275992	hsa-miR-935	CLIP-seq
MIRT1552711	hsa-miR-1305	CLIP-seq
MIRT1552712	hsa-miR-3973	CLIP-seq
MIRT1552713	hsa-miR-520g	CLIP-seq
MIRT1552714	hsa-miR-520h	CLIP-seq
MIRT1275977	hsa-miR-607	CLIP-seq
MIRT2081181	hsa-miR-3647-3p	CLIP-seq
MIRT1275930	hsa-miR-3689a-3p	CLIP-seq
MIRT1275931	hsa-miR-3689c	CLIP-seq
MIRT2081182	hsa-miR-4267	CLIP-seq
MIRT1275954	hsa-miR-4728-5p	CLIP-seq
MIRT2081183	hsa-miR-889	CLIP-seq
MIRT1275987	hsa-miR-890	CLIP-seq
MIRT1552711	hsa-miR-1305	CLIP-seq
MIRT1275904	hsa-miR-23a	CLIP-seq
MIRT1275905	hsa-miR-23b	CLIP-seq
MIRT1275906	hsa-miR-23c	CLIP-seq
MIRT1275977	hsa-miR-607	CLIP-seq
MIRT1275895	hsa-miR-1207-5p	CLIP-seq
MIRT2307080	hsa-miR-1293	CLIP-seq
MIRT1275898	hsa-miR-142-3p	CLIP-seq
MIRT2307081	hsa-miR-217	CLIP-seq
MIRT2307082	hsa-miR-3160-3p	CLIP-seq
MIRT2307083	hsa-miR-3165	CLIP-seq
MIRT1275917	hsa-miR-3174	CLIP-seq
MIRT1275919	hsa-miR-3192	CLIP-seq
MIRT1275930	hsa-miR-3689a-3p	CLIP-seq
MIRT1275931	hsa-miR-3689c	CLIP-seq
MIRT1275934	hsa-miR-4269	CLIP-seq
MIRT2307084	hsa-miR-4418	CLIP-seq
MIRT2307085	hsa-miR-4483	CLIP-seq
MIRT2307086	hsa-miR-4487	CLIP-seq
MIRT1275943	hsa-miR-4639-3p	CLIP-seq
MIRT2307087	hsa-miR-4672	CLIP-seq
MIRT1275954	hsa-miR-4728-5p	CLIP-seq
MIRT1275955	hsa-miR-4736	CLIP-seq
MIRT1275958	hsa-miR-4763-3p	CLIP-seq
MIRT1275959	hsa-miR-490-3p	CLIP-seq
MIRT2307088	hsa-miR-509-3-5p	CLIP-seq
MIRT2307089	hsa-miR-509-5p	CLIP-seq
MIRT2307090	hsa-miR-558	CLIP-seq
MIRT1275980	hsa-miR-658	CLIP-seq
MIRT1275989	hsa-miR-921	CLIP-seq
MIRT1275930	hsa-miR-3689a-3p	CLIP-seq
MIRT1275931	hsa-miR-3689c	CLIP-seq
MIRT1275954	hsa-miR-4728-5p	CLIP-seq
MIRT1275881	hsa-miR-1285	CLIP-seq
MIRT1275901	hsa-miR-2054	CLIP-seq
MIRT1275913	hsa-miR-3122	CLIP-seq
MIRT1275884	hsa-miR-3187-5p	CLIP-seq
MIRT1275930	hsa-miR-3689a-3p	CLIP-seq
MIRT1275931	hsa-miR-3689c	CLIP-seq
MIRT1275933	hsa-miR-3913-5p	CLIP-seq
MIRT1275886	hsa-miR-4252	CLIP-seq
MIRT1275943	hsa-miR-4639-3p	CLIP-seq
MIRT1275954	hsa-miR-4728-5p	CLIP-seq
MIRT1275888	hsa-miR-4793-3p	CLIP-seq
MIRT1275960	hsa-miR-500a	CLIP-seq
MIRT1275890	hsa-miR-508-5p	CLIP-seq
MIRT1275963	hsa-miR-548ae	CLIP-seq
MIRT1275967	hsa-miR-548aj	CLIP-seq
MIRT1275968	hsa-miR-548am	CLIP-seq
MIRT1275971	hsa-miR-548x	CLIP-seq
MIRT1275892	hsa-miR-612	CLIP-seq
MIRT1275979	hsa-miR-643	CLIP-seq
MIRT1275893	hsa-miR-661	CLIP-seq
MIRT1275894	hsa-miR-766	CLIP-seq
MIRT1275881	hsa-miR-1285	CLIP-seq
MIRT1275901	hsa-miR-2054	CLIP-seq
MIRT1275913	hsa-miR-3122	CLIP-seq
MIRT1275884	hsa-miR-3187-5p	CLIP-seq
MIRT1275930	hsa-miR-3689a-3p	CLIP-seq
MIRT1275931	hsa-miR-3689c	CLIP-seq
MIRT1275933	hsa-miR-3913-5p	CLIP-seq
MIRT1275942	hsa-miR-451b	CLIP-seq
MIRT1275943	hsa-miR-4639-3p	CLIP-seq
MIRT1275950	hsa-miR-4696	CLIP-seq
MIRT1275954	hsa-miR-4728-5p	CLIP-seq
MIRT1275960	hsa-miR-500a	CLIP-seq
MIRT1275890	hsa-miR-508-5p	CLIP-seq
MIRT1275974	hsa-miR-579	CLIP-seq
MIRT1275892	hsa-miR-612	CLIP-seq
MIRT1275979	hsa-miR-643	CLIP-seq
MIRT1275893	hsa-miR-661	CLIP-seq
MIRT1275894	hsa-miR-766	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IBA
GO:0001525	Process	Angiogenesis	IEA
GO:0001649	Process	Osteoblast differentiation	IDA	22869525
GO:0001649	Process	Osteoblast differentiation	IDA	22869525
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	TAS	2170109
GO:0005515	Function	Protein binding	IPI	12840032, 12907755, 16101282, 19167335, 19451274, 28065597, 31980649
GO:0005886	Component	Plasma membrane	IC	22869525
GO:0005886	Component	Plasma membrane	TAS	2170109
GO:0006470	Process	Protein dephosphorylation	TAS	2170109
GO:0006796	Process	Phosphate-containing compound metabolic process	TAS	2170109
GO:0008347	Process	Glial cell migration	IEA
GO:0016020	Component	Membrane	IEA
GO:0016311	Process	Dephosphorylation	IDA	19116766, 19136612
GO:0016787	Function	Hydrolase activity	IEA
GO:0032502	Process	Developmental process	IEA
GO:0035579	Component	Specific granule membrane	TAS
GO:0043235	Component	Receptor complex	IBA
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0045296	Function	Cadherin binding	IBA
GO:0045296	Function	Cadherin binding	IEA
GO:0045296	Function	Cadherin binding	IPI	28926625
GO:0045668	Process	Negative regulation of osteoblast differentiation	IDA	22869525
GO:0070821	Component	Tertiary granule membrane	TAS

MIM	HGNC	e!Ensembl
176882	9665	ENSG00000127329

P23467

Protein name

Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)

Protein function

Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and

PDB

2AHS , 2H02 , 2H03 , 2H04 , 2HC1 , 2HC2 , 2I3R , 2I3U , 2I4E , 2I4G , 2I4H , 2I5X , 8JBN , 8JBY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00041	fn3	24 → 103	Fibronectin type III domain	Domain
PF00041	fn3	112 → 194	Fibronectin type III domain	Domain
PF00041	fn3	290 → 368	Fibronectin type III domain	Domain
PF00041	fn3	378 → 460	Fibronectin type III domain	Domain
PF00041	fn3	468 → 547	Fibronectin type III domain	Domain
PF00041	fn3	555 → 633	Fibronectin type III domain	Domain
PF00041	fn3	644 → 725	Fibronectin type III domain	Domain
PF00041	fn3	732 → 812	Fibronectin type III domain	Domain
PF00041	fn3	819 → 899	Fibronectin type III domain	Domain
PF00041	fn3	908 → 986	Fibronectin type III domain	Domain
PF00041	fn3	996 → 1077	Fibronectin type III domain	Domain
PF00041	fn3	1086 → 1165	Fibronectin type III domain	Domain
PF00041	fn3	1174 → 1252	Fibronectin type III domain	Domain
PF00041	fn3	1262 → 1344	Fibronectin type III domain	Domain
PF00041	fn3	1356 → 1435	Fibronectin type III domain	Domain
PF18861	PTP_tm	1473 → 1643	Transmembrane domain of protein tyrosine phosphatase, receptor type J	Family
PF00102	Y_phosphatase	1727 → 1962	Protein-tyrosine phosphatase	Domain

Sequence

MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSS
DTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSK
EKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYN
IAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKG
ILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTND
GSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSC
VSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLL
NITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANE
TSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISG
DLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNES
ISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYL
SVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYE
NHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPK
SENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWS
GANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAF
IEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFE
HTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAA
GVAERYDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTE
GRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFS
FQNLLQGRMYKMVIVTHSGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGD
FDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTA
PSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVY
GLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDS
DFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDS
TITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDE
LKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCD
PTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAI
EGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTS
CPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYD
ATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVM
VTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLI
RHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRI
LQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPI
YENVNPEYHRDPVYSRH

Sequence length

1997

Interactions

View interactions

	KEGG		Reactome
	Adherens junction		Neutrophil degranulation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (15)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Adrenocortical carcinoma, hereditary	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEMANGIOSARCOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HIV-1 INFECTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIPHERAL NEUROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PTPRB-related disorder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign; -	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (17)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Carcinoma Renal Cell	Associate	37689589	★★★★★ ★☆☆☆☆ Found in Text Mining only
Central Serous Chorioretinopathy	Associate	30724488, 38263930	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Associate	30845793	★★★★★ ★☆☆☆☆ Found in Text Mining only
Epileptic Syndromes	Associate	30724488	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gaucher Disease	Associate	33568133	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma	Associate	36450729	★★★★★ ★☆☆☆☆ Found in Text Mining only
Graves Disease	Associate	36397361	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemangiosarcoma	Associate	24633157, 26440310, 32123305	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Associate	25393105	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopia	Associate	30826882	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Stimulate	34516350	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	24633157, 25176350, 25393105, 25537509, 31089155, 34516350	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Associate	30845793	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Associate	25176350	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma Myeloid	Associate	36871023	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Associate	32626543	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Stimulate	34516350	★★★★★ ★☆☆☆☆ Found in Text Mining only

PTPRB (protein tyrosine phosphatase receptor type B)