Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	5786
Gene name	Protein tyrosine phosphatase receptor type A
Gene symbol	PTPRA
Synonyms (NCBI Gene)	HEPTPHLPRHPTPAHPTPalphaLRPPTPAPTPRL2R-PTP-alphaRPTPA
Chromosome	20
Chromosome location	20p13
Summary	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017376	hsa-miR-335-5p	Microarray	18185580
MIRT735767	hsa-miR-636	Luciferase reporter assayWestern blottingImmunohistochemistry (IHC)qRT-PCRIn situ hybridization	31821171
MIRT1275840	hsa-miR-1185	CLIP-seq
MIRT1275841	hsa-miR-1238	CLIP-seq
MIRT1275842	hsa-miR-1275	CLIP-seq
MIRT1275843	hsa-miR-146a	CLIP-seq
MIRT1275844	hsa-miR-146b-5p	CLIP-seq
MIRT1275845	hsa-miR-185	CLIP-seq
MIRT1275846	hsa-miR-2113	CLIP-seq
MIRT1275847	hsa-miR-218	CLIP-seq
MIRT1275848	hsa-miR-3124-3p	CLIP-seq
MIRT1275849	hsa-miR-3140-3p	CLIP-seq
MIRT1275850	hsa-miR-3144-5p	CLIP-seq
MIRT1275851	hsa-miR-3145-3p	CLIP-seq
MIRT1275852	hsa-miR-3167	CLIP-seq
MIRT1275853	hsa-miR-3605-5p	CLIP-seq
MIRT1275854	hsa-miR-3679-5p	CLIP-seq
MIRT1275855	hsa-miR-3921	CLIP-seq
MIRT1275856	hsa-miR-4251	CLIP-seq
MIRT1275857	hsa-miR-4259	CLIP-seq
MIRT1275858	hsa-miR-4270	CLIP-seq
MIRT1275859	hsa-miR-4306	CLIP-seq
MIRT1275860	hsa-miR-4329	CLIP-seq
MIRT1275861	hsa-miR-4441	CLIP-seq
MIRT1275862	hsa-miR-4450	CLIP-seq
MIRT1275863	hsa-miR-4525	CLIP-seq
MIRT1275864	hsa-miR-4644	CLIP-seq
MIRT1275865	hsa-miR-4653-5p	CLIP-seq
MIRT1275866	hsa-miR-4665-5p	CLIP-seq
MIRT1275867	hsa-miR-4699-3p	CLIP-seq
MIRT1275868	hsa-miR-4715-5p	CLIP-seq
MIRT1275869	hsa-miR-4723-5p	CLIP-seq
MIRT1275870	hsa-miR-4728-5p	CLIP-seq
MIRT1275871	hsa-miR-491-5p	CLIP-seq
MIRT1275872	hsa-miR-499-3p	CLIP-seq
MIRT1275873	hsa-miR-499a-3p	CLIP-seq
MIRT1275874	hsa-miR-589	CLIP-seq
MIRT1275875	hsa-miR-625	CLIP-seq
MIRT1275876	hsa-miR-876-5p	CLIP-seq
MIRT1275877	hsa-miR-3148	CLIP-seq
MIRT1275878	hsa-miR-3978	CLIP-seq
MIRT1275879	hsa-miR-4759	CLIP-seq
MIRT1275867	hsa-miR-4699-3p	CLIP-seq
MIRT2604601	hsa-miR-3163	CLIP-seq
MIRT2604602	hsa-miR-3170	CLIP-seq
MIRT2604603	hsa-miR-3692	CLIP-seq
MIRT2604604	hsa-miR-4260	CLIP-seq
MIRT2604605	hsa-miR-4263	CLIP-seq
MIRT2604606	hsa-miR-4282	CLIP-seq
MIRT2604607	hsa-miR-4662a-3p	CLIP-seq
MIRT2604608	hsa-miR-4731-3p	CLIP-seq
MIRT2604609	hsa-miR-4789-5p	CLIP-seq
MIRT2604610	hsa-miR-4799-5p	CLIP-seq
MIRT2604611	hsa-miR-4801	CLIP-seq
MIRT2604612	hsa-miR-495	CLIP-seq
MIRT2604613	hsa-miR-513a-3p	CLIP-seq
MIRT2604614	hsa-miR-576-5p	CLIP-seq
MIRT2604615	hsa-miR-656	CLIP-seq
MIRT2604601	hsa-miR-3163	CLIP-seq
MIRT2604603	hsa-miR-3692	CLIP-seq
MIRT2604605	hsa-miR-4263	CLIP-seq
MIRT2604606	hsa-miR-4282	CLIP-seq
MIRT2604610	hsa-miR-4799-5p	CLIP-seq
MIRT2604613	hsa-miR-513a-3p	CLIP-seq
MIRT2604614	hsa-miR-576-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004721	Function	Phosphoprotein phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA
GO:0004725	Function	Protein tyrosine phosphatase activity	IEA
GO:0004725	Function	Protein tyrosine phosphatase activity	ISS
GO:0004725	Function	Protein tyrosine phosphatase activity	TAS	10748206
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	IEA
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	TAS	2169617
GO:0005515	Function	Protein binding	IPI	7518772, 9535845, 10698938, 11923305, 19380743, 22801373, 24189400, 28065597, 28330616, 28514442, 31980649, 33961781, 35271311
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	2169617
GO:0005925	Component	Focal adhesion	IEA
GO:0005925	Component	Focal adhesion	ISS
GO:0007165	Process	Signal transduction	IBA
GO:0007229	Process	Integrin-mediated signaling pathway	ISS
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0016787	Function	Hydrolase activity	IEA
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0051893	Process	Regulation of focal adhesion assembly	ISS
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070161	Component	Anchoring junction	IEA

MIM	HGNC	e!Ensembl
176884	9664	ENSG00000132670

P18433

Protein name

Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)

Protein function

Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphoryla

PDB

6UZT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00102	Y_phosphatase	265 → 500	Protein-tyrosine phosphatase	Domain
PF00102	Y_phosphatase	558 → 790	Protein-tyrosine phosphatase	Domain

Sequence

MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLS
VAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEP
WEGNSSTAATTPETFPPSGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKY
KQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKL
FREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASF
INGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCW
TYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGM
LKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQ
RCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKL
TSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQK
DSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITV
ELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQ
QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ
YEFCYKVVQEYIDAFSDYANFK

Sequence length

802

Interactions

View interactions

	Reactome
			NCAM signaling for neurite out-growth RAF/MAP kinase cascade

PTPRA (protein tyrosine phosphatase receptor type A)