SUGP1 (SURP and G-patch domain containing 1)

Gene

• Entrez ID: 57794
• Gene name: SURP and G-patch domain containing 1
• Gene symbol: SUGP1
• Synonyms (NCBI Gene): F23858, RBP, SF4
• Chromosome: 19
• Chromosome location: 19p13.11
• Summary: SF4 is a member of the SURP family of splicing factors.[supplied by OMIM, Sep 2003]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023869	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT049813	hsa-miR-92a-3p	CLASH	23622248
MIRT696466	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT696465	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT696464	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT696463	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT696462	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT696461	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT696460	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT696459	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT696458	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT696457	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT696456	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT696455	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT696454	hsa-miR-302e	HITS-CLIP	23313552
MIRT696453	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT696452	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT696451	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT696450	hsa-miR-520b	HITS-CLIP	23313552
MIRT696449	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT696448	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT696447	hsa-miR-520e	HITS-CLIP	23313552
MIRT696446	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT696445	hsa-miR-3973	HITS-CLIP	23313552
MIRT696444	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT696443	hsa-miR-520h	HITS-CLIP	23313552
MIRT696442	hsa-miR-212-5p	HITS-CLIP	23313552
MIRT696441	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT696440	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT696439	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT696438	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT696437	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT696436	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT696435	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT696434	hsa-miR-4707-3p	HITS-CLIP	23313552
MIRT696433	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT696432	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT696431	hsa-miR-6744-5p	HITS-CLIP	23313552
MIRT696430	hsa-miR-4757-5p	HITS-CLIP	23313552
MIRT696429	hsa-miR-6744-3p	HITS-CLIP	23313552
MIRT696428	hsa-miR-5187-5p	HITS-CLIP	23313552
MIRT696427	hsa-miR-6878-3p	HITS-CLIP	23313552
MIRT696426	hsa-miR-6728-5p	HITS-CLIP	23313552
MIRT696466	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT696465	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT696464	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT696463	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT696462	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT696461	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT696460	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT696459	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT696458	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT696457	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT696456	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT696455	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT696454	hsa-miR-302e	HITS-CLIP	23313552
MIRT696453	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT696452	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT696451	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT696450	hsa-miR-520b	HITS-CLIP	23313552
MIRT696449	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT696448	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT696447	hsa-miR-520e	HITS-CLIP	23313552
MIRT696446	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT696445	hsa-miR-3973	HITS-CLIP	23313552
MIRT696444	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT696443	hsa-miR-520h	HITS-CLIP	23313552
MIRT696442	hsa-miR-212-5p	HITS-CLIP	23313552
MIRT696441	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT696440	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT696439	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT696438	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT696437	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT696436	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT696435	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT696434	hsa-miR-4707-3p	HITS-CLIP	23313552
MIRT696433	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT696432	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT696431	hsa-miR-6744-5p	HITS-CLIP	23313552
MIRT696430	hsa-miR-4757-5p	HITS-CLIP	23313552
MIRT696429	hsa-miR-6744-3p	HITS-CLIP	23313552
MIRT696428	hsa-miR-5187-5p	HITS-CLIP	23313552
MIRT696427	hsa-miR-6878-3p	HITS-CLIP	23313552
MIRT696426	hsa-miR-6728-5p	HITS-CLIP	23313552
MIRT1402512	hsa-miR-191	CLIP-seq
MIRT1402513	hsa-miR-3177-3p	CLIP-seq
MIRT1402514	hsa-miR-3179	CLIP-seq
MIRT1402515	hsa-miR-3199	CLIP-seq
MIRT1402516	hsa-miR-3202	CLIP-seq
MIRT1402517	hsa-miR-3663-3p	CLIP-seq
MIRT1402518	hsa-miR-3936	CLIP-seq
MIRT1402519	hsa-miR-4504	CLIP-seq
MIRT1402520	hsa-miR-4636	CLIP-seq
MIRT1402521	hsa-miR-4651	CLIP-seq
MIRT1402522	hsa-miR-541	CLIP-seq
MIRT1402523	hsa-miR-549	CLIP-seq
MIRT1402524	hsa-miR-556-3p	CLIP-seq
MIRT1402525	hsa-miR-564	CLIP-seq
MIRT1402526	hsa-miR-602	CLIP-seq
MIRT1402527	hsa-miR-608	CLIP-seq
MIRT1402528	hsa-miR-654-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	TAS
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	21988832, 22365833
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA

Other IDs

• MIM: 607992
• HGNC: 18643
• e!Ensembl: ENSG00000105705

Protein

• UniProt ID: Q8IWZ8
• Protein name: SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4)
• Protein function: Plays a role in pre-mRNA splicing.
• PDB: 8EJM, 8GXL, 8GXM
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01805	Surp	189 → 241	Surp module	Family
  PF01805	Surp	264 → 316	Surp module	Family
  PF01585	G-patch	562 → 607	G-patch domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected in adult testis and heart, and in adult and fetal brain, kidney and skeletal muscle. {ECO:0000269|PubMed:12594045}.
• Sequence:

  MSLKMDNRDVAGKANRWFGVAPPKSGKMNMNILHQEELIAQKKREIEAKMEQKAKQNQVA
  SPQPPHPGEITNAHNSSCISNKFANDGSFLQQFLKLQKAQTSTDAPTSAPSAPPSTPTPS
  AGKRSLLISRRTGLGLASLPGPVKSYSHAKQLPVAHRPSVFQSPDEDEEEDYEQWLEIKV
  SPPEGAETRKVIEKLARFVAEGGPELEKVAMEDYKDNPAFAFLHDKNSREFLYYRKKVAE
  IRKEAQKSQAASQKVSPPEDEEVKNLAEKLARFIADGGPEVETIALQNNRENQAFSFLYE
  PNSQGYKYYRQKLEEFRKAKASSTGSFTAPDPGLKRKSPPEALSGSLPPATTCPASSTPA
  PTIIPAPAAPGKPASAATVKRKRKSRWGPEEDKVELPPAELVQRDVDASPSPLSVQDLKG
  LGYEKGKPVGLVGVTELSDAQKKQLKEQQEMQQMYDMIMQHKRAMQDMQLLWEKAVQQHQ
  HGYDSDEEVDSELGTWEHQLRRMEMDKTREWAEQLTKMGRGKHFIGDFLPPDELEKFMET
  FKALKEGREPDYSEYKEFKLTVENIGYQMLMKMGWKEGEGLGSEGQGIKNPVNKGTTTVD
  GAGFGIDRPAELSKEDDEYEAFRKRMMLAYRFRPNPLNNPRRPYY

• Sequence length: 645

Pathways

Reactome:

mRNA Splicing - Major Pathway

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557, rs587777558, rs587777559, rs587777560, rs886037778, rs769405762, rs770372675	27790247
Diabetes	Diabetes	rs80356611	27790247
Diabetes mellitus	Diabetes Mellitus, Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	27790247, 30054458, 22885922
Obesity	Obesity	rs74315349, rs1474810899, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs193922650, rs193922685, rs193922687, rs751160202, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829	25246029

Unknown
Disease term	Disease name	Evidence	References	Source
Coronary heart disease	Coronary heart disease		27790247, 21347282	ClinVar
Heart failure	Heart failure		27790247	ClinVar
Non-alcoholic Fatty Liver Disease	Non-alcoholic Fatty Liver Disease			GWAS
Cirrhosis	Cirrhosis			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	33057152
Alzheimer Disease	Associate	33271327
Amyotrophic Lateral Sclerosis	Associate	29134320, 37011198
Arthritis Rheumatoid	Associate	16260763
Breast Neoplasms	Associate	36722268
Burkitt Lymphoma	Associate	9878621
CADASIL	Associate	14714274
Carcinogenesis	Associate	31039132, 32059763, 33287884, 35194031
Carcinoma Hepatocellular	Associate	28231410, 30153342, 33297932, 33524497, 34656649
Carcinoma Squamous Cell	Associate	27186987, 36516959
Cardiovascular Diseases	Associate	35848884
Colorectal Neoplasms	Associate	19734850, 36895014
COVID 19	Associate	33299552
Diabetes Mellitus	Associate	34656649
Fibrosis	Associate	34656649
Glioblastoma	Associate	28035070, 35049227
Glioma	Associate	28035070
Hyperlipidemias	Associate	32568739
Liver Cirrhosis Alcoholic	Associate	34656649
Liver Diseases Alcoholic	Associate	30589442
Lupus Erythematosus Discoid	Associate	34083207
Lupus Erythematosus Systemic	Associate	15880830, 34083207
Lymphoma Large B Cell Diffuse	Associate	33749163
Neoplasm Metastasis	Associate	32879091
Neoplasms	Associate	24410894, 27186987, 27606879, 30153342, 31039132, 32332164, 32728046, 32879091, 33057152, 33297932, 35848884, 36459648, 36681772, 37977822, 39392600, 39511334
Neoplasms	Inhibit	33311452
Neurodegenerative Diseases	Associate	28467899, 30937520
Neurologic Manifestations	Associate	35848884
Neuromuscular Diseases	Associate	37011198
Non alcoholic Fatty Liver Disease	Associate	33105679, 34558842
Osteoarthritis	Associate	36641761
Parkinson Disease	Associate	33271327
Periodontitis	Associate	34285922
Precursor B Cell Lymphoblastic Leukemia Lymphoma	Associate	36875548
Prostatic Neoplasms	Associate	27102850, 32882325
Sarcoma	Associate	28701145
Stomach Neoplasms	Associate	34413861
Triple Negative Breast Neoplasms	Associate	32724453
Urinary Bladder Neoplasms	Associate	39392600
Vision Disorders	Associate	26325091