Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57794
Gene name Gene Name - the full gene name approved by the HGNC.	SURP and G-patch domain containing 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SUGP1
Synonyms (NCBI Gene) Gene synonyms aliases	F23858, RBP, SF4
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.11
Summary Summary of gene provided in NCBI Entrez Gene.	SF4 is a member of the SURP family of splicing factors.[supplied by OMIM, Sep 2003]

Show/Hide all(101)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023869	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT049813	hsa-miR-92a-3p	CLASH	23622248
MIRT696466	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT696465	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT696464	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT696463	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT696462	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT696461	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT696460	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT696459	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT696458	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT696457	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT696456	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT696455	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT696454	hsa-miR-302e	HITS-CLIP	23313552
MIRT696453	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT696452	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT696451	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT696450	hsa-miR-520b	HITS-CLIP	23313552
MIRT696449	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT696448	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT696447	hsa-miR-520e	HITS-CLIP	23313552
MIRT696446	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT696445	hsa-miR-3973	HITS-CLIP	23313552
MIRT696444	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT696443	hsa-miR-520h	HITS-CLIP	23313552
MIRT696442	hsa-miR-212-5p	HITS-CLIP	23313552
MIRT696441	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT696440	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT696439	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT696438	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT696437	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT696436	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT696435	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT696434	hsa-miR-4707-3p	HITS-CLIP	23313552
MIRT696433	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT696432	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT696431	hsa-miR-6744-5p	HITS-CLIP	23313552
MIRT696430	hsa-miR-4757-5p	HITS-CLIP	23313552
MIRT696429	hsa-miR-6744-3p	HITS-CLIP	23313552
MIRT696428	hsa-miR-5187-5p	HITS-CLIP	23313552
MIRT696427	hsa-miR-6878-3p	HITS-CLIP	23313552
MIRT696426	hsa-miR-6728-5p	HITS-CLIP	23313552
MIRT696466	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT696465	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT696464	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT696463	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT696462	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT696461	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT696460	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT696459	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT696458	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT696457	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT696456	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT696455	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT696454	hsa-miR-302e	HITS-CLIP	23313552
MIRT696453	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT696452	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT696451	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT696450	hsa-miR-520b	HITS-CLIP	23313552
MIRT696449	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT696448	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT696447	hsa-miR-520e	HITS-CLIP	23313552
MIRT696446	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT696445	hsa-miR-3973	HITS-CLIP	23313552
MIRT696444	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT696443	hsa-miR-520h	HITS-CLIP	23313552
MIRT696442	hsa-miR-212-5p	HITS-CLIP	23313552
MIRT696441	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT696440	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT696439	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT696438	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT696437	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT696436	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT696435	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT696434	hsa-miR-4707-3p	HITS-CLIP	23313552
MIRT696433	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT696432	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT696431	hsa-miR-6744-5p	HITS-CLIP	23313552
MIRT696430	hsa-miR-4757-5p	HITS-CLIP	23313552
MIRT696429	hsa-miR-6744-3p	HITS-CLIP	23313552
MIRT696428	hsa-miR-5187-5p	HITS-CLIP	23313552
MIRT696427	hsa-miR-6878-3p	HITS-CLIP	23313552
MIRT696426	hsa-miR-6728-5p	HITS-CLIP	23313552
MIRT1402512	hsa-miR-191	CLIP-seq
MIRT1402513	hsa-miR-3177-3p	CLIP-seq
MIRT1402514	hsa-miR-3179	CLIP-seq
MIRT1402515	hsa-miR-3199	CLIP-seq
MIRT1402516	hsa-miR-3202	CLIP-seq
MIRT1402517	hsa-miR-3663-3p	CLIP-seq
MIRT1402518	hsa-miR-3936	CLIP-seq
MIRT1402519	hsa-miR-4504	CLIP-seq
MIRT1402520	hsa-miR-4636	CLIP-seq
MIRT1402521	hsa-miR-4651	CLIP-seq
MIRT1402522	hsa-miR-541	CLIP-seq
MIRT1402523	hsa-miR-549	CLIP-seq
MIRT1402524	hsa-miR-556-3p	CLIP-seq
MIRT1402525	hsa-miR-564	CLIP-seq
MIRT1402526	hsa-miR-602	CLIP-seq
MIRT1402527	hsa-miR-608	CLIP-seq
MIRT1402528	hsa-miR-654-5p	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IEA
GO:0005515	Function	Protein binding	IPI	21988832, 22365833, 35271311, 39251607
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0006396	Process	RNA processing	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA

MIM	HGNC	e!Ensembl
607992	18643	ENSG00000105705

Protein

UniProt ID

Q8IWZ8

Protein name

SURP and G-patch domain-containing protein 1 (RNA-binding protein RBP) (Splicing factor 4)

Protein function

Plays a role in pre-mRNA splicing.

PDB

8EJM , 8GXL , 8GXM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01805	Surp	189 → 241	Surp module	Family
PF01805	Surp	264 → 316	Surp module	Family
PF01585	G-patch	562 → 607	G-patch domain	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in adult testis and heart, and in adult and fetal brain, kidney and skeletal muscle. {ECO:0000269|PubMed:12594045}.

Sequence

MSLKMDNRDVAGKANRWFGVAPPKSGKMNMNILHQEELIAQKKREIEAKMEQKAKQNQVA
SPQPPHPGEITNAHNSSCISNKFANDGSFLQQFLKLQKAQTSTDAPTSAPSAPPSTPTPS
AGKRSLLISRRTGLGLASLPGPVKSYSHAKQLPVAHRPSVFQSPDEDEEEDYEQWLEIKV
SPPEGAETRKVIEKLARFVAEGGPELEKVAMEDYKDNPAFAFLHDKNSREFLYYRKKVAE
IRKEAQKSQAASQKVSPPEDEEVKNLAEKLARFIADGGPEVETIALQNNRENQAFSFLYE
PNSQGYKYYRQKLEEFRKAKASSTGSFTAPDPGLKRKSPPEALSGSLPPATTCPASSTPA
PTIIPAPAAPGKPASAATVKRKRKSRWGPEEDKVELPPAELVQRDVDASPSPLSVQDLKG
LGYEKGKPVGLVGVTELSDAQKKQLKEQQEMQQMYDMIMQHKRAMQDMQLLWEKAVQQHQ
HGYDSDEEVDSELGTWEHQLRRMEMDKTREWAEQLTKMGRGKHFIGDFLPPDELEKFMET
FKALKEGREPDYSEYKEFKLTVENIGYQMLMKMGWKEGEGLGSEGQGIKNPVNKGTTTVD
GAGFGIDRPAELSKEDDEYEAFRKRMMLAYRFRPNPLNNPRRPYY

Sequence length

645

Interactions

View interactions

	Reactome
			mRNA Splicing - Major Pathway

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Cirrhosis	Cirrhosis	N/A	N/A	GWAS
Diabetes	Type 2 diabetes with ophthalmic manifestations (PheCode 250.23), Type 2 diabetes, Type 2 diabetes (PheCode 250.2), Type 2 diabetes mellitus or coronary artery disease (pleiotropy)	N/A	N/A	GWAS
Non-alcoholic Fatty Liver Disease	Nonalcoholic steatohepatitis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (40)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	33057152
Alzheimer Disease	Associate	33271327
Amyotrophic Lateral Sclerosis	Associate	29134320, 37011198
Arthritis Rheumatoid	Associate	16260763
Breast Neoplasms	Associate	36722268
Burkitt Lymphoma	Associate	9878621
CADASIL	Associate	14714274
Carcinogenesis	Associate	31039132, 32059763, 33287884, 35194031
Carcinoma Hepatocellular	Associate	28231410, 30153342, 33297932, 33524497, 34656649
Carcinoma Squamous Cell	Associate	27186987, 36516959
Cardiovascular Diseases	Associate	35848884
Colorectal Neoplasms	Associate	19734850, 36895014
COVID 19	Associate	33299552
Diabetes Mellitus	Associate	34656649
Fibrosis	Associate	34656649
Glioblastoma	Associate	28035070, 35049227
Glioma	Associate	28035070
Hyperlipidemias	Associate	32568739
Liver Cirrhosis Alcoholic	Associate	34656649
Liver Diseases Alcoholic	Associate	30589442
Lupus Erythematosus Discoid	Associate	34083207
Lupus Erythematosus Systemic	Associate	15880830, 34083207
Lymphoma Large B Cell Diffuse	Associate	33749163
Neoplasm Metastasis	Associate	32879091
Neoplasms	Associate	24410894, 27186987, 27606879, 30153342, 31039132, 32332164, 32728046, 32879091, 33057152, 33297932, 35848884, 36459648, 36681772, 37977822, 39392600, 39511334 View all (1 more)
Neoplasms	Inhibit	33311452
Neurodegenerative Diseases	Associate	28467899, 30937520
Neurologic Manifestations	Associate	35848884
Neuromuscular Diseases	Associate	37011198
Non alcoholic Fatty Liver Disease	Associate	33105679, 34558842
Osteoarthritis	Associate	36641761
Parkinson Disease	Associate	33271327
Periodontitis	Associate	34285922
Precursor B Cell Lymphoblastic Leukemia Lymphoma	Associate	36875548
Prostatic Neoplasms	Associate	27102850, 32882325
Sarcoma	Associate	28701145
Stomach Neoplasms	Associate	34413861
Triple Negative Breast Neoplasms	Associate	32724453
Urinary Bladder Neoplasms	Associate	39392600
Vision Disorders	Associate	26325091

SUGP1 (SURP and G-patch domain containing 1)