Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57761
Gene name Gene Name - the full gene name approved by the HGNC.	Tribbles pseudokinase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TRIB3
Synonyms (NCBI Gene) Gene synonyms aliases	C20orf97, NIPK, SINK, SKIP3, TRB3
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20p13
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, th

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miRTarBase ID	miRNA	Experiments	Reference
MIRT003354	hsa-miR-24-3p	qRT-PCR, Western blot	20019669
MIRT019155	hsa-miR-335-5p	Microarray	18185580
MIRT023198	hsa-miR-124-3p	Microarray	18668037
MIRT024900	hsa-miR-215-5p	Microarray	19074876
MIRT026958	hsa-miR-192-5p	Microarray	19074876
MIRT030272	hsa-miR-26b-5p	Microarray	19088304
MIRT003354	hsa-miR-24-3p	Microarray	19748357
MIRT049873	hsa-miR-31-5p	CLASH	23622248
MIRT438742	hsa-miR-219a-5p	qRT-PCR	24974767
MIRT438742	hsa-miR-219a-5p	qRT-PCR	24974767
MIRT438129	hsa-miR-96-5p	Immunoblot, Luciferase reporter assay, qRT-PCR	24375867
MIRT438129	hsa-miR-96-5p	Immunoblot, Luciferase reporter assay, qRT-PCR	24375867
MIRT438742	hsa-miR-219a-5p	qRT-PCR	24974767
MIRT438742	hsa-miR-219a-5p	qRT-PCR	24974767
MIRT438129	hsa-miR-96-5p	Immunoblot, Luciferase reporter assay, qRT-PCR	24375867
MIRT438129	hsa-miR-96-5p	Immunoblot, Luciferase reporter assay, qRT-PCR	24375867
MIRT023198	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT465294	hsa-miR-4464	PAR-CLIP	20371350
MIRT465293	hsa-miR-4748	PAR-CLIP	20371350
MIRT561426	hsa-miR-1237-3p	PAR-CLIP	20371350
MIRT561425	hsa-miR-875-3p	PAR-CLIP	20371350
MIRT561424	hsa-miR-6128	PAR-CLIP	20371350
MIRT370117	hsa-miR-605-3p	PAR-CLIP	20371350
MIRT465287	hsa-miR-493-3p	PAR-CLIP	20371350
MIRT561423	hsa-miR-4533	PAR-CLIP	20371350
MIRT561422	hsa-miR-3202	PAR-CLIP	20371350
MIRT465286	hsa-miR-4284	PAR-CLIP	20371350
MIRT003354	hsa-miR-24-3p	PAR-CLIP	20371350
MIRT561421	hsa-miR-1299	PAR-CLIP	20371350
MIRT561420	hsa-miR-516b-5p	PAR-CLIP	20371350
MIRT561419	hsa-miR-4782-5p	PAR-CLIP	20371350
MIRT561418	hsa-miR-5706	PAR-CLIP	20371350
MIRT465285	hsa-miR-8057	PAR-CLIP	20371350
MIRT023198	hsa-miR-124-3p	PAR-CLIP	23592263
MIRT370131	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT370133	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT370119	hsa-miR-940	PAR-CLIP	23592263
MIRT465294	hsa-miR-4464	PAR-CLIP	23592263
MIRT465293	hsa-miR-4748	PAR-CLIP	23592263
MIRT465292	hsa-miR-5000-5p	PAR-CLIP	23592263
MIRT465291	hsa-miR-6847-5p	PAR-CLIP	23592263
MIRT465290	hsa-miR-4257	PAR-CLIP	23592263
MIRT370126	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT465289	hsa-miR-584-3p	PAR-CLIP	23592263
MIRT465288	hsa-miR-4277	PAR-CLIP	23592263
MIRT465287	hsa-miR-493-3p	PAR-CLIP	23592263
MIRT370129	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT370120	hsa-miR-1827	PAR-CLIP	23592263
MIRT370125	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT370121	hsa-miR-4434	PAR-CLIP	23592263
MIRT370123	hsa-miR-4516	PAR-CLIP	23592263
MIRT370127	hsa-miR-5703	PAR-CLIP	23592263
MIRT465286	hsa-miR-4284	PAR-CLIP	23592263
MIRT003354	hsa-miR-24-3p	PAR-CLIP	23592263
MIRT465285	hsa-miR-8057	PAR-CLIP	23592263
MIRT023198	hsa-miR-124-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blot	27845424
MIRT023198	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT465294	hsa-miR-4464	PAR-CLIP	20371350
MIRT465293	hsa-miR-4748	PAR-CLIP	20371350
MIRT561426	hsa-miR-1237-3p	PAR-CLIP	20371350
MIRT561425	hsa-miR-875-3p	PAR-CLIP	20371350
MIRT561424	hsa-miR-6128	PAR-CLIP	20371350
MIRT370117	hsa-miR-605-3p	PAR-CLIP	20371350
MIRT465287	hsa-miR-493-3p	PAR-CLIP	20371350
MIRT561423	hsa-miR-4533	PAR-CLIP	20371350
MIRT561422	hsa-miR-3202	PAR-CLIP	20371350
MIRT465286	hsa-miR-4284	PAR-CLIP	20371350
MIRT003354	hsa-miR-24-3p	PAR-CLIP	20371350
MIRT561421	hsa-miR-1299	PAR-CLIP	20371350
MIRT561420	hsa-miR-516b-5p	PAR-CLIP	20371350
MIRT561419	hsa-miR-4782-5p	PAR-CLIP	20371350
MIRT561418	hsa-miR-5706	PAR-CLIP	20371350
MIRT465285	hsa-miR-8057	PAR-CLIP	20371350
MIRT023198	hsa-miR-124-3p	PAR-CLIP	23592263
MIRT370131	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT370133	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT370119	hsa-miR-940	PAR-CLIP	23592263
MIRT465294	hsa-miR-4464	PAR-CLIP	23592263
MIRT465293	hsa-miR-4748	PAR-CLIP	23592263
MIRT465292	hsa-miR-5000-5p	PAR-CLIP	23592263
MIRT465291	hsa-miR-6847-5p	PAR-CLIP	23592263
MIRT465290	hsa-miR-4257	PAR-CLIP	23592263
MIRT370126	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT465289	hsa-miR-584-3p	PAR-CLIP	23592263
MIRT465288	hsa-miR-4277	PAR-CLIP	23592263
MIRT465287	hsa-miR-493-3p	PAR-CLIP	23592263
MIRT370129	hsa-miR-6770-5p	PAR-CLIP	23592263
MIRT370120	hsa-miR-1827	PAR-CLIP	23592263
MIRT370125	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT370121	hsa-miR-4434	PAR-CLIP	23592263
MIRT370123	hsa-miR-4516	PAR-CLIP	23592263
MIRT370127	hsa-miR-5703	PAR-CLIP	23592263
MIRT465286	hsa-miR-4284	PAR-CLIP	23592263
MIRT003354	hsa-miR-24-3p	PAR-CLIP	23592263
MIRT465285	hsa-miR-8057	PAR-CLIP	23592263
MIRT1452813	hsa-miR-1237	CLIP-seq
MIRT1452814	hsa-miR-124	CLIP-seq
MIRT1452815	hsa-miR-1245b-5p	CLIP-seq
MIRT1452816	hsa-miR-1254	CLIP-seq
MIRT1452817	hsa-miR-1271	CLIP-seq
MIRT1452818	hsa-miR-1295	CLIP-seq
MIRT1452819	hsa-miR-132	CLIP-seq
MIRT1452820	hsa-miR-182	CLIP-seq
MIRT1452821	hsa-miR-204	CLIP-seq
MIRT1452822	hsa-miR-211	CLIP-seq
MIRT1452823	hsa-miR-212	CLIP-seq
MIRT1452824	hsa-miR-216b	CLIP-seq
MIRT1452825	hsa-miR-30a	CLIP-seq
MIRT1452826	hsa-miR-30b	CLIP-seq
MIRT1452827	hsa-miR-30c	CLIP-seq
MIRT1452828	hsa-miR-30d	CLIP-seq
MIRT1452829	hsa-miR-30e	CLIP-seq
MIRT1452830	hsa-miR-3116	CLIP-seq
MIRT1452831	hsa-miR-3142	CLIP-seq
MIRT1452832	hsa-miR-3180-5p	CLIP-seq
MIRT1452833	hsa-miR-3189-5p	CLIP-seq
MIRT1452834	hsa-miR-3612	CLIP-seq
MIRT1452835	hsa-miR-3622a-5p	CLIP-seq
MIRT1452836	hsa-miR-3907	CLIP-seq
MIRT1452837	hsa-miR-3921	CLIP-seq
MIRT1452838	hsa-miR-4287	CLIP-seq
MIRT1452839	hsa-miR-4323	CLIP-seq
MIRT1452840	hsa-miR-4423-3p	CLIP-seq
MIRT1452841	hsa-miR-4424	CLIP-seq
MIRT1452842	hsa-miR-4428	CLIP-seq
MIRT1452843	hsa-miR-4443	CLIP-seq
MIRT1452844	hsa-miR-4469	CLIP-seq
MIRT1452845	hsa-miR-4653-5p	CLIP-seq
MIRT1452846	hsa-miR-4685-3p	CLIP-seq
MIRT1452847	hsa-miR-4711-5p	CLIP-seq
MIRT1452848	hsa-miR-4768-5p	CLIP-seq
MIRT1452849	hsa-miR-4773	CLIP-seq
MIRT1452850	hsa-miR-493	CLIP-seq
MIRT1452851	hsa-miR-506	CLIP-seq
MIRT1452852	hsa-miR-516b	CLIP-seq
MIRT1452853	hsa-miR-520a-5p	CLIP-seq
MIRT1452854	hsa-miR-525-5p	CLIP-seq
MIRT1452855	hsa-miR-526b	CLIP-seq
MIRT1452856	hsa-miR-650	CLIP-seq
MIRT1452857	hsa-miR-875-5p	CLIP-seq
MIRT1452858	hsa-miR-96	CLIP-seq
MIRT2135614	hsa-miR-1178	CLIP-seq
MIRT1452815	hsa-miR-1245b-5p	CLIP-seq
MIRT1452816	hsa-miR-1254	CLIP-seq
MIRT1452817	hsa-miR-1271	CLIP-seq
MIRT1452818	hsa-miR-1295	CLIP-seq
MIRT2135615	hsa-miR-147	CLIP-seq
MIRT1452824	hsa-miR-216b	CLIP-seq
MIRT2135616	hsa-miR-217	CLIP-seq
MIRT2135617	hsa-miR-219-1-3p	CLIP-seq
MIRT2135618	hsa-miR-3065-3p	CLIP-seq
MIRT1452825	hsa-miR-30a	CLIP-seq
MIRT1452826	hsa-miR-30b	CLIP-seq
MIRT1452827	hsa-miR-30c	CLIP-seq
MIRT1452828	hsa-miR-30d	CLIP-seq
MIRT1452829	hsa-miR-30e	CLIP-seq
MIRT1452830	hsa-miR-3116	CLIP-seq
MIRT2135619	hsa-miR-3121-5p	CLIP-seq
MIRT1452831	hsa-miR-3142	CLIP-seq
MIRT2135620	hsa-miR-3190	CLIP-seq
MIRT2135621	hsa-miR-330-3p	CLIP-seq
MIRT1452835	hsa-miR-3622a-5p	CLIP-seq
MIRT2135622	hsa-miR-3911	CLIP-seq
MIRT2135623	hsa-miR-4279	CLIP-seq
MIRT2135624	hsa-miR-4421	CLIP-seq
MIRT1452840	hsa-miR-4423-3p	CLIP-seq
MIRT1452842	hsa-miR-4428	CLIP-seq
MIRT2135625	hsa-miR-4468	CLIP-seq
MIRT2135626	hsa-miR-4677-3p	CLIP-seq
MIRT2135627	hsa-miR-4679	CLIP-seq
MIRT2135628	hsa-miR-4682	CLIP-seq
MIRT2135629	hsa-miR-4718	CLIP-seq
MIRT2135630	hsa-miR-4725-5p	CLIP-seq
MIRT2135631	hsa-miR-500a	CLIP-seq
MIRT2135632	hsa-miR-504	CLIP-seq
MIRT2135633	hsa-miR-571	CLIP-seq
MIRT2135634	hsa-miR-576-3p	CLIP-seq
MIRT2135635	hsa-miR-644	CLIP-seq
MIRT2135636	hsa-miR-873	CLIP-seq
MIRT1452858	hsa-miR-96	CLIP-seq
MIRT2135614	hsa-miR-1178	CLIP-seq
MIRT1452813	hsa-miR-1237	CLIP-seq
MIRT1452814	hsa-miR-124	CLIP-seq
MIRT1452816	hsa-miR-1254	CLIP-seq
MIRT1452817	hsa-miR-1271	CLIP-seq
MIRT1452819	hsa-miR-132	CLIP-seq
MIRT1452823	hsa-miR-212	CLIP-seq
MIRT2356752	hsa-miR-2355-5p	CLIP-seq
MIRT2356753	hsa-miR-24	CLIP-seq
MIRT2135618	hsa-miR-3065-3p	CLIP-seq
MIRT1452825	hsa-miR-30a	CLIP-seq
MIRT1452826	hsa-miR-30b	CLIP-seq
MIRT1452827	hsa-miR-30c	CLIP-seq
MIRT1452828	hsa-miR-30d	CLIP-seq
MIRT1452829	hsa-miR-30e	CLIP-seq
MIRT1452830	hsa-miR-3116	CLIP-seq
MIRT2135619	hsa-miR-3121-5p	CLIP-seq
MIRT2356754	hsa-miR-3158-3p	CLIP-seq
MIRT2356755	hsa-miR-3161	CLIP-seq
MIRT2356756	hsa-miR-3177-5p	CLIP-seq
MIRT2356757	hsa-miR-3622a-3p	CLIP-seq
MIRT1452835	hsa-miR-3622a-5p	CLIP-seq
MIRT2356758	hsa-miR-3622b-3p	CLIP-seq
MIRT2356759	hsa-miR-3657	CLIP-seq
MIRT2356760	hsa-miR-3690	CLIP-seq
MIRT1452838	hsa-miR-4287	CLIP-seq
MIRT1452840	hsa-miR-4423-3p	CLIP-seq
MIRT1452841	hsa-miR-4424	CLIP-seq
MIRT2135625	hsa-miR-4468	CLIP-seq
MIRT1452844	hsa-miR-4469	CLIP-seq
MIRT2356761	hsa-miR-4511	CLIP-seq
MIRT2356762	hsa-miR-4523	CLIP-seq
MIRT2356763	hsa-miR-4650-5p	CLIP-seq
MIRT2356764	hsa-miR-4672	CLIP-seq
MIRT2135626	hsa-miR-4677-3p	CLIP-seq
MIRT2135627	hsa-miR-4679	CLIP-seq
MIRT1452846	hsa-miR-4685-3p	CLIP-seq
MIRT2356765	hsa-miR-4713-5p	CLIP-seq
MIRT2356766	hsa-miR-4727-5p	CLIP-seq
MIRT1452849	hsa-miR-4773	CLIP-seq
MIRT1452850	hsa-miR-493	CLIP-seq
MIRT1452851	hsa-miR-506	CLIP-seq
MIRT1452852	hsa-miR-516b	CLIP-seq
MIRT1452855	hsa-miR-526b	CLIP-seq
MIRT2135634	hsa-miR-576-3p	CLIP-seq
MIRT2356767	hsa-miR-711	CLIP-seq
MIRT1452858	hsa-miR-96	CLIP-seq
MIRT2396340	hsa-miR-3136-3p	CLIP-seq
MIRT2396341	hsa-miR-605	CLIP-seq
MIRT1452814	hsa-miR-124	CLIP-seq
MIRT2356753	hsa-miR-24	CLIP-seq
MIRT1452850	hsa-miR-493	CLIP-seq
MIRT1452851	hsa-miR-506	CLIP-seq
MIRT2462315	hsa-miR-1912	CLIP-seq
MIRT2462316	hsa-miR-199a-5p	CLIP-seq
MIRT2462317	hsa-miR-199b-5p	CLIP-seq
MIRT2462318	hsa-miR-3130-5p	CLIP-seq
MIRT2462319	hsa-miR-4280	CLIP-seq
MIRT2462320	hsa-miR-4482	CLIP-seq
MIRT2462321	hsa-miR-520d-5p	CLIP-seq
MIRT2462322	hsa-miR-520g	CLIP-seq
MIRT2462323	hsa-miR-520h	CLIP-seq
MIRT2462324	hsa-miR-524-5p	CLIP-seq
MIRT1452816	hsa-miR-1254	CLIP-seq
MIRT1452821	hsa-miR-204	CLIP-seq
MIRT1452822	hsa-miR-211	CLIP-seq
MIRT1452830	hsa-miR-3116	CLIP-seq
MIRT1452832	hsa-miR-3180-5p	CLIP-seq
MIRT1452833	hsa-miR-3189-5p	CLIP-seq
MIRT2356760	hsa-miR-3690	CLIP-seq
MIRT1452836	hsa-miR-3907	CLIP-seq
MIRT1452837	hsa-miR-3921	CLIP-seq
MIRT1452838	hsa-miR-4287	CLIP-seq
MIRT1452839	hsa-miR-4323	CLIP-seq
MIRT2135624	hsa-miR-4421	CLIP-seq
MIRT2356763	hsa-miR-4650-5p	CLIP-seq
MIRT1452845	hsa-miR-4653-5p	CLIP-seq
MIRT1452846	hsa-miR-4685-3p	CLIP-seq
MIRT2650245	hsa-miR-4714-3p	CLIP-seq
MIRT2135630	hsa-miR-4725-5p	CLIP-seq
MIRT2650246	hsa-miR-4766-5p	CLIP-seq
MIRT1452848	hsa-miR-4768-5p	CLIP-seq
MIRT1452849	hsa-miR-4773	CLIP-seq
MIRT2135631	hsa-miR-500a	CLIP-seq
MIRT2135632	hsa-miR-504	CLIP-seq
MIRT1452853	hsa-miR-520a-5p	CLIP-seq
MIRT1452854	hsa-miR-525-5p	CLIP-seq
MIRT2650247	hsa-miR-563	CLIP-seq
MIRT2356767	hsa-miR-711	CLIP-seq
MIRT1452857	hsa-miR-875-5p	CLIP-seq
MIRT2694109	hsa-miR-1207-3p	CLIP-seq
MIRT1452816	hsa-miR-1254	CLIP-seq
MIRT1452819	hsa-miR-132	CLIP-seq
MIRT1452821	hsa-miR-204	CLIP-seq
MIRT1452822	hsa-miR-211	CLIP-seq
MIRT1452823	hsa-miR-212	CLIP-seq
MIRT1452830	hsa-miR-3116	CLIP-seq
MIRT1452832	hsa-miR-3180-5p	CLIP-seq
MIRT1452833	hsa-miR-3189-5p	CLIP-seq
MIRT2356760	hsa-miR-3690	CLIP-seq
MIRT2694110	hsa-miR-3714	CLIP-seq
MIRT1452836	hsa-miR-3907	CLIP-seq
MIRT1452837	hsa-miR-3921	CLIP-seq
MIRT1452838	hsa-miR-4287	CLIP-seq
MIRT2694111	hsa-miR-4320	CLIP-seq
MIRT1452839	hsa-miR-4323	CLIP-seq
MIRT2135624	hsa-miR-4421	CLIP-seq
MIRT1452841	hsa-miR-4424	CLIP-seq
MIRT2356761	hsa-miR-4511	CLIP-seq
MIRT2356763	hsa-miR-4650-5p	CLIP-seq
MIRT1452845	hsa-miR-4653-5p	CLIP-seq
MIRT1452846	hsa-miR-4685-3p	CLIP-seq
MIRT2650245	hsa-miR-4714-3p	CLIP-seq
MIRT2135630	hsa-miR-4725-5p	CLIP-seq
MIRT2650246	hsa-miR-4766-5p	CLIP-seq
MIRT1452848	hsa-miR-4768-5p	CLIP-seq
MIRT1452849	hsa-miR-4773	CLIP-seq
MIRT2135631	hsa-miR-500a	CLIP-seq
MIRT2135632	hsa-miR-504	CLIP-seq
MIRT1452853	hsa-miR-520a-5p	CLIP-seq
MIRT2462321	hsa-miR-520d-5p	CLIP-seq
MIRT2462324	hsa-miR-524-5p	CLIP-seq
MIRT1452854	hsa-miR-525-5p	CLIP-seq
MIRT1452855	hsa-miR-526b	CLIP-seq
MIRT2694112	hsa-miR-548an	CLIP-seq
MIRT2694113	hsa-miR-548m	CLIP-seq
MIRT2650247	hsa-miR-563	CLIP-seq
MIRT2356767	hsa-miR-711	CLIP-seq
MIRT1452857	hsa-miR-875-5p	CLIP-seq

Transcription factors

Show/Hide all(4)

Transcription factor	Regulation	Reference
ATF4	Activation	15775988
ATF4	Unknown	20592469;21220698
DDIT3	Activation	15775988;18940792
RELA	Repression	12736262

Show/Hide all(34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	15775988
GO:0003714	Function	Transcription corepressor activity	ISS
GO:0004860	Function	Protein kinase inhibitor activity	IEA
GO:0005515	Function	Protein binding	IPI	12743605, 15775988, 16147992, 17872950, 23455924, 25416956, 25910212, 32296183, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006468	Process	Protein phosphorylation	IEA
GO:0006469	Process	Negative regulation of protein kinase activity	IDA	12791994
GO:0010506	Process	Regulation of autophagy	ISS
GO:0010827	Process	Regulation of glucose transmembrane transport	ISS	12791994
GO:0016301	Function	Kinase activity	IDA	12743605
GO:0019216	Process	Regulation of lipid metabolic process	TAS
GO:0019901	Function	Protein kinase binding	IPI	12791994, 15299019
GO:0019901	Function	Protein kinase binding	ISS
GO:0031434	Function	Mitogen-activated protein kinase kinase binding	IBA	21873635
GO:0031625	Function	Ubiquitin protein ligase binding	ISS	16794074
GO:0032092	Process	Positive regulation of protein binding	ISS	16794074
GO:0032436	Process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA	21873635
GO:0032869	Process	Cellular response to insulin stimulus	ISS	12791994
GO:0034976	Process	Response to endoplasmic reticulum stress	IDA	15775988
GO:0043405	Process	Regulation of MAP kinase activity	IBA	21873635
GO:0043405	Process	Regulation of MAP kinase activity	IDA	15299019
GO:0045599	Process	Negative regulation of fat cell differentiation	ISS	17576771
GO:0045717	Process	Negative regulation of fatty acid biosynthetic process	ISS	16794074
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IMP	15775988
GO:0051443	Process	Positive regulation of ubiquitin-protein transferase activity	ISS	16794074
GO:0051898	Process	Negative regulation of protein kinase B signaling	TAS
GO:0055106	Function	Ubiquitin-protein transferase regulator activity	ISS	20410507
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA	15775988
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	TAS	22934019

MIM	HGNC	e!Ensembl
607898	16228	ENSG00000101255

Protein

UniProt ID

Q96RU7

Protein name

Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (SINK) (p65-interacting inhibitor of NF-kappa-B)

Protein function

Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (PubMed:15775988, PubMed:15781252). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	78 → 315	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other exam

Sequence

MRATPLAAPAGSLSRKKRLELDDNLDTERPVQKRARSGPQPRLPPCLLPLSPPTAPDRAT
AVATASRLGPYVLLEPEEGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHV
ARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVL
RDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGK
AADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREP
AERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVVPDGLGLDEAREEEGDREVVLYG

Sequence length

358

Interactions

View interactions

	KEGG		Reactome
	Insulin resistance		PIP3 activates AKT signaling Activation of AKT2 PPARA activates gene expression Negative regulation of the PI3K/AKT network CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Glioblastoma	Glioblastoma Multiforme	rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888
Metabolic syndrome	Metabolic Syndrome X	rs367643250, rs587777380, rs777736953	18497449

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Myopathy	cardiomyopathy			GenCC

Show/Hide Text Mining Associations (67)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	29511103
Arthritis Psoriatic	Stimulate	28790132
Atherosclerosis	Associate	26253791, 34051802
Breast Neoplasms	Associate	21704407, 23185332, 23558942, 30763339, 36142452
Carcinoma Hepatocellular	Associate	32160655
Carcinoma Renal Cell	Associate	33896816, 35726370, 37153569, 37189176, 38006403
Cardiomyopathy Dilated	Associate	35728000
Carotid Artery Diseases	Associate	19389818
Chromosomal Instability	Stimulate	38254916
Colorectal Neoplasms	Associate	19904274, 28105922
Coronary Artery Disease	Associate	26253791, 35152560
COVID 19	Associate	36379381
Diabetes Mellitus	Associate	26253791, 35465829
Diabetes Mellitus Type 2	Associate	18984671, 20393693, 23633196, 25463099, 26253791
Diffuse Cerebral Sclerosis of Schilder	Associate	29511103
Endometrial Neoplasms	Associate	37285895, 37880674
Fibrosis	Associate	35776529, 36555349
Glioma	Associate	33896816
Glucose Intolerance	Associate	20393693
Glucose Metabolism Disorders	Associate	23633196
Hepatitis C	Associate	27252525
Hypertension	Associate	27400471
Hypertriglyceridemia	Associate	19389818
Hypoglycemia	Associate	23633196
Hypoxia	Associate	21704407
Hypoxia	Inhibit	23185332
Hypoxia	Stimulate	23558942
Hypoxia Brain	Associate	21704407, 23558942
Hypoxia Brain	Stimulate	23185332
Idiopathic Pulmonary Fibrosis	Inhibit	36555349
Insulin Resistance	Associate	19389818, 21492415, 24414038, 25463099, 26253791, 34051802
Leukemia	Associate	32621919
Leukemia Myeloid Acute	Associate	32621919
Leukemia Promyelocytic Acute	Associate	28486101, 33896816
Lung Diseases	Associate	36555349
Lung Neoplasms	Associate	35717579
Lymphoma Large B Cell Diffuse	Associate	37626099
Melanoma	Associate	17912026
Mesothelioma Malignant	Associate	29748013
Metabolic Diseases	Associate	28790132
Metabolic Syndrome	Associate	19389818
Microphthalmia Syndromic 10	Associate	29511103
Mitochondrial Myopathies	Stimulate	35850946
Neoplasm Metastasis	Associate	17912026, 36142452
Neoplasm Metastasis	Stimulate	35726370
Neoplasms	Associate	17912026, 28790132, 29757932, 31578236, 32397857, 32621919, 34580365, 35726370, 36008442, 36142452, 38235126
Neurodegenerative Diseases	Associate	29511103
Obesity	Associate	21492415
Obesity Abdominal	Associate	19389818
Obesity Maternal	Associate	30006153
Osteoarthritis	Stimulate	19180501
Osteoarthritis	Associate	35776529
Polycystic Ovary Syndrome	Associate	21492415
Postthrombotic Syndrome	Associate	27400471
Prostatic Neoplasms	Associate	17912026
Psoriasis	Stimulate	28790132
Pulmonary Fibrosis	Inhibit	36555349
Retinal Detachment	Associate	35465829
Retinoblastoma	Associate	33896816
Squamous Cell Carcinoma of Head and Neck	Associate	34580365
Squamous Cell Carcinoma of Head and Neck	Stimulate	38235126
Urinary Bladder Neoplasms	Associate	38307969
Varicose Ulcer	Associate	27400471
Vascular Diseases	Associate	26253791, 30006153
Ventricular Dysfunction Left	Associate	34051802
Virus Diseases	Associate	27252525
Wolfram Like Syndrome Autosomal Dominant	Associate	20393693

TRIB3 (tribbles pseudokinase 3)