Gene Gene information from NCBI Gene database.
Entrez ID 5774
Gene name Protein tyrosine phosphatase non-receptor type 3
Gene symbol PTPN3
Synonyms (NCBI Gene)
PTP-H1PTPH1
Chromosome 9
Chromosome location 9q31.3
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran
miRNA miRNA information provided by mirtarbase database.
718
miRTarBase ID miRNA Experiments Reference
MIRT027192 hsa-miR-103a-3p Sequencing 20371350
MIRT031028 hsa-miR-21-5p Microarray 18591254
MIRT032073 hsa-miR-16-5p Sequencing 20371350
MIRT612632 hsa-miR-4731-3p HITS-CLIP 23313552
MIRT612631 hsa-miR-4801 HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
28
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS
GO:0001784 Function Phosphotyrosine residue binding IPI 10364224
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004725 Function Protein tyrosine phosphatase activity IBA
GO:0004725 Function Protein tyrosine phosphatase activity IDA 10364224, 19167335
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
176877 9655 ENSG00000070159
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P26045
Protein name Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1)
Protein function May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
PDB 2B49 , 4QUM , 4QUN , 4RH5 , 4RH9 , 4RHG , 4RI4 , 4RI5 , 4S0G , 6HKS , 6T36 , 8CQY , 8OEP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09379 FERM_N 33 97 FERM N-terminal domain Domain
PF00373 FERM_M 113 222 FERM central domain Domain
PF09380 FERM_C 226 316 FERM C-terminal PH-like domain Domain
PF00595 PDZ 510 595 PDZ domain Domain
PF00102 Y_phosphatase 670 900 Protein-tyrosine phosphatase Domain
Sequence
MTSRLRALGGRINNIRTSELPKEKTRSEVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHN
HLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKG
GFPCTLHFRVRFFIPDPNTLQQE
QTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ
NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELH
SGRDLHNLDLMIGIASAG
VAVYRKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKS
CVEHHTFFQAKKLLPQ
EKNVLSQYWTMGSRNTKKSVNNQYCKKVIGGMVWNPAMRRSLSV
EHLETKSLPSRSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSL
APQDSDSEVSQNRSPHQESLSENNPAQSYLTQKSSSSVSPSSNAPGSCSPDGVDQQLLDD
FHRVTKGGSTEDASQYYCDKNDNGDSYLVLIRITPDEDGKFGFNLKGGVDQKMPLVVSRI
NPESPADTCIPKLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIR
RRAVR
SFADFKSEDELNQLFPEAIFPMCPEGGDTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGL
AITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGP
LPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCT
IAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLV
HCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR

VYEEGLVQMLDPS
Sequence length 913
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    EGFR downregulation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Prostate cancer Uncertain significance rs193920798 RCV000149070
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Stimulate 21119599
Breast Neoplasms Associate 38173048
Carcinoma Basal Cell Associate 32382535
Carcinoma Renal Cell Associate 38173048
Cholangiocarcinoma Associate 30348936
Colorectal Neoplasms Associate 16619586, 17166906, 20332238, 31350343
Glioblastoma Associate 30348936
Glioma Associate 27735041
Lung Neoplasms Associate 30348936, 38173048
Neoplasm Metastasis Stimulate 21119599