Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57719
Gene name Gene Name - the full gene name approved by the HGNC.	Anoctamin 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ANO8
Synonyms (NCBI Gene) Gene synonyms aliases	KIAA1623, TMEM16H
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.11

Show/Hide all(87)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028358	hsa-miR-32-5p	Sequencing	20371350
MIRT627119	hsa-miR-1267	HITS-CLIP	23824327
MIRT627118	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT627114	hsa-miR-4455	HITS-CLIP	23824327
MIRT627113	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT627119	hsa-miR-1267	HITS-CLIP	23824327
MIRT627118	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT627114	hsa-miR-4455	HITS-CLIP	23824327
MIRT627113	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT627119	hsa-miR-1267	HITS-CLIP	27418678
MIRT627119	hsa-miR-1267	HITS-CLIP	27418678
MIRT627119	hsa-miR-1267	HITS-CLIP	27418678
MIRT627119	hsa-miR-1267	HITS-CLIP	27418678
MIRT627118	hsa-miR-367-5p	HITS-CLIP	27418678
MIRT627118	hsa-miR-367-5p	HITS-CLIP	27418678
MIRT627118	hsa-miR-367-5p	HITS-CLIP	27418678
MIRT627118	hsa-miR-367-5p	HITS-CLIP	27418678
MIRT627114	hsa-miR-4455	HITS-CLIP	27418678
MIRT627114	hsa-miR-4455	HITS-CLIP	27418678
MIRT627114	hsa-miR-4455	HITS-CLIP	27418678
MIRT627114	hsa-miR-4455	HITS-CLIP	27418678
MIRT627114	hsa-miR-4455	HITS-CLIP	27418678
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627113	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627113	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627113	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627113	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627113	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627119	hsa-miR-1267	HITS-CLIP	23824327
MIRT627118	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT627114	hsa-miR-4455	HITS-CLIP	23824327
MIRT627113	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT627119	hsa-miR-1267	HITS-CLIP	23824327
MIRT627118	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT627114	hsa-miR-4455	HITS-CLIP	23824327
MIRT627113	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT785886	hsa-miR-1253	CLIP-seq
MIRT785887	hsa-miR-1257	CLIP-seq
MIRT785888	hsa-miR-137	CLIP-seq
MIRT785889	hsa-miR-153	CLIP-seq
MIRT785890	hsa-miR-25	CLIP-seq
MIRT785891	hsa-miR-3145-3p	CLIP-seq
MIRT785892	hsa-miR-32	CLIP-seq
MIRT785893	hsa-miR-33a	CLIP-seq
MIRT785894	hsa-miR-33b	CLIP-seq
MIRT785895	hsa-miR-363	CLIP-seq
MIRT785896	hsa-miR-367	CLIP-seq
MIRT785897	hsa-miR-3714	CLIP-seq
MIRT785898	hsa-miR-448	CLIP-seq
MIRT785899	hsa-miR-4632	CLIP-seq
MIRT785900	hsa-miR-4712-3p	CLIP-seq
MIRT785901	hsa-miR-4727-5p	CLIP-seq
MIRT785902	hsa-miR-520d-5p	CLIP-seq
MIRT785903	hsa-miR-524-5p	CLIP-seq
MIRT785904	hsa-miR-544	CLIP-seq
MIRT785905	hsa-miR-92a	CLIP-seq
MIRT785906	hsa-miR-92b	CLIP-seq
MIRT785901	hsa-miR-4727-5p	CLIP-seq
MIRT785902	hsa-miR-520d-5p	CLIP-seq
MIRT785903	hsa-miR-524-5p	CLIP-seq
MIRT785904	hsa-miR-544	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005229	Function	Intracellular calcium activated chloride channel activity	IDA	21984732, 22178883
GO:0005229	Function	Intracellular calcium activated chloride channel activity	IMP	22946059
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	22946059
GO:0005886	Component	Plasma membrane	TAS
GO:0006821	Process	Chloride transport	IMP	22946059
GO:0016021	Component	Integral component of membrane	IEA
GO:0034220	Process	Ion transmembrane transport	TAS
GO:0043687	Process	Post-translational protein modification	TAS
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0055085	Process	Transmembrane transport	IBA	21873635
GO:1902476	Process	Chloride transmembrane transport	IEA

MIM	HGNC	e!Ensembl
610216	29329	ENSG00000074855

Protein

UniProt ID

Q9HCE9

Protein name

Anoctamin-8 (Transmembrane protein 16H)

Protein function

Does not exhibit calcium-activated chloride channel (CaCC) activity.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04547	Anoctamin	237 → 878	Calcium-activated chloride channel	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in embryonic stem cells, fetal brain and neural tissues. {ECO:0000269|PubMed:15647853}.

Sequence

MAEAASGAGGTSLEGERGKRPPPEGEPAAPASGVLDKLFGKRLLQAGRYLVSHKAWMKTV
PTENCDVLMTFPDTTDDHTLLWLLNHIRVGIPELIVQVRHHRHTRAYAFFVTATYESLLR
GADELGLRKAVKAEFGGGTRGFSCEEDFIYENVESELRFFTSQERQSIIRFWLQNLRAKQ
GEALHNVRFLEDQPIIPELAARGIIQQVFPVHEQRILNRLMKSWVQAVCENQPLDDICDY
FGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEADQTSRDVSCVVFALFNVIWSTLFLE
EWKRRGAELAYKWGTLDSPGEAVEEPRPQFRGVRRISPITRAEEFYYPPWKRLLFQLLVS
LPLCLACLVCVFLLMLGCFQLQELVLSVKGLPRLARFLPKVMLALLVSVSAEGYKKLAIW
LNDMENYRLESAYEKHLIIKVVLFQFVNSYLSLFYIGFYLKDMERLKEMLATLLITRQFL
QNVREVLQPHLYRRLGRGELGLRAVWELARALLGLLSLRRPAPRRLEPQADEGGGGGSGG
GGRRCLSGGCGAPEEEEEAALVERRRAGEGGEEGDGPPGGKEEDEDDEEEEDEEEEEDEE
EGEEGGLLDCGLRLKKVSFAERGAGRRRPGPSPEALLEEGSPTMVEKGLEPGVFTLAEED
DEAEGAPGSPEREPPAILFRRAGGEGRDQGPDGGPDPEPGSNSDSTRRQRRQNRSSWIDP
PEEEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEI
RSDAFKLCTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWLSPE
AAIVSVVVLEHFALLLKYLIHVAIPDIPGWVAEEMAKLEYQRREAFKRHERQAQHRYQQQ
QRRRREEEERQRHAEHHARREHDSGGREEARAEGSGLDPATSSEKASAKAKGSTAGGHGP
ERPKRPGSLLAPNNVMKLKQIIPLQGKFLSSGATSSLAAAGAGATTRPPPAQSPTGSDTR
LPAFLSFKFLKSPETRRDSERSHSPPKAFHAGKLFPFGGTRAEPGSNGAGGQARPDGTPS
SGSSRVQRSGPVDEALAEELEAPRPEEEGSGTALAPVGAPALRTRRSRSPAPPPPMPLPR
PPTPPAGCWQWDGPWGCGGEGAAPRQALAAAECPPCAMAGPPPAPQPLPGDASFYSLPPP
PLPPTSDPLETPAPSPSPSPSPQAVCWPSGWH

Sequence length

1232

Interactions

View interactions

	Reactome
			Stimuli-sensing channels Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)	20852631
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	24390342

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental depression	Major Depressive Disorder		27777418	ClinVar
Mental Depression	Mental Depression			GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining
Intrahepatic Cholestasis of Pregnancy	Associate	32942997

ANO8 (anoctamin 8)