Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57719
Gene name Gene Name - the full gene name approved by the HGNC.	Anoctamin 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ANO8
Synonyms (NCBI Gene) Gene synonyms aliases	KIAA1623, TMEM16H
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.11

Show/Hide all(87)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028358	hsa-miR-32-5p	Sequencing	20371350
MIRT627119	hsa-miR-1267	HITS-CLIP	23824327
MIRT627118	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT627114	hsa-miR-4455	HITS-CLIP	23824327
MIRT627113	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT627119	hsa-miR-1267	HITS-CLIP	23824327
MIRT627118	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT627114	hsa-miR-4455	HITS-CLIP	23824327
MIRT627113	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT627119	hsa-miR-1267	HITS-CLIP	27418678
MIRT627119	hsa-miR-1267	HITS-CLIP	27418678
MIRT627119	hsa-miR-1267	HITS-CLIP	27418678
MIRT627119	hsa-miR-1267	HITS-CLIP	27418678
MIRT627118	hsa-miR-367-5p	HITS-CLIP	27418678
MIRT627118	hsa-miR-367-5p	HITS-CLIP	27418678
MIRT627118	hsa-miR-367-5p	HITS-CLIP	27418678
MIRT627118	hsa-miR-367-5p	HITS-CLIP	27418678
MIRT627114	hsa-miR-4455	HITS-CLIP	27418678
MIRT627114	hsa-miR-4455	HITS-CLIP	27418678
MIRT627114	hsa-miR-4455	HITS-CLIP	27418678
MIRT627114	hsa-miR-4455	HITS-CLIP	27418678
MIRT627114	hsa-miR-4455	HITS-CLIP	27418678
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT627113	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627113	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627113	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627113	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627113	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT627119	hsa-miR-1267	HITS-CLIP	23824327
MIRT627118	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT627114	hsa-miR-4455	HITS-CLIP	23824327
MIRT627113	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT627119	hsa-miR-1267	HITS-CLIP	23824327
MIRT627118	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT627117	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT627116	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT627115	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT627114	hsa-miR-4455	HITS-CLIP	23824327
MIRT627113	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT785886	hsa-miR-1253	CLIP-seq
MIRT785887	hsa-miR-1257	CLIP-seq
MIRT785888	hsa-miR-137	CLIP-seq
MIRT785889	hsa-miR-153	CLIP-seq
MIRT785890	hsa-miR-25	CLIP-seq
MIRT785891	hsa-miR-3145-3p	CLIP-seq
MIRT785892	hsa-miR-32	CLIP-seq
MIRT785893	hsa-miR-33a	CLIP-seq
MIRT785894	hsa-miR-33b	CLIP-seq
MIRT785895	hsa-miR-363	CLIP-seq
MIRT785896	hsa-miR-367	CLIP-seq
MIRT785897	hsa-miR-3714	CLIP-seq
MIRT785898	hsa-miR-448	CLIP-seq
MIRT785899	hsa-miR-4632	CLIP-seq
MIRT785900	hsa-miR-4712-3p	CLIP-seq
MIRT785901	hsa-miR-4727-5p	CLIP-seq
MIRT785902	hsa-miR-520d-5p	CLIP-seq
MIRT785903	hsa-miR-524-5p	CLIP-seq
MIRT785904	hsa-miR-544	CLIP-seq
MIRT785905	hsa-miR-92a	CLIP-seq
MIRT785906	hsa-miR-92b	CLIP-seq
MIRT785901	hsa-miR-4727-5p	CLIP-seq
MIRT785902	hsa-miR-520d-5p	CLIP-seq
MIRT785903	hsa-miR-524-5p	CLIP-seq
MIRT785904	hsa-miR-544	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005229	Function	Intracellularly calcium-gated chloride channel activity	IDA	21984732, 22178883
GO:0005229	Function	Intracellularly calcium-gated chloride channel activity	IMP	22946059
GO:0005254	Function	Chloride channel activity	IBA
GO:0005254	Function	Chloride channel activity	TAS
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	22946059
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	TAS
GO:1902476	Process	Chloride transmembrane transport	IBA
GO:1902476	Process	Chloride transmembrane transport	IMP	22946059

MIM	HGNC	e!Ensembl
610216	29329	ENSG00000074855

Protein

UniProt ID

Q9HCE9

Protein name

Anoctamin-8 (Transmembrane protein 16H)

Protein function

Does not exhibit calcium-activated chloride channel (CaCC) activity.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04547	Anoctamin	237 → 878	Calcium-activated chloride channel	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in embryonic stem cells, fetal brain and neural tissues. {ECO:0000269|PubMed:15647853}.

Sequence

MAEAASGAGGTSLEGERGKRPPPEGEPAAPASGVLDKLFGKRLLQAGRYLVSHKAWMKTV
PTENCDVLMTFPDTTDDHTLLWLLNHIRVGIPELIVQVRHHRHTRAYAFFVTATYESLLR
GADELGLRKAVKAEFGGGTRGFSCEEDFIYENVESELRFFTSQERQSIIRFWLQNLRAKQ
GEALHNVRFLEDQPIIPELAARGIIQQVFPVHEQRILNRLMKSWVQAVCENQPLDDICDY
FGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEADQTSRDVSCVVFALFNVIWSTLFLE
EWKRRGAELAYKWGTLDSPGEAVEEPRPQFRGVRRISPITRAEEFYYPPWKRLLFQLLVS
LPLCLACLVCVFLLMLGCFQLQELVLSVKGLPRLARFLPKVMLALLVSVSAEGYKKLAIW
LNDMENYRLESAYEKHLIIKVVLFQFVNSYLSLFYIGFYLKDMERLKEMLATLLITRQFL
QNVREVLQPHLYRRLGRGELGLRAVWELARALLGLLSLRRPAPRRLEPQADEGGGGGSGG
GGRRCLSGGCGAPEEEEEAALVERRRAGEGGEEGDGPPGGKEEDEDDEEEEDEEEEEDEE
EGEEGGLLDCGLRLKKVSFAERGAGRRRPGPSPEALLEEGSPTMVEKGLEPGVFTLAEED
DEAEGAPGSPEREPPAILFRRAGGEGRDQGPDGGPDPEPGSNSDSTRRQRRQNRSSWIDP
PEEEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEI
RSDAFKLCTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWLSPE
AAIVSVVVLEHFALLLKYLIHVAIPDIPGWVAEEMAKLEYQRREAFKRHERQAQHRYQQQ
QRRRREEEERQRHAEHHARREHDSGGREEARAEGSGLDPATSSEKASAKAKGSTAGGHGP
ERPKRPGSLLAPNNVMKLKQIIPLQGKFLSSGATSSLAAAGAGATTRPPPAQSPTGSDTR
LPAFLSFKFLKSPETRRDSERSHSPPKAFHAGKLFPFGGTRAEPGSNGAGGQARPDGTPS
SGSSRVQRSGPVDEALAEELEAPRPEEEGSGTALAPVGAPALRTRRSRSPAPPPPMPLPR
PPTPPAGCWQWDGPWGCGGEGAAPRQALAAAECPPCAMAGPPPAPQPLPGDASFYSLPPP
PLPPTSDPLETPAPSPSPSPSPQAVCWPSGWH

Sequence length

1232

Interactions

View interactions

	Reactome
			Stimuli-sensing channels Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Breast Cancer	Breast cancer subtype (triple negative vs luminal A-like)	N/A	N/A	GWAS
Mental Depression	Major depressive disorder	N/A	N/A	GWAS
Rheumatoid arthritis	Rheumatoid arthritis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Intrahepatic Cholestasis of Pregnancy	Associate	32942997

ANO8 (anoctamin 8)