Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	57699
Gene name	Copine 5
Gene symbol	CPNE5
Synonyms (NCBI Gene)	COPN5CPN5
Chromosome	6
Chromosome location	6p21.2
Summary	Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an in

Show/Hide all (92)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016953	hsa-miR-335-5p	Microarray	18185580
MIRT019270	hsa-miR-148b-3p	Microarray	17612493
MIRT023240	hsa-miR-122-5p	Microarray	17612493
MIRT570250	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT570249	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT570248	hsa-miR-940	PAR-CLIP	20371350
MIRT570247	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT570246	hsa-miR-6715a-3p	PAR-CLIP	20371350
MIRT570245	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT570244	hsa-miR-371a-5p	PAR-CLIP	20371350
MIRT570243	hsa-miR-1827	PAR-CLIP	20371350
MIRT570242	hsa-miR-6132	PAR-CLIP	20371350
MIRT570241	hsa-miR-6836-5p	PAR-CLIP	20371350
MIRT570240	hsa-miR-3612	PAR-CLIP	20371350
MIRT570239	hsa-miR-650	PAR-CLIP	20371350
MIRT570238	hsa-miR-1207-5p	PAR-CLIP	20371350
MIRT570237	hsa-miR-4763-3p	PAR-CLIP	20371350
MIRT570236	hsa-miR-4437	PAR-CLIP	20371350
MIRT570235	hsa-miR-6715b-3p	PAR-CLIP	20371350
MIRT491348	hsa-miR-6890-5p	PAR-CLIP	23592263
MIRT491347	hsa-miR-4738-5p	PAR-CLIP	23592263
MIRT491346	hsa-miR-4707-5p	PAR-CLIP	23592263
MIRT491344	hsa-miR-5587-3p	PAR-CLIP	23592263
MIRT491345	hsa-miR-4532	PAR-CLIP	23592263
MIRT491343	hsa-miR-6784-5p	PAR-CLIP	23592263
MIRT491342	hsa-miR-615-5p	PAR-CLIP	23592263
MIRT491341	hsa-miR-7704	PAR-CLIP	23592263
MIRT491340	hsa-miR-7977	PAR-CLIP	23592263
MIRT491339	hsa-miR-6763-3p	PAR-CLIP	23592263
MIRT570250	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT570249	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT570248	hsa-miR-940	PAR-CLIP	20371350
MIRT570247	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT570246	hsa-miR-6715a-3p	PAR-CLIP	20371350
MIRT570245	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT570244	hsa-miR-371a-5p	PAR-CLIP	20371350
MIRT570243	hsa-miR-1827	PAR-CLIP	20371350
MIRT570242	hsa-miR-6132	PAR-CLIP	20371350
MIRT570241	hsa-miR-6836-5p	PAR-CLIP	20371350
MIRT570240	hsa-miR-3612	PAR-CLIP	20371350
MIRT570239	hsa-miR-650	PAR-CLIP	20371350
MIRT570238	hsa-miR-1207-5p	PAR-CLIP	20371350
MIRT570237	hsa-miR-4763-3p	PAR-CLIP	20371350
MIRT570236	hsa-miR-4437	PAR-CLIP	20371350
MIRT570235	hsa-miR-6715b-3p	PAR-CLIP	20371350
MIRT491348	hsa-miR-6890-5p	PAR-CLIP	23592263
MIRT491347	hsa-miR-4738-5p	PAR-CLIP	23592263
MIRT491346	hsa-miR-4707-5p	PAR-CLIP	23592263
MIRT491344	hsa-miR-5587-3p	PAR-CLIP	23592263
MIRT491345	hsa-miR-4532	PAR-CLIP	23592263
MIRT491343	hsa-miR-6784-5p	PAR-CLIP	23592263
MIRT491342	hsa-miR-615-5p	PAR-CLIP	23592263
MIRT491341	hsa-miR-7704	PAR-CLIP	23592263
MIRT491340	hsa-miR-7977	PAR-CLIP	23592263
MIRT491339	hsa-miR-6763-3p	PAR-CLIP	23592263
MIRT906705	hsa-miR-1200	CLIP-seq
MIRT906706	hsa-miR-2467-3p	CLIP-seq
MIRT906707	hsa-miR-3127-5p	CLIP-seq
MIRT906708	hsa-miR-3140-5p	CLIP-seq
MIRT906709	hsa-miR-3192	CLIP-seq
MIRT906710	hsa-miR-3689a-3p	CLIP-seq
MIRT906711	hsa-miR-3689c	CLIP-seq
MIRT906712	hsa-miR-370	CLIP-seq
MIRT906713	hsa-miR-371-5p	CLIP-seq
MIRT906714	hsa-miR-3937	CLIP-seq
MIRT906715	hsa-miR-4271	CLIP-seq
MIRT906716	hsa-miR-4292	CLIP-seq
MIRT906717	hsa-miR-4308	CLIP-seq
MIRT906718	hsa-miR-4329	CLIP-seq
MIRT906719	hsa-miR-4433	CLIP-seq
MIRT906720	hsa-miR-4447	CLIP-seq
MIRT906721	hsa-miR-4472	CLIP-seq
MIRT906722	hsa-miR-4663	CLIP-seq
MIRT906723	hsa-miR-4723-5p	CLIP-seq
MIRT906724	hsa-miR-4725-3p	CLIP-seq
MIRT906725	hsa-miR-4728-5p	CLIP-seq
MIRT906726	hsa-miR-4763-5p	CLIP-seq
MIRT906727	hsa-miR-4786-3p	CLIP-seq
MIRT906728	hsa-miR-4786-5p	CLIP-seq
MIRT906729	hsa-miR-542-3p	CLIP-seq
MIRT906730	hsa-miR-665	CLIP-seq
MIRT906731	hsa-miR-7	CLIP-seq
MIRT906732	hsa-miR-769-5p	CLIP-seq
MIRT2204848	hsa-miR-483-5p	CLIP-seq
MIRT2386410	hsa-miR-188-3p	CLIP-seq
MIRT2386411	hsa-miR-2682	CLIP-seq
MIRT2386412	hsa-miR-34a	CLIP-seq
MIRT2386413	hsa-miR-34c-5p	CLIP-seq
MIRT2386414	hsa-miR-4423-3p	CLIP-seq
MIRT2386415	hsa-miR-449a	CLIP-seq
MIRT2386416	hsa-miR-449b	CLIP-seq
MIRT2386417	hsa-miR-449c	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA
GO:0005544	Function	Calcium-dependent phospholipid binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0030154	Process	Cell differentiation	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0071277	Process	Cellular response to calcium ion	IBA
GO:1903861	Process	Positive regulation of dendrite extension	IDA
GO:1903861	Process	Positive regulation of dendrite extension	IEA

MIM	HGNC	e!Ensembl
604209	2318	ENSG00000124772

Q9HCH3

Protein name

Copine-5 (Copine V)

Protein function

Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99829, ECO:000

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00168	C2	24 → 134	C2 domain	Domain
PF00168	C2	177 → 286	C2 domain	Domain
PF07002	Copine	347 → 566	Copine	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in the brain, heart, stomach, spleen, lymph node and testis (PubMed:12949241). Expressed in melanocytes (PubMed:23999003). {ECO:0000269|PubMed:12949241, ECO:0000269|PubMed:23999003}.

Sequence

MEQPEDMASLSEFDSLAGSIPATKVEITVSCRNLLDKDMFSKSDPLCVMYTQGMENKQWR
EFGRTEVIDNTLNPDFVRKFIVDYFFEEKQNLRFDLYDVDSKSPDLSKHDFLGQAFCTLG
EIVGSPGSRLEKPLTIGAFSLNSRTGKPMPAVSNGGVPGKKCGTIILSAEELSNCRDVAT
MQFCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVMKNTLNPVWQTFSIPVRALC
NGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELARGQSQFNIYEVVNPKKKMKKKKYVN
SGTVTLLSFAVESECTFLDYIKGGTQINFTVAIDFTASNGNPSQSTSLHYMSPYQLNAYA
LALTAVGEIIQHYDSDKMFPALGFGAKLPPDGRVSHEFPLNGNQENPSCCGIDGILEAYH
RSLRTVQLYGPTNFAPVVTHVARNAAAVQDGSQYSVLLIITDGVISDMAQTKEAIVNAAK
LPMSIIIVGVGQAEFDAMVELDGDDVRISSRGKLAERDIVQFVPFRDYVDRTGNHVLSMA
RLARDVLAEIPDQLVSYMKAQGIRPRPPPAAPTHSPSQSPARTPPASPLHTHI

Sequence length

593

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BILIARY TRACT DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BULLOUS PEMPHIGOID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Multiple Myeloma	Associate	33780365	★★★★★ ★☆☆☆☆ Found in Text Mining only

CPNE5 (copine 5)