Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57699
Gene name Gene Name - the full gene name approved by the HGNC.	Copine 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CPNE5
Synonyms (NCBI Gene) Gene synonyms aliases	COPN5, CPN5
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p21.2
Summary Summary of gene provided in NCBI Entrez Gene.	Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an in

Show/Hide all(92)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016953	hsa-miR-335-5p	Microarray	18185580
MIRT019270	hsa-miR-148b-3p	Microarray	17612493
MIRT023240	hsa-miR-122-5p	Microarray	17612493
MIRT570250	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT570249	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT570248	hsa-miR-940	PAR-CLIP	20371350
MIRT570247	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT570246	hsa-miR-6715a-3p	PAR-CLIP	20371350
MIRT570245	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT570244	hsa-miR-371a-5p	PAR-CLIP	20371350
MIRT570243	hsa-miR-1827	PAR-CLIP	20371350
MIRT570242	hsa-miR-6132	PAR-CLIP	20371350
MIRT570241	hsa-miR-6836-5p	PAR-CLIP	20371350
MIRT570240	hsa-miR-3612	PAR-CLIP	20371350
MIRT570239	hsa-miR-650	PAR-CLIP	20371350
MIRT570238	hsa-miR-1207-5p	PAR-CLIP	20371350
MIRT570237	hsa-miR-4763-3p	PAR-CLIP	20371350
MIRT570236	hsa-miR-4437	PAR-CLIP	20371350
MIRT570235	hsa-miR-6715b-3p	PAR-CLIP	20371350
MIRT491348	hsa-miR-6890-5p	PAR-CLIP	23592263
MIRT491347	hsa-miR-4738-5p	PAR-CLIP	23592263
MIRT491346	hsa-miR-4707-5p	PAR-CLIP	23592263
MIRT491344	hsa-miR-5587-3p	PAR-CLIP	23592263
MIRT491345	hsa-miR-4532	PAR-CLIP	23592263
MIRT491343	hsa-miR-6784-5p	PAR-CLIP	23592263
MIRT491342	hsa-miR-615-5p	PAR-CLIP	23592263
MIRT491341	hsa-miR-7704	PAR-CLIP	23592263
MIRT491340	hsa-miR-7977	PAR-CLIP	23592263
MIRT491339	hsa-miR-6763-3p	PAR-CLIP	23592263
MIRT570250	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT570249	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT570248	hsa-miR-940	PAR-CLIP	20371350
MIRT570247	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT570246	hsa-miR-6715a-3p	PAR-CLIP	20371350
MIRT570245	hsa-miR-6840-3p	PAR-CLIP	20371350
MIRT570244	hsa-miR-371a-5p	PAR-CLIP	20371350
MIRT570243	hsa-miR-1827	PAR-CLIP	20371350
MIRT570242	hsa-miR-6132	PAR-CLIP	20371350
MIRT570241	hsa-miR-6836-5p	PAR-CLIP	20371350
MIRT570240	hsa-miR-3612	PAR-CLIP	20371350
MIRT570239	hsa-miR-650	PAR-CLIP	20371350
MIRT570238	hsa-miR-1207-5p	PAR-CLIP	20371350
MIRT570237	hsa-miR-4763-3p	PAR-CLIP	20371350
MIRT570236	hsa-miR-4437	PAR-CLIP	20371350
MIRT570235	hsa-miR-6715b-3p	PAR-CLIP	20371350
MIRT491348	hsa-miR-6890-5p	PAR-CLIP	23592263
MIRT491347	hsa-miR-4738-5p	PAR-CLIP	23592263
MIRT491346	hsa-miR-4707-5p	PAR-CLIP	23592263
MIRT491344	hsa-miR-5587-3p	PAR-CLIP	23592263
MIRT491345	hsa-miR-4532	PAR-CLIP	23592263
MIRT491343	hsa-miR-6784-5p	PAR-CLIP	23592263
MIRT491342	hsa-miR-615-5p	PAR-CLIP	23592263
MIRT491341	hsa-miR-7704	PAR-CLIP	23592263
MIRT491340	hsa-miR-7977	PAR-CLIP	23592263
MIRT491339	hsa-miR-6763-3p	PAR-CLIP	23592263
MIRT906705	hsa-miR-1200	CLIP-seq
MIRT906706	hsa-miR-2467-3p	CLIP-seq
MIRT906707	hsa-miR-3127-5p	CLIP-seq
MIRT906708	hsa-miR-3140-5p	CLIP-seq
MIRT906709	hsa-miR-3192	CLIP-seq
MIRT906710	hsa-miR-3689a-3p	CLIP-seq
MIRT906711	hsa-miR-3689c	CLIP-seq
MIRT906712	hsa-miR-370	CLIP-seq
MIRT906713	hsa-miR-371-5p	CLIP-seq
MIRT906714	hsa-miR-3937	CLIP-seq
MIRT906715	hsa-miR-4271	CLIP-seq
MIRT906716	hsa-miR-4292	CLIP-seq
MIRT906717	hsa-miR-4308	CLIP-seq
MIRT906718	hsa-miR-4329	CLIP-seq
MIRT906719	hsa-miR-4433	CLIP-seq
MIRT906720	hsa-miR-4447	CLIP-seq
MIRT906721	hsa-miR-4472	CLIP-seq
MIRT906722	hsa-miR-4663	CLIP-seq
MIRT906723	hsa-miR-4723-5p	CLIP-seq
MIRT906724	hsa-miR-4725-3p	CLIP-seq
MIRT906725	hsa-miR-4728-5p	CLIP-seq
MIRT906726	hsa-miR-4763-5p	CLIP-seq
MIRT906727	hsa-miR-4786-3p	CLIP-seq
MIRT906728	hsa-miR-4786-5p	CLIP-seq
MIRT906729	hsa-miR-542-3p	CLIP-seq
MIRT906730	hsa-miR-665	CLIP-seq
MIRT906731	hsa-miR-7	CLIP-seq
MIRT906732	hsa-miR-769-5p	CLIP-seq
MIRT2204848	hsa-miR-483-5p	CLIP-seq
MIRT2386410	hsa-miR-188-3p	CLIP-seq
MIRT2386411	hsa-miR-2682	CLIP-seq
MIRT2386412	hsa-miR-34a	CLIP-seq
MIRT2386413	hsa-miR-34c-5p	CLIP-seq
MIRT2386414	hsa-miR-4423-3p	CLIP-seq
MIRT2386415	hsa-miR-449a	CLIP-seq
MIRT2386416	hsa-miR-449b	CLIP-seq
MIRT2386417	hsa-miR-449c	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA	21873635
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0030154	Process	Cell differentiation	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0071277	Process	Cellular response to calcium ion	IBA	21873635
GO:1903861	Process	Positive regulation of dendrite extension	IDA

MIM	HGNC	e!Ensembl
604209	2318	ENSG00000124772

Protein

UniProt ID

Q9HCH3

Protein name

Copine-5 (Copine V)

Protein function

Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q99829, ECO:000

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00168	C2	24 → 134	C2 domain	Domain
PF00168	C2	177 → 286	C2 domain	Domain
PF07002	Copine	347 → 566	Copine	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in the brain, heart, stomach, spleen, lymph node and testis (PubMed:12949241). Expressed in melanocytes (PubMed:23999003). {ECO:0000269|PubMed:12949241, ECO:0000269|PubMed:23999003}.

Sequence

MEQPEDMASLSEFDSLAGSIPATKVEITVSCRNLLDKDMFSKSDPLCVMYTQGMENKQWR
EFGRTEVIDNTLNPDFVRKFIVDYFFEEKQNLRFDLYDVDSKSPDLSKHDFLGQAFCTLG
EIVGSPGSRLEKPLTIGAFSLNSRTGKPMPAVSNGGVPGKKCGTIILSAEELSNCRDVAT
MQFCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVMKNTLNPVWQTFSIPVRALC
NGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELARGQSQFNIYEVVNPKKKMKKKKYVN
SGTVTLLSFAVESECTFLDYIKGGTQINFTVAIDFTASNGNPSQSTSLHYMSPYQLNAYA
LALTAVGEIIQHYDSDKMFPALGFGAKLPPDGRVSHEFPLNGNQENPSCCGIDGILEAYH
RSLRTVQLYGPTNFAPVVTHVARNAAAVQDGSQYSVLLIITDGVISDMAQTKEAIVNAAK
LPMSIIIVGVGQAEFDAMVELDGDDVRISSRGKLAERDIVQFVPFRDYVDRTGNHVLSMA
RLARDVLAEIPDQLVSYMKAQGIRPRPPPAAPTHSPSQSPARTPPASPLHTHI

Sequence length

593

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451 View all (71 more)	29059683

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Evidence	References	Source
Unknown
Heart failure	Heart failure		31113495	ClinVar
Systemic lupus erythematosus	Systemic lupus erythematosus			GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining
Multiple Myeloma	Associate	33780365

CPNE5 (copine 5)