SHTN1 (shootin 1)

Gene
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
57698
Gene name Gene Name - the full gene name approved by the HGNC.
Shootin 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SHTN1
Synonyms (NCBI Gene) Gene synonyms aliases
KIAA1598, shootin-1
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q25.3
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all(28)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956
GO:0005737 Component Cytoplasm IDA 25468996
GO:0005874 Component Microtubule IEA
GO:0005875 Component Microtubule associated complex ISS
GO:0006930 Process Substrate-dependent cell migration, cell extension ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
611171 29319 ENSG00000187164
Protein
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID A0MZ66
Protein name Shootin-1 (Shootin1)
Protein function Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC
Family and domains
Sequence 
MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH
MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID
DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN
KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI
EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLH
KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPP
PLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKG
VHLRPVNQTARPKTKPESSKGCESAVDELKGILGTLNKSTSSRSLKSLDPENSETELERI
LRRRKVTAEADSSSPTGILATSESKSMPVLGSVSSVTKTALNKKTLEAEFNSPSPPTPEP
GEGPRKLEGCTSSKVTFQPPSSIGCRKKYIDGEKQAEPVVVLDPVSTHEPQTKDQVAEKD
PTQHKEDEGEIQPENKEDSIENVRETDSSNC
Sequence length 631
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Cleft Lip With Or Without Cleft Palate Cleft Lip With Or Without Cleft Palate GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Show/Hide Text Mining Associations (10)
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 22806168
Carcinogenesis Associate 39260052
Cholangiocarcinoma Associate 24563076
Cleft Lip Associate 23463464, 27321816, 28662356, 30411541, 33132092
Cleft Palate Associate 23463464, 27369588, 28008912, 28383424, 28422192, 30411541, 32241273, 33132092, 35419918
Macular Degeneration Stimulate 29696386
Neoplasms Associate 39260052
Neoplasms Neuroepithelial Associate 34363682
Orofacial Cleft 1 Associate 28383424, 33132092
Urinary Bladder Neoplasms Stimulate 39260052