CACHD1 (cache domain containing 1)

Gene

• Entrez ID: 57685
• Gene name: Cache domain containing 1
• Gene symbol: CACHD1
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1p31.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051781	hsa-let-7c-5p	CLASH	23622248
MIRT045356	hsa-miR-185-5p	CLASH	23622248
MIRT043233	hsa-miR-324-5p	CLASH	23622248
MIRT040828	hsa-miR-18a-3p	CLASH	23622248
MIRT659936	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT659935	hsa-miR-623	HITS-CLIP	23824327
MIRT659934	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT659933	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT659932	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT659931	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT659930	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT659936	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT659935	hsa-miR-623	HITS-CLIP	23824327
MIRT659934	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT659933	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT659932	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT659931	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT659930	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT857378	hsa-miR-140-3p	CLIP-seq
MIRT857379	hsa-miR-144	CLIP-seq
MIRT857380	hsa-miR-3121-3p	CLIP-seq
MIRT857381	hsa-miR-3179	CLIP-seq
MIRT857382	hsa-miR-371-5p	CLIP-seq
MIRT857383	hsa-miR-3936	CLIP-seq
MIRT857384	hsa-miR-411	CLIP-seq
MIRT857385	hsa-miR-4514	CLIP-seq
MIRT857386	hsa-miR-4672	CLIP-seq
MIRT857387	hsa-miR-4692	CLIP-seq
MIRT857388	hsa-miR-4789-5p	CLIP-seq
MIRT857389	hsa-miR-553	CLIP-seq
MIRT857390	hsa-miR-590-3p	CLIP-seq
MIRT857391	hsa-miR-888	CLIP-seq
MIRT857392	hsa-miR-940	CLIP-seq
MIRT1954662	hsa-miR-145	CLIP-seq
MIRT1954663	hsa-miR-1913	CLIP-seq
MIRT1954664	hsa-miR-324-3p	CLIP-seq
MIRT1954665	hsa-miR-4749-3p	CLIP-seq
MIRT2192256	hsa-miR-1237	CLIP-seq
MIRT2192257	hsa-miR-3064-5p	CLIP-seq
MIRT857380	hsa-miR-3121-3p	CLIP-seq
MIRT2192258	hsa-miR-3182	CLIP-seq
MIRT2192259	hsa-miR-4652-3p	CLIP-seq
MIRT2192260	hsa-miR-4724-3p	CLIP-seq
MIRT2192261	hsa-miR-4794	CLIP-seq
MIRT2192262	hsa-miR-885-5p	CLIP-seq
MIRT2495647	hsa-miR-1321	CLIP-seq
MIRT2495648	hsa-miR-3130-3p	CLIP-seq
MIRT2495649	hsa-miR-330-3p	CLIP-seq
MIRT2495650	hsa-miR-4457	CLIP-seq
MIRT2495651	hsa-miR-4731-3p	CLIP-seq
MIRT2495652	hsa-miR-4739	CLIP-seq
MIRT2495653	hsa-miR-4756-5p	CLIP-seq
MIRT2495654	hsa-miR-4793-3p	CLIP-seq
MIRT2495655	hsa-miR-4801	CLIP-seq
MIRT2495647	hsa-miR-1321	CLIP-seq
MIRT2495648	hsa-miR-3130-3p	CLIP-seq
MIRT2495649	hsa-miR-330-3p	CLIP-seq
MIRT2495650	hsa-miR-4457	CLIP-seq
MIRT2495651	hsa-miR-4731-3p	CLIP-seq
MIRT2495652	hsa-miR-4739	CLIP-seq
MIRT2495653	hsa-miR-4756-5p	CLIP-seq
MIRT2495654	hsa-miR-4793-3p	CLIP-seq
MIRT2495655	hsa-miR-4801	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005245	Function	Voltage-gated calcium channel activity	IBA	21873635
GO:0005891	Component	Voltage-gated calcium channel complex	IBA	21873635
GO:0070588	Process	Calcium ion transmembrane transport	IEA

Other IDs

• MIM: 620144
• HGNC: 29314
• e!Ensembl: ENSG00000158966

Protein

• UniProt ID: Q5VU97
• Protein name: VWFA and cache domain-containing protein 1 (Cache domain-containing protein 1)
• Protein function: May regulate voltage-dependent calcium channels.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08399	VWA_N	89 → 204	VWA N-terminal	Family
  PF00092	VWA	228 → 413	von Willebrand factor type A domain	Domain

• Sequence:

  MARQPEEEETAVARARRPPLWLLCLVACWLLGAGAEADFSILDEAQVLASQMRRLAAEEL
  GVVTMQRIFNSFVYTEKISNGESEVQQLAKKIREKFNRYLDVVNRNKQVVEASYTAHLTS
  PLTAIQDCCTIPPSMMEFDGNFNTNVSRTISCDRLSTTVNSRAFNPGRDLNSVLADNLKS
  NPGIKWQYFSSEEGIFTVFPAHKFRCKGSYEHRSRPIYVSTVRPQSKHIVVILDHGASVT
  DTQLQIAKDAAQVILSAIDEHDKISVLTVADTVRTCSLDQCYKTFLSPATSETKRKMSTF
  VSSVKSSDSPTQHAVGFQKAFQLIRSTNNNTKFQANTDMVIIYLSAGITSKDSSEEDKKA
  TLQVINEENSFLNNSVMILTYALMNDGVTGLKELAFLRDLAEQNSGKYGVPDRMALPVIK
  GSMMVLNQLSNLETTVGRFYTNLPNRMIDEAVFSLPFSDEMGDGLIMTVSKPCYFGNLLL
  GIVGVDVNLAYILEDVTYYQDSLASYTFLIDDKGYTLMHPSLTRPYLLSEPPLHTDIIHY
  ENIPKFELVRQNILSLPLGSQIIAVPVNSSLSWHINKLRETGKEAYNVSYAWKMVQDTSF
  ILCIVVIQPEIPVKQLKNLNTVPSSKLLYHRLDLLGQPSACLHFKQLATLESPTIMLSAG
  SFSSPYEHLSQPETKRMVEHYTAYLSDNTRLIANPGLKFSVRNEVMATSHVTDEWMTQME
  MSSLNTYIVRRYIATPNGVLRIYPGSLMDKAFDPTRRQWYLHAVANPGLISLTGPYLDVG
  GAGYVVTISHTIHSSSTQLSSGHTVAVMGIDFTLRYFYKVLMDLLPVCNQDGGNKIRCFI
  MEDRGYLVAHPTLIDPKGHAPVEQQHITHKEPLVANDILNHPNFVKKNLCNSFSDRTVQR
  FYKFNTSLAGDLTNLVHGSHCSKYRLARIPGTNAFVGIVNETCDSLAFCACSMVDRLCLN
  CHRMEQNECECPCECPLEVNECTGNLTNAENRNPSCEVHQEPVTYTAIDPGLQDALHQCV
  NSRCSQRLESGDCFGVLDCEWCMVDSDGKTHLDKPYCAPQKECFGGIVGAKSPYVDDMGA
  IGDEVITLNMIKSAPVGPVAGGIMGCIMVLVLAVYAYRHQIHRRSHQHMSPLAAQEMSVR
  MSNLENDRDERDDDSHEDRGIISNTRFIAAVIERHAHSPERRRRYWGRSGTESDHGYSTM
  SPQEDSENPPCNNDPLSAGVDVGNHDEDLDLDTPPQTAALLSHKFHHYRSHHPTLHHSHH
  LQAAVTVHTVDAEC

• Sequence length: 1274

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	21926974

Unknown
Disease term	Disease name	Evidence	References	Source
Metabolic Syndrome	Metabolic Syndrome			GWAS