Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	57683
Gene name	Zinc finger DBF-type containing 2
Gene symbol	ZDBF2
Synonyms (NCBI Gene)	Slx9
Chromosome	2
Chromosome location	2q33.3
Summary	This gene encodes a protein containing DBF4-type zinc finger domains. This gene is imprinted and paternally expressed in lymphocytes but is more stochastically expressed in the placenta. Alternative splicing results in multiple transcript variants. [provi

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Show/Hide all (211)

miRTarBase ID	miRNA	Experiments	Reference
MIRT681054	hsa-miR-148a-5p	HITS-CLIP	23706177
MIRT681053	hsa-miR-1247-3p	HITS-CLIP	23706177
MIRT681052	hsa-miR-610	HITS-CLIP	23706177
MIRT681051	hsa-miR-6134	HITS-CLIP	23706177
MIRT681050	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT681049	hsa-miR-6086	HITS-CLIP	23706177
MIRT681048	hsa-miR-4746-3p	HITS-CLIP	23706177
MIRT681047	hsa-miR-3689d	HITS-CLIP	23706177
MIRT681046	hsa-miR-6851-5p	HITS-CLIP	23706177
MIRT681045	hsa-miR-6799-5p	HITS-CLIP	23706177
MIRT681044	hsa-miR-4792	HITS-CLIP	23706177
MIRT681043	hsa-miR-6880-5p	HITS-CLIP	23706177
MIRT681042	hsa-miR-7847-3p	HITS-CLIP	23706177
MIRT439240	hsa-miR-493-5p	HITS-CLIP	24374217
MIRT439240	hsa-miR-493-5p	HITS-CLIP	24374217
MIRT681054	hsa-miR-148a-5p	HITS-CLIP	23706177
MIRT681053	hsa-miR-1247-3p	HITS-CLIP	23706177
MIRT681052	hsa-miR-610	HITS-CLIP	23706177
MIRT681051	hsa-miR-6134	HITS-CLIP	23706177
MIRT681050	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT681049	hsa-miR-6086	HITS-CLIP	23706177
MIRT681048	hsa-miR-4746-3p	HITS-CLIP	23706177
MIRT681047	hsa-miR-3689d	HITS-CLIP	23706177
MIRT681046	hsa-miR-6851-5p	HITS-CLIP	23706177
MIRT681045	hsa-miR-6799-5p	HITS-CLIP	23706177
MIRT681044	hsa-miR-4792	HITS-CLIP	23706177
MIRT681043	hsa-miR-6880-5p	HITS-CLIP	23706177
MIRT681042	hsa-miR-7847-3p	HITS-CLIP	23706177
MIRT1507596	hsa-miR-1183	CLIP-seq
MIRT1507597	hsa-miR-1245	CLIP-seq
MIRT1507598	hsa-miR-1252	CLIP-seq
MIRT1507599	hsa-miR-1285	CLIP-seq
MIRT1507600	hsa-miR-129-5p	CLIP-seq
MIRT1507601	hsa-miR-155	CLIP-seq
MIRT1507602	hsa-miR-186	CLIP-seq
MIRT1507603	hsa-miR-203	CLIP-seq
MIRT1507604	hsa-miR-2114	CLIP-seq
MIRT1507605	hsa-miR-2276	CLIP-seq
MIRT1507606	hsa-miR-23a	CLIP-seq
MIRT1507607	hsa-miR-23b	CLIP-seq
MIRT1507608	hsa-miR-23c	CLIP-seq
MIRT1507609	hsa-miR-24	CLIP-seq
MIRT1507610	hsa-miR-2861	CLIP-seq
MIRT1507611	hsa-miR-297	CLIP-seq
MIRT1507612	hsa-miR-3120-5p	CLIP-seq
MIRT1507613	hsa-miR-3129-3p	CLIP-seq
MIRT1507614	hsa-miR-3150b-3p	CLIP-seq
MIRT1507615	hsa-miR-3163	CLIP-seq
MIRT1507616	hsa-miR-3187-5p	CLIP-seq
MIRT1507617	hsa-miR-3188	CLIP-seq
MIRT1507618	hsa-miR-323-3p	CLIP-seq
MIRT1507619	hsa-miR-3612	CLIP-seq
MIRT1507620	hsa-miR-3613-3p	CLIP-seq
MIRT1507621	hsa-miR-3622b-5p	CLIP-seq
MIRT1507622	hsa-miR-3646	CLIP-seq
MIRT1507623	hsa-miR-3647-3p	CLIP-seq
MIRT1507624	hsa-miR-3653	CLIP-seq
MIRT1507625	hsa-miR-3658	CLIP-seq
MIRT1507626	hsa-miR-3664-5p	CLIP-seq
MIRT1507627	hsa-miR-3672	CLIP-seq
MIRT1507628	hsa-miR-3688-3p	CLIP-seq
MIRT1507629	hsa-miR-3692	CLIP-seq
MIRT1507630	hsa-miR-371-5p	CLIP-seq
MIRT1507631	hsa-miR-371b-5p	CLIP-seq
MIRT1507632	hsa-miR-3929	CLIP-seq
MIRT1507633	hsa-miR-3945	CLIP-seq
MIRT1507634	hsa-miR-409-3p	CLIP-seq
MIRT1507635	hsa-miR-410	CLIP-seq
MIRT1507636	hsa-miR-412	CLIP-seq
MIRT1507637	hsa-miR-4253	CLIP-seq
MIRT1507638	hsa-miR-4284	CLIP-seq
MIRT1507639	hsa-miR-4419b	CLIP-seq
MIRT1507640	hsa-miR-4436b-5p	CLIP-seq
MIRT1507641	hsa-miR-4474-5p	CLIP-seq
MIRT1507642	hsa-miR-4477a	CLIP-seq
MIRT1507643	hsa-miR-4478	CLIP-seq
MIRT1507644	hsa-miR-4505	CLIP-seq
MIRT1507645	hsa-miR-4520a-3p	CLIP-seq
MIRT1507646	hsa-miR-4520b-3p	CLIP-seq
MIRT1507647	hsa-miR-4522	CLIP-seq
MIRT1507648	hsa-miR-4635	CLIP-seq
MIRT1507649	hsa-miR-4666-5p	CLIP-seq
MIRT1507650	hsa-miR-4687-3p	CLIP-seq
MIRT1507651	hsa-miR-4689	CLIP-seq
MIRT1507652	hsa-miR-4695-5p	CLIP-seq
MIRT1507653	hsa-miR-4698	CLIP-seq
MIRT1507654	hsa-miR-4762-3p	CLIP-seq
MIRT1507655	hsa-miR-4766-5p	CLIP-seq
MIRT1507656	hsa-miR-4772-3p	CLIP-seq
MIRT1507657	hsa-miR-4775	CLIP-seq
MIRT1507658	hsa-miR-4778-5p	CLIP-seq
MIRT1507659	hsa-miR-4781-3p	CLIP-seq
MIRT1507660	hsa-miR-4784	CLIP-seq
MIRT1507661	hsa-miR-4802-3p	CLIP-seq
MIRT1507662	hsa-miR-518a-5p	CLIP-seq
MIRT1507663	hsa-miR-526b	CLIP-seq
MIRT1507664	hsa-miR-527	CLIP-seq
MIRT1507665	hsa-miR-544	CLIP-seq
MIRT1507666	hsa-miR-548c-3p	CLIP-seq
MIRT1507667	hsa-miR-548u	CLIP-seq
MIRT1507668	hsa-miR-552	CLIP-seq
MIRT1507669	hsa-miR-567	CLIP-seq
MIRT1507670	hsa-miR-568	CLIP-seq
MIRT1507671	hsa-miR-586	CLIP-seq
MIRT1507672	hsa-miR-590-3p	CLIP-seq
MIRT1507673	hsa-miR-599	CLIP-seq
MIRT1507674	hsa-miR-612	CLIP-seq
MIRT1507675	hsa-miR-618	CLIP-seq
MIRT1507676	hsa-miR-650	CLIP-seq
MIRT1507677	hsa-miR-943	CLIP-seq
MIRT1507606	hsa-miR-23a	CLIP-seq
MIRT1507607	hsa-miR-23b	CLIP-seq
MIRT1507608	hsa-miR-23c	CLIP-seq
MIRT1507609	hsa-miR-24	CLIP-seq
MIRT2152885	hsa-miR-2909	CLIP-seq
MIRT2152886	hsa-miR-3606	CLIP-seq
MIRT1507627	hsa-miR-3672	CLIP-seq
MIRT2152887	hsa-miR-3926	CLIP-seq
MIRT2152888	hsa-miR-4278	CLIP-seq
MIRT1507638	hsa-miR-4284	CLIP-seq
MIRT2152889	hsa-miR-4433	CLIP-seq
MIRT2152890	hsa-miR-4459	CLIP-seq
MIRT2152891	hsa-miR-4668-5p	CLIP-seq
MIRT1507653	hsa-miR-4698	CLIP-seq
MIRT2152892	hsa-miR-4768-3p	CLIP-seq
MIRT2152893	hsa-miR-4786-5p	CLIP-seq
MIRT2152894	hsa-miR-548s	CLIP-seq
MIRT2152895	hsa-miR-769-5p	CLIP-seq
MIRT1507677	hsa-miR-943	CLIP-seq
MIRT1507604	hsa-miR-2114	CLIP-seq
MIRT1507606	hsa-miR-23a	CLIP-seq
MIRT1507607	hsa-miR-23b	CLIP-seq
MIRT1507608	hsa-miR-23c	CLIP-seq
MIRT2373223	hsa-miR-2682	CLIP-seq
MIRT2373224	hsa-miR-2964a-3p	CLIP-seq
MIRT2373225	hsa-miR-302f	CLIP-seq
MIRT1507617	hsa-miR-3188	CLIP-seq
MIRT2373226	hsa-miR-3197	CLIP-seq
MIRT2373227	hsa-miR-3656	CLIP-seq
MIRT1507629	hsa-miR-3692	CLIP-seq
MIRT1507632	hsa-miR-3929	CLIP-seq
MIRT1507636	hsa-miR-412	CLIP-seq
MIRT1507639	hsa-miR-4419b	CLIP-seq
MIRT2373228	hsa-miR-4423-3p	CLIP-seq
MIRT1507640	hsa-miR-4436b-5p	CLIP-seq
MIRT1507641	hsa-miR-4474-5p	CLIP-seq
MIRT1507643	hsa-miR-4478	CLIP-seq
MIRT2373229	hsa-miR-449c	CLIP-seq
MIRT2373230	hsa-miR-4649-3p	CLIP-seq
MIRT1507653	hsa-miR-4698	CLIP-seq
MIRT2373231	hsa-miR-4722-5p	CLIP-seq
MIRT2152892	hsa-miR-4768-3p	CLIP-seq
MIRT2373232	hsa-miR-485-5p	CLIP-seq
MIRT1507662	hsa-miR-518a-5p	CLIP-seq
MIRT1507664	hsa-miR-527	CLIP-seq
MIRT1507668	hsa-miR-552	CLIP-seq
MIRT2373233	hsa-miR-940	CLIP-seq
MIRT2397283	hsa-miR-1273e	CLIP-seq
MIRT2373224	hsa-miR-2964a-3p	CLIP-seq
MIRT2373225	hsa-miR-302f	CLIP-seq
MIRT2463884	hsa-miR-3668	CLIP-seq
MIRT2397283	hsa-miR-1273e	CLIP-seq
MIRT1507604	hsa-miR-2114	CLIP-seq
MIRT2666075	hsa-miR-217	CLIP-seq
MIRT2373223	hsa-miR-2682	CLIP-seq
MIRT2373224	hsa-miR-2964a-3p	CLIP-seq
MIRT2373225	hsa-miR-302f	CLIP-seq
MIRT1507612	hsa-miR-3120-5p	CLIP-seq
MIRT1507613	hsa-miR-3129-3p	CLIP-seq
MIRT2666076	hsa-miR-3143	CLIP-seq
MIRT1507615	hsa-miR-3163	CLIP-seq
MIRT2666077	hsa-miR-3545-3p	CLIP-seq
MIRT1507620	hsa-miR-3613-3p	CLIP-seq
MIRT1507621	hsa-miR-3622b-5p	CLIP-seq
MIRT1507626	hsa-miR-3664-5p	CLIP-seq
MIRT1507627	hsa-miR-3672	CLIP-seq
MIRT1507630	hsa-miR-371-5p	CLIP-seq
MIRT1507631	hsa-miR-371b-5p	CLIP-seq
MIRT1507637	hsa-miR-4253	CLIP-seq
MIRT2666078	hsa-miR-4282	CLIP-seq
MIRT2373228	hsa-miR-4423-3p	CLIP-seq
MIRT2373229	hsa-miR-449c	CLIP-seq
MIRT1507647	hsa-miR-4522	CLIP-seq
MIRT2666079	hsa-miR-4668-3p	CLIP-seq
MIRT2373231	hsa-miR-4722-5p	CLIP-seq
MIRT2152892	hsa-miR-4768-3p	CLIP-seq
MIRT1507666	hsa-miR-548c-3p	CLIP-seq
MIRT1507667	hsa-miR-548u	CLIP-seq
MIRT2666080	hsa-miR-579	CLIP-seq
MIRT1507675	hsa-miR-618	CLIP-seq
MIRT2373233	hsa-miR-940	CLIP-seq
MIRT2397283	hsa-miR-1273e	CLIP-seq
MIRT2373223	hsa-miR-2682	CLIP-seq
MIRT2373224	hsa-miR-2964a-3p	CLIP-seq
MIRT2373225	hsa-miR-302f	CLIP-seq
MIRT1507612	hsa-miR-3120-5p	CLIP-seq
MIRT1507615	hsa-miR-3163	CLIP-seq
MIRT1507620	hsa-miR-3613-3p	CLIP-seq
MIRT1507626	hsa-miR-3664-5p	CLIP-seq
MIRT1507627	hsa-miR-3672	CLIP-seq
MIRT1507630	hsa-miR-371-5p	CLIP-seq
MIRT1507631	hsa-miR-371b-5p	CLIP-seq
MIRT2666078	hsa-miR-4282	CLIP-seq
MIRT2373228	hsa-miR-4423-3p	CLIP-seq
MIRT2373229	hsa-miR-449c	CLIP-seq
MIRT1507647	hsa-miR-4522	CLIP-seq
MIRT2373231	hsa-miR-4722-5p	CLIP-seq
MIRT2152892	hsa-miR-4768-3p	CLIP-seq
MIRT1507666	hsa-miR-548c-3p	CLIP-seq
MIRT1507675	hsa-miR-618	CLIP-seq
MIRT2373233	hsa-miR-940	CLIP-seq

Show/Hide all (4)

GO ID	Ontology	Definition	Evidence
GO:0003676	Function	Nucleic acid binding	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0071514	Process	Genomic imprinting	IBA

MIM	HGNC	e!Ensembl
617059	29313	ENSG00000204186

Q9HCK1

Protein name

DBF4-type zinc finger-containing protein 2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07535	zf-DBF	3 → 36	DBF zinc finger	Domain

Sequence

MQKRQGYCSYCRVQYNNLEQHLFSAQHRSLTRQSRRQICTSSLMERFLQDVLQHHPYHCQ
ESSSTQDETHVNTGSSSEVVHLDDAFSEEEEEDEDKVEDEDATEERPSEVSEPIEELHSR
PHKSQEGTQEVSVRPSVIQKLEKGQQQPLEFVHKIGASVRKCNLVDIGQATNNRSNLVRP
PVICNAPASCLPESSNDRPVTANTTSLPPAAHLDSVSKCDPNKVEKYLEQPDGASRNPVP
SSHVETTSFSYQKHKESNRKSLRMNSDKLVLWKDVKSQGKTLSAGLKFHERMGTKGSLRV
KSPSKLAVNPNKTDMPSNKGIFEDTIAKNHEEFFSNMDCTQEEKHLVFNKTAFWEQKCSV
SSEMKFDCISLQSASDQPQETAQDLSLWKEEQIDQEDNYESRGSEMSFDCSSSFHSLTDQ
SKVSAKEVNLSKEVRTDVQYKNNKSYVSKISSDCDDILHLVTNQSQMIVKEISLQNARHI
SLVDQSYESSSSETNFDCDASPQSTSDYPQQSVTEVNLPKEVHIGLVDKNYGSSSSEVSA
DSVFPLQSVVDRPPVAVTETKLRKKAHTSLVDNYGSSCSETSFDCDVSLESVVDHPQLTV
KGRNLKGRQVHLKHKKRKPSSAKAHLDCDVSLGTVADESQRAVEKINLLKEKNADLMDMN
CESHGPEMGFQADAQLADQSQVAEIERQKVDVDLENKSVQSSRSSLSSDSPASLYHSAHD
EPQEALDEVNLKELNIDMEVRSYDCSSSELTFDSDPPLLSVTEQSHLDAEGKERHIDLED
ESCESDSSEITFDSDIPLYSVIDQPEVAVYEEETVDLESKSNESCVSEITFDSDIPLHSG
NDHPEVAVKEVIQKEEYIHLERKNDEPSGSEISSDSHAPLHSVTNSPEVAVKKLNPQKEE
QVHLENKENEPIDSEVSLDYNIIFHSVTGRSEDPIKEISLHTKEHMYLENKSVFETSLDS
DVPLQAATHKPEVIVKETWLQREKHAEFQGRSTEFSGSKTSLDSGVPHYSVTEPQVAVNK
INRKKQYVLENKNDKCSGSEIILDSNVPPQSMTDQPQLAFLKEKHVNLKDKNSKSGDSKI
TFDSEQLQEAVKKIDQWKEEVIGLKNKINEPSTYKLIHHPDVSVQSVADQPKVAIKHVNL
GNENHMYLEVKNSQYSCSEMNLDSGFLGQSIVNRPQITILEQEHIELEGKHNQCCGSEVS
FDSDDPLQSVADRLRETVKEISLWKDEEVDTEDRRNEAKGFEIMYDSDVLQPVAGQPEEV
VKEVSLWKEHVDLENKIVKPTDSRINFDSHEPLQSVTNKIPGANKEINLLREEHVCLDDK
GYVPSDSEIIYVSNIPLQSVIKQPHILEEEHASLEDKSSNSYSPEESSDSNDSFQAAADE
LQKPVKEINLWKEDHIYLEDKSYKLGDFDVSYASHIPVQFVTDQSSVPVKEINLQKKDHN
DLENKNCEVCGSEIKCHSCVHLQSEVDQPQVSYKEADLQKEEHVVMEEKTDQPSDSEMMY
DSDVPFQIVVNQFPGSVKETHLPKVVLVDLVPGDSDYEVISDDIPLQLVTDPPQLTVKDI
SCINTECIDIEDKSCDFFGSEVRCNCKASTPSMTNQCKETFKIINRKKDYIILGEPSCQS
CGSEMNFNVDASDQSMTYESQGPDEKMVKYIDSEDKSCGYNGSKGKFNLEDTSHRTTHRL
QKAHKEASLRKDPRNAGLKGKSCQSSASAVDFGASSKSALHRRADKKKRSKLKHRDLEVS
CEPDGFEMNFQCAPPLPSDTDQPQETVKKRHPCKKVSSDLKEKNHDSQSSSVLKVDSVRN
LKKAKDVIEDNPDEPVLEALPHVPPSFVGKTWSQIMREDDIKINALVKEFREGRFHCYFD
DDCETKKVSSKGKKKVTWADLQGKEDTAPTQAVSESDDIVCGISDIDDLSVALDKPCHRH
PPAERPPKQKGRVASQCQTAKISHSTQTSCKNYPVMKRKIIRQEEDPPKSKCSRLQDDRK
TKKKVKIGTVEFPASCTKVLKPMQPKALVCVLSSLNIKLKEGEGLPFPKMRHHSWDNDIR
FICKYKRNIFDYYEPLIKQIVISPPLSVIVPEFERRNWVKIHFNRSNQNSSAGDNDADGQ
GSASAPLMAVPARYGFNSHQGTSDSSLFLEESKVLHARELPKKRNFQLTFLNHDVVKISP
KSVRNKLLESQSKKKIHGKRVTTSSNKLGFPKKVYKPIILQQKPRKASEKQSIWIRTKPS
DIIRKYISKYSVFLRHRYQSRSAFLGRYLKKKKSVVSRLKKAKRTAKVLLNSSVPPAGAE
ELSSAMANPPPKRPVRASCRVARRRKKTDESYHGRQKGPSTPVRAYDLRSSSCLQQRERM
MTRLANKLRGNEVK

Sequence length

2354

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Breast ductal adenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NASOPALPEBRAL LIPOMA COLOBOMA SYNDROME	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nasopalpebral lipoma-coloboma syndrome	Uncertain significance	ClinVar GenCC	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SMALL CELL LUNG CARCINOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Beckwith Wiedemann Syndrome	Associate	30898153	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Associate	32721119	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopalpebral lipoma coloboma syndrome	Associate	27139419	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neoplasms	Associate	32721119	★★★★★ ★☆☆☆☆ Found in Text Mining only
Teratozoospermia	Associate	25762640	★★★★★ ★☆☆☆☆ Found in Text Mining only
Voice Disorders	Associate	30898153	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZDBF2 (zinc finger DBF-type containing 2)