Gene Gene information from NCBI Gene database.
Entrez ID 57678
Gene name Glycerol-3-phosphate acyltransferase, mitochondrial
Gene symbol GPAM
Synonyms (NCBI Gene)
GPATGPAT1
Chromosome 10
Chromosome location 10q25.2
Summary This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway`s first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochond
miRNA miRNA information provided by mirtarbase database.
470
miRTarBase ID miRNA Experiments Reference
MIRT001462 hsa-miR-16-5p pSILAC 18668040
MIRT020743 hsa-miR-155-5p Proteomics 18668040
MIRT022016 hsa-miR-128-3p Sequencing 20371350
MIRT027339 hsa-miR-101-3p Sequencing 20371350
MIRT028739 hsa-miR-27a-3p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
43
GO ID Ontology Definition Evidence Reference
GO:0001817 Process Regulation of cytokine production IEA
GO:0004366 Function Glycerol-3-phosphate O-acyltransferase activity EXP 18238778
GO:0004366 Function Glycerol-3-phosphate O-acyltransferase activity IBA
GO:0004366 Function Glycerol-3-phosphate O-acyltransferase activity IEA
GO:0004366 Function Glycerol-3-phosphate O-acyltransferase activity IMP 18238778, 19075029
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602395 24865 ENSG00000119927
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9HCL2
Protein name Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15)
Protein function Mitochondrial membrane protein that catalyzes the essential first step of biosynthesis of glycerolipids such as triglycerides, phosphatidic acids and lysophosphatidic acids (PubMed:18238778, PubMed:19075029, PubMed:36522428). Esterifies acyl-gro
PDB 8E4Y , 8E50
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01553 Acyltransferase 203 355 Acyltransferase Family
Sequence
MDESALTLGTIDVSYLPHSSEYSVGRCKHTSEEWGECGFRPTIFRSATLKWKESLMSRKR
PFVGRCCYSCTPQSWDKFFNPSIPSLGLRNVIYINETHTRHRGWLARRLSYVLFIQERDV
HKGMFATNVTENVLNSSRVQEAIAEVAAELNPDGSAQQQSKAVNKVKKKAKRILQEMVAT
VSPAMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLT
FILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRLDETPDGRKDVLYRALLHGHI
VELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSTNVIPDILIIPVGIS
YDRII
EGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGCVRVDFAQPFSLKEYLESQSQKPVSA
LLSLEQALLPAILPSRPSDAADEGRDTSINESRNATDESLRRRLIANLAEHILFTASKSC
AIMSTHIVACLLLYRHRQGIDLSTLVEDFFVMKEEVLARDFDLGFSGNSEDVVMHAIQLL
GNCVTITHTSRNDEFFITPSTTVPSVFELNFYSNGVLHVFIMEAIIACSLYAVLNKRGLG
GPTSTPPNLISQEQLVRKAASLCYLLSNEGTISLPCQTFYQVCHETVGKFIQYGILTVAE
HDDQEDISPSLAEQQWDKKLPEPLSWRSDEEDEDSDFGEEQRDCYLKVSQSKEHQQFITF
LQRLLGPLLEAYSSAAIFVHNFSGPVPEPEYLQKLHKYLITRTERNVAVYAESATYCLVK
NAVKMFKDIGVFKETKQKRVSVLELSSTFLPQCNRQKLLEYILSFVVL
Sequence length 828
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Glycerolipid metabolism
Glycerophospholipid metabolism
Metabolic pathways
  Synthesis of PA
Activation of gene expression by SREBF (SREBP)
Triglyceride biosynthesis
RUNX1 regulates estrogen receptor mediated transcription
Estrogen-dependent gene expression