Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
57678
Gene name Gene Name - the full gene name approved by the HGNC.
Glycerol-3-phosphate acyltransferase, mitochondrial
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GPAM
Synonyms (NCBI Gene) Gene synonyms aliases
GPAT, GPAT1
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q25.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway`s first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochond
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001462 hsa-miR-16-5p pSILAC 18668040
MIRT020743 hsa-miR-155-5p Proteomics 18668040
MIRT022016 hsa-miR-128-3p Sequencing 20371350
MIRT027339 hsa-miR-101-3p Sequencing 20371350
MIRT028739 hsa-miR-27a-3p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001817 Process Regulation of cytokine production IEA
GO:0004366 Function Glycerol-3-phosphate O-acyltransferase activity EXP 18238778
GO:0004366 Function Glycerol-3-phosphate O-acyltransferase activity IBA
GO:0004366 Function Glycerol-3-phosphate O-acyltransferase activity IEA
GO:0004366 Function Glycerol-3-phosphate O-acyltransferase activity IMP 18238778, 19075029
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602395 24865 ENSG00000119927
Protein
UniProt ID Q9HCL2
Protein name Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15)
Protein function Mitochondrial membrane protein that catalyzes the essential first step of biosynthesis of glycerolipids such as triglycerides, phosphatidic acids and lysophosphatidic acids (PubMed:18238778, PubMed:19075029, PubMed:36522428). Esterifies acyl-gro
PDB 8E4Y , 8E50
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01553 Acyltransferase 203 355 Acyltransferase Family
Sequence
MDESALTLGTIDVSYLPHSSEYSVGRCKHTSEEWGECGFRPTIFRSATLKWKESLMSRKR
PFVGRCCYSCTPQSWDKFFNPSIPSLGLRNVIYINETHTRHRGWLARRLSYVLFIQERDV
HKGMFATNVTENVLNSSRVQEAIAEVAAELNPDGSAQQQSKAVNKVKKKAKRILQEMVAT
VSPAMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLT
FILFCHNIKAPYIASGNNLNIPIFSTLIHKLGGFFIRRRLDETPDGRKDVLYRALLHGHI
VELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSTNVIPDILIIPVGIS
YDRII
EGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGCVRVDFAQPFSLKEYLESQSQKPVSA
LLSLEQALLPAILPSRPSDAADEGRDTSINESRNATDESLRRRLIANLAEHILFTASKSC
AIMSTHIVACLLLYRHRQGIDLSTLVEDFFVMKEEVLARDFDLGFSGNSEDVVMHAIQLL
GNCVTITHTSRNDEFFITPSTTVPSVFELNFYSNGVLHVFIMEAIIACSLYAVLNKRGLG
GPTSTPPNLISQEQLVRKAASLCYLLSNEGTISLPCQTFYQVCHETVGKFIQYGILTVAE
HDDQEDISPSLAEQQWDKKLPEPLSWRSDEEDEDSDFGEEQRDCYLKVSQSKEHQQFITF
LQRLLGPLLEAYSSAAIFVHNFSGPVPEPEYLQKLHKYLITRTERNVAVYAESATYCLVK
NAVKMFKDIGVFKETKQKRVSVLELSSTFLPQCNRQKLLEYILSFVVL
Sequence length 828
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycerolipid metabolism
Glycerophospholipid metabolism
Metabolic pathways
  Synthesis of PA
Activation of gene expression by SREBF (SREBP)
Triglyceride biosynthesis
RUNX1 regulates estrogen receptor mediated transcription
Estrogen-dependent gene expression
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Biliary Atresia Biliary atresia N/A N/A GWAS
Metabolic Syndrome Metabolic syndrome N/A N/A GWAS
Ovarian cancer Epithelial ovarian cancer N/A N/A GWAS
Psoriasis Psoriasis N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Chemical and Drug Induced Liver Injury Associate 33347879
Fatty Liver Associate 33347879, 34216018
Fibrosis Associate 35474605, 36280732
Insulin Resistance Inhibit 27627982
Liver Diseases Associate 33347879
Liver Failure Associate 34216018
Non alcoholic Fatty Liver Disease Associate 36280732