Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
57659
Gene name Gene Name - the full gene name approved by the HGNC.
Zinc finger and BTB domain containing 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ZBTB4
Synonyms (NCBI Gene) Gene synonyms aliases
KAISO-L1, ZNF903
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p13.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020226 hsa-miR-130b-3p Sequencing 20371350
MIRT023262 hsa-miR-122-5p Microarray 17612493
MIRT031203 hsa-miR-19b-3p Sequencing 20371350
MIRT048706 hsa-miR-99a-5p CLASH 23622248
MIRT047828 hsa-miR-30d-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 16354688
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 16354688
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0001227 Function DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 16354688
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612308 23847 ENSG00000174282
Protein
UniProt ID Q9P1Z0
Protein name Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1)
Protein function Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00651 BTB 20 77 BTB/POZ domain Domain
Sequence
MPPPAEVTDPSHAPAVLRQLNEQRLRGLFCDVTLIAGDTKFPAHRSVLAASSPFFREALL
TSAPLPLPPATGGAAPN
PATTTAASSSSSSSSSSSSSSSSASSSSSSSSSSPPPASPPAS
SPPRVLELPGVPAAAFSDVLNFIYSARLALPGGGGDGAAVAEIGALGRRLGISRLQGLGE
GGDAWVPPTPAPMATSQPEEDSFGPGPRPAGEWEGDRAEAQAPDLQCSLPRRPLPCPQCG
KSFIHPKRLQTHEAQCRRGASTRGSTGLGAGGAGPGGPAGVDASALPPPVGFRGGPEHVV
KVVGGHVLYVCAACERSYVTLSSLKRHSNVHSWRRKYPCRYCEKVFALAEYRTKHEVWHT
GERRYQCIFCWETFVTYYNLKTHQRAFHGISPGLLASEKTPNGGYKPKLNTLKLYRLLPM
RAAKRPYKTYSQGAPEAPLSPTLNTPAPVAMPASPPPGPPPAPEPGPPPSVITFAHPAPS
VIVHGGSSSGGGGSGTASTGGSQAASVITYTAPPRPPKKREYPPPPPEPAATPTSPATAV
SPATAAGPAMATTTEEAKGRNPRAGRTLTYTAKPVGGIGGGGGPPTGAGRGPSQLQAPPP
LCQITVRIGEEAIVKRRISETDLRPGELSGEEMEESEEDEEEEDEEEEEEDEEESKAGGE
DQLWRPYYSYKPKRKAGAAGGASVGGSGLPRGRRPPRWRQKLERRSWEETPAAESPAGRA
RTERRHRCGDCAQTFTTLRKLRKHQEAHGGGSHSSRAGRRPSTRFTCPHCAKVCKTAAAL
SRHGQRHAAERPGGTPTPVIAYSKGSAGTRPGDVKEEAPQEMQVSSSSGEAGGGSTAAEE
ASETASLQDPIISGGEEPPVVASGGSYVYPPVQEFPLALIGGGREPGGGRGKSGSEGPVG
AGEGDRMEGIGAAKVTFYPEPYPLVYGPQLLAAYPYNFSNLAALPVALNMVLPDEKGAGA
LPFLPGVFGYAVNPQAAPPAPPTPPPPTLPPPIPPKGEGERAGVERTQKGDVG
Sequence length 1013
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Uterine Fibroids Uterine Fibroids GWAS
Heart Failure Heart Failure GWAS
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 29045054
Brain Injuries Traumatic Stimulate 36646969
Breast Neoplasms Inhibit 21765466, 23251453
Glioblastoma Associate 34047477
Glioma Associate 34047477
Neoplasms Inhibit 18451802
Neoplasms Associate 36949454
Oncogene Addiction Inhibit 21765466
Pancreatic Neoplasms Inhibit 36949454
Prostatic Neoplasms Associate 26501111