Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	57623
Gene name	Zinc finger and AT-hook domain containing
Gene symbol	ZFAT
Synonyms (NCBI Gene)	AITD3ZFAT1ZNF406
Chromosome	8
Chromosome location	8q24.22
Summary	This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splic

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miRTarBase ID	miRNA	Experiments	Reference
MIRT047133	hsa-miR-183-5p	CLASH	23622248
MIRT439238	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439238	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1509757	hsa-miR-1324	CLIP-seq
MIRT1509758	hsa-miR-452	CLIP-seq
MIRT1509759	hsa-miR-4676-3p	CLIP-seq
MIRT1509760	hsa-miR-873	CLIP-seq
MIRT1509761	hsa-miR-1207-5p	CLIP-seq
MIRT1509762	hsa-miR-1226	CLIP-seq
MIRT1509763	hsa-miR-1229	CLIP-seq
MIRT1509764	hsa-miR-1245b-3p	CLIP-seq
MIRT1509765	hsa-miR-1321	CLIP-seq
MIRT1509757	hsa-miR-1324	CLIP-seq
MIRT1509766	hsa-miR-153	CLIP-seq
MIRT1509767	hsa-miR-217	CLIP-seq
MIRT1509768	hsa-miR-29a	CLIP-seq
MIRT1509769	hsa-miR-29b	CLIP-seq
MIRT1509770	hsa-miR-29c	CLIP-seq
MIRT1509771	hsa-miR-3616-3p	CLIP-seq
MIRT1509772	hsa-miR-3663-3p	CLIP-seq
MIRT1509773	hsa-miR-3678-3p	CLIP-seq
MIRT1509774	hsa-miR-4270	CLIP-seq
MIRT1509775	hsa-miR-4287	CLIP-seq
MIRT1509776	hsa-miR-4321	CLIP-seq
MIRT1509777	hsa-miR-4428	CLIP-seq
MIRT1509778	hsa-miR-4441	CLIP-seq
MIRT1509779	hsa-miR-4469	CLIP-seq
MIRT1509780	hsa-miR-4494	CLIP-seq
MIRT1509758	hsa-miR-452	CLIP-seq
MIRT1509759	hsa-miR-4676-3p	CLIP-seq
MIRT1509781	hsa-miR-4685-3p	CLIP-seq
MIRT1509782	hsa-miR-4728-5p	CLIP-seq
MIRT1509783	hsa-miR-4733-3p	CLIP-seq
MIRT1509784	hsa-miR-4739	CLIP-seq
MIRT1509785	hsa-miR-4756-5p	CLIP-seq
MIRT1509786	hsa-miR-4763-3p	CLIP-seq
MIRT1509787	hsa-miR-642a	CLIP-seq
MIRT1509788	hsa-miR-767-5p	CLIP-seq
MIRT1509760	hsa-miR-873	CLIP-seq
MIRT1509789	hsa-miR-137	CLIP-seq
MIRT1509790	hsa-miR-138	CLIP-seq
MIRT1509791	hsa-miR-4299	CLIP-seq
MIRT1509792	hsa-miR-4728-3p	CLIP-seq
MIRT1509793	hsa-miR-628-5p	CLIP-seq
MIRT1509761	hsa-miR-1207-5p	CLIP-seq
MIRT2153544	hsa-miR-1264	CLIP-seq
MIRT1509765	hsa-miR-1321	CLIP-seq
MIRT1509768	hsa-miR-29a	CLIP-seq
MIRT1509769	hsa-miR-29b	CLIP-seq
MIRT1509770	hsa-miR-29c	CLIP-seq
MIRT2153545	hsa-miR-3117-5p	CLIP-seq
MIRT1509771	hsa-miR-3616-3p	CLIP-seq
MIRT1509772	hsa-miR-3663-3p	CLIP-seq
MIRT1509774	hsa-miR-4270	CLIP-seq
MIRT1509777	hsa-miR-4428	CLIP-seq
MIRT1509778	hsa-miR-4441	CLIP-seq
MIRT1509792	hsa-miR-4728-3p	CLIP-seq
MIRT1509782	hsa-miR-4728-5p	CLIP-seq
MIRT1509784	hsa-miR-4739	CLIP-seq
MIRT1509785	hsa-miR-4756-5p	CLIP-seq
MIRT1509786	hsa-miR-4763-3p	CLIP-seq
MIRT1509788	hsa-miR-767-5p	CLIP-seq
MIRT1509760	hsa-miR-873	CLIP-seq
MIRT1509762	hsa-miR-1226	CLIP-seq
MIRT1509763	hsa-miR-1229	CLIP-seq
MIRT2153544	hsa-miR-1264	CLIP-seq
MIRT1509766	hsa-miR-153	CLIP-seq
MIRT1509767	hsa-miR-217	CLIP-seq
MIRT2153545	hsa-miR-3117-5p	CLIP-seq
MIRT1509771	hsa-miR-3616-3p	CLIP-seq
MIRT1509775	hsa-miR-4287	CLIP-seq
MIRT1509779	hsa-miR-4469	CLIP-seq
MIRT1509780	hsa-miR-4494	CLIP-seq
MIRT2373850	hsa-miR-4501	CLIP-seq
MIRT1509781	hsa-miR-4685-3p	CLIP-seq
MIRT1509783	hsa-miR-4733-3p	CLIP-seq
MIRT1509787	hsa-miR-642a	CLIP-seq
MIRT2695667	hsa-miR-127-5p	CLIP-seq
MIRT2695668	hsa-miR-3936	CLIP-seq
MIRT2695669	hsa-miR-4635	CLIP-seq
MIRT2695670	hsa-miR-493	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0002244	Process	Hematopoietic progenitor cell differentiation	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	36162510
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0030097	Process	Hemopoiesis	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
610931	19899	ENSG00000066827

Q9P243

Protein name

Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406)

Protein function

May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity).

PDB

2ELM , 2ELN , 2ELO , 2ELP , 2ELQ , 2ELR , 2ELS , 2ELT , 2ELU , 2ELV , 2RSH , 2RSI , 2RSJ , 2RUT , 2RUU , 2RUV , 2RUW , 2RUX , 2RUY , 2RUZ , 2RV0 , 2RV1 , 2RV2 , 2RV3 , 2RV6 , 2RV7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00096	zf-C2H2	271 → 293	Zinc finger, C2H2 type	Domain
PF13909	zf-H2C2_5	299 → 323		Domain
PF00096	zf-C2H2	909 → 931	Zinc finger, C2H2 type	Domain
PF13909	zf-H2C2_5	966 → 989		Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 is strongly expressed in placenta, spleen, kidney, testis and peripheral blood leukocytes. Expressed in CD4+ and CD8+ T-cells, CD19+ B-cells and CB14+ monocytes. Isoform 3 is strongly expressed in placenta, ovary, tonsil, CD1

Sequence

METRAAENTAIFMCKCCNLFSPNQSELLSHVSEKHMEEGVNVDEIIIPLRPLSTPEPPNS
SKTGDEFLVMKRKRGRPKGSTKKSSTEEELAENIVSPTEDSPLAPEEGNSLPPSSLECSK
CCRKFSNTRQLRKHICIIVLNLGEEEGEAGNESDLELEKKCKEDDREKASKRPRSQKTEK
VQKISGKEARQLSGAKKPIISVVLTAHEAIPGATKIVPVEAGPPETGATNSETTSADLVP
RRGYQEYAIQQTPYEQPMKSSRLGPTQLKIFTCEYCNKVFKFKHSLQAHLRIHTNEKPYK
CPQCSYASAIKANLNVHLRKHTGEKFACDYCSFTCLSKGHLKVHIERVHKKIKQHCRFCK
KKYSDVKNLIKHIRDAHDPQDKKVKEALDELCLMTREGKRQLLYDCHICERKFKNELDRD
RHMLVHGDKWPFACELCGHGATKYQALELHVRKHPFVYVCAVCRKKFVSSIRLRTHIKEV
HGAAQEALVFTSSINQSFCLLEPGGDIQQEALGDQLQLVEEEFALQGVNALKEEACPGDT
QLEEGRKEPEAPGEMPAPAVHLASPQAESTALPPCELETTVVSSSDLHSQEVVSDDFLLK
NDTSSAEAHAAPEKPPDMQHRSSVQTQGEVITLLLSKAQSAGSDQESHGAQSPLGEGQNM
AVLSAGDPDPSRCLRSNPAEASDLLPPVAGGGDTITHQPDSCKAAPEHRSGITAFMKVLN
SLQKKQMNTSLCERIRKVYGDLECEYCGKLFWYQVHFDMHVRTHTREHLYYCSQCHYSSI
TKNCLKRHVIQKHSNILLKCPTDGCDYSTPDKYKLQAHLKVHTALDKRSYSCPVCEKSFS
EDRLIKSHIKTNHPEVSMSTISEVLGRRVQLKGLIGKRAMKCPYCDFYFMKNGSDLQRHI
WAHEGVKPFKCSLCEYATRSKSNLKAHMNRHSTEKTHLCDMCGKKFKSKGTLKSHKLLHT
ADGKQFKCTVCDYTAAQKPQLLRHMEQHVSFKPFRCAHCHYSCNISGSLKRHYNRKHPNE
EYANVGTGELAAEVLIQQGGLKCPVCSFVYGTKWEFNRHLKNKHGLKVVEIDGDPKWETA
TEAPEEPSTQYLHITEAEEDVQGTQAAVAALQDLRYTSESGDRLDPTAVNILQQIIELGA
ETHDATALASVVAMAPGTVTVVKQVTEEEPSSNHTVMIQETVQQASVELAEQHHLVVSSD
DVEGIETVTVYTQGGEASEFIVYVQEAMQPVEEQAVEQPAQEL

Sequence length

1243

Interactions

View interactions

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs75824083	RCV005913514
Autoimmune thyroid disease, susceptibility to, 3	risk factor; Uncertain significance	rs16905194, rs1428157950, rs2488654636	RCV000001139 RCV002272659 RCV003988761
Cervical cancer	Benign	rs75824083	RCV005913515
Melanoma	Uncertain significance	rs192292042	RCV005929020
Ovarian serous cystadenocarcinoma	Benign	rs75824083	RCV005913517
Sarcoma	Uncertain significance; Benign	rs192292042, rs75824083	RCV005929019 RCV005913516
Uterine corpus endometrial carcinoma	Benign	rs75824083	RCV005913518
Uveal melanoma	Uncertain significance	rs192292042	RCV005929018

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	30153862
Cleft Palate	Associate	34382870
Hypertension	Associate	21626137
Medulloblastoma	Associate	19584924
Multiple Sclerosis	Associate	27572828
Pelvic Organ Prolapse	Associate	22105264, 30153862
Thyroiditis Autoimmune	Associate	30153862

ZFAT (zinc finger and AT-hook domain containing)