SHROOM3 (shroom family member 3)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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57619 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Shroom family member 3 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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SHROOM3 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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APXL3, MSTP013, SHRM, ShrmL |
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Chromosome
Chromosome number
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4 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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4q21.1 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a PDZ-domain-containing protein that belongs to a family of Shroom-related proteins. This protein may be involved in regulating cell shape in certain tissues. A similar protein in mice is required for proper neurulation. [provided by Ref |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||
| UniProt ID | Q8TF72 | ||||||||||||||||||||
| Protein name | Protein Shroom3 (Shroom-related protein) (hShrmL) | ||||||||||||||||||||
| Protein function | Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). | ||||||||||||||||||||
| PDB | 6FBB , 6FCP | ||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 1996 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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