Gene Gene information from NCBI Gene database.
Entrez ID 57606
Gene name SLAIN motif family member 2
Gene symbol SLAIN2
Synonyms (NCBI Gene)
KIAA1458
Chromosome 4
Chromosome location 4p11
miRNA miRNA information provided by mirtarbase database.
362
miRTarBase ID miRNA Experiments Reference
MIRT030692 hsa-miR-21-5p Microarray 18591254
MIRT093988 hsa-miR-409-3p PAR-CLIP 21572407
MIRT093983 hsa-miR-103a-3p PAR-CLIP 21572407
MIRT093984 hsa-miR-107 PAR-CLIP 21572407
MIRT093990 hsa-miR-944 PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21646404, 26496610, 33961781
GO:0005737 Component Cytoplasm IEA
GO:0005813 Component Centrosome IDA 21399614
GO:0005829 Component Cytosol IDA
GO:0005856 Component Cytoskeleton IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610492 29282 ENSG00000109171
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9P270
Protein name SLAIN motif-containing protein 2
Protein function Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. {
PDB 3RDV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15301 SLAIN 130 581 SLAIN motif-containing family Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed with highest levels in adult liver, testis and ovary, and lowest levels in adult pancreas and spleen and in fetal brain. {ECO:0000269|PubMed:10819331}.
Sequence
Sequence length 581
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Uterine corpus endometrial carcinoma Uncertain significance rs1715864613 RCV005927290
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Colorectal Neoplasms Associate 30797712
Dementia Associate 28600779
Intellectual Disability Associate 28600779
Neoplasm Metastasis Associate 30797712