Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	57595
Gene name	PDZ domain containing 4
Gene symbol	PDZD4
Synonyms (NCBI Gene)	LNX5LU1PDZK4PDZRN4L
Chromosome	X
Chromosome location	Xq28

153

Show/Hide all (153)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018281	hsa-miR-335-5p	Microarray	18185580
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT622840	hsa-miR-6888-5p	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT491712	hsa-miR-6777-5p	PAR-CLIP	23592263
MIRT491711	hsa-miR-6889-5p	PAR-CLIP	23592263
MIRT491710	hsa-miR-6089	PAR-CLIP	23592263
MIRT491708	hsa-miR-6869-3p	PAR-CLIP	23592263
MIRT491709	hsa-miR-3960	PAR-CLIP	23592263
MIRT491707	hsa-miR-8072	PAR-CLIP	23592263
MIRT491706	hsa-miR-4706	PAR-CLIP	23592263
MIRT491705	hsa-miR-4749-5p	PAR-CLIP	23592263
MIRT491704	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT491703	hsa-miR-663a	PAR-CLIP	23592263
MIRT491702	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT491701	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT491700	hsa-miR-8085	PAR-CLIP	23592263
MIRT491699	hsa-miR-3175	PAR-CLIP	23592263
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT622840	hsa-miR-6888-5p	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT491712	hsa-miR-6777-5p	PAR-CLIP	23592263
MIRT491711	hsa-miR-6889-5p	PAR-CLIP	23592263
MIRT491710	hsa-miR-6089	PAR-CLIP	23592263
MIRT491708	hsa-miR-6869-3p	PAR-CLIP	23592263
MIRT491709	hsa-miR-3960	PAR-CLIP	23592263
MIRT491707	hsa-miR-8072	PAR-CLIP	23592263
MIRT491706	hsa-miR-4706	PAR-CLIP	23592263
MIRT491705	hsa-miR-4749-5p	PAR-CLIP	23592263
MIRT491704	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT491703	hsa-miR-663a	PAR-CLIP	23592263
MIRT491702	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT491701	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT491700	hsa-miR-8085	PAR-CLIP	23592263
MIRT491699	hsa-miR-3175	PAR-CLIP	23592263
MIRT1224064	hsa-miR-185	CLIP-seq
MIRT1224065	hsa-miR-3650	CLIP-seq
MIRT1224066	hsa-miR-4455	CLIP-seq
MIRT1224067	hsa-miR-548aa	CLIP-seq
MIRT1224068	hsa-miR-548ac	CLIP-seq
MIRT1224069	hsa-miR-548d-3p	CLIP-seq
MIRT1224070	hsa-miR-548z	CLIP-seq
MIRT1224071	hsa-miR-609	CLIP-seq
MIRT2065302	hsa-miR-1224-3p	CLIP-seq
MIRT2065303	hsa-miR-1260	CLIP-seq
MIRT2065304	hsa-miR-1260b	CLIP-seq
MIRT2065305	hsa-miR-1280	CLIP-seq
MIRT2065306	hsa-miR-2115	CLIP-seq
MIRT2065307	hsa-miR-3074-5p	CLIP-seq
MIRT2065308	hsa-miR-3190	CLIP-seq
MIRT2065309	hsa-miR-4514	CLIP-seq
MIRT2065310	hsa-miR-4688	CLIP-seq
MIRT2065311	hsa-miR-4691-5p	CLIP-seq
MIRT2065312	hsa-miR-4692	CLIP-seq
MIRT2065313	hsa-miR-4773	CLIP-seq
MIRT2065314	hsa-miR-4786-3p	CLIP-seq
MIRT2065315	hsa-miR-516a-3p	CLIP-seq
MIRT2065316	hsa-miR-532-3p	CLIP-seq
MIRT2065317	hsa-miR-671-5p	CLIP-seq
MIRT2065318	hsa-miR-759	CLIP-seq
MIRT2065308	hsa-miR-3190	CLIP-seq
MIRT2065313	hsa-miR-4773	CLIP-seq
MIRT2065314	hsa-miR-4786-3p	CLIP-seq
MIRT2065317	hsa-miR-671-5p	CLIP-seq
MIRT2456212	hsa-miR-1470	CLIP-seq
MIRT2456213	hsa-miR-3127-3p	CLIP-seq
MIRT2456214	hsa-miR-4446-5p	CLIP-seq
MIRT2456215	hsa-miR-4667-3p	CLIP-seq
MIRT2456216	hsa-miR-4755-5p	CLIP-seq
MIRT2456217	hsa-miR-642a	CLIP-seq
MIRT2456212	hsa-miR-1470	CLIP-seq
MIRT2456213	hsa-miR-3127-3p	CLIP-seq
MIRT2456214	hsa-miR-4446-5p	CLIP-seq
MIRT2456215	hsa-miR-4667-3p	CLIP-seq
MIRT2456216	hsa-miR-4755-5p	CLIP-seq
MIRT2456217	hsa-miR-642a	CLIP-seq
MIRT2591193	hsa-miR-1266	CLIP-seq
MIRT2591194	hsa-miR-4279	CLIP-seq
MIRT2591195	hsa-miR-4518	CLIP-seq

Show/Hide all (2)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0005938	Component	Cell cortex	IEA

MIM	HGNC	e!Ensembl
300634	21167	ENSG00000067840

Q76G19

Protein name

PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00595	PDZ	130 → 212	PDZ domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Brain-specific. Expressed in fetal and adult brain. Up-regulated in synovial carcinomas. {ECO:0000269|PubMed:15077175}.

Sequence

MGCNMCVVQKPEEQYKVMLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDS
SCHDLQLVDSGTQTDITFEHIMALGKLRPPTPPMVILEPPPISHEYYDPAEFMEGGPQEA
DRLDELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDR
IIQINGVDVQNREEAVAILSQEENTNISLLVARPESQLAKRWKDSDRDDFLDDFGSENEG
ELRARKLKSPPAQQPGNEEEKGAPDAGPGLSNSQELDSGVGRTDESTRNEESSEHDLLGD
EPPSSTNTPGSLRKFGLQGDALQSRDFHFSMDSLLAEGAGLGGGDVPGLTDEEYERYREL
LEIKCHLENGNQLGLLFPRASGGNSALDVNRNESLGHEMAMLEEELRHLEFKCRNILRAQ
KMQQLRERCMKAWLLEEESLYDLAASEPKKHELSDISELPEKSDKDSTSAYNTGESCRST
PLLVEPLPESPLRRAMAGNSNLNRTPPGPAVATPAKAAPPPGSPAKFRSLSRDPEAGRRQ
HAEERGRRNPKTGLTLERVGPESSPYLSRRHRGQGQEGEHYHSCVQLAPTRGLEELGHGP
LSLAGGPRVGGVAAAATEAPRMEWKVKVRSDGTRYVAKRPVRDRLLKARALKIREERSGM
TTDDDAVSEMKMGRYWSKEERKQHLIRAREQRKRREFMMQSRLECLREQQNGDSKPELNI
IALSHRKTMKKRNKKILDNWITIQEMLAHGARSADGKRVYNPLLSVTTV

Sequence length

769

Interactions

View interactions

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Abnormal facial shape	Uncertain significance	rs2092188098	RCV002291085
Autism	Uncertain significance	rs2092188098, rs782527593	RCV002291085 RCV003328503
Coarse facial features	Uncertain significance	rs2520875070	RCV002291084
Hand tremor	Uncertain significance	rs2092188098	RCV002291085
Hyperactivity	Uncertain significance	rs2520875070	RCV002291084
Hypotonia	Uncertain significance	rs2092188098	RCV002291085
Intellectual disability	Uncertain significance	rs2520875070	RCV002291084
Kyphoscoliosis	Uncertain significance	rs2092188098	RCV002291085
Microcephaly	Uncertain significance	rs2520875070	RCV002291084
Movement disorder	Uncertain significance	rs2520875070	RCV002291084

PDZD4 (PDZ domain containing 4)