PDZD4 (PDZ domain containing 4)

Gene

• Entrez ID: 57595
• Gene name: PDZ domain containing 4
• Gene symbol: PDZD4
• Synonyms (NCBI Gene): LNX5, LU1, PDZK4, PDZRN4L
• Chromosome: X
• Chromosome location: Xq28

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018281	hsa-miR-335-5p	Microarray	18185580
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT622840	hsa-miR-6888-5p	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT491712	hsa-miR-6777-5p	PAR-CLIP	23592263
MIRT491711	hsa-miR-6889-5p	PAR-CLIP	23592263
MIRT491710	hsa-miR-6089	PAR-CLIP	23592263
MIRT491708	hsa-miR-6869-3p	PAR-CLIP	23592263
MIRT491709	hsa-miR-3960	PAR-CLIP	23592263
MIRT491707	hsa-miR-8072	PAR-CLIP	23592263
MIRT491706	hsa-miR-4706	PAR-CLIP	23592263
MIRT491705	hsa-miR-4749-5p	PAR-CLIP	23592263
MIRT491704	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT491703	hsa-miR-663a	PAR-CLIP	23592263
MIRT491702	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT491701	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT491700	hsa-miR-8085	PAR-CLIP	23592263
MIRT491699	hsa-miR-3175	PAR-CLIP	23592263
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT622840	hsa-miR-6888-5p	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT612266	hsa-miR-216b-5p	HITS-CLIP	23824327
MIRT612265	hsa-miR-8485	HITS-CLIP	23824327
MIRT612264	hsa-miR-3675-3p	HITS-CLIP	23824327
MIRT491712	hsa-miR-6777-5p	PAR-CLIP	23592263
MIRT491711	hsa-miR-6889-5p	PAR-CLIP	23592263
MIRT491710	hsa-miR-6089	PAR-CLIP	23592263
MIRT491708	hsa-miR-6869-3p	PAR-CLIP	23592263
MIRT491709	hsa-miR-3960	PAR-CLIP	23592263
MIRT491707	hsa-miR-8072	PAR-CLIP	23592263
MIRT491706	hsa-miR-4706	PAR-CLIP	23592263
MIRT491705	hsa-miR-4749-5p	PAR-CLIP	23592263
MIRT491704	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT491703	hsa-miR-663a	PAR-CLIP	23592263
MIRT491702	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT491701	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT491700	hsa-miR-8085	PAR-CLIP	23592263
MIRT491699	hsa-miR-3175	PAR-CLIP	23592263
MIRT1224064	hsa-miR-185	CLIP-seq
MIRT1224065	hsa-miR-3650	CLIP-seq
MIRT1224066	hsa-miR-4455	CLIP-seq
MIRT1224067	hsa-miR-548aa	CLIP-seq
MIRT1224068	hsa-miR-548ac	CLIP-seq
MIRT1224069	hsa-miR-548d-3p	CLIP-seq
MIRT1224070	hsa-miR-548z	CLIP-seq
MIRT1224071	hsa-miR-609	CLIP-seq
MIRT2065302	hsa-miR-1224-3p	CLIP-seq
MIRT2065303	hsa-miR-1260	CLIP-seq
MIRT2065304	hsa-miR-1260b	CLIP-seq
MIRT2065305	hsa-miR-1280	CLIP-seq
MIRT2065306	hsa-miR-2115	CLIP-seq
MIRT2065307	hsa-miR-3074-5p	CLIP-seq
MIRT2065308	hsa-miR-3190	CLIP-seq
MIRT2065309	hsa-miR-4514	CLIP-seq
MIRT2065310	hsa-miR-4688	CLIP-seq
MIRT2065311	hsa-miR-4691-5p	CLIP-seq
MIRT2065312	hsa-miR-4692	CLIP-seq
MIRT2065313	hsa-miR-4773	CLIP-seq
MIRT2065314	hsa-miR-4786-3p	CLIP-seq
MIRT2065315	hsa-miR-516a-3p	CLIP-seq
MIRT2065316	hsa-miR-532-3p	CLIP-seq
MIRT2065317	hsa-miR-671-5p	CLIP-seq
MIRT2065318	hsa-miR-759	CLIP-seq
MIRT2065308	hsa-miR-3190	CLIP-seq
MIRT2065313	hsa-miR-4773	CLIP-seq
MIRT2065314	hsa-miR-4786-3p	CLIP-seq
MIRT2065317	hsa-miR-671-5p	CLIP-seq
MIRT2456212	hsa-miR-1470	CLIP-seq
MIRT2456213	hsa-miR-3127-3p	CLIP-seq
MIRT2456214	hsa-miR-4446-5p	CLIP-seq
MIRT2456215	hsa-miR-4667-3p	CLIP-seq
MIRT2456216	hsa-miR-4755-5p	CLIP-seq
MIRT2456217	hsa-miR-642a	CLIP-seq
MIRT2456212	hsa-miR-1470	CLIP-seq
MIRT2456213	hsa-miR-3127-3p	CLIP-seq
MIRT2456214	hsa-miR-4446-5p	CLIP-seq
MIRT2456215	hsa-miR-4667-3p	CLIP-seq
MIRT2456216	hsa-miR-4755-5p	CLIP-seq
MIRT2456217	hsa-miR-642a	CLIP-seq
MIRT2591193	hsa-miR-1266	CLIP-seq
MIRT2591194	hsa-miR-4279	CLIP-seq
MIRT2591195	hsa-miR-4518	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005938	Component	Cell cortex	IEA

Other IDs

• MIM: 300634
• HGNC: 21167
• e!Ensembl: ENSG00000067840

Protein

• UniProt ID: Q76G19
• Protein name: PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00595	PDZ	130 → 212	PDZ domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Brain-specific. Expressed in fetal and adult brain. Up-regulated in synovial carcinomas. {ECO:0000269|PubMed:15077175}.
• Sequence:

  MGCNMCVVQKPEEQYKVMLQVNGKELSKLSQEQTLQALRSSKEPLVIQVLRRSPRLRGDS
  SCHDLQLVDSGTQTDITFEHIMALGKLRPPTPPMVILEPPPISHEYYDPAEFMEGGPQEA
  DRLDELEYEEVELYKSSHRDKLGLMVCYRTDDEEDLGIYVGEVNPNSIAAKDGRIREGDR
  IIQINGVDVQNREEAVAILSQEENTNISLLVARPESQLAKRWKDSDRDDFLDDFGSENEG
  ELRARKLKSPPAQQPGNEEEKGAPDAGPGLSNSQELDSGVGRTDESTRNEESSEHDLLGD
  EPPSSTNTPGSLRKFGLQGDALQSRDFHFSMDSLLAEGAGLGGGDVPGLTDEEYERYREL
  LEIKCHLENGNQLGLLFPRASGGNSALDVNRNESLGHEMAMLEEELRHLEFKCRNILRAQ
  KMQQLRERCMKAWLLEEESLYDLAASEPKKHELSDISELPEKSDKDSTSAYNTGESCRST
  PLLVEPLPESPLRRAMAGNSNLNRTPPGPAVATPAKAAPPPGSPAKFRSLSRDPEAGRRQ
  HAEERGRRNPKTGLTLERVGPESSPYLSRRHRGQGQEGEHYHSCVQLAPTRGLEELGHGP
  LSLAGGPRVGGVAAAATEAPRMEWKVKVRSDGTRYVAKRPVRDRLLKARALKIREERSGM
  TTDDDAVSEMKMGRYWSKEERKQHLIRAREQRKRREFMMQSRLECLREQQNGDSKPELNI
  IALSHRKTMKKRNKKILDNWITIQEMLAHGARSADGKRVYNPLLSVTTV

• Sequence length: 769

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243