SYT13 (synaptotagmin 13)

Gene

• Entrez ID: 57586
• Gene name: Synaptotagmin 13
• Gene symbol: SYT13
• Synonyms (NCBI Gene): -
• Chromosome: 11
• Chromosome location: 11p11.2
• Summary: This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B). Synaptotogmin family members can form homo- a

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT712055	hsa-miR-4688	HITS-CLIP	19536157
MIRT712054	hsa-miR-6743-5p	HITS-CLIP	19536157
MIRT712053	hsa-miR-6798-5p	HITS-CLIP	19536157
MIRT712052	hsa-miR-4775	HITS-CLIP	19536157
MIRT439494	hsa-miR-382-5p	HITS-CLIP	24374217
MIRT439494	hsa-miR-382-5p	HITS-CLIP	24374217
MIRT712055	hsa-miR-4688	HITS-CLIP	19536157
MIRT712054	hsa-miR-6743-5p	HITS-CLIP	19536157
MIRT712053	hsa-miR-6798-5p	HITS-CLIP	19536157
MIRT712052	hsa-miR-4775	HITS-CLIP	19536157
MIRT1407312	hsa-miR-1193	CLIP-seq
MIRT1407313	hsa-miR-1207-3p	CLIP-seq
MIRT1407314	hsa-miR-1224-3p	CLIP-seq
MIRT1407315	hsa-miR-1227	CLIP-seq
MIRT1407316	hsa-miR-1252	CLIP-seq
MIRT1407317	hsa-miR-1285	CLIP-seq
MIRT1407318	hsa-miR-1321	CLIP-seq
MIRT1407319	hsa-miR-134	CLIP-seq
MIRT1407320	hsa-miR-151-5p	CLIP-seq
MIRT1407321	hsa-miR-151b	CLIP-seq
MIRT1407322	hsa-miR-1827	CLIP-seq
MIRT1407323	hsa-miR-1912	CLIP-seq
MIRT1407324	hsa-miR-1972	CLIP-seq
MIRT1407325	hsa-miR-219-1-3p	CLIP-seq
MIRT1407326	hsa-miR-2392	CLIP-seq
MIRT1407327	hsa-miR-24	CLIP-seq
MIRT1407328	hsa-miR-2467-3p	CLIP-seq
MIRT1407329	hsa-miR-296-5p	CLIP-seq
MIRT1407330	hsa-miR-3064-5p	CLIP-seq
MIRT1407331	hsa-miR-3118	CLIP-seq
MIRT1407332	hsa-miR-3122	CLIP-seq
MIRT1407333	hsa-miR-3128	CLIP-seq
MIRT1407334	hsa-miR-3130-3p	CLIP-seq
MIRT1407335	hsa-miR-3130-5p	CLIP-seq
MIRT1407336	hsa-miR-3140-5p	CLIP-seq
MIRT1407337	hsa-miR-3150b-3p	CLIP-seq
MIRT1407338	hsa-miR-3154	CLIP-seq
MIRT1407339	hsa-miR-3163	CLIP-seq
MIRT1407340	hsa-miR-3173-3p	CLIP-seq
MIRT1407341	hsa-miR-3178	CLIP-seq
MIRT1407342	hsa-miR-3187-5p	CLIP-seq
MIRT1407343	hsa-miR-3545-3p	CLIP-seq
MIRT1407344	hsa-miR-3605-5p	CLIP-seq
MIRT1407345	hsa-miR-3612	CLIP-seq
MIRT1407346	hsa-miR-3616-5p	CLIP-seq
MIRT1407347	hsa-miR-3622a-3p	CLIP-seq
MIRT1407348	hsa-miR-3622b-3p	CLIP-seq
MIRT1407349	hsa-miR-3647-5p	CLIP-seq
MIRT1407350	hsa-miR-3658	CLIP-seq
MIRT1407351	hsa-miR-3678-3p	CLIP-seq
MIRT1407352	hsa-miR-3689a-3p	CLIP-seq
MIRT1407353	hsa-miR-3689c	CLIP-seq
MIRT1407354	hsa-miR-378g	CLIP-seq
MIRT1407355	hsa-miR-3908	CLIP-seq
MIRT1407356	hsa-miR-3913-3p	CLIP-seq
MIRT1407357	hsa-miR-3913-5p	CLIP-seq
MIRT1407358	hsa-miR-3926	CLIP-seq
MIRT1407359	hsa-miR-3929	CLIP-seq
MIRT1407360	hsa-miR-3942-3p	CLIP-seq
MIRT1407361	hsa-miR-3942-5p	CLIP-seq
MIRT1407362	hsa-miR-3945	CLIP-seq
MIRT1407363	hsa-miR-4252	CLIP-seq
MIRT1407364	hsa-miR-4253	CLIP-seq
MIRT1407365	hsa-miR-4257	CLIP-seq
MIRT1407366	hsa-miR-4282	CLIP-seq
MIRT1407367	hsa-miR-4284	CLIP-seq
MIRT1407368	hsa-miR-4314	CLIP-seq
MIRT1407369	hsa-miR-4419b	CLIP-seq
MIRT1407370	hsa-miR-4459	CLIP-seq
MIRT1407371	hsa-miR-4478	CLIP-seq
MIRT1407372	hsa-miR-4482	CLIP-seq
MIRT1407373	hsa-miR-4486	CLIP-seq
MIRT1407374	hsa-miR-4508	CLIP-seq
MIRT1407375	hsa-miR-4520a-3p	CLIP-seq
MIRT1407376	hsa-miR-4537	CLIP-seq
MIRT1407377	hsa-miR-4650-5p	CLIP-seq
MIRT1407378	hsa-miR-4653-3p	CLIP-seq
MIRT1407379	hsa-miR-4662a-3p	CLIP-seq
MIRT1407380	hsa-miR-4670-3p	CLIP-seq
MIRT1407381	hsa-miR-4690-3p	CLIP-seq
MIRT1407382	hsa-miR-4691-5p	CLIP-seq
MIRT1407383	hsa-miR-4694-3p	CLIP-seq
MIRT1407384	hsa-miR-4695-5p	CLIP-seq
MIRT1407385	hsa-miR-4698	CLIP-seq
MIRT1407386	hsa-miR-4703-5p	CLIP-seq
MIRT1407387	hsa-miR-4708-3p	CLIP-seq
MIRT1407388	hsa-miR-4709-3p	CLIP-seq
MIRT1407389	hsa-miR-4712-5p	CLIP-seq
MIRT1407390	hsa-miR-4720-5p	CLIP-seq
MIRT1407391	hsa-miR-4728-5p	CLIP-seq
MIRT1407392	hsa-miR-4739	CLIP-seq
MIRT1407393	hsa-miR-4756-5p	CLIP-seq
MIRT1407394	hsa-miR-4766-3p	CLIP-seq
MIRT1407395	hsa-miR-4779	CLIP-seq
MIRT1407396	hsa-miR-4784	CLIP-seq
MIRT1407397	hsa-miR-4795-5p	CLIP-seq
MIRT1407398	hsa-miR-4799-3p	CLIP-seq
MIRT1407399	hsa-miR-485-5p	CLIP-seq
MIRT1407400	hsa-miR-489	CLIP-seq
MIRT1407401	hsa-miR-515-5p	CLIP-seq
MIRT1407402	hsa-miR-516b	CLIP-seq
MIRT1407403	hsa-miR-548ac	CLIP-seq
MIRT1407404	hsa-miR-548ae	CLIP-seq
MIRT1407405	hsa-miR-548aj	CLIP-seq
MIRT1407406	hsa-miR-548am	CLIP-seq
MIRT1407407	hsa-miR-548d-3p	CLIP-seq
MIRT1407408	hsa-miR-548s	CLIP-seq
MIRT1407409	hsa-miR-548x	CLIP-seq
MIRT1407410	hsa-miR-548z	CLIP-seq
MIRT1407411	hsa-miR-573	CLIP-seq
MIRT1407412	hsa-miR-577	CLIP-seq
MIRT1407413	hsa-miR-604	CLIP-seq
MIRT1407414	hsa-miR-612	CLIP-seq
MIRT1407415	hsa-miR-647	CLIP-seq
MIRT1407416	hsa-miR-650	CLIP-seq
MIRT1407417	hsa-miR-658	CLIP-seq
MIRT1407418	hsa-miR-665	CLIP-seq
MIRT1407419	hsa-miR-767-5p	CLIP-seq
MIRT1407420	hsa-miR-770-5p	CLIP-seq
MIRT1407421	hsa-miR-892b	CLIP-seq
MIRT1407319	hsa-miR-134	CLIP-seq
MIRT1407331	hsa-miR-3118	CLIP-seq
MIRT1407336	hsa-miR-3140-5p	CLIP-seq
MIRT1407346	hsa-miR-3616-5p	CLIP-seq
MIRT1407349	hsa-miR-3647-5p	CLIP-seq
MIRT1407382	hsa-miR-4691-5p	CLIP-seq
MIRT1407397	hsa-miR-4795-5p	CLIP-seq
MIRT1407411	hsa-miR-573	CLIP-seq
MIRT2122092	hsa-miR-203	CLIP-seq
MIRT2122093	hsa-miR-205	CLIP-seq
MIRT2122094	hsa-miR-3065-5p	CLIP-seq
MIRT2122095	hsa-miR-3675-3p	CLIP-seq
MIRT2122096	hsa-miR-4476	CLIP-seq
MIRT2122097	hsa-miR-4786-3p	CLIP-seq
MIRT2122098	hsa-miR-541	CLIP-seq
MIRT2122099	hsa-miR-654-5p	CLIP-seq
MIRT1407315	hsa-miR-1227	CLIP-seq
MIRT2344346	hsa-miR-1245b-3p	CLIP-seq
MIRT1407319	hsa-miR-134	CLIP-seq
MIRT1407320	hsa-miR-151-5p	CLIP-seq
MIRT1407321	hsa-miR-151b	CLIP-seq
MIRT2344347	hsa-miR-198	CLIP-seq
MIRT2122093	hsa-miR-205	CLIP-seq
MIRT2344348	hsa-miR-3074-5p	CLIP-seq
MIRT1407331	hsa-miR-3118	CLIP-seq
MIRT1407332	hsa-miR-3122	CLIP-seq
MIRT1407336	hsa-miR-3140-5p	CLIP-seq
MIRT2344349	hsa-miR-3198	CLIP-seq
MIRT2344350	hsa-miR-3613-3p	CLIP-seq
MIRT1407346	hsa-miR-3616-5p	CLIP-seq
MIRT1407349	hsa-miR-3647-5p	CLIP-seq
MIRT1407352	hsa-miR-3689a-3p	CLIP-seq
MIRT1407353	hsa-miR-3689c	CLIP-seq
MIRT1407357	hsa-miR-3913-5p	CLIP-seq
MIRT1407358	hsa-miR-3926	CLIP-seq
MIRT1407363	hsa-miR-4252	CLIP-seq
MIRT2344351	hsa-miR-4309	CLIP-seq
MIRT2122096	hsa-miR-4476	CLIP-seq
MIRT1407376	hsa-miR-4537	CLIP-seq
MIRT1407382	hsa-miR-4691-5p	CLIP-seq
MIRT1407388	hsa-miR-4709-3p	CLIP-seq
MIRT1407389	hsa-miR-4712-5p	CLIP-seq
MIRT1407391	hsa-miR-4728-5p	CLIP-seq
MIRT1407395	hsa-miR-4779	CLIP-seq
MIRT2344352	hsa-miR-4793-3p	CLIP-seq
MIRT1407397	hsa-miR-4795-5p	CLIP-seq
MIRT2344353	hsa-miR-548p	CLIP-seq
MIRT1407408	hsa-miR-548s	CLIP-seq
MIRT1407411	hsa-miR-573	CLIP-seq
MIRT1407420	hsa-miR-770-5p	CLIP-seq
MIRT1407336	hsa-miR-3140-5p	CLIP-seq
MIRT1407343	hsa-miR-3545-3p	CLIP-seq
MIRT1407352	hsa-miR-3689a-3p	CLIP-seq
MIRT1407353	hsa-miR-3689c	CLIP-seq
MIRT1407376	hsa-miR-4537	CLIP-seq
MIRT1407391	hsa-miR-4728-5p	CLIP-seq
MIRT1407417	hsa-miR-658	CLIP-seq
MIRT1407320	hsa-miR-151-5p	CLIP-seq
MIRT1407321	hsa-miR-151b	CLIP-seq
MIRT1407324	hsa-miR-1972	CLIP-seq
MIRT1407332	hsa-miR-3122	CLIP-seq
MIRT2122095	hsa-miR-3675-3p	CLIP-seq
MIRT1407352	hsa-miR-3689a-3p	CLIP-seq
MIRT1407353	hsa-miR-3689c	CLIP-seq
MIRT1407357	hsa-miR-3913-5p	CLIP-seq
MIRT2461017	hsa-miR-4645-5p	CLIP-seq
MIRT1407377	hsa-miR-4650-5p	CLIP-seq
MIRT2461018	hsa-miR-4662a-5p	CLIP-seq
MIRT2461019	hsa-miR-4673	CLIP-seq
MIRT2461020	hsa-miR-4676-5p	CLIP-seq
MIRT2461021	hsa-miR-4684-5p	CLIP-seq
MIRT1407389	hsa-miR-4712-5p	CLIP-seq
MIRT1407391	hsa-miR-4728-5p	CLIP-seq
MIRT2461022	hsa-miR-4755-3p	CLIP-seq
MIRT1407395	hsa-miR-4779	CLIP-seq
MIRT2461023	hsa-miR-548k	CLIP-seq
MIRT2461024	hsa-miR-548n	CLIP-seq
MIRT2461025	hsa-miR-548t	CLIP-seq
MIRT2461026	hsa-miR-575	CLIP-seq
MIRT1407420	hsa-miR-770-5p	CLIP-seq
MIRT2122095	hsa-miR-3675-3p	CLIP-seq
MIRT2461018	hsa-miR-4662a-5p	CLIP-seq
MIRT2461020	hsa-miR-4676-5p	CLIP-seq
MIRT2461021	hsa-miR-4684-5p	CLIP-seq
MIRT2461022	hsa-miR-4755-3p	CLIP-seq
MIRT2461023	hsa-miR-548k	CLIP-seq
MIRT2461024	hsa-miR-548n	CLIP-seq
MIRT2461025	hsa-miR-548t	CLIP-seq
MIRT2461026	hsa-miR-575	CLIP-seq
MIRT1407320	hsa-miR-151-5p	CLIP-seq
MIRT1407321	hsa-miR-151b	CLIP-seq
MIRT1407324	hsa-miR-1972	CLIP-seq
MIRT1407332	hsa-miR-3122	CLIP-seq
MIRT1407337	hsa-miR-3150b-3p	CLIP-seq
MIRT1407343	hsa-miR-3545-3p	CLIP-seq
MIRT2122095	hsa-miR-3675-3p	CLIP-seq
MIRT1407352	hsa-miR-3689a-3p	CLIP-seq
MIRT1407353	hsa-miR-3689c	CLIP-seq
MIRT1407357	hsa-miR-3913-5p	CLIP-seq
MIRT1407376	hsa-miR-4537	CLIP-seq
MIRT2461017	hsa-miR-4645-5p	CLIP-seq
MIRT1407377	hsa-miR-4650-5p	CLIP-seq
MIRT2461018	hsa-miR-4662a-5p	CLIP-seq
MIRT2461019	hsa-miR-4673	CLIP-seq
MIRT2461020	hsa-miR-4676-5p	CLIP-seq
MIRT2461021	hsa-miR-4684-5p	CLIP-seq
MIRT1407389	hsa-miR-4712-5p	CLIP-seq
MIRT1407391	hsa-miR-4728-5p	CLIP-seq
MIRT2461022	hsa-miR-4755-3p	CLIP-seq
MIRT1407395	hsa-miR-4779	CLIP-seq
MIRT1407396	hsa-miR-4784	CLIP-seq
MIRT2461023	hsa-miR-548k	CLIP-seq
MIRT2461024	hsa-miR-548n	CLIP-seq
MIRT2461025	hsa-miR-548t	CLIP-seq
MIRT2461026	hsa-miR-575	CLIP-seq
MIRT1407417	hsa-miR-658	CLIP-seq
MIRT1407420	hsa-miR-770-5p	CLIP-seq
MIRT1407320	hsa-miR-151-5p	CLIP-seq
MIRT1407321	hsa-miR-151b	CLIP-seq
MIRT1407324	hsa-miR-1972	CLIP-seq
MIRT1407332	hsa-miR-3122	CLIP-seq
MIRT2122095	hsa-miR-3675-3p	CLIP-seq
MIRT1407352	hsa-miR-3689a-3p	CLIP-seq
MIRT1407353	hsa-miR-3689c	CLIP-seq
MIRT1407357	hsa-miR-3913-5p	CLIP-seq
MIRT2461017	hsa-miR-4645-5p	CLIP-seq
MIRT1407377	hsa-miR-4650-5p	CLIP-seq
MIRT2461018	hsa-miR-4662a-5p	CLIP-seq
MIRT2461019	hsa-miR-4673	CLIP-seq
MIRT2461020	hsa-miR-4676-5p	CLIP-seq
MIRT2461021	hsa-miR-4684-5p	CLIP-seq
MIRT1407389	hsa-miR-4712-5p	CLIP-seq
MIRT1407391	hsa-miR-4728-5p	CLIP-seq
MIRT2461022	hsa-miR-4755-3p	CLIP-seq
MIRT1407395	hsa-miR-4779	CLIP-seq
MIRT2461023	hsa-miR-548k	CLIP-seq
MIRT2461024	hsa-miR-548n	CLIP-seq
MIRT2461025	hsa-miR-548t	CLIP-seq
MIRT2461026	hsa-miR-575	CLIP-seq
MIRT1407420	hsa-miR-770-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000149	Function	SNARE binding	IBA
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IBA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0017158	Process	Regulation of calcium ion-dependent exocytosis	IBA
GO:0030133	Component	Transport vesicle	IDA
GO:0030424	Component	Axon	IBA
GO:0030672	Component	Synaptic vesicle membrane	IBA
GO:0031045	Component	Dense core granule	IBA
GO:0061891	Function	Calcium ion sensor activity	IBA
GO:0070382	Component	Exocytic vesicle	IBA
GO:0099502	Process	Calcium-dependent activation of synaptic vesicle fusion	IBA
GO:2000300	Process	Regulation of synaptic vesicle exocytosis	IBA

Other IDs

• MIM: 607716
• HGNC: 14962
• e!Ensembl: ENSG00000019505

Protein

• UniProt ID: Q7L8C5
• Protein name: Synaptotagmin-13 (Synaptotagmin XIII) (SytXIII)
• Protein function: May be involved in transport vesicle docking to the plasma membrane.
• PDB: 1WFM
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00168	C2	171 → 277	C2 domain	Domain
  PF00168	C2	302 → 410	C2 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in brain, pancreas and kidney. {ECO:0000269|PubMed:11543631}.
• Sequence:

  MVLSVPVIALGATLGTATSILALCGVTCLCRHMHPKKGLLPRDQDPDLEKAKPSLLGSAQ
  QFNVKKSTEPVQPRALLKFPDIYGPRPAVTAPEVINYADYSLRSTEEPTAPASPQPPNDS
  RLKRQVTEELFILPQNGVVEDVCVMETWNPEKAASWNQAPKLHYCLDYDCQKAELFVTRL
  EAVTSNHDGGCDCYVQGSVANRTGSVEAQTALKKRQLHTTWEEGLVLPLAEEELPTATLT
  LTLRTCDRFSRHSVAGELRLGLDGTSVPLGAAQWGELKTSAKEPSAGAGEVLLSISYLPA
  ANRLLVVLIKAKNLHSNQSKELLGKDVSVKVTLKHQARKLKKKQTKRAKHKINPVWNEMI
  MFELPDDLLQASSVELEVLGQDDSGQSCALGHCSLGLHTSGSERSHWEEMLKNPRRQIAM
  WHQLHL

• Sequence length: 426

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Atrial Fibrillation	Associate	37960721	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	34677264	★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	29154080	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	34677264	★☆☆☆☆ Found in Text Mining only
Neuroendocrine Tumors	Associate	29154080	★☆☆☆☆ Found in Text Mining only