Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57584
Gene name Gene Name - the full gene name approved by the HGNC.	Rho GTPase activating protein 21
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ARHGAP21
Synonyms (NCBI Gene) Gene synonyms aliases	ARHGAP10
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10p12.1\|10p12.3
Summary Summary of gene provided in NCBI Entrez Gene.	ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[suppli

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1060499743	A>C	Likely-pathogenic	Non coding transcript variant, missense variant, coding sequence variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017485	hsa-miR-335-5p	Microarray	18185580
MIRT030816	hsa-miR-21-5p	Microarray	18591254
MIRT047126	hsa-miR-183-5p	CLASH	23622248
MIRT038266	hsa-miR-361-3p	CLASH	23622248
MIRT515398	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT515397	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT515396	hsa-miR-3182	HITS-CLIP	21572407
MIRT515395	hsa-miR-2116-5p	HITS-CLIP	21572407
MIRT515394	hsa-miR-22-5p	HITS-CLIP	21572407
MIRT515393	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT515392	hsa-miR-4677-5p	HITS-CLIP	21572407
MIRT515391	hsa-miR-4659a-3p	HITS-CLIP	21572407
MIRT515390	hsa-miR-4659b-3p	HITS-CLIP	21572407
MIRT515398	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT515397	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT515396	hsa-miR-3182	PAR-CLIP	21572407
MIRT515395	hsa-miR-2116-5p	PAR-CLIP	21572407
MIRT515394	hsa-miR-22-5p	PAR-CLIP	21572407
MIRT515393	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT515392	hsa-miR-4677-5p	PAR-CLIP	21572407
MIRT515391	hsa-miR-4659a-3p	PAR-CLIP	21572407
MIRT515390	hsa-miR-4659b-3p	PAR-CLIP	21572407
MIRT515398	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT515397	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT515396	hsa-miR-3182	PAR-CLIP	23446348
MIRT515395	hsa-miR-2116-5p	PAR-CLIP	23446348
MIRT515394	hsa-miR-22-5p	PAR-CLIP	23446348
MIRT515393	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT515392	hsa-miR-4677-5p	PAR-CLIP	23446348
MIRT515391	hsa-miR-4659a-3p	PAR-CLIP	23446348
MIRT515390	hsa-miR-4659b-3p	PAR-CLIP	23446348
MIRT515398	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT515397	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT515396	hsa-miR-3182	HITS-CLIP	21572407
MIRT515395	hsa-miR-2116-5p	HITS-CLIP	21572407
MIRT515394	hsa-miR-22-5p	HITS-CLIP	21572407
MIRT515393	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT515392	hsa-miR-4677-5p	HITS-CLIP	21572407
MIRT515391	hsa-miR-4659a-3p	HITS-CLIP	21572407
MIRT515390	hsa-miR-4659b-3p	HITS-CLIP	21572407
MIRT515398	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT515397	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT515396	hsa-miR-3182	PAR-CLIP	21572407
MIRT515395	hsa-miR-2116-5p	PAR-CLIP	21572407
MIRT515394	hsa-miR-22-5p	PAR-CLIP	21572407
MIRT515393	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT515392	hsa-miR-4677-5p	PAR-CLIP	21572407
MIRT515391	hsa-miR-4659a-3p	PAR-CLIP	21572407
MIRT515390	hsa-miR-4659b-3p	PAR-CLIP	21572407
MIRT515398	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT515397	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT515396	hsa-miR-3182	PAR-CLIP	23446348
MIRT515395	hsa-miR-2116-5p	PAR-CLIP	23446348
MIRT515394	hsa-miR-22-5p	PAR-CLIP	23446348
MIRT515393	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT515392	hsa-miR-4677-5p	PAR-CLIP	23446348
MIRT515391	hsa-miR-4659a-3p	PAR-CLIP	23446348
MIRT515390	hsa-miR-4659b-3p	PAR-CLIP	23446348
MIRT794076	hsa-miR-149	CLIP-seq
MIRT794077	hsa-miR-186	CLIP-seq
MIRT794078	hsa-miR-2116	CLIP-seq
MIRT794079	hsa-miR-3064-5p	CLIP-seq
MIRT794080	hsa-miR-3133	CLIP-seq
MIRT794081	hsa-miR-4676-5p	CLIP-seq
MIRT794082	hsa-miR-4687-3p	CLIP-seq
MIRT794083	hsa-miR-4742-3p	CLIP-seq
MIRT794084	hsa-miR-4786-3p	CLIP-seq
MIRT794085	hsa-miR-4794	CLIP-seq
MIRT794086	hsa-miR-548aa	CLIP-seq
MIRT794087	hsa-miR-548ac	CLIP-seq
MIRT794088	hsa-miR-548ae	CLIP-seq
MIRT794089	hsa-miR-548aj	CLIP-seq
MIRT794090	hsa-miR-548am	CLIP-seq
MIRT794091	hsa-miR-548d-3p	CLIP-seq
MIRT794092	hsa-miR-548x	CLIP-seq
MIRT794093	hsa-miR-548z	CLIP-seq
MIRT794094	hsa-miR-575	CLIP-seq
MIRT794095	hsa-miR-665	CLIP-seq
MIRT1934312	hsa-miR-1202	CLIP-seq
MIRT1934313	hsa-miR-1228	CLIP-seq
MIRT1934314	hsa-miR-1245	CLIP-seq
MIRT1934315	hsa-miR-1272	CLIP-seq
MIRT1934316	hsa-miR-1322	CLIP-seq
MIRT1934317	hsa-miR-1827	CLIP-seq
MIRT1934318	hsa-miR-300	CLIP-seq
MIRT1934319	hsa-miR-3065-5p	CLIP-seq
MIRT1934320	hsa-miR-3074-3p	CLIP-seq
MIRT1934321	hsa-miR-3194-5p	CLIP-seq
MIRT1934322	hsa-miR-329	CLIP-seq
MIRT1934323	hsa-miR-3606	CLIP-seq
MIRT1934324	hsa-miR-362-3p	CLIP-seq
MIRT1934325	hsa-miR-3668	CLIP-seq
MIRT1934326	hsa-miR-3713	CLIP-seq
MIRT1934327	hsa-miR-381	CLIP-seq
MIRT1934328	hsa-miR-382	CLIP-seq
MIRT1934329	hsa-miR-3941	CLIP-seq
MIRT1934330	hsa-miR-3972	CLIP-seq
MIRT1934331	hsa-miR-4528	CLIP-seq
MIRT1934332	hsa-miR-4661-3p	CLIP-seq
MIRT1934333	hsa-miR-4666-3p	CLIP-seq
MIRT1934334	hsa-miR-4684-3p	CLIP-seq
MIRT794083	hsa-miR-4742-3p	CLIP-seq
MIRT1934335	hsa-miR-4762-5p	CLIP-seq
MIRT1934336	hsa-miR-548a-3p	CLIP-seq
MIRT794086	hsa-miR-548aa	CLIP-seq
MIRT794087	hsa-miR-548ac	CLIP-seq
MIRT794088	hsa-miR-548ae	CLIP-seq
MIRT794089	hsa-miR-548aj	CLIP-seq
MIRT794090	hsa-miR-548am	CLIP-seq
MIRT794091	hsa-miR-548d-3p	CLIP-seq
MIRT1934337	hsa-miR-548e	CLIP-seq
MIRT1934338	hsa-miR-548f	CLIP-seq
MIRT794092	hsa-miR-548x	CLIP-seq
MIRT794093	hsa-miR-548z	CLIP-seq
MIRT1934339	hsa-miR-603	CLIP-seq
MIRT1934340	hsa-miR-642b	CLIP-seq
MIRT794095	hsa-miR-665	CLIP-seq
MIRT1934341	hsa-miR-921	CLIP-seq
MIRT2174138	hsa-miR-1225-5p	CLIP-seq
MIRT1934313	hsa-miR-1228	CLIP-seq
MIRT2174139	hsa-miR-1243	CLIP-seq
MIRT2174140	hsa-miR-1244	CLIP-seq
MIRT2174141	hsa-miR-132	CLIP-seq
MIRT2174142	hsa-miR-194	CLIP-seq
MIRT2174143	hsa-miR-199a-3p	CLIP-seq
MIRT2174144	hsa-miR-199b-3p	CLIP-seq
MIRT2174145	hsa-miR-212	CLIP-seq
MIRT1934319	hsa-miR-3065-5p	CLIP-seq
MIRT2174146	hsa-miR-3129-5p	CLIP-seq
MIRT1934322	hsa-miR-329	CLIP-seq
MIRT1934324	hsa-miR-362-3p	CLIP-seq
MIRT2174147	hsa-miR-3646	CLIP-seq
MIRT2174148	hsa-miR-3654	CLIP-seq
MIRT1934325	hsa-miR-3668	CLIP-seq
MIRT1934328	hsa-miR-382	CLIP-seq
MIRT1934329	hsa-miR-3941	CLIP-seq
MIRT2174149	hsa-miR-4276	CLIP-seq
MIRT1934332	hsa-miR-4661-3p	CLIP-seq
MIRT794081	hsa-miR-4676-5p	CLIP-seq
MIRT1934334	hsa-miR-4684-3p	CLIP-seq
MIRT2174150	hsa-miR-4690-3p	CLIP-seq
MIRT794094	hsa-miR-575	CLIP-seq
MIRT1934339	hsa-miR-603	CLIP-seq
MIRT794095	hsa-miR-665	CLIP-seq
MIRT2384377	hsa-miR-501-3p	CLIP-seq
MIRT2384378	hsa-miR-502-3p	CLIP-seq
MIRT1934340	hsa-miR-642b	CLIP-seq
MIRT2426389	hsa-miR-4320	CLIP-seq
MIRT2426390	hsa-miR-4464	CLIP-seq
MIRT2426391	hsa-miR-4748	CLIP-seq
MIRT1934340	hsa-miR-642b	CLIP-seq
MIRT2426392	hsa-miR-664	CLIP-seq
MIRT2426389	hsa-miR-4320	CLIP-seq
MIRT2426390	hsa-miR-4464	CLIP-seq
MIRT2426391	hsa-miR-4748	CLIP-seq
MIRT1934340	hsa-miR-642b	CLIP-seq
MIRT2426392	hsa-miR-664	CLIP-seq
MIRT2477817	hsa-miR-1178	CLIP-seq
MIRT1934312	hsa-miR-1202	CLIP-seq
MIRT2174138	hsa-miR-1225-5p	CLIP-seq
MIRT1934313	hsa-miR-1228	CLIP-seq
MIRT2174140	hsa-miR-1244	CLIP-seq
MIRT2174141	hsa-miR-132	CLIP-seq
MIRT794077	hsa-miR-186	CLIP-seq
MIRT2174142	hsa-miR-194	CLIP-seq
MIRT2174143	hsa-miR-199a-3p	CLIP-seq
MIRT2174144	hsa-miR-199b-3p	CLIP-seq
MIRT2174145	hsa-miR-212	CLIP-seq
MIRT2477818	hsa-miR-298	CLIP-seq
MIRT1934318	hsa-miR-300	CLIP-seq
MIRT1934319	hsa-miR-3065-5p	CLIP-seq
MIRT1934320	hsa-miR-3074-3p	CLIP-seq
MIRT2174146	hsa-miR-3129-5p	CLIP-seq
MIRT794080	hsa-miR-3133	CLIP-seq
MIRT2477819	hsa-miR-3138	CLIP-seq
MIRT2477820	hsa-miR-3146	CLIP-seq
MIRT2477821	hsa-miR-3149	CLIP-seq
MIRT2477822	hsa-miR-3185	CLIP-seq
MIRT1934321	hsa-miR-3194-5p	CLIP-seq
MIRT2477823	hsa-miR-3200-3p	CLIP-seq
MIRT2477824	hsa-miR-3200-5p	CLIP-seq
MIRT1934322	hsa-miR-329	CLIP-seq
MIRT1934324	hsa-miR-362-3p	CLIP-seq
MIRT1934325	hsa-miR-3668	CLIP-seq
MIRT1934327	hsa-miR-381	CLIP-seq
MIRT1934328	hsa-miR-382	CLIP-seq
MIRT1934329	hsa-miR-3941	CLIP-seq
MIRT1934330	hsa-miR-3972	CLIP-seq
MIRT2174149	hsa-miR-4276	CLIP-seq
MIRT2426389	hsa-miR-4320	CLIP-seq
MIRT2426390	hsa-miR-4464	CLIP-seq
MIRT2477825	hsa-miR-4490	CLIP-seq
MIRT1934331	hsa-miR-4528	CLIP-seq
MIRT1934332	hsa-miR-4661-3p	CLIP-seq
MIRT1934333	hsa-miR-4666-3p	CLIP-seq
MIRT794081	hsa-miR-4676-5p	CLIP-seq
MIRT1934334	hsa-miR-4684-3p	CLIP-seq
MIRT2426391	hsa-miR-4748	CLIP-seq
MIRT1934335	hsa-miR-4762-5p	CLIP-seq
MIRT2477826	hsa-miR-4774-5p	CLIP-seq
MIRT794084	hsa-miR-4786-3p	CLIP-seq
MIRT2477827	hsa-miR-516a-5p	CLIP-seq
MIRT2477828	hsa-miR-568	CLIP-seq
MIRT794094	hsa-miR-575	CLIP-seq
MIRT2477829	hsa-miR-579	CLIP-seq
MIRT1934339	hsa-miR-603	CLIP-seq
MIRT1934340	hsa-miR-642b	CLIP-seq
MIRT2426392	hsa-miR-664	CLIP-seq
MIRT794095	hsa-miR-665	CLIP-seq
MIRT2477830	hsa-miR-942	CLIP-seq
MIRT2477817	hsa-miR-1178	CLIP-seq
MIRT1934312	hsa-miR-1202	CLIP-seq
MIRT2174138	hsa-miR-1225-5p	CLIP-seq
MIRT1934313	hsa-miR-1228	CLIP-seq
MIRT2174140	hsa-miR-1244	CLIP-seq
MIRT2174141	hsa-miR-132	CLIP-seq
MIRT794077	hsa-miR-186	CLIP-seq
MIRT2174142	hsa-miR-194	CLIP-seq
MIRT2174143	hsa-miR-199a-3p	CLIP-seq
MIRT2174144	hsa-miR-199b-3p	CLIP-seq
MIRT2174145	hsa-miR-212	CLIP-seq
MIRT2477818	hsa-miR-298	CLIP-seq
MIRT1934318	hsa-miR-300	CLIP-seq
MIRT1934319	hsa-miR-3065-5p	CLIP-seq
MIRT1934320	hsa-miR-3074-3p	CLIP-seq
MIRT2174146	hsa-miR-3129-5p	CLIP-seq
MIRT794080	hsa-miR-3133	CLIP-seq
MIRT2477820	hsa-miR-3146	CLIP-seq
MIRT2477821	hsa-miR-3149	CLIP-seq
MIRT2477822	hsa-miR-3185	CLIP-seq
MIRT1934321	hsa-miR-3194-5p	CLIP-seq
MIRT2477823	hsa-miR-3200-3p	CLIP-seq
MIRT2477824	hsa-miR-3200-5p	CLIP-seq
MIRT1934322	hsa-miR-329	CLIP-seq
MIRT1934324	hsa-miR-362-3p	CLIP-seq
MIRT1934325	hsa-miR-3668	CLIP-seq
MIRT1934327	hsa-miR-381	CLIP-seq
MIRT1934328	hsa-miR-382	CLIP-seq
MIRT1934329	hsa-miR-3941	CLIP-seq
MIRT1934330	hsa-miR-3972	CLIP-seq
MIRT2174149	hsa-miR-4276	CLIP-seq
MIRT2426389	hsa-miR-4320	CLIP-seq
MIRT2426390	hsa-miR-4464	CLIP-seq
MIRT2477825	hsa-miR-4490	CLIP-seq
MIRT1934331	hsa-miR-4528	CLIP-seq
MIRT1934332	hsa-miR-4661-3p	CLIP-seq
MIRT1934333	hsa-miR-4666-3p	CLIP-seq
MIRT794081	hsa-miR-4676-5p	CLIP-seq
MIRT1934334	hsa-miR-4684-3p	CLIP-seq
MIRT2426391	hsa-miR-4748	CLIP-seq
MIRT1934335	hsa-miR-4762-5p	CLIP-seq
MIRT2477826	hsa-miR-4774-5p	CLIP-seq
MIRT794084	hsa-miR-4786-3p	CLIP-seq
MIRT2477827	hsa-miR-516a-5p	CLIP-seq
MIRT2477828	hsa-miR-568	CLIP-seq
MIRT794094	hsa-miR-575	CLIP-seq
MIRT2477829	hsa-miR-579	CLIP-seq
MIRT1934339	hsa-miR-603	CLIP-seq
MIRT1934340	hsa-miR-642b	CLIP-seq
MIRT2426392	hsa-miR-664	CLIP-seq
MIRT794095	hsa-miR-665	CLIP-seq
MIRT2477830	hsa-miR-942	CLIP-seq

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	TAS
GO:0005515	Function	Protein binding	IPI	15161933, 15778465, 17347647, 20195357, 28514442, 33961781, 36931259
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA	20525016
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0007030	Process	Golgi organization	IMP	20525016
GO:0007165	Process	Signal transduction	IEA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0016020	Component	Membrane	IEA
GO:0030054	Component	Cell junction	IDA
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0051645	Process	Golgi localization	IBA
GO:0051683	Process	Establishment of Golgi localization	IDA	20525016
GO:0051684	Process	Maintenance of Golgi location	IMP	20525016
GO:0070161	Component	Anchoring junction	IEA
GO:0072384	Process	Organelle transport along microtubule	IMP	20525016

MIM	HGNC	e!Ensembl
609870	23725	ENSG00000107863

Protein

UniProt ID

Q5T5U3

Protein name

Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21)

Protein function

Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions. {ECO:0000269|PubMed:15793564, ECO

PDB

2DHJ , 2J59 , 2YUY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17820	PDZ_6	103 → 156	PDZ domain	Domain
PF00169	PH	932 → 1040	PH domain	Domain
PF00620	RhoGAP	1162 → 1316	RhoGAP domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with higher expression in brain, heart, skeletal muscle and placenta. {ECO:0000269|PubMed:12056806}.

Sequence

MMATRRTGLSEGDGDKLKACEVSKNKDGKEQSETVSLSEDETFSWPGPKTVTLKRTSQGF
GFTLRHFIVYPPESAIQFSYKDEENGNRGGKQRNRLEPMDTIFVKQVKEGGPAFEAGLCT
GDRIIKVNGESVIGKTYSQVIALIQNSDTTLELSVMPKDEDILQVLQFTKDVTALAYSQD
AYLKGNEAYSGNARNIPEPPPICYPWLPSAPSAMAQPVEISPPDSSLSKQQTSTPVLTQP
GRAYRMEIQVPPSPTDVAKSNTAVCVCNESVRTVIVPSEKVVDLLSNRNNHTGPSHRTEE
VRYGVSEQTSLKTVSRTTSPPLSIPTTHLIHQPAGSRSLEPSGILLKSGNYSGHSDGISS
SRSQAVEAPSVSVNHYSPNSHQHIDWKNYKTYKEYIDNRRLHIGCRTIQERLDSLRAASQ
STTDYNQVVPNRTTLQGRRRSTSHDRVPQSVQIRQRSVSQERLEDSVLMKYCPRSASQGA
LTSPSVSFSNHRTRSWDYIEGQDETLENVNSGTPIPDSNGEKKQTYKWSGFTEQDDRRGI
CERPRQQEIHKSFRGSNFTVAPSVVNSDNRRMSGRGVGSVSQFKKIPPDLKTLQSNRNFQ
TTCGMSLPRGISQDRSPLVKVRSNSLKAPSTHVTKPSFSQKSFVSIKDQRPVNHLHQNSL
LNQQTWVRTDSAPDQQVETGKSPSLSGASAKPAPQSSENAGTSDLELPVSQRNQDLSLQE
AETEQSDTLDNKEAVILREKPPSGRQTPQPLRHQSYILAVNDQETGSDTTCWLPNDARRE
VHIKRMEERKASSTSPPGDSLASIPFIDEPTSPSIDHDIAHIPASAVISASTSQVPSIAT
VPPCLTTSAPLIRRQLSHDHESVGPPSLDAQPNSKTERSKSYDEGLDDYREDAKLSFKHV
SSLKGIKIADSQKSSEDSGSRKDSSSEVFSDAAKEGWLHFRPLVTDKGKRVGGSIRPWKQ
MYVVLRGHSLYLYKDKREQTTPSEEEQPISVNACLIDISYSETKRKNVFRLTTSDCECLF
QAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPRQSLS
IRQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTSPPKDKGTWRKGIPSIMRKTFEKKPT
ATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELN
KGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLK
RLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTH
MPDQYKIVETLIQHHDWFFTEEGAEEPLTTVQEESTVDSQPVPNIDHLLTNIGRTGVSPG
DVSDSATSDSTKSKGSWGSGKDQYSRELLVSSIFAAASRKRKKPKEKAQPSSSEDELDNV
FFKKENVEQCHNDTKEESKKESETLGRKQKIIIAKENSTRKDPSTTKDEKISLGKESTPS
EEPSPPHNSKHNKSPTLSCRFAILKESPRSLLAQKSSHLEETGSDSGTLLSTSSQASLAR
FSMKKSTSPETKHSEFLANVSTITSDYSTTSSATYLTSLDSSRLSPEVQSVAESKGDEAD
DERSELISEGRPVETDSESEFPVFPTALTSERLFRGKLQEVTKSSRRNSEGSELSCTEGS
LTSSLDSRRQLFSSHKLIECDTLSRKKSARFKSDSGSLGDAKNEKEAPSLTKVFDVMKKG
KSTGSLLTPTRGESEKQEPTWKTKIADRLKLRPRAPADDMFGVGNHKVNAETAKRKSIRR
RHTLGGHRDATEISVLNFWKVHEQSGERESELSAVNRLKPKCSAQDLSISDWLARERLRT
STSDLSRGEIGDPQTENPSTREIATTDTPLSLHCNTGSSSSTLASTNRPLLSIPPQSPDQ
INGESFQNVSKNASSAANAQPHKLSETPGSKAEFHPCL

Sequence length

1958

Interactions

View interactions

	Reactome
			Rho GTPase cycle

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS
Hypertension	Ischemic stroke in hypertension	N/A	N/A	GWAS
Insomnia	Insomnia	N/A	N/A	GWAS
Ischemic Stroke	Ischemic stroke	N/A	N/A	GWAS

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma	Associate	23200924
Cholangiocarcinoma	Associate	34211100, 36676763
Glioblastoma	Associate	23200924
Liver Failure	Associate	30692208
Malocclusion	Associate	28257739
Malocclusion Angle Class III	Associate	28257739
Neoplasms	Associate	30504808
Prostatic Neoplasms	Associate	23200924
Squamous Cell Carcinoma of Head and Neck	Stimulate	23200924

ARHGAP21 (Rho GTPase activating protein 21)