Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
57583
Gene name Gene Name - the full gene name approved by the HGNC.
Transmembrane protein 181
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TMEM181
Synonyms (NCBI Gene) Gene synonyms aliases
GPR178, KIAA1423
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q25.3
Summary Summary of gene provided in NCBI Entrez Gene.
The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018233 hsa-miR-335-5p Microarray 18185580
MIRT036698 hsa-miR-935 CLASH 23622248
MIRT665787 hsa-miR-124-3p HITS-CLIP 23824327
MIRT665788 hsa-miR-506-3p HITS-CLIP 23824327
MIRT665787 hsa-miR-124-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0015643 Function Toxic substance binding IBA
GO:0015643 Function Toxic substance binding IDA 19965467
GO:0015643 Function Toxic substance binding IEA
GO:0016020 Component Membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
613209 20958 ENSG00000146433
Protein
UniProt ID Q9P2C4
Protein name Transmembrane protein 181
Protein function Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06664 MIG-14_Wnt-bd 265 560 Family
Sequence
MGAAPSPTQASSRGGGPGPPAPTRAVSSSSRARGGALSALGPSPARPLTTSPAPAPPPRS
RPARQQPDPQCWEKRGGAGGDTKGGAAGPGPGRLRGMDAEYPAFEPPLCSELKHLCRRLR
EAYRELKEDLTPFKDDRYYRLAPMRLYTLSKRHFVLVFVVFFICFGLTIFVGIRGPKVIQ
TSAANFSLNNSKKLKPIQILSNPLSTYNQQLWLTCVVELDQSKETSIKTSFPMTVKVDGV
AQDGTTMYIHNKVHNRTRTLTCAGKCAEIIVAHLGYLNYTQYTVIVGFEHLKLPIKGMNF
TWKTYNPAFSRLEIWFRFFFVVLTFIVTCLFAHSLRKFSMRDWGIEQKWMSVLLPLLLLY
NDPFFPLSFLVNSWLPGMLDDLFQSMFLCALLLFWLCVYHGIRVQGERKCLTFYLPKFFI
VGLLWLASVTLGIWQTVNELHDPMYQYRVDTGNFQGMKVFFMVVAAVYILYLLFLIVRAC
SELRHMPYVDLRLKFLTALTFVVLVISIAILYLRFGAQVLQDNFVAELSTHYQNSAEFLS
FYGLLNFYLYTLAFVYSPSK
NALYESQLKDNPAFSMLNDSDDDVIYGSDYEEMPLQNGQA
IRAKYKEESDSD
Sequence length 612
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Glaucoma Glaucoma N/A N/A GWAS
Glioblastoma Glioblastoma N/A N/A GWAS
Prostate cancer Prostate cancer (early onset) N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Dental Caries Associate 29859070