PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 57580 |
| Gene name | Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 |
| Gene symbol | PREX1 |
| Synonyms (NCBI Gene) |
P-REX1
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| Chromosome | 20 |
| Chromosome location | 20q13.13 |
| Summary | The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is foun |
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miRNA
miRNA information provided by mirtarbase database.
622
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q8TCU6 | ||||||||||||||||||||
| Protein name | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1) | ||||||||||||||||||||
| Protein function | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits | ||||||||||||||||||||
| PDB | 3QIK , 4YON , 5D27 , 5D3V , 5D3W , 5D3X , 5D3Y , 5FI0 , 5FI1 , 6PCV , 6VSK , 7RX9 , 8TUA | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. | ||||||||||||||||||||
| Sequence |
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| Sequence length | 1659 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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