KIF17 (kinesin family member 17)

Gene

• Entrez ID: 57576
• Gene name: Kinesin family member 17
• Gene symbol: KIF17
• Synonyms (NCBI Gene): KIF17B, KIF3X, KLP-2, OSM-3
• Chromosome: 1
• Chromosome location: 1p36.12

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016958	hsa-miR-335-5p	Microarray	18185580
MIRT1093454	hsa-miR-148a	CLIP-seq
MIRT1093455	hsa-miR-148b	CLIP-seq
MIRT1093456	hsa-miR-152	CLIP-seq
MIRT1093457	hsa-miR-34a	CLIP-seq
MIRT1093458	hsa-miR-34c-5p	CLIP-seq
MIRT1093459	hsa-miR-449a	CLIP-seq
MIRT1093460	hsa-miR-449b	CLIP-seq
MIRT1093461	hsa-miR-4651	CLIP-seq
MIRT1093462	hsa-miR-541	CLIP-seq
MIRT1093463	hsa-miR-608	CLIP-seq
MIRT1093464	hsa-miR-654-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001750	Component	Photoreceptor outer segment	IEA
GO:0001917	Component	Photoreceptor inner segment	IEA
GO:0003777	Function	Microtubule motor activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005815	Component	Microtubule organizing center	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005871	Component	Kinesin complex	IBA
GO:0005871	Component	Kinesin complex	IEA
GO:0005874	Component	Microtubule	IBA
GO:0005874	Component	Microtubule	IEA
GO:0005929	Component	Cilium	IBA
GO:0005929	Component	Cilium	IEA
GO:0005929	Component	Cilium	ISS
GO:0005929	Component	Cilium	TAS
GO:0005930	Component	Axoneme	IEA
GO:0007017	Process	Microtubule-based process	IEA
GO:0007018	Process	Microtubule-based movement	IEA
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	IEA
GO:0008574	Function	Plus-end-directed microtubule motor activity	IBA
GO:0015031	Process	Protein transport	IEA
GO:0015630	Component	Microtubule cytoskeleton	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0030030	Process	Cell projection organization	IBA
GO:0030425	Component	Dendrite	IEA
GO:0031503	Process	Protein-containing complex localization	IEA
GO:0032391	Component	Photoreceptor connecting cilium	IEA
GO:0032839	Component	Dendrite cytoplasm	IEA
GO:0036064	Component	Ciliary basal body	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IBA
GO:0098794	Component	Postsynapse	IEA
GO:0098971	Process	Anterograde dendritic transport of neurotransmitter receptor complex	IBA
GO:0098971	Process	Anterograde dendritic transport of neurotransmitter receptor complex	IEA
GO:1990075	Component	Periciliary membrane compartment	IEA

Other IDs

• MIM: 605037
• HGNC: 19167
• e!Ensembl: ENSG00000117245

Protein

• UniProt ID: Q9P2E2
• Protein name: Kinesin-like protein KIF17 (KIF3-related motor protein)
• Protein function: Dendrite-specific motor protein which, in association with the Apba1-containing complex (LIN-10-LIN-2-LIN-7 complex), transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. {ECO:0000250|UniProtKB:Q99
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00225	Kinesin	11 → 335	Kinesin motor domain	Domain

• Sequence:

  MASEAVKVVVRCRPMNQRERELRCQPVVTVDCARAQCCIQNPGAADEPPKQFTFDGAYHV
  DHVTEQIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPSQRGIIPRAFEH
  VFESVQCAENTKFLVRASYLEIYNEDVRDLLGADTKQKLELKEHPEKGVYVKGLSMHTVH
  SVAQCEHIMETGWKNRSVGYTLMNKDSSRSHSIFTISIEMSAVDERGKDHLRAGKLNLVD
  LAGSERQSKTGATGERLKEATKINLSLSALGNVISALVDGRCKHVPYRDSKLTRLLQDSL
  GGNTKTLMVACLSPADNNYDETLSTLRYANRAKNIRNKPRINEDPKDALLREYQEEIKKL
  KAILTQQMSPSSLSALLSRQVPPDPVQVEEKLLPQPVIQHDVEAEKQLIREEYEERLARL
  KADYKAEQESRARLEEDITAMRNSYDVRLSTLEENLRKETEAVLQVGVLYKAEVMSRAEF
  ASSAEYPPAFQYETVVKPKVFSTTDTLPSDDVSKTQVSSRFAELPKVEPSKSEISLGSSE
  SSSLEETSVSEAFPGPEEPSNVEVSMPTEESRSRYFLDECLGQEAAGHLLGEQNYLPQEE
  PQEVPLQGLLGLQDPFAEVEAKLARLSSTVARTDAPQADVPKVPVQVPAPTDLLEPSDAR
  PEAEAADDFPPRPEVDLASEVALEVVRTAEPGVWLEAQAPVALVAQPEPLPATAGVKRES
  VGMEVAVLTDDPLPVVDQQQVLARLQLLEQQVVGGEQAKNKDLKEKHKRRKRYADERRKQ
  LVAALQNSDEDSGDWVLLNVYDSIQEEVRAKSKLLEKMQRKLRAAEVEIKDLQSEFQLEK
  IDYLATIRRQERDSMLLQQLLEQVQPLIRRDCNYSNLEKILRESCWDEDNGFWKIPHPVI
  TKTSLPVAVSTGPQNKPARKTSAADNGEPNMEDDRYRLMLSRSNSENIASNYFRSKRASQ
  ILSTDARKSLTHHNSPPGLSCPLSNNSAIPPTQAPEMPQPRPFRLESLDIPFTKAKRKKS
  KSNFGSEPL

• Sequence length: 1029

Pathways

KEGG:

Motor proteins

Reactome:

Intraflagellar transport

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
KIF17-related disorder	Likely benign; Uncertain significance	rs191366066, rs149468609, rs553263913, rs143758204, rs137916833	RCV003914267 RCV003911505 RCV003933955 RCV003964215 RCV003917052

Associations from Text Mining
Disease Name	Relationship Type	References
Anophthalmia with pulmonary hypoplasia	Associate	33922911
Breast Neoplasms	Associate	39218304
Coloboma	Associate	33922911
Microphthalmos	Associate	33922911