ARHGAP20 (Rho GTPase activating protein 20)

Gene

• Entrez ID: 57569
• Gene name: Rho GTPase activating protein 20
• Gene symbol: ARHGAP20
• Synonyms (NCBI Gene): RARHOGAP
• Chromosome: 11
• Chromosome location: 11q22.3-q23.1
• Summary: The protein encoded by this gene is an activator of RHO-type GTPases, transducing a signal from RAP1 to RHO and impacting neurite outgrowth. [provided by RefSeq, Sep 2016]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT794051	hsa-miR-1303	CLIP-seq
MIRT794052	hsa-miR-1324	CLIP-seq
MIRT794053	hsa-miR-148a	CLIP-seq
MIRT794054	hsa-miR-148b	CLIP-seq
MIRT794055	hsa-miR-152	CLIP-seq
MIRT794056	hsa-miR-23a	CLIP-seq
MIRT794057	hsa-miR-23b	CLIP-seq
MIRT794058	hsa-miR-23c	CLIP-seq
MIRT794059	hsa-miR-3123	CLIP-seq
MIRT794060	hsa-miR-3925-5p	CLIP-seq
MIRT794061	hsa-miR-4310	CLIP-seq
MIRT794062	hsa-miR-4312	CLIP-seq
MIRT794063	hsa-miR-4422	CLIP-seq
MIRT794064	hsa-miR-4659a-3p	CLIP-seq
MIRT794065	hsa-miR-4659b-3p	CLIP-seq
MIRT794066	hsa-miR-4711-5p	CLIP-seq
MIRT794067	hsa-miR-4778-3p	CLIP-seq
MIRT794068	hsa-miR-515-3p	CLIP-seq
MIRT794069	hsa-miR-519e	CLIP-seq
MIRT794070	hsa-miR-548aa	CLIP-seq
MIRT794071	hsa-miR-570	CLIP-seq
MIRT794072	hsa-miR-577	CLIP-seq
MIRT794073	hsa-miR-599	CLIP-seq
MIRT794074	hsa-miR-622	CLIP-seq
MIRT794075	hsa-miR-656	CLIP-seq
MIRT1934309	hsa-miR-150	CLIP-seq
MIRT1934310	hsa-miR-216a	CLIP-seq
MIRT1934311	hsa-miR-3163	CLIP-seq
MIRT1934311	hsa-miR-3163	CLIP-seq
MIRT2435453	hsa-miR-1266	CLIP-seq
MIRT2435454	hsa-miR-1289	CLIP-seq
MIRT2435455	hsa-miR-199a-3p	CLIP-seq
MIRT2435456	hsa-miR-199b-3p	CLIP-seq
MIRT2435457	hsa-miR-2114	CLIP-seq
MIRT1934310	hsa-miR-216a	CLIP-seq
MIRT2435458	hsa-miR-3129-5p	CLIP-seq
MIRT2435459	hsa-miR-3153	CLIP-seq
MIRT2435460	hsa-miR-3157-3p	CLIP-seq
MIRT2435461	hsa-miR-342-3p	CLIP-seq
MIRT2435462	hsa-miR-3664-3p	CLIP-seq
MIRT2435463	hsa-miR-370	CLIP-seq
MIRT2435464	hsa-miR-3913-3p	CLIP-seq
MIRT2435465	hsa-miR-4436a	CLIP-seq
MIRT2435466	hsa-miR-4475	CLIP-seq
MIRT2435467	hsa-miR-4518	CLIP-seq
MIRT2435468	hsa-miR-4645-3p	CLIP-seq
MIRT2435469	hsa-miR-628-5p	CLIP-seq
MIRT2435470	hsa-miR-942	CLIP-seq
MIRT2477712	hsa-miR-106a	CLIP-seq
MIRT2477713	hsa-miR-106b	CLIP-seq
MIRT2477714	hsa-miR-1264	CLIP-seq
MIRT2477715	hsa-miR-1276	CLIP-seq
MIRT2435454	hsa-miR-1289	CLIP-seq
MIRT2477716	hsa-miR-1297	CLIP-seq
MIRT2477717	hsa-miR-1299	CLIP-seq
MIRT794051	hsa-miR-1303	CLIP-seq
MIRT2477718	hsa-miR-142-5p	CLIP-seq
MIRT794053	hsa-miR-148a	CLIP-seq
MIRT794054	hsa-miR-148b	CLIP-seq
MIRT1934309	hsa-miR-150	CLIP-seq
MIRT794055	hsa-miR-152	CLIP-seq
MIRT2477719	hsa-miR-15a	CLIP-seq
MIRT2477720	hsa-miR-15b	CLIP-seq
MIRT2477721	hsa-miR-16	CLIP-seq
MIRT2477722	hsa-miR-17	CLIP-seq
MIRT2477723	hsa-miR-190	CLIP-seq
MIRT2477724	hsa-miR-190b	CLIP-seq
MIRT2477725	hsa-miR-1915	CLIP-seq
MIRT2477726	hsa-miR-195	CLIP-seq
MIRT2435455	hsa-miR-199a-3p	CLIP-seq
MIRT2435456	hsa-miR-199b-3p	CLIP-seq
MIRT2477727	hsa-miR-20a	CLIP-seq
MIRT2477728	hsa-miR-20b	CLIP-seq
MIRT2435457	hsa-miR-2114	CLIP-seq
MIRT2477729	hsa-miR-2276	CLIP-seq
MIRT2477730	hsa-miR-2355-3p	CLIP-seq
MIRT2477731	hsa-miR-26a	CLIP-seq
MIRT2477732	hsa-miR-26b	CLIP-seq
MIRT2477733	hsa-miR-300	CLIP-seq
MIRT2477734	hsa-miR-3117-3p	CLIP-seq
MIRT794059	hsa-miR-3123	CLIP-seq
MIRT2435458	hsa-miR-3129-5p	CLIP-seq
MIRT2477735	hsa-miR-3133	CLIP-seq
MIRT2477736	hsa-miR-3144-3p	CLIP-seq
MIRT2477737	hsa-miR-3146	CLIP-seq
MIRT2435459	hsa-miR-3153	CLIP-seq
MIRT2435460	hsa-miR-3157-3p	CLIP-seq
MIRT2477738	hsa-miR-3169	CLIP-seq
MIRT2477739	hsa-miR-340	CLIP-seq
MIRT2477740	hsa-miR-3609	CLIP-seq
MIRT2477741	hsa-miR-3613-3p	CLIP-seq
MIRT2477742	hsa-miR-361-5p	CLIP-seq
MIRT2477743	hsa-miR-3617	CLIP-seq
MIRT2477744	hsa-miR-3647-3p	CLIP-seq
MIRT2477745	hsa-miR-3668	CLIP-seq
MIRT2477746	hsa-miR-3673	CLIP-seq
MIRT2477747	hsa-miR-3688-3p	CLIP-seq
MIRT2435463	hsa-miR-370	CLIP-seq
MIRT2477748	hsa-miR-381	CLIP-seq
MIRT2477749	hsa-miR-3908	CLIP-seq
MIRT794060	hsa-miR-3925-5p	CLIP-seq
MIRT2477750	hsa-miR-3936	CLIP-seq
MIRT2477751	hsa-miR-3942-5p	CLIP-seq
MIRT2477752	hsa-miR-424	CLIP-seq
MIRT2477753	hsa-miR-4260	CLIP-seq
MIRT2477754	hsa-miR-4282	CLIP-seq
MIRT2477755	hsa-miR-4299	CLIP-seq
MIRT2477756	hsa-miR-4311	CLIP-seq
MIRT794062	hsa-miR-4312	CLIP-seq
MIRT2477757	hsa-miR-4453	CLIP-seq
MIRT2477758	hsa-miR-4456	CLIP-seq
MIRT2477759	hsa-miR-4465	CLIP-seq
MIRT2477760	hsa-miR-4474-5p	CLIP-seq
MIRT2435466	hsa-miR-4475	CLIP-seq
MIRT2477761	hsa-miR-448	CLIP-seq
MIRT2477762	hsa-miR-4515	CLIP-seq
MIRT2477763	hsa-miR-4517	CLIP-seq
MIRT2477764	hsa-miR-4524	CLIP-seq
MIRT2477765	hsa-miR-4538	CLIP-seq
MIRT2435468	hsa-miR-4645-3p	CLIP-seq
MIRT794064	hsa-miR-4659a-3p	CLIP-seq
MIRT794065	hsa-miR-4659b-3p	CLIP-seq
MIRT2477766	hsa-miR-4666-3p	CLIP-seq
MIRT2477767	hsa-miR-4703-5p	CLIP-seq
MIRT2477768	hsa-miR-4713-5p	CLIP-seq
MIRT2477769	hsa-miR-4726-3p	CLIP-seq
MIRT2477770	hsa-miR-4759	CLIP-seq
MIRT2477771	hsa-miR-4766-3p	CLIP-seq
MIRT2477772	hsa-miR-4772-3p	CLIP-seq
MIRT2477773	hsa-miR-4773	CLIP-seq
MIRT794067	hsa-miR-4778-3p	CLIP-seq
MIRT2477774	hsa-miR-4789-5p	CLIP-seq
MIRT2477775	hsa-miR-4796-3p	CLIP-seq
MIRT2477776	hsa-miR-485-3p	CLIP-seq
MIRT2477777	hsa-miR-486-3p	CLIP-seq
MIRT2477778	hsa-miR-494	CLIP-seq
MIRT2477779	hsa-miR-497	CLIP-seq
MIRT2477780	hsa-miR-500a	CLIP-seq
MIRT2477781	hsa-miR-503	CLIP-seq
MIRT794068	hsa-miR-515-3p	CLIP-seq
MIRT2477782	hsa-miR-519d	CLIP-seq
MIRT794069	hsa-miR-519e	CLIP-seq
MIRT2477783	hsa-miR-520d-5p	CLIP-seq
MIRT2477784	hsa-miR-524-5p	CLIP-seq
MIRT2477785	hsa-miR-532-3p	CLIP-seq
MIRT2477786	hsa-miR-544	CLIP-seq
MIRT2477787	hsa-miR-548a-5p	CLIP-seq
MIRT794070	hsa-miR-548aa	CLIP-seq
MIRT2477788	hsa-miR-548ab	CLIP-seq
MIRT2477789	hsa-miR-548ah	CLIP-seq
MIRT2477790	hsa-miR-548ak	CLIP-seq
MIRT2477791	hsa-miR-548b-5p	CLIP-seq
MIRT2477792	hsa-miR-548c-5p	CLIP-seq
MIRT2477793	hsa-miR-548d-5p	CLIP-seq
MIRT2477794	hsa-miR-548h	CLIP-seq
MIRT2477795	hsa-miR-548i	CLIP-seq
MIRT2477796	hsa-miR-548j	CLIP-seq
MIRT2477797	hsa-miR-548k	CLIP-seq
MIRT2477798	hsa-miR-548l	CLIP-seq
MIRT2477799	hsa-miR-548n	CLIP-seq
MIRT2477800	hsa-miR-548p	CLIP-seq
MIRT2477801	hsa-miR-548q	CLIP-seq
MIRT2477802	hsa-miR-548t	CLIP-seq
MIRT2477803	hsa-miR-548w	CLIP-seq
MIRT2477804	hsa-miR-548y	CLIP-seq
MIRT2477805	hsa-miR-559	CLIP-seq
MIRT794071	hsa-miR-570	CLIP-seq
MIRT2477806	hsa-miR-583	CLIP-seq
MIRT2477807	hsa-miR-591	CLIP-seq
MIRT2435469	hsa-miR-628-5p	CLIP-seq
MIRT2477808	hsa-miR-641	CLIP-seq
MIRT2477809	hsa-miR-646	CLIP-seq
MIRT794075	hsa-miR-656	CLIP-seq
MIRT2477810	hsa-miR-671-5p	CLIP-seq
MIRT2477811	hsa-miR-676	CLIP-seq
MIRT2477812	hsa-miR-875-3p	CLIP-seq
MIRT2477813	hsa-miR-885-5p	CLIP-seq
MIRT2477814	hsa-miR-889	CLIP-seq
MIRT2477815	hsa-miR-93	CLIP-seq
MIRT2477816	hsa-miR-944	CLIP-seq
MIRT2477714	hsa-miR-1264	CLIP-seq
MIRT2477715	hsa-miR-1276	CLIP-seq
MIRT2435454	hsa-miR-1289	CLIP-seq
MIRT2477716	hsa-miR-1297	CLIP-seq
MIRT2477718	hsa-miR-142-5p	CLIP-seq
MIRT794053	hsa-miR-148a	CLIP-seq
MIRT794054	hsa-miR-148b	CLIP-seq
MIRT794055	hsa-miR-152	CLIP-seq
MIRT2477723	hsa-miR-190	CLIP-seq
MIRT2477724	hsa-miR-190b	CLIP-seq
MIRT2435455	hsa-miR-199a-3p	CLIP-seq
MIRT2435456	hsa-miR-199b-3p	CLIP-seq
MIRT2435457	hsa-miR-2114	CLIP-seq
MIRT2477730	hsa-miR-2355-3p	CLIP-seq
MIRT2477731	hsa-miR-26a	CLIP-seq
MIRT2477732	hsa-miR-26b	CLIP-seq
MIRT2477734	hsa-miR-3117-3p	CLIP-seq
MIRT794059	hsa-miR-3123	CLIP-seq
MIRT2435458	hsa-miR-3129-5p	CLIP-seq
MIRT2477735	hsa-miR-3133	CLIP-seq
MIRT2477736	hsa-miR-3144-3p	CLIP-seq
MIRT2477737	hsa-miR-3146	CLIP-seq
MIRT2435459	hsa-miR-3153	CLIP-seq
MIRT2435460	hsa-miR-3157-3p	CLIP-seq
MIRT2477738	hsa-miR-3169	CLIP-seq
MIRT2477741	hsa-miR-3613-3p	CLIP-seq
MIRT2477742	hsa-miR-361-5p	CLIP-seq
MIRT2477743	hsa-miR-3617	CLIP-seq
MIRT2477744	hsa-miR-3647-3p	CLIP-seq
MIRT2477745	hsa-miR-3668	CLIP-seq
MIRT2477746	hsa-miR-3673	CLIP-seq
MIRT2477747	hsa-miR-3688-3p	CLIP-seq
MIRT2435463	hsa-miR-370	CLIP-seq
MIRT2477749	hsa-miR-3908	CLIP-seq
MIRT2477751	hsa-miR-3942-5p	CLIP-seq
MIRT2477753	hsa-miR-4260	CLIP-seq
MIRT2477754	hsa-miR-4282	CLIP-seq
MIRT2477755	hsa-miR-4299	CLIP-seq
MIRT2477756	hsa-miR-4311	CLIP-seq
MIRT794062	hsa-miR-4312	CLIP-seq
MIRT2477757	hsa-miR-4453	CLIP-seq
MIRT2477758	hsa-miR-4456	CLIP-seq
MIRT2477759	hsa-miR-4465	CLIP-seq
MIRT2477760	hsa-miR-4474-5p	CLIP-seq
MIRT2435466	hsa-miR-4475	CLIP-seq
MIRT2477761	hsa-miR-448	CLIP-seq
MIRT2477762	hsa-miR-4515	CLIP-seq
MIRT2477763	hsa-miR-4517	CLIP-seq
MIRT2477765	hsa-miR-4538	CLIP-seq
MIRT2435468	hsa-miR-4645-3p	CLIP-seq
MIRT2477767	hsa-miR-4703-5p	CLIP-seq
MIRT2477770	hsa-miR-4759	CLIP-seq
MIRT2477771	hsa-miR-4766-3p	CLIP-seq
MIRT2477773	hsa-miR-4773	CLIP-seq
MIRT2477776	hsa-miR-485-3p	CLIP-seq
MIRT2477777	hsa-miR-486-3p	CLIP-seq
MIRT2477778	hsa-miR-494	CLIP-seq
MIRT2477780	hsa-miR-500a	CLIP-seq
MIRT794068	hsa-miR-515-3p	CLIP-seq
MIRT794069	hsa-miR-519e	CLIP-seq
MIRT2477787	hsa-miR-548a-5p	CLIP-seq
MIRT794070	hsa-miR-548aa	CLIP-seq
MIRT2477788	hsa-miR-548ab	CLIP-seq
MIRT2477790	hsa-miR-548ak	CLIP-seq
MIRT2477791	hsa-miR-548b-5p	CLIP-seq
MIRT2477792	hsa-miR-548c-5p	CLIP-seq
MIRT2477793	hsa-miR-548d-5p	CLIP-seq
MIRT2477794	hsa-miR-548h	CLIP-seq
MIRT2477795	hsa-miR-548i	CLIP-seq
MIRT2477796	hsa-miR-548j	CLIP-seq
MIRT2477797	hsa-miR-548k	CLIP-seq
MIRT2477798	hsa-miR-548l	CLIP-seq
MIRT2477801	hsa-miR-548q	CLIP-seq
MIRT2477803	hsa-miR-548w	CLIP-seq
MIRT2477804	hsa-miR-548y	CLIP-seq
MIRT2477805	hsa-miR-559	CLIP-seq
MIRT794071	hsa-miR-570	CLIP-seq
MIRT2477806	hsa-miR-583	CLIP-seq
MIRT2477807	hsa-miR-591	CLIP-seq
MIRT2435469	hsa-miR-628-5p	CLIP-seq
MIRT2477808	hsa-miR-641	CLIP-seq
MIRT794075	hsa-miR-656	CLIP-seq
MIRT2477811	hsa-miR-676	CLIP-seq
MIRT2477813	hsa-miR-885-5p	CLIP-seq
MIRT2477814	hsa-miR-889	CLIP-seq
MIRT2477816	hsa-miR-944	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	TAS
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0035023	Process	Regulation of Rho protein signal transduction	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS

Other IDs

• MIM: 609568
• HGNC: 18357
• e!Ensembl: ENSG00000137727

Protein

• UniProt ID: Q9P2F6
• Protein name: Rho GTPase-activating protein 20 (Rho-type GTPase-activating protein 20)
• Protein function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
• PDB: 3MSX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00788	RA	194 → 291	Ras association (RalGDS/AF-6) domain	Domain
  PF00620	RhoGAP	377 → 527	RhoGAP domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed predominantly in the brain. Lower expression is found in lymph nodes. {ECO:0000269|PubMed:15543602}.
• Sequence:

  MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCTKKKMKTLAERRRSAPSLILDKALQKRP
  TTRDSPSASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYN
  NNFKIKNKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLL
  QRYINLEKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSER
  DYQLWVNSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLP
  REMQCQFILKPSRLAAAQQLSDSGHKTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPG
  QLFGISLPNICENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEV
  HLDCESIFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRA
  NVVLLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLI
  QFLIENCLRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPC
  SDLVKKLGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPV
  NILVYTKIPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLRE
  FYQKKLRKSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKK
  SLSGSEGNHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPR
  THRRCSEPNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLIN
  QSLVMGIEVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQI
  SEHSVFTPTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDT
  MEWHSQMHSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGV
  PEANSLQEEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSH
  EEIEPGSQSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI

• Sequence length: 1191

Pathways

Reactome:

Rho GTPase cycle

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BENIGN CHONDROGENIC NEOPLASM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BONE BENIGN NEOPLASM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BONE NEOPLASM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CUTANEOUS MELANOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Neoplasms	Associate	33949771	★☆☆☆☆ Found in Text Mining only
Rectal Neoplasms	Associate	33949771	★☆☆☆☆ Found in Text Mining only