SIPA1L2 (signal induced proliferation associated 1 like 2)

Gene

• Entrez ID: 57568
• Gene name: Signal induced proliferation associated 1 like 2
• Gene symbol: SIPA1L2
• Synonyms (NCBI Gene): SPAL2, SPAR2
• Chromosome: 1
• Chromosome location: 1q42.2
• Summary: This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper. A similar protein in rat acts as a

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027031	hsa-miR-103a-3p	Sequencing	20371350
MIRT031520	hsa-miR-16-5p	Sequencing	20371350
MIRT042334	hsa-miR-484	CLASH	23622248
MIRT616578	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT616577	hsa-miR-520f-3p	HITS-CLIP	23824327
MIRT616576	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT554305	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT554304	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT554303	hsa-miR-3609	PAR-CLIP	21572407
MIRT554302	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT554301	hsa-miR-300	PAR-CLIP	21572407
MIRT554300	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT554299	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT554298	hsa-miR-1284	PAR-CLIP	21572407
MIRT554297	hsa-miR-4795-5p	PAR-CLIP	21572407
MIRT554296	hsa-miR-219a-1-3p	PAR-CLIP	21572407
MIRT554295	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT554294	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT554293	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT554292	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT554291	hsa-miR-7158-3p	PAR-CLIP	21572407
MIRT554290	hsa-miR-3616-5p	PAR-CLIP	21572407
MIRT554289	hsa-miR-573	PAR-CLIP	21572407
MIRT439631	hsa-miR-543	HITS-CLIP	24374217
MIRT439631	hsa-miR-543	HITS-CLIP	24374217
MIRT616578	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT616577	hsa-miR-520f-3p	HITS-CLIP	23824327
MIRT616576	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT554305	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT554304	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT554303	hsa-miR-3609	PAR-CLIP	21572407
MIRT554302	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT554301	hsa-miR-300	PAR-CLIP	21572407
MIRT554300	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT554299	hsa-miR-4666a-3p	PAR-CLIP	21572407
MIRT554298	hsa-miR-1284	PAR-CLIP	21572407
MIRT554297	hsa-miR-4795-5p	PAR-CLIP	21572407
MIRT554296	hsa-miR-219a-1-3p	PAR-CLIP	21572407
MIRT554295	hsa-let-7a-3p	PAR-CLIP	21572407
MIRT554294	hsa-let-7b-3p	PAR-CLIP	21572407
MIRT554293	hsa-let-7f-1-3p	PAR-CLIP	21572407
MIRT554292	hsa-miR-98-3p	PAR-CLIP	21572407
MIRT554291	hsa-miR-7158-3p	PAR-CLIP	21572407
MIRT554290	hsa-miR-3616-5p	PAR-CLIP	21572407
MIRT554289	hsa-miR-573	PAR-CLIP	21572407
MIRT1349725	hsa-miR-103a	CLIP-seq
MIRT1349726	hsa-miR-107	CLIP-seq
MIRT1349727	hsa-miR-1208	CLIP-seq
MIRT1349728	hsa-miR-1228	CLIP-seq
MIRT1349729	hsa-miR-1264	CLIP-seq
MIRT1349730	hsa-miR-129-5p	CLIP-seq
MIRT1349731	hsa-miR-1298	CLIP-seq
MIRT1349732	hsa-miR-141	CLIP-seq
MIRT1349733	hsa-miR-15a	CLIP-seq
MIRT1349734	hsa-miR-15b	CLIP-seq
MIRT1349735	hsa-miR-16	CLIP-seq
MIRT1349736	hsa-miR-181a	CLIP-seq
MIRT1349737	hsa-miR-181b	CLIP-seq
MIRT1349738	hsa-miR-181c	CLIP-seq
MIRT1349739	hsa-miR-181d	CLIP-seq
MIRT1349740	hsa-miR-195	CLIP-seq
MIRT1349741	hsa-miR-200a	CLIP-seq
MIRT1349742	hsa-miR-2053	CLIP-seq
MIRT1349743	hsa-miR-216b	CLIP-seq
MIRT1349744	hsa-miR-217	CLIP-seq
MIRT1349745	hsa-miR-221	CLIP-seq
MIRT1349746	hsa-miR-222	CLIP-seq
MIRT1349747	hsa-miR-2278	CLIP-seq
MIRT1349748	hsa-miR-23a	CLIP-seq
MIRT1349749	hsa-miR-23b	CLIP-seq
MIRT1349750	hsa-miR-23c	CLIP-seq
MIRT1349751	hsa-miR-299-5p	CLIP-seq
MIRT1349752	hsa-miR-3074-5p	CLIP-seq
MIRT1349753	hsa-miR-3120-3p	CLIP-seq
MIRT1349754	hsa-miR-3121-3p	CLIP-seq
MIRT1349755	hsa-miR-3143	CLIP-seq
MIRT1349756	hsa-miR-3152-3p	CLIP-seq
MIRT1349757	hsa-miR-3663-3p	CLIP-seq
MIRT1349758	hsa-miR-375	CLIP-seq
MIRT1349759	hsa-miR-377	CLIP-seq
MIRT1349760	hsa-miR-3910	CLIP-seq
MIRT1349761	hsa-miR-3920	CLIP-seq
MIRT1349762	hsa-miR-3924	CLIP-seq
MIRT1349763	hsa-miR-3942-5p	CLIP-seq
MIRT1349764	hsa-miR-412	CLIP-seq
MIRT1349765	hsa-miR-424	CLIP-seq
MIRT1349766	hsa-miR-4262	CLIP-seq
MIRT1349767	hsa-miR-4269	CLIP-seq
MIRT1349768	hsa-miR-4326	CLIP-seq
MIRT1349769	hsa-miR-4422	CLIP-seq
MIRT1349770	hsa-miR-4433	CLIP-seq
MIRT1349771	hsa-miR-4514	CLIP-seq
MIRT1349772	hsa-miR-4521	CLIP-seq
MIRT1349773	hsa-miR-4524	CLIP-seq
MIRT1349774	hsa-miR-4539	CLIP-seq
MIRT1349775	hsa-miR-4653-3p	CLIP-seq
MIRT1349776	hsa-miR-4661-5p	CLIP-seq
MIRT1349777	hsa-miR-4672	CLIP-seq
MIRT1349778	hsa-miR-4692	CLIP-seq
MIRT1349779	hsa-miR-4703-5p	CLIP-seq
MIRT1349780	hsa-miR-4733-3p	CLIP-seq
MIRT1349781	hsa-miR-4742-5p	CLIP-seq
MIRT1349782	hsa-miR-4792	CLIP-seq
MIRT1349783	hsa-miR-488	CLIP-seq
MIRT1349784	hsa-miR-497	CLIP-seq
MIRT1349785	hsa-miR-503	CLIP-seq
MIRT1349786	hsa-miR-522	CLIP-seq
MIRT1349787	hsa-miR-545	CLIP-seq
MIRT1349788	hsa-miR-548a-5p	CLIP-seq
MIRT1349789	hsa-miR-548aa	CLIP-seq
MIRT1349790	hsa-miR-548ab	CLIP-seq
MIRT1349791	hsa-miR-548ac	CLIP-seq
MIRT1349792	hsa-miR-548ag	CLIP-seq
MIRT1349793	hsa-miR-548ai	CLIP-seq
MIRT1349794	hsa-miR-548ak	CLIP-seq
MIRT1349795	hsa-miR-548b-5p	CLIP-seq
MIRT1349796	hsa-miR-548c-5p	CLIP-seq
MIRT1349797	hsa-miR-548d-3p	CLIP-seq
MIRT1349798	hsa-miR-548d-5p	CLIP-seq
MIRT1349799	hsa-miR-548h	CLIP-seq
MIRT1349800	hsa-miR-548i	CLIP-seq
MIRT1349801	hsa-miR-548j	CLIP-seq
MIRT1349802	hsa-miR-548k	CLIP-seq
MIRT1349803	hsa-miR-548l	CLIP-seq
MIRT1349804	hsa-miR-548p	CLIP-seq
MIRT1349805	hsa-miR-548v	CLIP-seq
MIRT1349806	hsa-miR-548w	CLIP-seq
MIRT1349807	hsa-miR-548y	CLIP-seq
MIRT1349808	hsa-miR-548z	CLIP-seq
MIRT1349809	hsa-miR-559	CLIP-seq
MIRT1349810	hsa-miR-563	CLIP-seq
MIRT1349811	hsa-miR-569	CLIP-seq
MIRT1349812	hsa-miR-624	CLIP-seq
MIRT1349813	hsa-miR-629	CLIP-seq
MIRT1349814	hsa-miR-646	CLIP-seq
MIRT1349815	hsa-miR-654-3p	CLIP-seq
MIRT1349816	hsa-miR-664	CLIP-seq
MIRT1349817	hsa-miR-665	CLIP-seq
MIRT1349818	hsa-miR-767-5p	CLIP-seq
MIRT1349819	hsa-miR-889	CLIP-seq
MIRT1349727	hsa-miR-1208	CLIP-seq
MIRT1349728	hsa-miR-1228	CLIP-seq
MIRT2103638	hsa-miR-1256	CLIP-seq
MIRT1349729	hsa-miR-1264	CLIP-seq
MIRT1349731	hsa-miR-1298	CLIP-seq
MIRT2103639	hsa-miR-130a	CLIP-seq
MIRT2103640	hsa-miR-130b	CLIP-seq
MIRT1349732	hsa-miR-141	CLIP-seq
MIRT2103641	hsa-miR-1469	CLIP-seq
MIRT1349736	hsa-miR-181a	CLIP-seq
MIRT1349737	hsa-miR-181b	CLIP-seq
MIRT1349738	hsa-miR-181c	CLIP-seq
MIRT1349739	hsa-miR-181d	CLIP-seq
MIRT2103642	hsa-miR-1972	CLIP-seq
MIRT1349741	hsa-miR-200a	CLIP-seq
MIRT1349742	hsa-miR-2053	CLIP-seq
MIRT2103643	hsa-miR-219-1-3p	CLIP-seq
MIRT1349748	hsa-miR-23a	CLIP-seq
MIRT1349749	hsa-miR-23b	CLIP-seq
MIRT1349750	hsa-miR-23c	CLIP-seq
MIRT2103644	hsa-miR-2467-5p	CLIP-seq
MIRT2103645	hsa-miR-301a	CLIP-seq
MIRT2103646	hsa-miR-301b	CLIP-seq
MIRT1349752	hsa-miR-3074-5p	CLIP-seq
MIRT2103647	hsa-miR-3124-3p	CLIP-seq
MIRT2103648	hsa-miR-3126-3p	CLIP-seq
MIRT2103649	hsa-miR-3128	CLIP-seq
MIRT2103650	hsa-miR-3168	CLIP-seq
MIRT2103651	hsa-miR-3174	CLIP-seq
MIRT2103652	hsa-miR-3180-5p	CLIP-seq
MIRT2103653	hsa-miR-3182	CLIP-seq
MIRT2103654	hsa-miR-330-3p	CLIP-seq
MIRT2103655	hsa-miR-338-3p	CLIP-seq
MIRT2103656	hsa-miR-3622a-3p	CLIP-seq
MIRT2103657	hsa-miR-3622b-3p	CLIP-seq
MIRT2103658	hsa-miR-3647-5p	CLIP-seq
MIRT2103659	hsa-miR-3666	CLIP-seq
MIRT2103660	hsa-miR-3686	CLIP-seq
MIRT1349758	hsa-miR-375	CLIP-seq
MIRT1349759	hsa-miR-377	CLIP-seq
MIRT2103661	hsa-miR-381	CLIP-seq
MIRT1349760	hsa-miR-3910	CLIP-seq
MIRT1349762	hsa-miR-3924	CLIP-seq
MIRT2103662	hsa-miR-3926	CLIP-seq
MIRT2103663	hsa-miR-409-5p	CLIP-seq
MIRT1349764	hsa-miR-412	CLIP-seq
MIRT1349766	hsa-miR-4262	CLIP-seq
MIRT1349767	hsa-miR-4269	CLIP-seq
MIRT2103664	hsa-miR-4295	CLIP-seq
MIRT1349768	hsa-miR-4326	CLIP-seq
MIRT1349770	hsa-miR-4433	CLIP-seq
MIRT1349771	hsa-miR-4514	CLIP-seq
MIRT1349772	hsa-miR-4521	CLIP-seq
MIRT2103665	hsa-miR-4523	CLIP-seq
MIRT1349773	hsa-miR-4524	CLIP-seq
MIRT2103666	hsa-miR-4530	CLIP-seq
MIRT2103667	hsa-miR-454	CLIP-seq
MIRT2103668	hsa-miR-4633-5p	CLIP-seq
MIRT2103669	hsa-miR-4639-3p	CLIP-seq
MIRT1349775	hsa-miR-4653-3p	CLIP-seq
MIRT2103670	hsa-miR-4666-3p	CLIP-seq
MIRT2103671	hsa-miR-4671-3p	CLIP-seq
MIRT2103672	hsa-miR-4684-5p	CLIP-seq
MIRT1349778	hsa-miR-4692	CLIP-seq
MIRT2103673	hsa-miR-4700-3p	CLIP-seq
MIRT2103674	hsa-miR-4720-5p	CLIP-seq
MIRT1349780	hsa-miR-4733-3p	CLIP-seq
MIRT1349781	hsa-miR-4742-5p	CLIP-seq
MIRT2103675	hsa-miR-4762-5p	CLIP-seq
MIRT1349782	hsa-miR-4792	CLIP-seq
MIRT2103676	hsa-miR-4799-3p	CLIP-seq
MIRT2103677	hsa-miR-520d-5p	CLIP-seq
MIRT2103678	hsa-miR-520f	CLIP-seq
MIRT2103679	hsa-miR-524-5p	CLIP-seq
MIRT2103680	hsa-miR-532-5p	CLIP-seq
MIRT2103681	hsa-miR-548a-3p	CLIP-seq
MIRT1349792	hsa-miR-548ag	CLIP-seq
MIRT2103682	hsa-miR-548ah	CLIP-seq
MIRT1349793	hsa-miR-548ai	CLIP-seq
MIRT2103683	hsa-miR-548e	CLIP-seq
MIRT2103684	hsa-miR-548f	CLIP-seq
MIRT2103685	hsa-miR-548t	CLIP-seq
MIRT1349811	hsa-miR-569	CLIP-seq
MIRT2103686	hsa-miR-577	CLIP-seq
MIRT1349812	hsa-miR-624	CLIP-seq
MIRT1349816	hsa-miR-664	CLIP-seq
MIRT1349817	hsa-miR-665	CLIP-seq
MIRT1349818	hsa-miR-767-5p	CLIP-seq
MIRT1349819	hsa-miR-889	CLIP-seq
MIRT2103687	hsa-miR-921	CLIP-seq
MIRT2103688	hsa-miR-922	CLIP-seq
MIRT2327775	hsa-miR-1184	CLIP-seq
MIRT1349728	hsa-miR-1228	CLIP-seq
MIRT2327776	hsa-miR-1236	CLIP-seq
MIRT1349729	hsa-miR-1264	CLIP-seq
MIRT1349731	hsa-miR-1298	CLIP-seq
MIRT2327777	hsa-miR-1301	CLIP-seq
MIRT1349736	hsa-miR-181a	CLIP-seq
MIRT1349737	hsa-miR-181b	CLIP-seq
MIRT1349738	hsa-miR-181c	CLIP-seq
MIRT1349739	hsa-miR-181d	CLIP-seq
MIRT1349744	hsa-miR-217	CLIP-seq
MIRT2103643	hsa-miR-219-1-3p	CLIP-seq
MIRT2103653	hsa-miR-3182	CLIP-seq
MIRT2103658	hsa-miR-3647-5p	CLIP-seq
MIRT1349766	hsa-miR-4262	CLIP-seq
MIRT2327778	hsa-miR-4303	CLIP-seq
MIRT1349770	hsa-miR-4433	CLIP-seq
MIRT1349772	hsa-miR-4521	CLIP-seq
MIRT1349775	hsa-miR-4653-3p	CLIP-seq
MIRT2327779	hsa-miR-4660	CLIP-seq
MIRT1349780	hsa-miR-4733-3p	CLIP-seq
MIRT2327780	hsa-miR-5047	CLIP-seq
MIRT1349792	hsa-miR-548ag	CLIP-seq
MIRT1349793	hsa-miR-548ai	CLIP-seq
MIRT2327781	hsa-miR-596	CLIP-seq
MIRT2327782	hsa-miR-622	CLIP-seq
MIRT1349816	hsa-miR-664	CLIP-seq
MIRT1349817	hsa-miR-665	CLIP-seq
MIRT2459388	hsa-miR-1257	CLIP-seq
MIRT1349745	hsa-miR-221	CLIP-seq
MIRT1349746	hsa-miR-222	CLIP-seq
MIRT2459389	hsa-miR-3907	CLIP-seq
MIRT1349777	hsa-miR-4672	CLIP-seq
MIRT2459390	hsa-miR-4790-3p	CLIP-seq
MIRT1349805	hsa-miR-548v	CLIP-seq
MIRT2459388	hsa-miR-1257	CLIP-seq
MIRT2103639	hsa-miR-130a	CLIP-seq
MIRT2103640	hsa-miR-130b	CLIP-seq
MIRT2103642	hsa-miR-1972	CLIP-seq
MIRT1349745	hsa-miR-221	CLIP-seq
MIRT1349746	hsa-miR-222	CLIP-seq
MIRT2103645	hsa-miR-301a	CLIP-seq
MIRT2103646	hsa-miR-301b	CLIP-seq
MIRT2103659	hsa-miR-3666	CLIP-seq
MIRT2459389	hsa-miR-3907	CLIP-seq
MIRT2103662	hsa-miR-3926	CLIP-seq
MIRT2103664	hsa-miR-4295	CLIP-seq
MIRT2103667	hsa-miR-454	CLIP-seq
MIRT2103671	hsa-miR-4671-3p	CLIP-seq
MIRT1349777	hsa-miR-4672	CLIP-seq
MIRT2459390	hsa-miR-4790-3p	CLIP-seq
MIRT1349805	hsa-miR-548v	CLIP-seq
MIRT2459388	hsa-miR-1257	CLIP-seq
MIRT2103639	hsa-miR-130a	CLIP-seq
MIRT2103640	hsa-miR-130b	CLIP-seq
MIRT2103642	hsa-miR-1972	CLIP-seq
MIRT1349745	hsa-miR-221	CLIP-seq
MIRT1349746	hsa-miR-222	CLIP-seq
MIRT2103645	hsa-miR-301a	CLIP-seq
MIRT2103646	hsa-miR-301b	CLIP-seq
MIRT2103659	hsa-miR-3666	CLIP-seq
MIRT2459389	hsa-miR-3907	CLIP-seq
MIRT2103662	hsa-miR-3926	CLIP-seq
MIRT2103664	hsa-miR-4295	CLIP-seq
MIRT2103667	hsa-miR-454	CLIP-seq
MIRT2103671	hsa-miR-4671-3p	CLIP-seq
MIRT1349777	hsa-miR-4672	CLIP-seq
MIRT2459390	hsa-miR-4790-3p	CLIP-seq
MIRT1349805	hsa-miR-548v	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 27107012, 32296183
GO:0005575	Component	Cellular_component	ND
GO:0005737	Component	Cytoplasm	IBA
GO:0008150	Process	Biological_process	ND
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IEA
GO:0098928	Process	Presynaptic signal transduction	IEA
GO:0098978	Component	Glutamatergic synapse	IEA

Other IDs

• MIM: 611609
• HGNC: 23800
• e!Ensembl: ENSG00000116991

Protein

• UniProt ID: Q9P2F8
• Protein name: Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02145	Rap_GAP	624 → 806	Rap/ran-GAP	Family
  PF00595	PDZ	950 → 1022	PDZ domain	Domain
  PF11881	SPAR_C	1420 → 1666	C-terminal domain of SPAR protein	Family

• Sequence:

  MSDPRQSQEEKHKLGRASSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLNASNSNETG
  GGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKALWESRSQTSYESITSVLQNGQSD
  QSEGQQDEQLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAV
  NPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVENYDHKAMVPFGFPEFFRCDPAI
  SPSLHAAAQISRGEFVRISGLDYVDSALLMGRDRDKPFKRRLKSESVETSLFRKLRTVKS
  EHETFKFTSELEESRLERGIRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTG
  ASAASQTQMPTGQTGNCESPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEG
  DRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHI
  DLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSEL
  TTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDE
  QGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNK
  TDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFT
  PKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFL
  LAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEK
  VKPRKDAHLFSIGAIMWHVIARDFGQSADIECLLGISNEFIMLIEKDSKNVVFNCSCRDV
  IGWTSGLVSIKVFYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQ
  LGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVV
  IIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRA
  SPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRP
  QVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQ
  KDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKG
  ASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYA
  STISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVP
  GSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDA
  VAETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSS
  FGSSRSSVLDQALPNDILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKSKCA
  DPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTDMQH
  GQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQDKA
  VLQAEVQHLRQDNMRLQEESQTATAQLRKFTEWFFTTIDKKS

• Sequence length: 1722

Pathways

KEGG:

Rap1 signaling pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BENIGN CHONDROGENIC NEOPLASM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BONE BENIGN NEOPLASM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BONE NEOPLASM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOVASCULAR DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
High myopia	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POST-TRAUMATIC STRESS DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE ACUTE RESPIRATORY SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE MYOPIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SMOOTH SURFACE DENTAL CARIES	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Abortion Spontaneous	Associate	39684334	★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Associate	38563508	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Aortic Valve Stenosis	Associate	37175670	★☆☆☆☆ Found in Text Mining only
Gallbladder Neoplasms	Associate	39579640	★☆☆☆☆ Found in Text Mining only