Gene Gene information from NCBI Gene database.
Entrez ID 57561
Gene name Arrestin domain containing 3
Gene symbol ARRDC3
Synonyms (NCBI Gene)
TLIMP
Chromosome 5
Chromosome location 5q14.3
Summary This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4,
miRNA miRNA information provided by mirtarbase database.
584
miRTarBase ID miRNA Experiments Reference
MIRT017348 hsa-miR-335-5p Microarray 18185580
MIRT020215 hsa-miR-130b-3p Sequencing 20371350
MIRT026009 hsa-miR-148a-3p Sequencing 20371350
MIRT031205 hsa-miR-19b-3p Sequencing 20371350
MIRT052564 hsa-let-7a-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
GO ID Ontology Definition Evidence Reference
GO:0001659 Process Temperature homeostasis IEA
GO:0005515 Function Protein binding IPI 20603614, 23208550, 23236378, 23886940, 25416956, 28514442, 32296183, 33961781, 38270169
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
GO:0005764 Component Lysosome IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612464 29263 ENSG00000113369
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96B67
Protein name Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP)
Protein function Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitinatio
PDB 4N7H , 4R7V , 4R7X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00339 Arrestin_N 9 165 Arrestin (or S-antigen), N-terminal domain Domain
PF02752 Arrestin_C 187 314 Arrestin (or S-antigen), C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in skeletal muscle, placenta, kidney, lung, liver, blood, adrenal gland, lymph node, mammary gland, thyroid, and trachea (PubMed:16269462, PubMed:21982743). Very low levels in colon, thymus, spleen, small intestine, bl
Sequence
Sequence length 414
Interactions View interactions