ARRDC3 (arrestin domain containing 3)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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57561 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Arrestin domain containing 3 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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ARRDC3 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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TLIMP |
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Chromosome
Chromosome number
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5 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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5q14.3 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4, |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||
| UniProt ID | Q96B67 | |||||||||||||||
| Protein name | Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP) | |||||||||||||||
| Protein function | Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitinatio | |||||||||||||||
| PDB | 4N7H , 4R7V , 4R7X | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Highly expressed in skeletal muscle, placenta, kidney, lung, liver, blood, adrenal gland, lymph node, mammary gland, thyroid, and trachea (PubMed:16269462, PubMed:21982743). Very low levels in colon, thymus, spleen, small intestine, bl | |||||||||||||||
| Sequence |
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| Sequence length | 414 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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