Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
57561
Gene name Gene Name - the full gene name approved by the HGNC.
Arrestin domain containing 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ARRDC3
Synonyms (NCBI Gene) Gene synonyms aliases
TLIMP
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q14.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4,
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017348 hsa-miR-335-5p Microarray 18185580
MIRT020215 hsa-miR-130b-3p Sequencing 20371350
MIRT026009 hsa-miR-148a-3p Sequencing 20371350
MIRT031205 hsa-miR-19b-3p Sequencing 20371350
MIRT052564 hsa-let-7a-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001659 Process Temperature homeostasis IEA
GO:0005515 Function Protein binding IPI 20603614, 23208550, 23236378, 23886940, 25416956, 28514442, 32296183
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005764 Component Lysosome IEA
GO:0005768 Component Endosome IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612464 29263 ENSG00000113369
Protein
UniProt ID Q96B67
Protein name Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP)
Protein function Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitinatio
PDB 4N7H , 4R7V , 4R7X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00339 Arrestin_N 9 165 Arrestin (or S-antigen), N-terminal domain Domain
PF02752 Arrestin_C 187 314 Arrestin (or S-antigen), C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in skeletal muscle, placenta, kidney, lung, liver, blood, adrenal gland, lymph node, mammary gland, thyroid, and trachea (PubMed:16269462, PubMed:21982743). Very low levels in colon, thymus, spleen, small intestine, bl
Sequence
Sequence length 414
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
25038754
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
25038754
Marfan syndrome Mammary Carcinoma, Human rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465
View all (942 more)
25038754
Unknown
Disease term Disease name Evidence References Source
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Schizophrenia Schizophrenia GWAS
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 23319801, 25038754
Breast Neoplasms Inhibit 24457910, 29348172
Carcinoma Non Small Cell Lung Associate 37062135
Fatty Liver Alcoholic Associate 31341404
Neoplasm Metastasis Inhibit 31295851
Neoplasms Inhibit 24457910, 29348172
Neoplasms Adipose Tissue Associate 31341404
Non alcoholic Fatty Liver Disease Associate 31341404
Obesity Associate 31187853, 31341404
Oropharyngeal Neoplasms Associate 37486532