Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	57559
Gene name	STAM binding protein like 1
Gene symbol	STAMBPL1
Synonyms (NCBI Gene)	ALMalphaAMSH-FPAMSH-LPbA399O19.2
Chromosome	10
Chromosome location	10q23.31

Show/Hide all (74)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024279	hsa-miR-215-5p	Microarray	19074876
MIRT026552	hsa-miR-192-5p	Microarray	19074876
MIRT027048	hsa-miR-103a-3p	Sequencing	20371350
MIRT036575	hsa-miR-941	CLASH	23622248
MIRT528487	hsa-miR-5197-5p	PAR-CLIP	22012620
MIRT528485	hsa-miR-548p	PAR-CLIP	22012620
MIRT528484	hsa-miR-1237-3p	PAR-CLIP	22012620
MIRT528483	hsa-miR-1248	PAR-CLIP	22012620
MIRT528482	hsa-miR-412-3p	PAR-CLIP	22012620
MIRT528481	hsa-miR-6754-3p	PAR-CLIP	22012620
MIRT528479	hsa-miR-6837-3p	PAR-CLIP	22012620
MIRT528480	hsa-miR-4778-3p	PAR-CLIP	22012620
MIRT528478	hsa-miR-130a-5p	PAR-CLIP	22012620
MIRT528477	hsa-miR-23a-3p	PAR-CLIP	22012620
MIRT528476	hsa-miR-23b-3p	PAR-CLIP	22012620
MIRT528475	hsa-miR-23c	PAR-CLIP	22012620
MIRT528474	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT512872	hsa-miR-508-5p	PAR-CLIP	23446348
MIRT512871	hsa-miR-6849-3p	PAR-CLIP	23446348
MIRT512870	hsa-miR-885-5p	PAR-CLIP	23446348
MIRT512869	hsa-miR-766-3p	PAR-CLIP	23446348
MIRT512868	hsa-miR-4633-5p	PAR-CLIP	23446348
MIRT512867	hsa-miR-6512-3p	PAR-CLIP	23446348
MIRT512866	hsa-miR-6720-5p	PAR-CLIP	23446348
MIRT528487	hsa-miR-5197-5p	PAR-CLIP	22012620
MIRT528485	hsa-miR-548p	PAR-CLIP	22012620
MIRT528484	hsa-miR-1237-3p	PAR-CLIP	22012620
MIRT528483	hsa-miR-1248	PAR-CLIP	22012620
MIRT528482	hsa-miR-412-3p	PAR-CLIP	22012620
MIRT528481	hsa-miR-6754-3p	PAR-CLIP	22012620
MIRT528479	hsa-miR-6837-3p	PAR-CLIP	22012620
MIRT528480	hsa-miR-4778-3p	PAR-CLIP	22012620
MIRT528478	hsa-miR-130a-5p	PAR-CLIP	22012620
MIRT528477	hsa-miR-23a-3p	PAR-CLIP	22012620
MIRT528476	hsa-miR-23b-3p	PAR-CLIP	22012620
MIRT528475	hsa-miR-23c	PAR-CLIP	22012620
MIRT528474	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT512872	hsa-miR-508-5p	PAR-CLIP	23446348
MIRT512871	hsa-miR-6849-3p	PAR-CLIP	23446348
MIRT512870	hsa-miR-885-5p	PAR-CLIP	23446348
MIRT512869	hsa-miR-766-3p	PAR-CLIP	23446348
MIRT512868	hsa-miR-4633-5p	PAR-CLIP	23446348
MIRT512867	hsa-miR-6512-3p	PAR-CLIP	23446348
MIRT512866	hsa-miR-6720-5p	PAR-CLIP	23446348
MIRT1395006	hsa-miR-103a	CLIP-seq
MIRT1395007	hsa-miR-107	CLIP-seq
MIRT1395008	hsa-miR-1225-5p	CLIP-seq
MIRT1395009	hsa-miR-1301	CLIP-seq
MIRT1395010	hsa-miR-3126-3p	CLIP-seq
MIRT1395011	hsa-miR-3176	CLIP-seq
MIRT1395012	hsa-miR-3187-3p	CLIP-seq
MIRT1395013	hsa-miR-323-3p	CLIP-seq
MIRT1395014	hsa-miR-3591-3p	CLIP-seq
MIRT1395015	hsa-miR-361-5p	CLIP-seq
MIRT1395016	hsa-miR-3922-3p	CLIP-seq
MIRT1395017	hsa-miR-4529-5p	CLIP-seq
MIRT1395018	hsa-miR-4795-3p	CLIP-seq
MIRT1395019	hsa-miR-5047	CLIP-seq
MIRT2634484	hsa-miR-19a	CLIP-seq
MIRT2634485	hsa-miR-19b	CLIP-seq
MIRT2634486	hsa-miR-3120-3p	CLIP-seq
MIRT2634487	hsa-miR-3662	CLIP-seq
MIRT2634488	hsa-miR-3942-5p	CLIP-seq
MIRT2634489	hsa-miR-4703-5p	CLIP-seq
MIRT2634490	hsa-miR-568	CLIP-seq
MIRT2634491	hsa-miR-642b	CLIP-seq
MIRT2634484	hsa-miR-19a	CLIP-seq
MIRT2634485	hsa-miR-19b	CLIP-seq
MIRT2634486	hsa-miR-3120-3p	CLIP-seq
MIRT2634487	hsa-miR-3662	CLIP-seq
MIRT2634488	hsa-miR-3942-5p	CLIP-seq
MIRT2634489	hsa-miR-4703-5p	CLIP-seq
MIRT2634490	hsa-miR-568	CLIP-seq
MIRT2634491	hsa-miR-642b	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21163940, 21516116, 25416956, 32296183, 33961781
GO:0005768	Component	Endosome	IBA
GO:0005829	Component	Cytosol	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA
GO:0016579	Process	Protein deubiquitination	IEA
GO:0016579	Process	Protein deubiquitination	TAS
GO:0016787	Function	Hydrolase activity	IEA
GO:0031669	Process	Cellular response to nutrient levels	IDA	36528027
GO:0046872	Function	Metal ion binding	IEA
GO:0061578	Function	K63-linked deubiquitinase activity	IBA
GO:0061578	Function	K63-linked deubiquitinase activity	IDA	34425109, 35114100
GO:0061578	Function	K63-linked deubiquitinase activity	IEA
GO:0061578	Function	K63-linked deubiquitinase activity	TAS
GO:0070536	Process	Protein K63-linked deubiquitination	IEA
GO:0071233	Process	Cellular response to L-leucine	IDA	35114100
GO:0085020	Process	Protein K6-linked ubiquitination	IDA	36528027
GO:0140492	Function	Metal-dependent deubiquitinase activity	IEA
GO:1904262	Process	Negative regulation of TORC1 signaling	IDA	35114100
GO:1904263	Process	Positive regulation of TORC1 signaling	IBA
GO:1904263	Process	Positive regulation of TORC1 signaling	IDA	36528027
GO:1904263	Process	Positive regulation of TORC1 signaling	IDA	35114100
GO:1990253	Process	Cellular response to leucine starvation	IDA	35114100

MIM	HGNC	e!Ensembl
612352	24105	ENSG00000138134

Q96FJ0

Protein name

AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1)

Protein function

Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:18758443, PubMed:35114100). Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby i

PDB

2ZNR , 2ZNV , 7L97

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08969	USP8_dimer	22 → 132	USP8 dimerisation domain	Domain
PF01398	JAB	264 → 373	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:12810066}.

Sequence

MDQPFTVNSLKKLAAMPDHTDVSLSPEERVRALSKLGCNITISEDITPRRYFRSGVEMER
MASVYLEEGNLENAFVLYNKFITLFVEKLPNHRDYQQCAVPEKQDIMKKLKEIAFPRTDE
LKNDLLKKYNVEYQEYLQSKNKYKAEILKKLEHQRLIEAERKRIAQMRQQQLESEQFLFF
EDQLKKQELARGQMRSQQTSGLSEQIDGSALSCFSTHQNNSLLNVFADQPNKSDATNYAS
HSPPVNRALTPAATLSAVQNLVVEGLRCVVLPEDLCHKFLQLAESNTVRGIETCGILCGK
LTHNEFTITHVIVPKQSAGPDYCDMENVEELFNVQDQHDLLTLGWIHTHPTQTAFLSSVD
LHTHCSYQLMLPEAIAIVCSPKHKDTGIFRLTNAGMLEVSACKKKGFHPHTKEPRLFSIC
KHVLVKDIKIIVLDLR

Sequence length

436

Interactions

View interactions

	Reactome
			Metalloprotease DUBs

STAMBPL1 (STAM binding protein like 1)