LRRC7 (leucine rich repeat containing 7)

Gene

• Entrez ID: 57554
• Gene name: Leucine rich repeat containing 7
• Gene symbol: LRRC7
• Synonyms (NCBI Gene): DENSIN
• Chromosome: 1
• Chromosome location: 1p31.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1120461	hsa-miR-1264	CLIP-seq
MIRT1120462	hsa-miR-1276	CLIP-seq
MIRT1120463	hsa-miR-185	CLIP-seq
MIRT1120464	hsa-miR-2278	CLIP-seq
MIRT1120465	hsa-miR-3115	CLIP-seq
MIRT1120466	hsa-miR-3134	CLIP-seq
MIRT1120467	hsa-miR-3658	CLIP-seq
MIRT1120468	hsa-miR-4306	CLIP-seq
MIRT1120469	hsa-miR-4311	CLIP-seq
MIRT1120470	hsa-miR-4468	CLIP-seq
MIRT1120471	hsa-miR-4534	CLIP-seq
MIRT1120472	hsa-miR-4644	CLIP-seq
MIRT1120473	hsa-miR-4662a-3p	CLIP-seq
MIRT1120474	hsa-miR-4760-3p	CLIP-seq
MIRT1120475	hsa-miR-583	CLIP-seq
MIRT2034129	hsa-miR-218	CLIP-seq
MIRT1120465	hsa-miR-3115	CLIP-seq
MIRT2264475	hsa-miR-3129-3p	CLIP-seq
MIRT2264476	hsa-miR-374c	CLIP-seq
MIRT2264477	hsa-miR-655	CLIP-seq
MIRT1120465	hsa-miR-3115	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12390249, 28130356
GO:0005576	Component	Extracellular region	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005912	Component	Adherens junction	IBA
GO:0010976	Process	Positive regulation of neuron projection development	IBA
GO:0014069	Component	Postsynaptic density	IBA
GO:0014069	Component	Postsynaptic density	IEA
GO:0016323	Component	Basolateral plasma membrane	IBA
GO:0019901	Function	Protein kinase binding	IBA
GO:0035580	Component	Specific granule lumen	TAS
GO:0043113	Process	Receptor clustering	IBA
GO:0043194	Component	Axon initial segment	IBA
GO:0045197	Process	Establishment or maintenance of epithelial cell apical/basal polarity	IBA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IBA
GO:0098609	Process	Cell-cell adhesion	IBA
GO:0098887	Process	Neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA

Other IDs

• MIM: 614453
• HGNC: 18531
• e!Ensembl: ENSG00000033122

Protein

• UniProt ID: Q96NW7
• Protein name: Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1)
• Protein function: Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long ter
• PDB: 6X5G, 7QQM
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	138 → 196	Leucine rich repeat	Repeat
  PF00595	PDZ	1448 → 1532	PDZ domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Brain-specific. Isoform 3 is ubiquitously expressed. {ECO:0000269|PubMed:12525888}.
• Sequence:

  MTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEE
  LPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTII
  EASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSM
  HKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKN
  RIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSL
  LEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFL
  PEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQR
  VLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKDLS
  CQAPWERGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQNDPQLAWGCISGLQQERSM
  CTPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENSN
  PTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLG
  KDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNTRVKVGSLQTTAKDAVHNS
  LWGNRIAPSFPQPLDSKPLLSQREAVPPGNIPQRPDRLPMSDTFTDNWTDGSHYDNTGFV
  AEETTAENANSNPLLSSKSRSTSSHGRRPLIRQDRIVGVPLELEQSTHRHTPETEVPPSN
  PWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKEHIKESTEIPSPFSPGVPWEYHDSN
  PNRSLSNVFSQIHCRPESSKGVISISKSTERLSPLMKDIKSNKFKKSQSIDEIDIGTYKV
  YNIPLENYASGSDHLGSHERPDKMLGPEHGMSSMSRSQSVPMLDDEMLTYGSSKGPQQQK
  ASMTKKVYQFDQSFNPQGSVEVKAEKRIPPPFQHNPEYVQQASKNIAKDLISPRAYRGYP
  PMEQMFSFSQPSVNEDAVVNAQFASQGARAGFLRRADSLVSATEMAMFRRVNEPHELPPT
  DRYGRPPYRGGLDRQSSVTVTESQFLKRNGRYEDEHPSYQEVKAQAGSFPVKNLTQRRPL
  SARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKPSDNSDLKTRPTPVKGE
  ESCGKMPADWRQQLLRHIEARRLDRNAAYKHNTVNLGMLPYGGISAMHAGRSMTLNLQTK
  SKFDHQELPLQKTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTL
  MGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSM
  DGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKI
  LQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV

• Sequence length: 1537

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL DOMINANT 77	Uncertain significance	rs1135401780	RCV006252698
Intellectual disability	Uncertain significance	rs1135401780	RCV000496100
See cases	Uncertain significance	rs2523919523	RCV002467424

Associations from Text Mining
Disease Name	Relationship Type	References
Colorectal Neoplasms	Associate	33078631
Hypertension	Associate	22322875
Respiratory Distress Syndrome	Associate	26077880
Schizophrenia	Associate	33246498