Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
57552
Gene name Gene Name - the full gene name approved by the HGNC.
Neutral cholesterol ester hydrolase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NCEH1
Synonyms (NCBI Gene) Gene synonyms aliases
AADACL1, NCEH
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q26.31
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005151 hsa-miR-30a-5p pSILAC 18668040
MIRT020097 hsa-miR-361-5p Sequencing 20371350
MIRT024804 hsa-miR-215-5p Microarray 19074876
MIRT025849 hsa-miR-7-5p Microarray 19073608
MIRT026590 hsa-miR-192-5p Microarray 19074876
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004771 Function Sterol esterase activity TAS
GO:0005789 Component Endoplasmic reticulum membrane TAS
GO:0005886 Component Plasma membrane IEA
GO:0016020 Component Membrane HDA 19946888
GO:0016021 Component Integral component of membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
613234 29260 ENSG00000144959
Protein
UniProt ID Q6PIU2
Protein name Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Acetylalkylglycerol acetylhydrolase) (2-acetyl MAGE hydrolase) (EC 3.1.1.71) (Arylacetamide deacetylase-like 1)
Protein function Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (PubMed:17052608). May be responsible for the hydrolysis of cholesterol es
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07859 Abhydrolase_3 109 283 alpha/beta hydrolase fold Domain
PF07859 Abhydrolase_3 287 382 alpha/beta hydrolase fold Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in monocyte-derived macrophages. Up-regulated in invasive melanoma and breast carcinoma cell lines. {ECO:0000269|PubMed:12149457, ECO:0000269|PubMed:18782767}.
Sequence
Sequence length 408
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cortisol synthesis and secretion
Cushing syndrome
Bile secretion
Cholesterol metabolism
  LDL clearance
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Unknown
Disease term Disease name Evidence References Source
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 22414021
Atherosclerosis Associate 20353815, 20947831
Inflammation Associate 27015452
Plaque Atherosclerotic Associate 20947831
Stomach Neoplasms Associate 33219617, 38062450