ZNF398 (zinc finger protein 398)

Gene

• Entrez ID: 57541
• Gene name: Zinc finger protein 398
• Gene symbol: ZNF398
• Synonyms (NCBI Gene): P51, P71, ZER6
• Chromosome: 7
• Chromosome location: 7q36.1
• Summary: This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. The encoded protein acts as a transcriptional activator. Two transcript variants encoding distinct isoforms have been identified for this gene. Other

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028302	hsa-miR-32-5p	Sequencing	20371350
MIRT050546	hsa-miR-20a-5p	CLASH	23622248
MIRT048224	hsa-miR-196a-5p	CLASH	23622248
MIRT713003	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT713001	hsa-miR-5695	HITS-CLIP	19536157
MIRT713002	hsa-miR-4720-3p	HITS-CLIP	19536157
MIRT713000	hsa-miR-6792-5p	HITS-CLIP	19536157
MIRT712999	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT712998	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT712997	hsa-miR-4503	HITS-CLIP	19536157
MIRT651128	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT651143	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT651142	hsa-miR-4469	HITS-CLIP	23824327
MIRT651141	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT651140	hsa-miR-4287	HITS-CLIP	23824327
MIRT651138	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT651139	hsa-miR-6822-3p	HITS-CLIP	23824327
MIRT651137	hsa-miR-760	HITS-CLIP	23824327
MIRT651136	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT651135	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT651134	hsa-miR-4420	HITS-CLIP	23824327
MIRT651133	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT651132	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT651131	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT409070	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT651130	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT651129	hsa-miR-8057	HITS-CLIP	23824327
MIRT651128	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT651127	hsa-miR-5096	HITS-CLIP	23824327
MIRT651126	hsa-miR-6743-3p	HITS-CLIP	23824327
MIRT486915	hsa-miR-497-3p	PAR-CLIP	20371350
MIRT486914	hsa-miR-4257	PAR-CLIP	20371350
MIRT486915	hsa-miR-497-3p	PAR-CLIP	20371350
MIRT486914	hsa-miR-4257	PAR-CLIP	20371350
MIRT486915	hsa-miR-497-3p	PAR-CLIP	22012620
MIRT486914	hsa-miR-4257	PAR-CLIP	22012620
MIRT532903	hsa-miR-4504	PAR-CLIP	22012620
MIRT532902	hsa-miR-4474-3p	PAR-CLIP	22012620
MIRT486915	hsa-miR-497-3p	PAR-CLIP	23592263
MIRT486914	hsa-miR-4257	PAR-CLIP	23592263
MIRT486914	hsa-miR-4257	PAR-CLIP	26701625
MIRT486914	hsa-miR-4257	PAR-CLIP	26701625
MIRT486914	hsa-miR-4257	PAR-CLIP	26701625
MIRT532903	hsa-miR-4504	PAR-CLIP	26701625
MIRT532903	hsa-miR-4504	PAR-CLIP	26701625
MIRT532903	hsa-miR-4504	PAR-CLIP	26701625
MIRT486915	hsa-miR-497-3p	PAR-CLIP	26701625
MIRT486915	hsa-miR-497-3p	PAR-CLIP	26701625
MIRT486915	hsa-miR-497-3p	PAR-CLIP	26701625
MIRT713003	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT713001	hsa-miR-5695	HITS-CLIP	19536157
MIRT713002	hsa-miR-4720-3p	HITS-CLIP	19536157
MIRT713000	hsa-miR-6792-5p	HITS-CLIP	19536157
MIRT712999	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT712998	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT712997	hsa-miR-4503	HITS-CLIP	19536157
MIRT651128	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT651143	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT651142	hsa-miR-4469	HITS-CLIP	23824327
MIRT651141	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT651140	hsa-miR-4287	HITS-CLIP	23824327
MIRT651138	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT651139	hsa-miR-6822-3p	HITS-CLIP	23824327
MIRT651137	hsa-miR-760	HITS-CLIP	23824327
MIRT651136	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT651135	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT651134	hsa-miR-4420	HITS-CLIP	23824327
MIRT651133	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT651132	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT651131	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT409070	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT651130	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT651129	hsa-miR-8057	HITS-CLIP	23824327
MIRT651128	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT651127	hsa-miR-5096	HITS-CLIP	23824327
MIRT651126	hsa-miR-6743-3p	HITS-CLIP	23824327
MIRT486915	hsa-miR-497-3p	PAR-CLIP	20371350
MIRT486914	hsa-miR-4257	PAR-CLIP	20371350
MIRT486915	hsa-miR-497-3p	PAR-CLIP	20371350
MIRT486914	hsa-miR-4257	PAR-CLIP	20371350
MIRT486915	hsa-miR-497-3p	PAR-CLIP	22012620
MIRT486914	hsa-miR-4257	PAR-CLIP	22012620
MIRT532903	hsa-miR-4504	PAR-CLIP	22012620
MIRT532902	hsa-miR-4474-3p	PAR-CLIP	22012620
MIRT486915	hsa-miR-497-3p	PAR-CLIP	23592263
MIRT486914	hsa-miR-4257	PAR-CLIP	23592263
MIRT1523893	hsa-miR-1225-3p	CLIP-seq
MIRT1523894	hsa-miR-1228	CLIP-seq
MIRT1523895	hsa-miR-335	CLIP-seq
MIRT1523896	hsa-miR-4323	CLIP-seq
MIRT1523897	hsa-miR-4530	CLIP-seq
MIRT1523898	hsa-miR-4758-3p	CLIP-seq
MIRT1523899	hsa-miR-922	CLIP-seq
MIRT1523900	hsa-miR-1207-5p	CLIP-seq
MIRT1523901	hsa-miR-1271	CLIP-seq
MIRT1523902	hsa-miR-182	CLIP-seq
MIRT1523903	hsa-miR-2053	CLIP-seq
MIRT1523904	hsa-miR-3120-5p	CLIP-seq
MIRT1523905	hsa-miR-3127-5p	CLIP-seq
MIRT1523906	hsa-miR-3153	CLIP-seq
MIRT1523907	hsa-miR-3180-5p	CLIP-seq
MIRT1523908	hsa-miR-320e	CLIP-seq
MIRT1523909	hsa-miR-3650	CLIP-seq
MIRT1523910	hsa-miR-378g	CLIP-seq
MIRT1523911	hsa-miR-3907	CLIP-seq
MIRT1523912	hsa-miR-4270	CLIP-seq
MIRT1523913	hsa-miR-4289	CLIP-seq
MIRT1523914	hsa-miR-4314	CLIP-seq
MIRT1523915	hsa-miR-4437	CLIP-seq
MIRT1523916	hsa-miR-4441	CLIP-seq
MIRT1523917	hsa-miR-4448	CLIP-seq
MIRT1523918	hsa-miR-4475	CLIP-seq
MIRT1523919	hsa-miR-4521	CLIP-seq
MIRT1523920	hsa-miR-4536	CLIP-seq
MIRT1523921	hsa-miR-4674	CLIP-seq
MIRT1523922	hsa-miR-4684-5p	CLIP-seq
MIRT1523923	hsa-miR-4691-3p	CLIP-seq
MIRT1523924	hsa-miR-4698	CLIP-seq
MIRT1523925	hsa-miR-4731-5p	CLIP-seq
MIRT1523926	hsa-miR-4736	CLIP-seq
MIRT1523927	hsa-miR-4763-3p	CLIP-seq
MIRT1523928	hsa-miR-4790-3p	CLIP-seq
MIRT1523929	hsa-miR-578	CLIP-seq
MIRT1523930	hsa-miR-593	CLIP-seq
MIRT1523931	hsa-miR-607	CLIP-seq
MIRT1523932	hsa-miR-616	CLIP-seq
MIRT1523933	hsa-miR-619	CLIP-seq
MIRT1523934	hsa-miR-629	CLIP-seq
MIRT1523935	hsa-miR-630	CLIP-seq
MIRT1523936	hsa-miR-643	CLIP-seq
MIRT1523937	hsa-miR-96	CLIP-seq
MIRT2158366	hsa-miR-1208	CLIP-seq
MIRT2158367	hsa-miR-141	CLIP-seq
MIRT2158368	hsa-miR-200a	CLIP-seq
MIRT2158369	hsa-miR-24	CLIP-seq
MIRT2158370	hsa-miR-2682	CLIP-seq
MIRT2158371	hsa-miR-3065-5p	CLIP-seq
MIRT2158372	hsa-miR-3921	CLIP-seq
MIRT2158373	hsa-miR-4284	CLIP-seq
MIRT2158374	hsa-miR-4468	CLIP-seq
MIRT2158375	hsa-miR-449c	CLIP-seq
MIRT2158376	hsa-miR-4502	CLIP-seq
MIRT2158377	hsa-miR-4528	CLIP-seq
MIRT2158378	hsa-miR-4639-3p	CLIP-seq
MIRT2158379	hsa-miR-4653-5p	CLIP-seq
MIRT2158380	hsa-miR-4686	CLIP-seq
MIRT2158381	hsa-miR-4786-3p	CLIP-seq
MIRT2377836	hsa-miR-127-5p	CLIP-seq
MIRT2377837	hsa-miR-2114	CLIP-seq
MIRT2377838	hsa-miR-31	CLIP-seq
MIRT2377839	hsa-miR-3133	CLIP-seq
MIRT2377840	hsa-miR-370	CLIP-seq
MIRT2377841	hsa-miR-3973	CLIP-seq
MIRT2377842	hsa-miR-3978	CLIP-seq
MIRT2377843	hsa-miR-4426	CLIP-seq
MIRT1523915	hsa-miR-4437	CLIP-seq
MIRT2377844	hsa-miR-4647	CLIP-seq
MIRT2377845	hsa-miR-4662b	CLIP-seq
MIRT2377846	hsa-miR-4742-5p	CLIP-seq
MIRT2377847	hsa-miR-4762-3p	CLIP-seq
MIRT2158381	hsa-miR-4786-3p	CLIP-seq
MIRT2377848	hsa-miR-520g	CLIP-seq
MIRT2377849	hsa-miR-520h	CLIP-seq
MIRT2397548	hsa-miR-3192	CLIP-seq
MIRT2397549	hsa-miR-326	CLIP-seq
MIRT2397550	hsa-miR-330-5p	CLIP-seq
MIRT2377840	hsa-miR-370	CLIP-seq
MIRT1523914	hsa-miR-4314	CLIP-seq
MIRT2397551	hsa-miR-4646-5p	CLIP-seq
MIRT2670199	hsa-miR-1231	CLIP-seq
MIRT2670200	hsa-miR-1245b-3p	CLIP-seq
MIRT2670201	hsa-miR-1827	CLIP-seq
MIRT2670202	hsa-miR-2052	CLIP-seq
MIRT2670203	hsa-miR-3124-3p	CLIP-seq
MIRT2670204	hsa-miR-3127-3p	CLIP-seq
MIRT2670205	hsa-miR-3170	CLIP-seq
MIRT2670206	hsa-miR-337-3p	CLIP-seq
MIRT2670207	hsa-miR-3612	CLIP-seq
MIRT2670208	hsa-miR-3616-5p	CLIP-seq
MIRT2670209	hsa-miR-3647-5p	CLIP-seq
MIRT2670210	hsa-miR-3655	CLIP-seq
MIRT2670211	hsa-miR-3663-5p	CLIP-seq
MIRT2670212	hsa-miR-3679-3p	CLIP-seq
MIRT2670213	hsa-miR-3685	CLIP-seq
MIRT2670214	hsa-miR-384	CLIP-seq
MIRT2670215	hsa-miR-4277	CLIP-seq
MIRT2670216	hsa-miR-4288	CLIP-seq
MIRT1523914	hsa-miR-4314	CLIP-seq
MIRT2670217	hsa-miR-4667-5p	CLIP-seq
MIRT2670218	hsa-miR-4695-5p	CLIP-seq
MIRT2670219	hsa-miR-4700-5p	CLIP-seq
MIRT2670220	hsa-miR-4709-3p	CLIP-seq
MIRT2670221	hsa-miR-4795-5p	CLIP-seq
MIRT2670222	hsa-miR-573	CLIP-seq
MIRT2670223	hsa-miR-632	CLIP-seq
MIRT2670224	hsa-miR-637	CLIP-seq
MIRT2670225	hsa-miR-650	CLIP-seq
MIRT2670201	hsa-miR-1827	CLIP-seq
MIRT2670202	hsa-miR-2052	CLIP-seq
MIRT2670207	hsa-miR-3612	CLIP-seq
MIRT2670218	hsa-miR-4695-5p	CLIP-seq
MIRT2670225	hsa-miR-650	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	21516116, 25416956, 28514442, 31403225, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	11779858
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	11779858
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	NAS	11779858
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 618593
• HGNC: 18373
• e!Ensembl: ENSG00000197024

Protein

• UniProt ID: Q8TD17
• Protein name: Zinc finger protein 398 (Zinc finger DNA-binding protein p52/p71)
• Protein function: Functions as a transcriptional activator.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12417	DUF3669	43 → 113	Zinc finger protein	Family
  PF01352	KRAB	142 → 183	KRAB box	Family
  PF00096	zf-C2H2	399 → 420	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	427 → 449	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	455 → 477	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	483 → 505	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	511 → 533	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	539 → 561	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	567 → 590	Zinc finger, C2H2 type	Domain

• Sequence:

  MAEAAPAPTSEWDSECLTSLQPLPLPTPPAANEAHLQTAAISLWTVVAAVQAIERKVEIH
  SRRLLHLEGRTGTAEKKLASCEKTVTELGNQLEGKWAVLGTLLQEYGLLQRRLENLENLL
  RNRNFWILRLPPGIKGDIPKVPVAFDDVSIYFSTPEWEKLEEWQKELYKNIMKGNYESLI
  SMDYAINQPDVLSQIQPEGEHNTEDQAGPEESEIPTDPSEEPGISTSDILSWIKQEEEPQ
  VGAPPESKESDVYKSTYADEELVIKAEGLARSSLCPEVPVPFSSPPAAAKDAFSDVAFKS
  QQSTSMTPFGRPATDLPEASEGQVTFTQLGSYPLPPPVGEQVFSCHHCGKNLSQDMLLTH
  QCSHATEHPLPCAQCPKHFTPQADLSSTSQDHASETPPTCPHCARTFTHPSRLTYHLRVH
  NSTERPFPCPDCPKRFADQARLTSHRRAHASERPFRCAQCGRSFSLKISLLLHQRGHAQE
  RPFSCPQCGIDFNGHSALIRHQMIHTGERPYPCTDCSKSFMRKEHLLNHRRLHTGERPFS
  CPHCGKSFIRKHHLMKHQRIHTGERPYPCSYCGRSFRYKQTLKDHLRSGHNGGCGGDSDP
  SGQPPNPPGPLITGLETSGLGVNTEGLETNQWYGEGSGGGVL

• Sequence length: 642

Pathways

Reactome:

Generic Transcription Pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
RETINAL DEGENERATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Colorectal Neoplasms	Associate	31521611	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	31521611	★☆☆☆☆ Found in Text Mining only