SORCS2 (sortilin related VPS10 domain containing receptor 2)
| Gene | |
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
57537 |
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Sortilin related VPS10 domain containing receptor 2 |
|
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
SORCS2 |
|
Synonyms (NCBI Gene)
Gene synonyms aliases
|
- |
|
Chromosome
Chromosome number
|
4 |
|
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
4p16.1 |
|
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many e |
|
miRNA
miRNA information provided by mirtarbase database.
|
|||||||||||||||||||||||||
|
|||||||||||||||||||||||||
|
Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
|
|||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||
|
Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|||||||
|
|||||||
| Protein | |||||||||||||||||||||
| UniProt ID | Q96PQ0 | ||||||||||||||||||||
| Protein name | VPS10 domain-containing receptor SorCS2 [Cleaved into: SorCS2 122 kDa chain; SorCS2 104 kDa chain; SorCS2 18 kDa chain] | ||||||||||||||||||||
| Protein function | The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:2 | ||||||||||||||||||||
| PDB | 1WGO | ||||||||||||||||||||
| Family and domains |
Pfam
|
||||||||||||||||||||
| Tissue specificity | TISSUE SPECIFICITY: Detected on neurons in the caudate region (PubMed:28469074). Detected on neurons in the hippocampus (at protein level) (PubMed:30840898). Highly expressed in brain and kidney. Detected at low levels in heart, liver, small intestine, sk | ||||||||||||||||||||
| Sequence | |||||||||||||||||||||
| Sequence length | 1159 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
|
Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||