KCTD16 (potassium channel tetramerization domain containing 16)

Gene

• Entrez ID: 57528
• Gene name: Potassium channel tetramerization domain containing 16
• Gene symbol: KCTD16
• Synonyms (NCBI Gene): -
• Chromosome: 5
• Chromosome location: 5q31.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT712799	hsa-miR-603	HITS-CLIP	19536157
MIRT712798	hsa-miR-4643	HITS-CLIP	19536157
MIRT712797	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT712797	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT712796	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT712795	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT708668	hsa-miR-205-5p	HITS-CLIP	19536157
MIRT708667	hsa-miR-3121-5p	HITS-CLIP	19536157
MIRT708666	hsa-miR-6837-3p	HITS-CLIP	19536157
MIRT708665	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT712799	hsa-miR-603	HITS-CLIP	19536157
MIRT712798	hsa-miR-4643	HITS-CLIP	19536157
MIRT712797	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT712797	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT712796	hsa-miR-342-3p	HITS-CLIP	19536157
MIRT712795	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT708668	hsa-miR-205-5p	HITS-CLIP	19536157
MIRT708667	hsa-miR-3121-5p	HITS-CLIP	19536157
MIRT708666	hsa-miR-6837-3p	HITS-CLIP	19536157
MIRT708665	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT1082947	hsa-let-7a	CLIP-seq
MIRT1082948	hsa-let-7b	CLIP-seq
MIRT1082949	hsa-let-7c	CLIP-seq
MIRT1082950	hsa-let-7d	CLIP-seq
MIRT1082951	hsa-let-7e	CLIP-seq
MIRT1082952	hsa-let-7f	CLIP-seq
MIRT1082953	hsa-let-7g	CLIP-seq
MIRT1082954	hsa-let-7i	CLIP-seq
MIRT1082955	hsa-miR-1255a	CLIP-seq
MIRT1082956	hsa-miR-1255b	CLIP-seq
MIRT1082957	hsa-miR-1276	CLIP-seq
MIRT1082958	hsa-miR-1278	CLIP-seq
MIRT1082959	hsa-miR-1297	CLIP-seq
MIRT1082960	hsa-miR-1321	CLIP-seq
MIRT1082961	hsa-miR-193a-3p	CLIP-seq
MIRT1082962	hsa-miR-193b	CLIP-seq
MIRT1082963	hsa-miR-26a	CLIP-seq
MIRT1082964	hsa-miR-26b	CLIP-seq
MIRT1082965	hsa-miR-3153	CLIP-seq
MIRT1082966	hsa-miR-3154	CLIP-seq
MIRT1082967	hsa-miR-3161	CLIP-seq
MIRT1082968	hsa-miR-3166	CLIP-seq
MIRT1082969	hsa-miR-3168	CLIP-seq
MIRT1082970	hsa-miR-3173-3p	CLIP-seq
MIRT1082971	hsa-miR-3185	CLIP-seq
MIRT1082972	hsa-miR-330-3p	CLIP-seq
MIRT1082973	hsa-miR-3611	CLIP-seq
MIRT1082974	hsa-miR-3614-5p	CLIP-seq
MIRT1082975	hsa-miR-3662	CLIP-seq
MIRT1082976	hsa-miR-3927	CLIP-seq
MIRT1082977	hsa-miR-4272	CLIP-seq
MIRT1082978	hsa-miR-4318	CLIP-seq
MIRT1082979	hsa-miR-4419a	CLIP-seq
MIRT1082980	hsa-miR-4435	CLIP-seq
MIRT1082981	hsa-miR-4458	CLIP-seq
MIRT1082982	hsa-miR-4465	CLIP-seq
MIRT1082983	hsa-miR-4500	CLIP-seq
MIRT1082984	hsa-miR-4505	CLIP-seq
MIRT1082985	hsa-miR-4510	CLIP-seq
MIRT1082986	hsa-miR-4535	CLIP-seq
MIRT1082987	hsa-miR-4646-5p	CLIP-seq
MIRT1082988	hsa-miR-4650-3p	CLIP-seq
MIRT1082989	hsa-miR-4658	CLIP-seq
MIRT1082990	hsa-miR-4668-5p	CLIP-seq
MIRT1082991	hsa-miR-4693-5p	CLIP-seq
MIRT1082992	hsa-miR-4694-3p	CLIP-seq
MIRT1082993	hsa-miR-4739	CLIP-seq
MIRT1082994	hsa-miR-4756-5p	CLIP-seq
MIRT1082995	hsa-miR-4758-5p	CLIP-seq
MIRT1082996	hsa-miR-4764-3p	CLIP-seq
MIRT1082997	hsa-miR-4765	CLIP-seq
MIRT1082998	hsa-miR-4771	CLIP-seq
MIRT1082999	hsa-miR-4779	CLIP-seq
MIRT1083000	hsa-miR-4786-3p	CLIP-seq
MIRT1083001	hsa-miR-4799-5p	CLIP-seq
MIRT1083002	hsa-miR-492	CLIP-seq
MIRT1083003	hsa-miR-579	CLIP-seq
MIRT1083004	hsa-miR-671-5p	CLIP-seq
MIRT1083005	hsa-miR-892a	CLIP-seq
MIRT1083006	hsa-miR-892b	CLIP-seq
MIRT1083007	hsa-miR-98	CLIP-seq
MIRT2020713	hsa-miR-1284	CLIP-seq
MIRT2020714	hsa-miR-150	CLIP-seq
MIRT2020715	hsa-miR-199a-3p	CLIP-seq
MIRT2020716	hsa-miR-199b-3p	CLIP-seq
MIRT2020717	hsa-miR-2682	CLIP-seq
MIRT2020718	hsa-miR-300	CLIP-seq
MIRT2020719	hsa-miR-3074-3p	CLIP-seq
MIRT2020720	hsa-miR-3129-5p	CLIP-seq
MIRT2020721	hsa-miR-3192	CLIP-seq
MIRT2020722	hsa-miR-381	CLIP-seq
MIRT2020723	hsa-miR-3922-5p	CLIP-seq
MIRT2020724	hsa-miR-3940-5p	CLIP-seq
MIRT2020725	hsa-miR-4300	CLIP-seq
MIRT2020726	hsa-miR-449c	CLIP-seq
MIRT2020727	hsa-miR-4507	CLIP-seq
MIRT2020728	hsa-miR-4528	CLIP-seq
MIRT2020729	hsa-miR-4666-3p	CLIP-seq
MIRT2020730	hsa-miR-4722-5p	CLIP-seq
MIRT2020731	hsa-miR-4731-5p	CLIP-seq
MIRT2020732	hsa-miR-4753-3p	CLIP-seq
MIRT2020733	hsa-miR-4796-5p	CLIP-seq
MIRT2020734	hsa-miR-549	CLIP-seq
MIRT2020735	hsa-miR-920	CLIP-seq
MIRT2020736	hsa-miR-940	CLIP-seq
MIRT2252421	hsa-miR-130a	CLIP-seq
MIRT2252422	hsa-miR-130b	CLIP-seq
MIRT2252423	hsa-miR-148a	CLIP-seq
MIRT2252424	hsa-miR-148b	CLIP-seq
MIRT2252425	hsa-miR-152	CLIP-seq
MIRT2252426	hsa-miR-301a	CLIP-seq
MIRT2252427	hsa-miR-301b	CLIP-seq
MIRT2252428	hsa-miR-3125	CLIP-seq
MIRT2252429	hsa-miR-3666	CLIP-seq
MIRT2252430	hsa-miR-3916	CLIP-seq
MIRT2252431	hsa-miR-3928	CLIP-seq
MIRT2252432	hsa-miR-4257	CLIP-seq
MIRT2252433	hsa-miR-4276	CLIP-seq
MIRT2252434	hsa-miR-4295	CLIP-seq
MIRT2252435	hsa-miR-4310	CLIP-seq
MIRT2252436	hsa-miR-454	CLIP-seq
MIRT2465518	hsa-miR-4434	CLIP-seq
MIRT2465519	hsa-miR-4516	CLIP-seq
MIRT2465520	hsa-miR-4531	CLIP-seq
MIRT2465521	hsa-miR-4802-3p	CLIP-seq
MIRT2465522	hsa-miR-570	CLIP-seq
MIRT2555677	hsa-miR-4662a-3p	CLIP-seq
MIRT2555678	hsa-miR-4766-5p	CLIP-seq
MIRT1083003	hsa-miR-579	CLIP-seq
MIRT2555677	hsa-miR-4662a-3p	CLIP-seq
MIRT2555678	hsa-miR-4766-5p	CLIP-seq
MIRT1083003	hsa-miR-579	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001662	Process	Behavioral fear response	IEA
GO:0005515	Function	Protein binding	IPI	26960425
GO:0005886	Component	Plasma membrane	IEA
GO:0007613	Process	Memory	IEA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IBA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0042734	Component	Presynaptic membrane	IBA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043235	Component	Receptor complex	IBA
GO:0043235	Component	Receptor complex	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IBA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0051260	Process	Protein homooligomerization	IEA
GO:0060078	Process	Regulation of postsynaptic membrane potential	IEA
GO:0099505	Process	Regulation of presynaptic membrane potential	IEA
GO:0099579	Function	G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	IEA
GO:0150047	Function	G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	IEA

Other IDs

• MIM: 613423
• HGNC: 29244
• e!Ensembl: ENSG00000183775

Protein

• UniProt ID: Q68DU8
• Protein name: BTB/POZ domain-containing protein KCTD16 (Potassium channel tetramerization domain-containing protein 16)
• Protein function: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitizatio
• PDB: 5A15, 6I0Q, 6M8R, 6OCP, 6OCR, 6OCT, 6QB7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02214	BTB_2	27 → 122	BTB/POZ domain	Domain

• Sequence:

  MALSGNCSRYYPREQGSAVPNSFPEVVELNVGGQVYFTRHSTLISIPHSLLWKMFSPKRD
  TANDLAKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPEKGRLKREAEYFQLPDLVK
  LLTPDEIKQSPDEFCHSDFEDASQGSDTRICPPSSLLPADRKWGFITVGYRGSCTLGREG
  QADAKFRRVPRILVCGRISLAKEVFGETLNESRDPDRAPERYTSRFYLKFKHLERAFDML
  SECGFHMVACNSSVTASFINQYTDDKIWSSYTEYVFYREPSRWSPSHCDCCCKNGKGDKE
  GESGTSCNDLSTSSCDSQSEASSPQETVICGPVTRQTNIQTLDRPIKKGPVQLIQQSEMR
  RKSDLLRTLTSGSRESNMSSKKKAVKEKLSIEEELEKCIQDFLKIKIPDRFPERKHPWQS
  ELLRKYHL

• Sequence length: 428

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations