Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57512
Gene name Gene Name - the full gene name approved by the HGNC.	G protein-coupled receptor 158
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GPR158
Synonyms (NCBI Gene) Gene synonyms aliases	mGlyR
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10p12.1

Show/Hide all(94)

miRTarBase ID	miRNA	Experiments	Reference
MIRT645324	hsa-miR-1266-3p	HITS-CLIP	23824327
MIRT645323	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT662812	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT662811	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT645322	hsa-miR-374a-3p	HITS-CLIP	23824327
MIRT645321	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT645324	hsa-miR-1266-3p	HITS-CLIP	23824327
MIRT645323	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT645322	hsa-miR-374a-3p	HITS-CLIP	23824327
MIRT645321	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT504116	hsa-miR-944	PAR-CLIP	23446348
MIRT504115	hsa-miR-4699-3p	PAR-CLIP	23446348
MIRT504114	hsa-miR-4772-3p	PAR-CLIP	23446348
MIRT504113	hsa-miR-4666a-5p	PAR-CLIP	23446348
MIRT504112	hsa-miR-374a-5p	PAR-CLIP	23446348
MIRT504111	hsa-miR-374b-5p	PAR-CLIP	23446348
MIRT645324	hsa-miR-1266-3p	HITS-CLIP	23824327
MIRT645323	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT662812	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT662811	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT645322	hsa-miR-374a-3p	HITS-CLIP	23824327
MIRT645321	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT645324	hsa-miR-1266-3p	HITS-CLIP	23824327
MIRT645323	hsa-miR-136-5p	HITS-CLIP	23824327
MIRT645322	hsa-miR-374a-3p	HITS-CLIP	23824327
MIRT645321	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT504116	hsa-miR-944	PAR-CLIP	23446348
MIRT504115	hsa-miR-4699-3p	PAR-CLIP	23446348
MIRT504114	hsa-miR-4772-3p	PAR-CLIP	23446348
MIRT504113	hsa-miR-4666a-5p	PAR-CLIP	23446348
MIRT504112	hsa-miR-374a-5p	PAR-CLIP	23446348
MIRT504111	hsa-miR-374b-5p	PAR-CLIP	23446348
MIRT1030804	hsa-miR-1	CLIP-seq
MIRT1030805	hsa-miR-1279	CLIP-seq
MIRT1030806	hsa-miR-136	CLIP-seq
MIRT1030807	hsa-miR-203	CLIP-seq
MIRT1030808	hsa-miR-206	CLIP-seq
MIRT1030809	hsa-miR-3121-3p	CLIP-seq
MIRT1030810	hsa-miR-3190	CLIP-seq
MIRT1030811	hsa-miR-3620	CLIP-seq
MIRT1030812	hsa-miR-3646	CLIP-seq
MIRT1030813	hsa-miR-3673	CLIP-seq
MIRT1030814	hsa-miR-3911	CLIP-seq
MIRT1030815	hsa-miR-3973	CLIP-seq
MIRT1030816	hsa-miR-4302	CLIP-seq
MIRT1030817	hsa-miR-4480	CLIP-seq
MIRT1030818	hsa-miR-4659a-3p	CLIP-seq
MIRT1030819	hsa-miR-4659b-3p	CLIP-seq
MIRT1030820	hsa-miR-4666-5p	CLIP-seq
MIRT1030821	hsa-miR-4778-3p	CLIP-seq
MIRT1030822	hsa-miR-4803	CLIP-seq
MIRT1030823	hsa-miR-490-5p	CLIP-seq
MIRT1030824	hsa-miR-513a-3p	CLIP-seq
MIRT1030825	hsa-miR-520g	CLIP-seq
MIRT1030826	hsa-miR-520h	CLIP-seq
MIRT1030827	hsa-miR-548u	CLIP-seq
MIRT1030828	hsa-miR-613	CLIP-seq
MIRT2005817	hsa-miR-2113	CLIP-seq
MIRT2005818	hsa-miR-218	CLIP-seq
MIRT2005819	hsa-miR-3192	CLIP-seq
MIRT2005820	hsa-miR-4731-5p	CLIP-seq
MIRT2005821	hsa-miR-494	CLIP-seq
MIRT2238407	hsa-miR-1183	CLIP-seq
MIRT2238408	hsa-miR-135a	CLIP-seq
MIRT2238409	hsa-miR-135b	CLIP-seq
MIRT2238410	hsa-miR-137	CLIP-seq
MIRT2238411	hsa-miR-2467-3p	CLIP-seq
MIRT2238412	hsa-miR-25	CLIP-seq
MIRT2238413	hsa-miR-32	CLIP-seq
MIRT2238414	hsa-miR-363	CLIP-seq
MIRT2238415	hsa-miR-367	CLIP-seq
MIRT2238416	hsa-miR-3678-3p	CLIP-seq
MIRT2238417	hsa-miR-374a	CLIP-seq
MIRT2238418	hsa-miR-374b	CLIP-seq
MIRT2238419	hsa-miR-3919	CLIP-seq
MIRT2238420	hsa-miR-4307	CLIP-seq
MIRT2238421	hsa-miR-4327	CLIP-seq
MIRT1030820	hsa-miR-4666-5p	CLIP-seq
MIRT2238422	hsa-miR-4670-3p	CLIP-seq
MIRT2238423	hsa-miR-4693-5p	CLIP-seq
MIRT2238424	hsa-miR-550b	CLIP-seq
MIRT2238425	hsa-miR-636	CLIP-seq
MIRT2238426	hsa-miR-92a	CLIP-seq
MIRT2238427	hsa-miR-92b	CLIP-seq
MIRT1030806	hsa-miR-136	CLIP-seq
MIRT1030811	hsa-miR-3620	CLIP-seq
MIRT1030806	hsa-miR-136	CLIP-seq
MIRT1030811	hsa-miR-3620	CLIP-seq
MIRT2450610	hsa-miR-129-5p	CLIP-seq
MIRT2450611	hsa-miR-4470	CLIP-seq
MIRT2450612	hsa-miR-488	CLIP-seq
MIRT2450613	hsa-miR-548an	CLIP-seq
MIRT2542429	hsa-miR-577	CLIP-seq
MIRT2542429	hsa-miR-577	CLIP-seq

Show/Hide all(34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001956	Process	Positive regulation of neurotransmitter secretion	IEA
GO:0001956	Process	Positive regulation of neurotransmitter secretion	ISS	28851741
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	ISS
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005886	Component	Plasma membrane	IDA	31189666
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	31189666
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007420	Process	Brain development	IEA
GO:0007420	Process	Brain development	ISS
GO:0008047	Function	Enzyme activator activity	IDA	31189666, 36996198
GO:0008047	Function	Enzyme activator activity	IEA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IDA	36996198
GO:0016020	Component	Membrane	IEA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0042995	Component	Cell projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045211	Component	Postsynaptic membrane	ISS
GO:0045744	Process	Negative regulation of G protein-coupled receptor signaling pathway	IDA	36996198
GO:0050807	Process	Regulation of synapse organization	IEA
GO:0050807	Process	Regulation of synapse organization	ISS
GO:0050890	Process	Cognition	IEA
GO:0050890	Process	Cognition	ISS
GO:0072659	Process	Protein localization to plasma membrane	IDA	31189666
GO:0072659	Process	Protein localization to plasma membrane	IEA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0160079	Function	G protein-coupled glycine receptor activity	IDA	36996198

MIM	HGNC	e!Ensembl
614573	23689	ENSG00000151025

Protein

UniProt ID

Q5T848

Protein name

Metabotropic glycine receptor (mGlyR) (G-protein coupled receptor 158)

Protein function

Metabotropic receptor for glycine that controls synapse formation and function in the brain (PubMed:36996198). Acts as an atypical G-protein coupled receptor that recruits and regulates the RGS7-GNB5 complex instead of activating G proteins (Pub

PDB

7EWL , 7EWP , 7EWR , 7SHE , 7SHF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00003	7tm_3	426 → 669	7 transmembrane sweet-taste receptor of 3 GCPR	Family

Sequence

MGAMAYPLLLCLLLAQLGLGAVGASRDPQGRPDSPRERTPKGKPHAQQPGRASASDSSAP
WSRSTDGTILAQKLAEEVPMDVASYLYTGDSHQLKRANCSGRYELAGLPGKWPALASAHP
SLHRALDTLTHATNFLNVMLQSNKSREQNLQDDLDWYQALVWSLLEGEPSISRAAITFST
DSLSAPAPQVFLQATREESRILLQDLSSSAPHLANATLETEWFHGLRRKWRPHLHRRGPN
QGPRGLGHSWRRKDGLGGDKSHFKWSPPYLECENGSYKPGWLVTLSSAIYGLQPNLVPEF
RGVMKVDINLQKVDIDQCSSDGWFSGTHKCHLNNSECMPIKGLGFVLGAYECICKAGFYH
PGVLPVNNFRRRGPDQHISGSTKDVSEEAYVCLPCREGCPFCADDSPCFVQEDKYLRLAI
ISFQALCMLLDFVSMLVVYHFRKAKSIRASGLILLETILFGSLLLYFPVVILYFEPSTFR
CILLRWARLLGFATVYGTVTLKLHRVLKVFLSRTAQRIPYMTGGRVMRMLAVILLVVFWF
LIGWTSSVCQNLEKQISLIGQGKTSDHLIFNMCLIDRWDYMTAVAEFLFLLWGVYLCYAV
RTVPSAFHEPRYMAVAVHNELIISAIFHTIRFVLASRLQSDWMLMLYFAHTHLTVTVTIG
LLLIPKFSHSSNNPRDDIATEAYEDELDMGRSGSYLNSSINSAWSEHSLDPEDIRDELKK
LYAQLEIYKRKKMITNNPHLQKKRCSKKGLGRSIMRRITEIPETVSRQCSKEDKEGADHG
TAKGTALIRKNPPESSGNTGKSKEETLKNRVFSLKKSHSTYDHVRDQTEESSSLPTESQE
EETTENSTLESLSGKKLTQKLKEDSEAESTESVPLVCKSASAHNLSSEKKTGHPRTSMLQ
KSLSVIASAKEKTLGLAGKTQTAGVEERTKSQKPLPKDKETNRNHSNSDNTETKDPAPQN
SNPAEEPRKPQKSGIMKQQRVNPTTANSDLNPGTTQMKDNFDIGEVCPWEVYDLTPGPVP
SESKVQKHVSIVASEMEKNPTFSLKEKSHHKPKAAEVCQQSNQKRIDKAEVCLWESQGQS
ILEDEKLLISKTPVLPERAKEENGGQPRAANVCAGQSEELPPKAVASKTENENLNQIGHQ
EKKTSSSEENVRGSYNSSNNFQQPLTSRAEVCPWEFETPAQPNAGRSVALPASSALSANK
IAGPRKEEIWDSFKV

Sequence length

1215

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Diabetic kidney disease in type 2 diabetes	N/A	N/A	GWAS
Ovarian cancer	Epithelial ovarian cancer	N/A	N/A	GWAS

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Colorectal Neoplasms	Associate	40001597
Esophageal Neoplasms	Associate	19472401
Glaucoma	Associate	31189666
Mental Disorders	Associate	28476931
Neoplasms	Associate	31189666
Neoplasms Adipose Tissue	Associate	28476931
Obesity	Associate	28476931
Ocular Hypertension	Associate	23451275
Ovarian Neoplasms	Stimulate	31533654
Squamous Cell Carcinoma of Head and Neck	Associate	38420803
Weight Gain	Associate	28476931

GPR158 (G protein-coupled receptor 158)