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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9HAV4 |
| Protein name |
Exportin-5 (Exp5) (Ran-binding protein 21) |
| Protein function |
Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins conta |
| PDB |
3A6P
, 5YU6
, 5YU7
|
| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
| PF08389 |
Xpo1 |
109 → 271 |
Exportin 1-like protein |
Family |
|
| Tissue specificity |
TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11777942}. |
| Sequence |
MAMDQVNALCEQLVKAVTVMMDPNSTQRYRLEALKFCEEFKEKCPICVPCGLRLAEKTQV AIVRHFGLQILEHVVKFRWNGMSRLEKVYLKNSVMELIANGTLNILEEENHIKDALSRIV VEMIKREWPQHWPDMLIELDTLSKQGETQTELVMFILLRLAEDVVTFQTLPPQRRRDIQQ TLTQNMERIFSFLLNTLQENVNKYQQVKTDTSQESKAQANCRVGVAALNTLAGYIDWVSM SHITAENCKLLEILCLLLNEQELQLGAAECLLIAVSRKGKLEDRKPLMVLFGDVAMHYIL SAAQTADGGGLVEKHYVFLKRLCQVLCALGNQLCALLGADSDVETPSNFGKYLESFLAFT THPSQFLRSSTQMTWGALFRHEILSRDPLLLAIIPKYLRASMTNLVKMGFPSKTDSPSCE YSRFDFDSDEDFNAFFNSSRAQQGEVMRLACRLDPKTSFQMAGEWLKYQLSTFLDAGSVN SCSAVGTGEGSLCSVFSPSFVQWEAMTLFLESVITQMFRTLNREEIPVNDGIELLQMVLN FDTKDPLILSCVLTNVSALFPFVTYRPEFLPQVFSKLFSSVTFETVEESKAPRTRAVRNV RRHACSSIIKMCRDYPQLVLPNFDMLYNHVKQLLSNELLLTQMEKCALMEALVLISNQFK NYERQKVFLEELMAPVASIWLSQDMHRVLSDVDAFIAYVGTDQKSCDPGLEDPCGLNRAR MSFCVYSILGVVKRTCWPTDLEEAKAGGFVVGYTSSGNPIFRNPCTEQILKLLDNLLALI RTHNTLYAPEMLAKMAEPFTKALDMLDAEKSAILGLPQPLLELNDSPVFKTVLERMQRFF STLYENCFHILGKAGPSMQQDFYTVEDLATQLLSSAFVNLNNIPDYRLRPMLRVFVKPLV LFCPPEHYEALVSPILGPLFTYLHMRLSQKWQVINQRSLLCGEDEAADENPESQEMLEEQ LVRMLTREVMDLITVCCVSKKGADHSSAPPADGDDEEMMATEVTPSAMAELTDLGKCLMK HEDVCTALLITAFNSLAWKDTLSCQRTTSQLCWPLLKQVLSGTLLADAVTWLFTSVLKGL QMHGQHDGCMASLVHLAFQIYEALRPRYLEIRAVMEQIPEIQKDSLDQFDCKLLNPSLQK VADKRRKDQFKRLIAGCIGKPLGEQFRKEVHIKNLPSLFKKTKPMLETEVLDNDGGGLAT IFEP
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| Sequence length |
1204 |
| Interactions |
View interactions |
| Phenotype Name |
Clinical Significance |
dbSNP ID |
RCV Accession |
| Acute myeloid leukemia |
Benign |
rs78822980 |
RCV005920253 |
| Cervical cancer |
Benign |
rs6458340, rs73733591 |
RCV005920305 RCV005921921 |
| Familial cancer of breast |
Benign; Likely benign |
rs73733591, rs771450577 |
RCV005921919 RCV005868348 |
| Malignant lymphoma, large B-cell, diffuse |
Likely benign |
rs771450577 |
RCV005868349 |
| Malignant tumor of esophagus |
Benign |
rs78822980, rs73733591 |
RCV005920254 RCV005921920 |
| Melanoma |
Uncertain significance |
rs201138656 |
RCV005926480 |
| Ovarian serous cystadenocarcinoma |
Benign; Uncertain significance |
rs78822980, rs201138656 |
RCV005920255 RCV005926479 |
| Sarcoma |
Benign |
rs73733591, rs114918329 |
RCV005921922 RCV005904581 |
| Uterine carcinosarcoma |
Benign |
rs78822980 |
RCV005920256 |
| Uterine corpus endometrial carcinoma |
Benign |
rs73733591 |
RCV005921923 |
| XPO5-related disorder |
Uncertain significance; Benign; Likely benign; Conflicting classifications of pathogenicity |
rs202182348, rs200787086, rs377196219, rs369471517, rs529074766, rs532701280, rs370390582, rs115410573, rs186877420, rs41281818, rs201138656, rs200605932, rs373634302, rs61762965, rs367803997, rs372441079, rs2483082027, rs2482924993, rs577775126, rs778510766, rs1000553470, rs530521285, rs1455366535, rs772235929, rs750361482, rs767010581, rs749301680, rs2532277821, rs745435024, rs779637378, rs765427694, rs2482974302, rs376843416, rs369645572, rs114918329 View all (20 more) |
RCV003892960 RCV003913443 RCV003911202 RCV003963579 RCV003926672 RCV003906505 RCV003953912 RCV003963379 RCV003906279 RCV003943601 RCV004754905 RCV003961263 RCV003973615 RCV003973600 RCV003898687 RCV003427842 RCV003404629 RCV003404545 RCV003966476 RCV003929267 RCV003954293 RCV003893456 RCV003904706 RCV003902173 RCV003906925 RCV003904683 RCV003982503 RCV003901679 RCV003977165 RCV003913921 RCV003941947 RCV003942059 RCV003976829 RCV003962225 RCV003955920 |
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| Disease Name |
Relationship Type |
References |
| Adenocarcinoma |
Associate |
34227026 |
| Breast Neoplasms |
Associate |
29699373 |
| Carcinogenesis |
Associate |
28383405 |
| Carcinoma Hepatocellular |
Associate |
24676133, 27611467, 27846390, 31371628, 32763246 |
| Carcinoma Non Small Cell Lung |
Associate |
21799879, 26358254 |
| Cholangiocarcinoma |
Associate |
29406621 |
| Colitis Ulcerative |
Associate |
35484353 |
| Colorectal Neoplasms |
Associate |
26147304, 31510013 |
| Dysplastic Nevus Syndrome |
Associate |
34227026 |
| Esophageal Squamous Cell Carcinoma |
Associate |
29226993 |
| Genetic Diseases Inborn |
Associate |
20951941, 21346411 |
| Glomerulosclerosis Focal Segmental |
Associate |
36371311, 37565816 |
| Hereditary Breast and Ovarian Cancer Syndrome |
Associate |
29699373 |
| Hodgkin Disease |
Associate |
23705004 |
| Hypertension |
Associate |
26147304 |
| Kidney Failure Chronic |
Associate |
32770606 |
| Laryngeal Neoplasms |
Associate |
26688807 |
| Lung Diseases |
Associate |
23705004 |
| Lung Neoplasms |
Associate |
21346411 |
| Lymphatic Metastasis |
Associate |
26358254 |
| Melanoma |
Associate |
27556702 |
| Monosomy |
Inhibit |
27453764 |
| Neoplasm Metastasis |
Associate |
27556702, 28383405 |
| Neoplasms |
Associate |
20951941, 21346411, 27453764, 28383405, 29226993, 29683064, 29699373, 31235936, 32763246 |
| Neoplasms |
Inhibit |
23977393, 27846390 |
| Prostatic Neoplasms |
Stimulate |
29699373 |
| Renal Insufficiency Chronic |
Associate |
36371311 |
| Stomach Neoplasms |
Associate |
22559327, 29683064 |
| Tertiary Lymphoid Structures |
Associate |
29699373 |
| Thyroid Neoplasms |
Associate |
28383405 |
| Urinary Bladder Diseases |
Associate |
29699373 |
| Venous Thromboembolism |
Associate |
31374978, 37311119 |
| Wilms Tumor |
Associate |
28825729 |
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