Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
57510
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Exportin 5 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
XPO5 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
exp5 |
Chromosome
Chromosome number
|
6 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
6p21.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a |
UniProt ID |
Q9HAV4
|
Protein name |
Exportin-5 (Exp5) (Ran-binding protein 21) |
Protein function |
Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins conta |
PDB |
3A6P
,
5YU6
,
5YU7
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF08389
|
Xpo1 |
109 → 271 |
Exportin 1-like protein |
Family |
|
Tissue specificity |
TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11777942}. |
Sequence |
MAMDQVNALCEQLVKAVTVMMDPNSTQRYRLEALKFCEEFKEKCPICVPCGLRLAEKTQV AIVRHFGLQILEHVVKFRWNGMSRLEKVYLKNSVMELIANGTLNILEEENHIKDALSRIV VEMIKREWPQHWPDMLIELDTLSKQGETQTELVMFILLRLAEDVVTFQTLPPQRRRDIQQ TLTQNMERIFSFLLNTLQENVNKYQQVKTDTSQESKAQANCRVGVAALNTLAGYIDWVSM SHITAENCKLLEILCLLLNEQELQLGAAECLLIAVSRKGKLEDRKPLMVLFGDVAMHYIL SAAQTADGGGLVEKHYVFLKRLCQVLCALGNQLCALLGADSDVETPSNFGKYLESFLAFT THPSQFLRSSTQMTWGALFRHEILSRDPLLLAIIPKYLRASMTNLVKMGFPSKTDSPSCE YSRFDFDSDEDFNAFFNSSRAQQGEVMRLACRLDPKTSFQMAGEWLKYQLSTFLDAGSVN SCSAVGTGEGSLCSVFSPSFVQWEAMTLFLESVITQMFRTLNREEIPVNDGIELLQMVLN FDTKDPLILSCVLTNVSALFPFVTYRPEFLPQVFSKLFSSVTFETVEESKAPRTRAVRNV RRHACSSIIKMCRDYPQLVLPNFDMLYNHVKQLLSNELLLTQMEKCALMEALVLISNQFK NYERQKVFLEELMAPVASIWLSQDMHRVLSDVDAFIAYVGTDQKSCDPGLEDPCGLNRAR MSFCVYSILGVVKRTCWPTDLEEAKAGGFVVGYTSSGNPIFRNPCTEQILKLLDNLLALI RTHNTLYAPEMLAKMAEPFTKALDMLDAEKSAILGLPQPLLELNDSPVFKTVLERMQRFF STLYENCFHILGKAGPSMQQDFYTVEDLATQLLSSAFVNLNNIPDYRLRPMLRVFVKPLV LFCPPEHYEALVSPILGPLFTYLHMRLSQKWQVINQRSLLCGEDEAADENPESQEMLEEQ LVRMLTREVMDLITVCCVSKKGADHSSAPPADGDDEEMMATEVTPSAMAELTDLGKCLMK HEDVCTALLITAFNSLAWKDTLSCQRTTSQLCWPLLKQVLSGTLLADAVTWLFTSVLKGL QMHGQHDGCMASLVHLAFQIYEALRPRYLEIRAVMEQIPEIQKDSLDQFDCKLLNPSLQK VADKRRKDQFKRLIAGCIGKPLGEQFRKEVHIKNLPSLFKKTKPMLETEVLDNDGGGLAT IFEP
|
|
Sequence length |
1204 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Nephroblastoma |
Nephroblastoma |
rs1553551874, rs1555913934, rs769116796 |
28825729 |
Nephrotic syndrome |
Nephrotic Syndrome |
rs876657369, rs121912601, rs121912602, rs876657370, rs121912603, rs121912604, rs121912605, rs121907900, rs121907901, rs28941778, rs587776576, rs28942089, rs587776577, rs28941777, rs121907910, rs1568296260, rs119473033, rs74315342, rs74315343, rs74315345, rs74315346, rs74315347, rs74315348, rs121434394, rs267606919, rs121912488, rs267606953, rs267606954, rs267606955, rs104886210, rs1591732280, rs1591750243, rs140511594, rs140781106, rs147972030, rs587776969, rs386833863, rs386833880, rs386833882, rs386833892, rs386833895, rs386833909, rs386833911, rs386833920, rs386833935, rs386833947, rs1555763603, rs398122978, rs398122979, rs398122980, rs369573693, rs398122981, rs398122982, rs398122983, rs200482683, rs730882194, rs180177201, rs587777552, rs587777553, rs775170915, rs749740335, rs12568913, rs530318579, rs786204583, rs786204708, rs786204632, rs138656762, rs797044992, rs797044994, rs797044995, rs864321632, rs864321687, rs864321688, rs864321633, rs869025495, rs869025541, rs869312747, rs145473779, rs757674160, rs869320695, rs138909849, rs869312984, rs1057516900, rs763818901, rs199506378, rs1057517164, rs1057516523, rs1057516414, rs778055996, rs1057516395, rs1057516747, rs1057516880, rs1057516680, rs778217926, rs1057519347, rs764587648, rs1060499703, rs121907903, rs769259446, rs1131692252, rs1131692253, rs1131692254, rs1131692255, rs1131692256, rs746887949, rs1131692235, rs1135402911, rs1135402912, rs1135402913, rs1554946480, rs1555331969, rs773173317, rs1555816634, rs775006954, rs1320543506, rs534522842, rs1272948499, rs1191455921, rs1291398331, rs1554939785, rs776016942, rs1031744496, rs748812981, rs755972674, rs1553312833, rs967339926, rs1462028977, rs1212702104, rs1167223941, rs762631237, rs1553316575, rs1553315173, rs1553316648, rs1553316611, rs780761368, rs368572297, rs1568070817, rs1321552081, rs1558108130, rs1558091788, rs1565707103, rs1558355124, rs1564622701, rs1351580598, rs1589475328, rs1589413498, rs1572255744, rs1572262824, rs761410195, rs1602413491, rs1590326226, rs375998390, rs570583897, rs369363545, rs201488687, rs1334894971, rs763782471, rs138047529, rs895782232, rs1572255047, rs1589433172, rs1589509476, rs1572277600, rs1572282458, rs1584675898, rs759043857, rs1853443391 View all (152 more) |
26878725 |
Wilms tumor |
Bilateral Wilms Tumor |
rs121918261, rs2116574924, rs587776573, rs587776574, rs121907900, rs121907901, rs587776576, rs121907909, rs121907906, rs587776577, rs121907911, rs80359604, rs80358785, rs104894855, rs122453119, rs122453121, rs869025310, rs121907903, rs1131690795, rs1554945033, rs1423753702, rs1556297749, rs1569392947, rs1569408743, rs1603240717, rs1602581162, rs771527206, rs2071072322 View all (13 more) |
28825729 |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Adenocarcinoma |
Associate
|
34227026 |
Breast Neoplasms |
Associate
|
29699373 |
Carcinogenesis |
Associate
|
28383405 |
Carcinoma Hepatocellular |
Associate
|
24676133, 27611467, 27846390, 31371628, 32763246 |
Carcinoma Non Small Cell Lung |
Associate
|
21799879, 26358254 |
Cholangiocarcinoma |
Associate
|
29406621 |
Colitis Ulcerative |
Associate
|
35484353 |
Colorectal Neoplasms |
Associate
|
26147304, 31510013 |
Dysplastic Nevus Syndrome |
Associate
|
34227026 |
Esophageal Squamous Cell Carcinoma |
Associate
|
29226993 |
Genetic Diseases Inborn |
Associate
|
20951941, 21346411 |
Glomerulosclerosis Focal Segmental |
Associate
|
36371311, 37565816 |
Hereditary Breast and Ovarian Cancer Syndrome |
Associate
|
29699373 |
Hodgkin Disease |
Associate
|
23705004 |
Hypertension |
Associate
|
26147304 |
Kidney Failure Chronic |
Associate
|
32770606 |
Laryngeal Neoplasms |
Associate
|
26688807 |
Lung Diseases |
Associate
|
23705004 |
Lung Neoplasms |
Associate
|
21346411 |
Lymphatic Metastasis |
Associate
|
26358254 |
Melanoma |
Associate
|
27556702 |
Monosomy |
Inhibit
|
27453764 |
Neoplasm Metastasis |
Associate
|
27556702, 28383405 |
Neoplasms |
Associate
|
20951941, 21346411, 27453764, 28383405, 29226993, 29683064, 29699373, 31235936, 32763246 |
Neoplasms |
Inhibit
|
23977393, 27846390 |
Prostatic Neoplasms |
Stimulate
|
29699373 |
Renal Insufficiency Chronic |
Associate
|
36371311 |
Stomach Neoplasms |
Associate
|
22559327, 29683064 |
Tertiary Lymphoid Structures |
Associate
|
29699373 |
Thyroid Neoplasms |
Associate
|
28383405 |
Urinary Bladder Diseases |
Associate
|
29699373 |
Venous Thromboembolism |
Associate
|
31374978, 37311119 |
Wilms Tumor |
Associate
|
28825729 |
|