INTS2 (integrator complex subunit 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 57508 |
| Gene name | Integrator complex subunit 2 |
| Gene symbol | INTS2 |
| Synonyms (NCBI Gene) |
INT2KIAA1287
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| Chromosome | 17 |
| Chromosome location | 17q23.2 |
| Summary | INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Ba |
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miRNA
miRNA information provided by mirtarbase database.
739
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9H0H0 | ||||||||||
| Protein name | Integrator complex subunit 2 (Int2) | ||||||||||
| Protein function | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoin | ||||||||||
| PDB | 7CUN , 7PKS , 7YCX , 8RBX , 8RBZ , 8RC4 , 8YJB | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 1204 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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