INTS2 (integrator complex subunit 2)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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57508 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Integrator complex subunit 2 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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INTS2 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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INT2, KIAA1287 |
Chromosome
Chromosome number
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17 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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17q23.2 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Ba |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | Q9H0H0 | ||||||||||
Protein name | Integrator complex subunit 2 (Int2) | ||||||||||
Protein function | Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoin | ||||||||||
PDB | 7CUN , 7PKS , 7YCX , 8RBX , 8RBZ , 8RC4 , 8YJB | ||||||||||
Family and domains |
Pfam
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Sequence |
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Sequence length | 1204 | ||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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