RIMKLB (ribosomal modification protein rimK like family member B)

Gene

• Entrez ID: 57494
• Gene name: Ribosomal modification protein rimK like family member B
• Gene symbol: RIMKLB
• Synonyms (NCBI Gene): FAM80B, NAAGS, NAAGS-I
• Chromosome: 12
• Chromosome location: 12p13.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT700188	hsa-miR-4323	HITS-CLIP	23313552
MIRT700187	hsa-miR-520f-5p	HITS-CLIP	23313552
MIRT700186	hsa-miR-4667-5p	HITS-CLIP	23313552
MIRT700185	hsa-miR-4700-5p	HITS-CLIP	23313552
MIRT700184	hsa-miR-8089	HITS-CLIP	23313552
MIRT700183	hsa-miR-5699-5p	HITS-CLIP	23313552
MIRT700182	hsa-miR-4758-3p	HITS-CLIP	23313552
MIRT700181	hsa-miR-4450	HITS-CLIP	23313552
MIRT700180	hsa-miR-6895-3p	HITS-CLIP	23313552
MIRT700179	hsa-miR-593-3p	HITS-CLIP	23313552
MIRT700178	hsa-miR-513b-5p	HITS-CLIP	23313552
MIRT700177	hsa-miR-181b-2-3p	HITS-CLIP	23313552
MIRT700176	hsa-miR-181b-3p	HITS-CLIP	23313552
MIRT700175	hsa-miR-4420	HITS-CLIP	23313552
MIRT700174	hsa-miR-653-3p	HITS-CLIP	23313552
MIRT700173	hsa-miR-6857-5p	HITS-CLIP	23313552
MIRT700172	hsa-miR-6818-3p	HITS-CLIP	23313552
MIRT067440	hsa-miR-8066	PAR-CLIP	22100165
MIRT441937	hsa-miR-636	PAR-CLIP	22100165
MIRT441936	hsa-miR-1273e	PAR-CLIP	22100165
MIRT441935	hsa-miR-218-5p	PAR-CLIP	22100165
MIRT067440	hsa-miR-8066	PAR-CLIP	22100165
MIRT446290	hsa-miR-3973	PAR-CLIP	22100165
MIRT446289	hsa-miR-520g-3p	PAR-CLIP	22100165
MIRT446288	hsa-miR-520h	PAR-CLIP	22100165
MIRT441937	hsa-miR-636	PAR-CLIP	22100165
MIRT441936	hsa-miR-1273e	PAR-CLIP	22100165
MIRT441935	hsa-miR-218-5p	PAR-CLIP	22100165
MIRT441940	hsa-miR-3184-3p	PAR-CLIP	22100165
MIRT441939	hsa-miR-3691-3p	PAR-CLIP	22100165
MIRT441938	hsa-miR-4480	PAR-CLIP	22100165
MIRT441937	hsa-miR-636	PAR-CLIP	22100165
MIRT441936	hsa-miR-1273e	PAR-CLIP	22100165
MIRT441935	hsa-miR-218-5p	PAR-CLIP	22100165
MIRT700188	hsa-miR-4323	HITS-CLIP	23313552
MIRT700187	hsa-miR-520f-5p	HITS-CLIP	23313552
MIRT700186	hsa-miR-4667-5p	HITS-CLIP	23313552
MIRT700185	hsa-miR-4700-5p	HITS-CLIP	23313552
MIRT700184	hsa-miR-8089	HITS-CLIP	23313552
MIRT700183	hsa-miR-5699-5p	HITS-CLIP	23313552
MIRT700182	hsa-miR-4758-3p	HITS-CLIP	23313552
MIRT700181	hsa-miR-4450	HITS-CLIP	23313552
MIRT700180	hsa-miR-6895-3p	HITS-CLIP	23313552
MIRT700179	hsa-miR-593-3p	HITS-CLIP	23313552
MIRT700178	hsa-miR-513b-5p	HITS-CLIP	23313552
MIRT700177	hsa-miR-181b-2-3p	HITS-CLIP	23313552
MIRT700176	hsa-miR-181b-3p	HITS-CLIP	23313552
MIRT700175	hsa-miR-4420	HITS-CLIP	23313552
MIRT700174	hsa-miR-653-3p	HITS-CLIP	23313552
MIRT700173	hsa-miR-6857-5p	HITS-CLIP	23313552
MIRT700172	hsa-miR-6818-3p	HITS-CLIP	23313552
MIRT067440	hsa-miR-8066	PAR-CLIP	22100165
MIRT441937	hsa-miR-636	PAR-CLIP	22100165
MIRT441936	hsa-miR-1273e	PAR-CLIP	22100165
MIRT441935	hsa-miR-218-5p	PAR-CLIP	22100165
MIRT067440	hsa-miR-8066	PAR-CLIP	22100165
MIRT446290	hsa-miR-3973	PAR-CLIP	22100165
MIRT446289	hsa-miR-520g-3p	PAR-CLIP	22100165
MIRT446288	hsa-miR-520h	PAR-CLIP	22100165
MIRT441937	hsa-miR-636	PAR-CLIP	22100165
MIRT441936	hsa-miR-1273e	PAR-CLIP	22100165
MIRT441935	hsa-miR-218-5p	PAR-CLIP	22100165
MIRT441940	hsa-miR-3184-3p	PAR-CLIP	22100165
MIRT441939	hsa-miR-3691-3p	PAR-CLIP	22100165
MIRT441938	hsa-miR-4480	PAR-CLIP	22100165
MIRT441937	hsa-miR-636	PAR-CLIP	22100165
MIRT441936	hsa-miR-1273e	PAR-CLIP	22100165
MIRT441935	hsa-miR-218-5p	PAR-CLIP	22100165
MIRT1306865	hsa-miR-1200	CLIP-seq
MIRT1306866	hsa-miR-1206	CLIP-seq
MIRT1306867	hsa-miR-1244	CLIP-seq
MIRT1306868	hsa-miR-1245b-3p	CLIP-seq
MIRT1306869	hsa-miR-1251	CLIP-seq
MIRT1306870	hsa-miR-1252	CLIP-seq
MIRT1306871	hsa-miR-1270	CLIP-seq
MIRT1306872	hsa-miR-137	CLIP-seq
MIRT1306873	hsa-miR-142-3p	CLIP-seq
MIRT1306874	hsa-miR-185	CLIP-seq
MIRT1306875	hsa-miR-200b	CLIP-seq
MIRT1306876	hsa-miR-200c	CLIP-seq
MIRT1306877	hsa-miR-202	CLIP-seq
MIRT1306878	hsa-miR-203	CLIP-seq
MIRT1306879	hsa-miR-2053	CLIP-seq
MIRT1306880	hsa-miR-2117	CLIP-seq
MIRT1306881	hsa-miR-218	CLIP-seq
MIRT1306882	hsa-miR-2681	CLIP-seq
MIRT1306883	hsa-miR-297	CLIP-seq
MIRT1306884	hsa-miR-300	CLIP-seq
MIRT1306885	hsa-miR-3074-5p	CLIP-seq
MIRT1306886	hsa-miR-31	CLIP-seq
MIRT1306887	hsa-miR-3148	CLIP-seq
MIRT1306888	hsa-miR-3152-5p	CLIP-seq
MIRT1306889	hsa-miR-325	CLIP-seq
MIRT1306890	hsa-miR-3607-5p	CLIP-seq
MIRT1306891	hsa-miR-3613-3p	CLIP-seq
MIRT1306892	hsa-miR-3620	CLIP-seq
MIRT1306893	hsa-miR-3659	CLIP-seq
MIRT1306894	hsa-miR-3680	CLIP-seq
MIRT1306895	hsa-miR-371-5p	CLIP-seq
MIRT1306896	hsa-miR-371b-5p	CLIP-seq
MIRT1306897	hsa-miR-374c	CLIP-seq
MIRT1306898	hsa-miR-381	CLIP-seq
MIRT1306899	hsa-miR-3924	CLIP-seq
MIRT1306900	hsa-miR-3974	CLIP-seq
MIRT1306901	hsa-miR-4257	CLIP-seq
MIRT1306902	hsa-miR-4273	CLIP-seq
MIRT1306903	hsa-miR-429	CLIP-seq
MIRT1306904	hsa-miR-4297	CLIP-seq
MIRT1306905	hsa-miR-4306	CLIP-seq
MIRT1306906	hsa-miR-4307	CLIP-seq
MIRT1306907	hsa-miR-4422	CLIP-seq
MIRT1306908	hsa-miR-4434	CLIP-seq
MIRT1306909	hsa-miR-4438	CLIP-seq
MIRT1306910	hsa-miR-4477a	CLIP-seq
MIRT1306911	hsa-miR-4477b	CLIP-seq
MIRT1306912	hsa-miR-4501	CLIP-seq
MIRT1306913	hsa-miR-4516	CLIP-seq
MIRT1306914	hsa-miR-4531	CLIP-seq
MIRT1306915	hsa-miR-4637	CLIP-seq
MIRT1306916	hsa-miR-4644	CLIP-seq
MIRT1306917	hsa-miR-4652-3p	CLIP-seq
MIRT1306918	hsa-miR-4658	CLIP-seq
MIRT1306919	hsa-miR-4666-3p	CLIP-seq
MIRT1306920	hsa-miR-4678	CLIP-seq
MIRT1306921	hsa-miR-4699-5p	CLIP-seq
MIRT1306922	hsa-miR-4712-3p	CLIP-seq
MIRT1306923	hsa-miR-4724-5p	CLIP-seq
MIRT1306924	hsa-miR-4731-3p	CLIP-seq
MIRT1306925	hsa-miR-4789-5p	CLIP-seq
MIRT1306926	hsa-miR-4795-3p	CLIP-seq
MIRT1306927	hsa-miR-4798-3p	CLIP-seq
MIRT1306928	hsa-miR-4801	CLIP-seq
MIRT1306929	hsa-miR-495	CLIP-seq
MIRT1306930	hsa-miR-513b	CLIP-seq
MIRT1306931	hsa-miR-513c	CLIP-seq
MIRT1306932	hsa-miR-514b-5p	CLIP-seq
MIRT1306933	hsa-miR-520g	CLIP-seq
MIRT1306934	hsa-miR-532-5p	CLIP-seq
MIRT1306935	hsa-miR-548g	CLIP-seq
MIRT1306936	hsa-miR-548l	CLIP-seq
MIRT1306937	hsa-miR-548n	CLIP-seq
MIRT1306938	hsa-miR-548u	CLIP-seq
MIRT1306939	hsa-miR-567	CLIP-seq
MIRT1306940	hsa-miR-569	CLIP-seq
MIRT1306941	hsa-miR-574-5p	CLIP-seq
MIRT1306942	hsa-miR-593	CLIP-seq
MIRT1306943	hsa-miR-606	CLIP-seq
MIRT1306944	hsa-miR-607	CLIP-seq
MIRT1306945	hsa-miR-620	CLIP-seq
MIRT1306946	hsa-miR-628-3p	CLIP-seq
MIRT1306947	hsa-miR-655	CLIP-seq
MIRT1306948	hsa-miR-889	CLIP-seq
MIRT1306887	hsa-miR-3148	CLIP-seq
MIRT1306879	hsa-miR-2053	CLIP-seq
MIRT2090996	hsa-miR-2276	CLIP-seq
MIRT2090997	hsa-miR-3908	CLIP-seq
MIRT2090998	hsa-miR-3942-5p	CLIP-seq
MIRT1306901	hsa-miR-4257	CLIP-seq
MIRT2090999	hsa-miR-452	CLIP-seq
MIRT1306919	hsa-miR-4666-3p	CLIP-seq
MIRT2091000	hsa-miR-4676-3p	CLIP-seq
MIRT2091001	hsa-miR-4703-5p	CLIP-seq
MIRT2091002	hsa-miR-4762-5p	CLIP-seq
MIRT2091003	hsa-miR-4766-3p	CLIP-seq
MIRT2091004	hsa-miR-4772-3p	CLIP-seq
MIRT1306925	hsa-miR-4789-5p	CLIP-seq
MIRT2091005	hsa-miR-544	CLIP-seq
MIRT2315698	hsa-miR-1273f	CLIP-seq
MIRT2315699	hsa-miR-1276	CLIP-seq
MIRT2315700	hsa-miR-1289	CLIP-seq
MIRT2315701	hsa-miR-1321	CLIP-seq
MIRT2315702	hsa-miR-136	CLIP-seq
MIRT1306872	hsa-miR-137	CLIP-seq
MIRT2315703	hsa-miR-142-5p	CLIP-seq
MIRT2315704	hsa-miR-144	CLIP-seq
MIRT1306875	hsa-miR-200b	CLIP-seq
MIRT1306876	hsa-miR-200c	CLIP-seq
MIRT1306879	hsa-miR-2053	CLIP-seq
MIRT2315705	hsa-miR-2278	CLIP-seq
MIRT1306883	hsa-miR-297	CLIP-seq
MIRT2315706	hsa-miR-3138	CLIP-seq
MIRT1306887	hsa-miR-3148	CLIP-seq
MIRT2315707	hsa-miR-3158-3p	CLIP-seq
MIRT2315708	hsa-miR-3162-5p	CLIP-seq
MIRT2315709	hsa-miR-3187-3p	CLIP-seq
MIRT2315710	hsa-miR-3198	CLIP-seq
MIRT2315711	hsa-miR-324-5p	CLIP-seq
MIRT2315712	hsa-miR-340	CLIP-seq
MIRT1306891	hsa-miR-3613-3p	CLIP-seq
MIRT2315713	hsa-miR-3688-3p	CLIP-seq
MIRT1306897	hsa-miR-374c	CLIP-seq
MIRT2315714	hsa-miR-412	CLIP-seq
MIRT1306901	hsa-miR-4257	CLIP-seq
MIRT1306903	hsa-miR-429	CLIP-seq
MIRT2315715	hsa-miR-4294	CLIP-seq
MIRT1306906	hsa-miR-4307	CLIP-seq
MIRT2315716	hsa-miR-4309	CLIP-seq
MIRT2315717	hsa-miR-4311	CLIP-seq
MIRT2315718	hsa-miR-4435	CLIP-seq
MIRT2315719	hsa-miR-4446-3p	CLIP-seq
MIRT2315720	hsa-miR-4493	CLIP-seq
MIRT2315721	hsa-miR-4520a-3p	CLIP-seq
MIRT2315722	hsa-miR-4529-5p	CLIP-seq
MIRT2315723	hsa-miR-4643	CLIP-seq
MIRT2315724	hsa-miR-4645-3p	CLIP-seq
MIRT2315725	hsa-miR-4659a-3p	CLIP-seq
MIRT2315726	hsa-miR-4659b-3p	CLIP-seq
MIRT2315727	hsa-miR-466	CLIP-seq
MIRT2315728	hsa-miR-4666-5p	CLIP-seq
MIRT2315729	hsa-miR-4668-5p	CLIP-seq
MIRT2315730	hsa-miR-4691-5p	CLIP-seq
MIRT2315731	hsa-miR-4701-5p	CLIP-seq
MIRT2315732	hsa-miR-4720-3p	CLIP-seq
MIRT2315733	hsa-miR-4729	CLIP-seq
MIRT2315734	hsa-miR-4739	CLIP-seq
MIRT2315735	hsa-miR-4756-5p	CLIP-seq
MIRT2315736	hsa-miR-4789-3p	CLIP-seq
MIRT1306926	hsa-miR-4795-3p	CLIP-seq
MIRT1306933	hsa-miR-520g	CLIP-seq
MIRT2315737	hsa-miR-548a-3p	CLIP-seq
MIRT2315738	hsa-miR-548ae	CLIP-seq
MIRT2315739	hsa-miR-548aj	CLIP-seq
MIRT2315740	hsa-miR-548am	CLIP-seq
MIRT2315741	hsa-miR-548e	CLIP-seq
MIRT2315742	hsa-miR-548f	CLIP-seq
MIRT1306935	hsa-miR-548g	CLIP-seq
MIRT2315743	hsa-miR-548s	CLIP-seq
MIRT2315744	hsa-miR-548x	CLIP-seq
MIRT1306939	hsa-miR-567	CLIP-seq
MIRT2315745	hsa-miR-583	CLIP-seq
MIRT2315746	hsa-miR-586	CLIP-seq
MIRT2315747	hsa-miR-588	CLIP-seq
MIRT2315748	hsa-miR-625	CLIP-seq
MIRT1306947	hsa-miR-655	CLIP-seq
MIRT1306874	hsa-miR-185	CLIP-seq
MIRT1306886	hsa-miR-31	CLIP-seq
MIRT2315707	hsa-miR-3158-3p	CLIP-seq
MIRT1306905	hsa-miR-4306	CLIP-seq
MIRT1306916	hsa-miR-4644	CLIP-seq
MIRT2458240	hsa-miR-561	CLIP-seq
MIRT2458241	hsa-miR-624	CLIP-seq
MIRT2315700	hsa-miR-1289	CLIP-seq
MIRT2611862	hsa-miR-18a	CLIP-seq
MIRT2611863	hsa-miR-18b	CLIP-seq
MIRT2315710	hsa-miR-3198	CLIP-seq
MIRT1306892	hsa-miR-3620	CLIP-seq
MIRT2315715	hsa-miR-4294	CLIP-seq
MIRT1306906	hsa-miR-4307	CLIP-seq
MIRT2315716	hsa-miR-4309	CLIP-seq
MIRT1306911	hsa-miR-4477b	CLIP-seq
MIRT2611864	hsa-miR-4735-3p	CLIP-seq
MIRT2611865	hsa-miR-570	CLIP-seq
MIRT2611866	hsa-miR-875-5p	CLIP-seq
MIRT2611867	hsa-miR-934	CLIP-seq
MIRT2315700	hsa-miR-1289	CLIP-seq
MIRT2611862	hsa-miR-18a	CLIP-seq
MIRT2611863	hsa-miR-18b	CLIP-seq
MIRT2315710	hsa-miR-3198	CLIP-seq
MIRT1306892	hsa-miR-3620	CLIP-seq
MIRT2315715	hsa-miR-4294	CLIP-seq
MIRT1306906	hsa-miR-4307	CLIP-seq
MIRT2315716	hsa-miR-4309	CLIP-seq
MIRT1306911	hsa-miR-4477b	CLIP-seq
MIRT2611864	hsa-miR-4735-3p	CLIP-seq
MIRT2611865	hsa-miR-570	CLIP-seq
MIRT2611866	hsa-miR-875-5p	CLIP-seq
MIRT2611867	hsa-miR-934	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	TAS
GO:0009064	Process	Glutamine family amino acid metabolic process	IEA
GO:0009064	Process	Glutamine family amino acid metabolic process	TAS
GO:0016874	Function	Ligase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0072590	Function	N-acetyl-L-aspartate-L-glutamate ligase activity	IBA
GO:0072590	Function	N-acetyl-L-aspartate-L-glutamate ligase activity	IEA
GO:0072590	Function	N-acetyl-L-aspartate-L-glutamate ligase activity	ISS
GO:0072590	Function	N-acetyl-L-aspartate-L-glutamate ligase activity	TAS
GO:0072591	Function	Citrate-L-glutamate ligase activity	IEA
GO:0072591	Function	Citrate-L-glutamate ligase activity	ISS

Other IDs

• MIM: 614054
• HGNC: 29228
• e!Ensembl: ENSG00000166532

Protein

• UniProt ID: Q9ULI2
• Protein name: Beta-citrylglutamate synthase B (EC 6.3.1.17) (N-acetyl-aspartylglutamate synthetase B) (NAAG synthetase B) (NAAGS) (EC 6.3.2.41) (Ribosomal protein S6 modification-like protein B)
• Protein function: Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08443	RimK	112 → 303	RimK-like ATP-grasp domain	Domain

• Sequence:

  MCSSVAAKLWFLTDRRIREDYPQKEILRALKAKCCEEELDFRAVVMDEVVLTIEQGNLGL
  RINGELITAYPQVVVVRVPTPWVQSDSDITVLRHLEKMGCRLMNRPQAILNCVNKFWTFQ
  ELAGHGVPLPDTFSYGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHLADL
  SHLIRHEAPYLFQKYVKESHGRDVRVIVVGGRVVGTMLRCSTDGRMQSNCSLGGVGMMCS
  LSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFIAFDKACNLDVAGIIA
  DYAASLLPSGRLTRRMSLLSVVSTASETSEPELGPPASTAVDNMSASSSSVDSDPESTER
  ELLTKLPGGLFNMNQLLANEIKLLVD

• Sequence length: 386

Pathways

KEGG:

Alanine, aspartate and glutamate metabolism
Metabolic pathways

Reactome:

Glutamate and glutamine metabolism

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Colonic Neoplasms	Associate	35712285, 36181111	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	38167072, 38466182	★☆☆☆☆ Found in Text Mining only