Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57491
Gene name Gene Name - the full gene name approved by the HGNC.	Aryl hydrocarbon receptor repressor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	AHRR
Synonyms (NCBI Gene) Gene synonyms aliases	AHH, AHHR, bHLHe77
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5p15.33
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing Ah

Show/Hide all(193)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002644	hsa-miR-124-3p	Microarray	18668037
MIRT050696	hsa-miR-18a-5p	CLASH	23622248
MIRT050165	hsa-miR-26a-5p	CLASH	23622248
MIRT438200	hsa-miR-125b-5p	Immunoblot, Luciferase reporter assay	24176857
MIRT438200	hsa-miR-125b-5p	Immunoblot, Luciferase reporter assay	24176857
MIRT438200	hsa-miR-125b-5p	Immunoblot, Luciferase reporter assay	24176857
MIRT438200	hsa-miR-125b-5p	Immunoblot, Luciferase reporter assay	24176857
MIRT773939	hsa-miR-1205	CLIP-seq
MIRT773940	hsa-miR-124	CLIP-seq
MIRT773941	hsa-miR-1265	CLIP-seq
MIRT773942	hsa-miR-1273f	CLIP-seq
MIRT773943	hsa-miR-1286	CLIP-seq
MIRT773944	hsa-miR-1909	CLIP-seq
MIRT773945	hsa-miR-2392	CLIP-seq
MIRT773946	hsa-miR-3190	CLIP-seq
MIRT773947	hsa-miR-3202	CLIP-seq
MIRT773948	hsa-miR-34a	CLIP-seq
MIRT773949	hsa-miR-34c-5p	CLIP-seq
MIRT773950	hsa-miR-3689d	CLIP-seq
MIRT773951	hsa-miR-4279	CLIP-seq
MIRT773952	hsa-miR-4282	CLIP-seq
MIRT773953	hsa-miR-4436b-3p	CLIP-seq
MIRT773954	hsa-miR-4484	CLIP-seq
MIRT773955	hsa-miR-4493	CLIP-seq
MIRT773956	hsa-miR-449a	CLIP-seq
MIRT773957	hsa-miR-449b	CLIP-seq
MIRT773958	hsa-miR-4509	CLIP-seq
MIRT773959	hsa-miR-4533	CLIP-seq
MIRT773960	hsa-miR-4753-5p	CLIP-seq
MIRT773961	hsa-miR-4802-5p	CLIP-seq
MIRT773962	hsa-miR-485-5p	CLIP-seq
MIRT773963	hsa-miR-488	CLIP-seq
MIRT773964	hsa-miR-506	CLIP-seq
MIRT773965	hsa-miR-516a-3p	CLIP-seq
MIRT773966	hsa-miR-548an	CLIP-seq
MIRT773967	hsa-miR-106a	CLIP-seq
MIRT773968	hsa-miR-106b	CLIP-seq
MIRT773969	hsa-miR-1303	CLIP-seq
MIRT773970	hsa-miR-17	CLIP-seq
MIRT773971	hsa-miR-192	CLIP-seq
MIRT773972	hsa-miR-20a	CLIP-seq
MIRT773973	hsa-miR-20b	CLIP-seq
MIRT773974	hsa-miR-215	CLIP-seq
MIRT773975	hsa-miR-302a	CLIP-seq
MIRT773976	hsa-miR-302b	CLIP-seq
MIRT773977	hsa-miR-302c	CLIP-seq
MIRT773978	hsa-miR-302d	CLIP-seq
MIRT773979	hsa-miR-302e	CLIP-seq
MIRT773980	hsa-miR-3200-3p	CLIP-seq
MIRT773981	hsa-miR-3609	CLIP-seq
MIRT773982	hsa-miR-372	CLIP-seq
MIRT773983	hsa-miR-373	CLIP-seq
MIRT773984	hsa-miR-4473	CLIP-seq
MIRT773985	hsa-miR-4671-3p	CLIP-seq
MIRT773986	hsa-miR-4720-3p	CLIP-seq
MIRT773987	hsa-miR-4731-5p	CLIP-seq
MIRT773988	hsa-miR-4796-3p	CLIP-seq
MIRT773989	hsa-miR-512-3p	CLIP-seq
MIRT773990	hsa-miR-519d	CLIP-seq
MIRT773991	hsa-miR-520a-3p	CLIP-seq
MIRT773992	hsa-miR-520b	CLIP-seq
MIRT773993	hsa-miR-520c-3p	CLIP-seq
MIRT773994	hsa-miR-520d-3p	CLIP-seq
MIRT773995	hsa-miR-520e	CLIP-seq
MIRT773996	hsa-miR-520f	CLIP-seq
MIRT773997	hsa-miR-548ah	CLIP-seq
MIRT773998	hsa-miR-649	CLIP-seq
MIRT773999	hsa-miR-93	CLIP-seq
MIRT773939	hsa-miR-1205	CLIP-seq
MIRT1928409	hsa-miR-1207-5p	CLIP-seq
MIRT1928410	hsa-miR-1254	CLIP-seq
MIRT1928411	hsa-miR-1827	CLIP-seq
MIRT773944	hsa-miR-1909	CLIP-seq
MIRT1928412	hsa-miR-3116	CLIP-seq
MIRT1928413	hsa-miR-330-3p	CLIP-seq
MIRT1928414	hsa-miR-3612	CLIP-seq
MIRT1928415	hsa-miR-3665	CLIP-seq
MIRT1928416	hsa-miR-4252	CLIP-seq
MIRT1928417	hsa-miR-4459	CLIP-seq
MIRT773958	hsa-miR-4509	CLIP-seq
MIRT1928418	hsa-miR-4695-5p	CLIP-seq
MIRT1928419	hsa-miR-4763-3p	CLIP-seq
MIRT1928420	hsa-miR-549	CLIP-seq
MIRT1928421	hsa-miR-558	CLIP-seq
MIRT1928422	hsa-miR-650	CLIP-seq
MIRT1928423	hsa-miR-657	CLIP-seq
MIRT1928424	hsa-miR-661	CLIP-seq
MIRT773939	hsa-miR-1205	CLIP-seq
MIRT2169180	hsa-miR-128	CLIP-seq
MIRT2169181	hsa-miR-1343	CLIP-seq
MIRT1928411	hsa-miR-1827	CLIP-seq
MIRT2169182	hsa-miR-3176	CLIP-seq
MIRT2169183	hsa-miR-3192	CLIP-seq
MIRT1928413	hsa-miR-330-3p	CLIP-seq
MIRT2169184	hsa-miR-3545-3p	CLIP-seq
MIRT1928414	hsa-miR-3612	CLIP-seq
MIRT2169185	hsa-miR-3663-5p	CLIP-seq
MIRT1928415	hsa-miR-3665	CLIP-seq
MIRT2169186	hsa-miR-3689a-3p	CLIP-seq
MIRT2169187	hsa-miR-3689c	CLIP-seq
MIRT2169188	hsa-miR-378g	CLIP-seq
MIRT2169189	hsa-miR-3922-3p	CLIP-seq
MIRT1928416	hsa-miR-4252	CLIP-seq
MIRT2169190	hsa-miR-4446-3p	CLIP-seq
MIRT1928417	hsa-miR-4459	CLIP-seq
MIRT2169191	hsa-miR-4656	CLIP-seq
MIRT2169192	hsa-miR-4663	CLIP-seq
MIRT773985	hsa-miR-4671-3p	CLIP-seq
MIRT2169193	hsa-miR-4680-5p	CLIP-seq
MIRT1928418	hsa-miR-4695-5p	CLIP-seq
MIRT773986	hsa-miR-4720-3p	CLIP-seq
MIRT2169194	hsa-miR-4721	CLIP-seq
MIRT2169195	hsa-miR-4728-5p	CLIP-seq
MIRT1928420	hsa-miR-549	CLIP-seq
MIRT1928421	hsa-miR-558	CLIP-seq
MIRT2169196	hsa-miR-602	CLIP-seq
MIRT1928422	hsa-miR-650	CLIP-seq
MIRT1928423	hsa-miR-657	CLIP-seq
MIRT1928424	hsa-miR-661	CLIP-seq
MIRT773958	hsa-miR-4509	CLIP-seq
MIRT773939	hsa-miR-1205	CLIP-seq
MIRT1928409	hsa-miR-1207-5p	CLIP-seq
MIRT2471793	hsa-miR-1226	CLIP-seq
MIRT773941	hsa-miR-1265	CLIP-seq
MIRT773943	hsa-miR-1286	CLIP-seq
MIRT2169181	hsa-miR-1343	CLIP-seq
MIRT773944	hsa-miR-1909	CLIP-seq
MIRT773945	hsa-miR-2392	CLIP-seq
MIRT2471794	hsa-miR-2861	CLIP-seq
MIRT2471795	hsa-miR-3117-5p	CLIP-seq
MIRT2471796	hsa-miR-3179	CLIP-seq
MIRT2471797	hsa-miR-3189-3p	CLIP-seq
MIRT2169183	hsa-miR-3192	CLIP-seq
MIRT2169186	hsa-miR-3689a-3p	CLIP-seq
MIRT2169187	hsa-miR-3689c	CLIP-seq
MIRT773951	hsa-miR-4279	CLIP-seq
MIRT2471798	hsa-miR-4314	CLIP-seq
MIRT773953	hsa-miR-4436b-3p	CLIP-seq
MIRT1928417	hsa-miR-4459	CLIP-seq
MIRT773958	hsa-miR-4509	CLIP-seq
MIRT2471799	hsa-miR-4512	CLIP-seq
MIRT2471800	hsa-miR-4646-5p	CLIP-seq
MIRT2471801	hsa-miR-4691-3p	CLIP-seq
MIRT2169195	hsa-miR-4728-5p	CLIP-seq
MIRT2471802	hsa-miR-4733-3p	CLIP-seq
MIRT2471803	hsa-miR-4744	CLIP-seq
MIRT1928419	hsa-miR-4763-3p	CLIP-seq
MIRT2471804	hsa-miR-4779	CLIP-seq
MIRT2471805	hsa-miR-4794	CLIP-seq
MIRT773962	hsa-miR-485-5p	CLIP-seq
MIRT2471806	hsa-miR-548m	CLIP-seq
MIRT2471807	hsa-miR-593	CLIP-seq
MIRT2471808	hsa-miR-635	CLIP-seq
MIRT2471809	hsa-miR-665	CLIP-seq
MIRT1928409	hsa-miR-1207-5p	CLIP-seq
MIRT2471793	hsa-miR-1226	CLIP-seq
MIRT773941	hsa-miR-1265	CLIP-seq
MIRT2674770	hsa-miR-1266	CLIP-seq
MIRT773944	hsa-miR-1909	CLIP-seq
MIRT2674771	hsa-miR-1915	CLIP-seq
MIRT773945	hsa-miR-2392	CLIP-seq
MIRT2674772	hsa-miR-3127-5p	CLIP-seq
MIRT2674773	hsa-miR-3155	CLIP-seq
MIRT2674774	hsa-miR-3155b	CLIP-seq
MIRT2471797	hsa-miR-3189-3p	CLIP-seq
MIRT2169183	hsa-miR-3192	CLIP-seq
MIRT2674775	hsa-miR-3613-3p	CLIP-seq
MIRT2674776	hsa-miR-3664-3p	CLIP-seq
MIRT2169186	hsa-miR-3689a-3p	CLIP-seq
MIRT2169187	hsa-miR-3689c	CLIP-seq
MIRT2674777	hsa-miR-3918	CLIP-seq
MIRT773951	hsa-miR-4279	CLIP-seq
MIRT773952	hsa-miR-4282	CLIP-seq
MIRT2471798	hsa-miR-4314	CLIP-seq
MIRT1928417	hsa-miR-4459	CLIP-seq
MIRT773958	hsa-miR-4509	CLIP-seq
MIRT2471799	hsa-miR-4512	CLIP-seq
MIRT2674778	hsa-miR-4518	CLIP-seq
MIRT2471800	hsa-miR-4646-5p	CLIP-seq
MIRT2674779	hsa-miR-4726-3p	CLIP-seq
MIRT2169195	hsa-miR-4728-5p	CLIP-seq
MIRT2471802	hsa-miR-4733-3p	CLIP-seq
MIRT2471803	hsa-miR-4744	CLIP-seq
MIRT1928419	hsa-miR-4763-3p	CLIP-seq
MIRT2471804	hsa-miR-4779	CLIP-seq
MIRT2674780	hsa-miR-484	CLIP-seq
MIRT2674781	hsa-miR-486-5p	CLIP-seq
MIRT773963	hsa-miR-488	CLIP-seq
MIRT773965	hsa-miR-516a-3p	CLIP-seq
MIRT2471806	hsa-miR-548m	CLIP-seq
MIRT2471808	hsa-miR-635	CLIP-seq
MIRT2471809	hsa-miR-665	CLIP-seq
MIRT2674782	hsa-miR-720	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
AHR	Activation	18848529

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription cis-regulatory region binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0004879	Function	Nuclear receptor activity	IBA
GO:0005515	Function	Protein binding	IPI	28904176
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006805	Process	Xenobiotic metabolic process	IEA
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0030522	Process	Intracellular receptor signaling pathway	IEA
GO:0034751	Component	Aryl hydrocarbon receptor complex	IBA
GO:0046983	Function	Protein dimerization activity	IEA

MIM	HGNC	e!Ensembl
606517	346	ENSG00000063438

Protein

UniProt ID

A9YTQ3

Protein name

Aryl hydrocarbon receptor repressor (AhR repressor) (AhRR) (Class E basic helix-loop-helix protein 77) (bHLHe77)

Protein function

Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding t

PDB

5Y7Y

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00010	HLH	33 → 80	Helix-loop-helix DNA-binding domain	Domain
PF00989	PAS	114 → 187	PAS fold	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue fro

Sequence

MPRTMIPPGECTYAGRKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAELDHLASLLPFPPD
IISKLDKLSVLRLSVSYLRVKSFFQVVQEQSSRQPAAGAPSPGDSCPLAGSAVLEGRLLL
ESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMD
PPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRCFICRVRCLLDSTSGFL
TMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADT
AATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCL
RGGPDLVLDPKGGSGDREEEQHRMLSRASGVTGRRETPGPTKPLPWTAGKHSEDGARPRL
QPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVGEDQV
HPPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKME
KDSGCEGAADGCVPSQVWLGASDRSHPATFPTRMHLKTEPDSRQQVYISHLGHGVRGAQP
HGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAAPVVK
REPLDSPQWATHSQGMVPGMLPKSALATLVPPQASGCTFLP

Sequence length

701

Interactions

View interactions

	Reactome
			PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Alzheimer disease	Alzheimer's disease or family history of Alzheimer's disease	N/A	N/A	GWAS
Breast Cancer	Breast cancer	N/A	N/A	GWAS

Show/Hide Text Mining Associations (42)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	32928150
Angiofibroma	Associate	22337624, 27633981, 37680034
Arthritis Rheumatoid	Associate	28403070, 34302046, 35309329
Atherosclerosis	Associate	30915882, 35039093
Azoospermia	Associate	17559847
Breast Neoplasms	Inhibit	16755028
Breast Neoplasms	Associate	28681081
Carcinogenesis	Associate	22412903, 36093686
Cardiovascular Diseases	Associate	31369996
Chromosome Aberrations	Associate	23344457
Cleft Palate	Stimulate	28425186
Colitis Ulcerative	Associate	38001042, 38238335
Crohn Disease	Associate	38001042
Dermatitis Atopic	Associate	31868801
Endometriosis	Associate	16084889, 17513317, 19501819, 32295439
Essential Hypertension	Associate	27977510
Gallbladder Neoplasms	Inhibit	32801256
Hepatitis Autoimmune	Associate	32663496
Infertility Male	Associate	15474075, 17559847
Inflammation	Associate	28393844
Inflammatory Bowel Diseases	Associate	38238335
Lung Diseases	Associate	30343628, 30915882
Lung Neoplasms	Associate	27632354, 27924164, 28100713, 28453567, 29262847, 29722794, 30730943, 31060609, 31369996, 32962699, 37150141, 37442331, 37691855
Lymphoma Non Hodgkin	Associate	37691855
Mitochondrial Diseases	Associate	36359818
Mouth Neoplasms	Associate	23648678
Neoplasm Metastasis	Inhibit	32801256
Neoplasms	Inhibit	22232023, 22952704, 28056099, 32801256
Neoplasms	Associate	23583445, 23648678, 27633981, 29722794, 34570895
Obesity	Associate	26252179
Obesity Maternal	Associate	26252179
Oligospermia	Associate	17559847
Ovarian Neoplasms	Associate	37511212
Penis agenesis	Associate	15758562
Polycystic Ovary Syndrome	Associate	33124502
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	6946844
Pulmonary Disease Chronic Obstructive	Associate	28100713, 30940135, 36359818
Sleep Initiation and Maintenance Disorders	Associate	23768840, 36219910
Sleep Wake Disorders	Associate	23768840
Smoke Inhalation Injury	Associate	28453567, 36359818
Stomach Neoplasms	Inhibit	22952704
Urinary Bladder Neoplasms	Associate	36093686

AHRR (aryl hydrocarbon receptor repressor)