Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57480
Gene name Gene Name - the full gene name approved by the HGNC.	Pleckstrin homology and RhoGEF domain containing G1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PLEKHG1
Synonyms (NCBI Gene) Gene synonyms aliases	ARHGEF41
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q25.1

Show/Hide all(97)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016820	hsa-miR-335-5p	Microarray	18185580
MIRT535163	hsa-miR-498	PAR-CLIP	22012620
MIRT535163	hsa-miR-498	PAR-CLIP	22012620
MIRT1241754	hsa-miR-1908	CLIP-seq
MIRT1241755	hsa-miR-205	CLIP-seq
MIRT1241756	hsa-miR-24	CLIP-seq
MIRT1241757	hsa-miR-3148	CLIP-seq
MIRT1241758	hsa-miR-3157-5p	CLIP-seq
MIRT1241759	hsa-miR-3161	CLIP-seq
MIRT1241760	hsa-miR-3613-3p	CLIP-seq
MIRT1241761	hsa-miR-3934	CLIP-seq
MIRT1241762	hsa-miR-4284	CLIP-seq
MIRT1241763	hsa-miR-4297	CLIP-seq
MIRT1241764	hsa-miR-4662a-5p	CLIP-seq
MIRT1241765	hsa-miR-4676-5p	CLIP-seq
MIRT1241766	hsa-miR-4686	CLIP-seq
MIRT1241767	hsa-miR-4691-3p	CLIP-seq
MIRT1241768	hsa-miR-4743	CLIP-seq
MIRT1241769	hsa-miR-4753-3p	CLIP-seq
MIRT1241770	hsa-miR-4767	CLIP-seq
MIRT1241771	hsa-miR-4768-5p	CLIP-seq
MIRT1241772	hsa-miR-495	CLIP-seq
MIRT1241773	hsa-miR-548aa	CLIP-seq
MIRT1241774	hsa-miR-548ac	CLIP-seq
MIRT1241775	hsa-miR-548d-3p	CLIP-seq
MIRT1241776	hsa-miR-548z	CLIP-seq
MIRT1241777	hsa-miR-566	CLIP-seq
MIRT1241778	hsa-miR-575	CLIP-seq
MIRT1241779	hsa-miR-578	CLIP-seq
MIRT1241780	hsa-miR-579	CLIP-seq
MIRT1241781	hsa-miR-663	CLIP-seq
MIRT1241782	hsa-miR-873	CLIP-seq
MIRT2071180	hsa-miR-129-5p	CLIP-seq
MIRT2071181	hsa-miR-4423-5p	CLIP-seq
MIRT2071182	hsa-miR-4768-3p	CLIP-seq
MIRT2298405	hsa-miR-1305	CLIP-seq
MIRT2298406	hsa-miR-3612	CLIP-seq
MIRT2298407	hsa-miR-3689d	CLIP-seq
MIRT2298408	hsa-miR-421	CLIP-seq
MIRT2298409	hsa-miR-4433	CLIP-seq
MIRT2298410	hsa-miR-4443	CLIP-seq
MIRT2298411	hsa-miR-4459	CLIP-seq
MIRT2298412	hsa-miR-4709-5p	CLIP-seq
MIRT1241768	hsa-miR-4743	CLIP-seq
MIRT2071182	hsa-miR-4768-3p	CLIP-seq
MIRT2298413	hsa-miR-4772-5p	CLIP-seq
MIRT2298414	hsa-miR-485-5p	CLIP-seq
MIRT2298415	hsa-miR-5096	CLIP-seq
MIRT1241779	hsa-miR-578	CLIP-seq
MIRT1241780	hsa-miR-579	CLIP-seq
MIRT2298416	hsa-miR-650	CLIP-seq
MIRT2298417	hsa-miR-656	CLIP-seq
MIRT2298418	hsa-miR-664	CLIP-seq
MIRT2392655	hsa-miR-1827	CLIP-seq
MIRT2392656	hsa-miR-335	CLIP-seq
MIRT2392657	hsa-miR-3929	CLIP-seq
MIRT2392658	hsa-miR-4272	CLIP-seq
MIRT2392659	hsa-miR-4419b	CLIP-seq
MIRT2392660	hsa-miR-4478	CLIP-seq
MIRT2392661	hsa-miR-4649-3p	CLIP-seq
MIRT1241770	hsa-miR-4767	CLIP-seq
MIRT2298414	hsa-miR-485-5p	CLIP-seq
MIRT1241777	hsa-miR-566	CLIP-seq
MIRT2456647	hsa-miR-3140-3p	CLIP-seq
MIRT2456648	hsa-miR-3167	CLIP-seq
MIRT2456649	hsa-miR-3662	CLIP-seq
MIRT2456650	hsa-miR-4328	CLIP-seq
MIRT2456651	hsa-miR-4456	CLIP-seq
MIRT2456652	hsa-miR-4654	CLIP-seq
MIRT2456653	hsa-miR-4698	CLIP-seq
MIRT2456654	hsa-miR-4711-5p	CLIP-seq
MIRT2456655	hsa-miR-4769-5p	CLIP-seq
MIRT2456656	hsa-miR-541	CLIP-seq
MIRT2456657	hsa-miR-544	CLIP-seq
MIRT2456658	hsa-miR-654-5p	CLIP-seq
MIRT2456659	hsa-miR-876-5p	CLIP-seq
MIRT2392655	hsa-miR-1827	CLIP-seq
MIRT2595550	hsa-miR-3192	CLIP-seq
MIRT2595551	hsa-miR-326	CLIP-seq
MIRT2595552	hsa-miR-330-5p	CLIP-seq
MIRT2595553	hsa-miR-3689a-3p	CLIP-seq
MIRT2595554	hsa-miR-3689c	CLIP-seq
MIRT2595555	hsa-miR-4314	CLIP-seq
MIRT2595556	hsa-miR-4646-5p	CLIP-seq
MIRT2595557	hsa-miR-4728-5p	CLIP-seq
MIRT2392655	hsa-miR-1827	CLIP-seq
MIRT2595550	hsa-miR-3192	CLIP-seq
MIRT2595551	hsa-miR-326	CLIP-seq
MIRT2595552	hsa-miR-330-5p	CLIP-seq
MIRT2595553	hsa-miR-3689a-3p	CLIP-seq
MIRT2595554	hsa-miR-3689c	CLIP-seq
MIRT2688088	hsa-miR-410	CLIP-seq
MIRT2595555	hsa-miR-4314	CLIP-seq
MIRT2595556	hsa-miR-4646-5p	CLIP-seq
MIRT2456653	hsa-miR-4698	CLIP-seq
MIRT2688089	hsa-miR-4719	CLIP-seq
MIRT2595557	hsa-miR-4728-5p	CLIP-seq

Show/Hide all(8)

GO ID	Ontology	Definition	Evidence
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0031267	Function	Small GTPase binding	IBA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS

MIM	HGNC	e!Ensembl
620134	20884	ENSG00000120278

Protein

UniProt ID

Q9ULL1

Protein name

Pleckstrin homology domain-containing family G member 1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00621	RhoGEF	117 → 291	RhoGEF domain	Domain

Sequence

MELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPAR
PFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQE
ILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENC
ENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLP
LGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHA
VRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLLLITKKRDDTFTY
KAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHA
AKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSRSHKVLK
TSETAQDIQKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWTDHQIRQ
ALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLCEDSTSSRPCSWHMGQMESTETSS
SGHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTIDDIDHV
YDNISYEDLKLMVAKREEAESTPSKSARDSVRPKSTPELAFTKRQAGHSKGSLYAQTDGT
LSGGEASSQSTHELQAVEENIYDTIGLPDPPSLGFKCSSLKRAKRSTFLGLEADFVCCDS
LRPFVSQDSLQLSEDEAPYHQATPDHGYLSLLYDSPSGNLSMPHKPVSDKLSEEVDEIWN
DLENYIKKNEDKARDRLLAAFPVSKDDVPDRLHAESTPELSRDVGRSVSTLSLPESQALL
TPVKSRAGRASRANCPFEEDLISKEGSFMSLNRLSLASEMPLMDNPYDLANSGLSQTDPE
NPDLGMEATDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKSMHKDLAAI
LEEKKQGGPAIGARIAEYSQLYDQIVFRESPLKIQKDGWASPQESSLLRSVSPSQVHHGS
GDWLLHSTYSNGELADFCLPPEQDLRSRYPTFEINTKSTPRQLSAACSVPSLQTSDPLPG
SVQRCSVVVSQPNKENWCQDHLYNSLGRKGISAKSQPYHRSQSSSSVLINKSMDSINYPS
DVGKQQLLSLHRSSRCESHQDLLPDIADSHQQGTEKLSDLTLQDSQKVVVVNRNLPLNAQ
IATQNYFSNFKETDGDEDDYVEIKSEEDESELELSHNRRRKSDSKFVDADFSDNVCSGNT
LHSLNSPRTPKKPVNSKLGLSPYLTPYNDSDKLNDYLWRGPSPNQQNIVQSLREKFQCLS
SSSFA

Sequence length

1385

Interactions

View interactions

Show/Hide Unknown Diseases (6)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Hypertension	High blood pressure / hypertension, Hypertension (PheCode 401), Essential hypertension (PheCode 401.1), Hypertension, Hypertension (confirmatory factor analysis Factor 12)	N/A	N/A	GWAS
Myocardial Infarction	Myocardial infarction	N/A	N/A	GWAS
Panic Disorder	Panic disorder	N/A	N/A	GWAS
Periventricular Leukomalacia	periventricular leukomalacia	N/A	N/A	GenCC

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Carotid Artery Injuries	Associate	30659137
Cerebral Infarction	Associate	30659137
Heart Murmurs	Associate	34793544
Leukoencephalopathies	Associate	30659137, 39202455
Leukomalacia Periventricular	Associate	39202455
Neoplasms	Associate	36335125
Neurologic Manifestations	Associate	29967039
Pre Eclampsia	Associate	29967039
Waldenstrom Macroglobulinemia	Associate	24366360

PLEKHG1 (pleckstrin homology and RhoGEF domain containing G1)