Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
57476
Gene name Gene Name - the full gene name approved by the HGNC.
GRAM domain containing 1B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GRAMD1B
Synonyms (NCBI Gene) Gene synonyms aliases
LINC01059
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q24.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT716051 hsa-miR-877-3p HITS-CLIP 19536157
MIRT716050 hsa-miR-2116-3p HITS-CLIP 19536157
MIRT716049 hsa-miR-4691-5p HITS-CLIP 19536157
MIRT716048 hsa-miR-6792-3p HITS-CLIP 19536157
MIRT716047 hsa-miR-6749-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001786 Function Phosphatidylserine binding ISS
GO:0005783 Component Endoplasmic reticulum IEA
GO:0005789 Component Endoplasmic reticulum membrane IBA
GO:0005789 Component Endoplasmic reticulum membrane IDA 30220461
GO:0005789 Component Endoplasmic reticulum membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
620179 29214 ENSG00000023171
Protein
UniProt ID Q3KR37
Protein name Protein Aster-B (GRAM domain-containing protein 1B)
Protein function Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecu
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02893 GRAM 96 205 GRAM domain Domain
PF16016 VASt 375 523 VAD1 Analog of StAR-related lipid transfer domain Domain
Sequence
MKGFKLSCTASNSNRSTPACSPILRKRSRSPTPQNQDGDTMVEKGSDHSSDKSPSTPEQG
VQRSCSSQSGRSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQ
RDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEK
HFFTSFGARDRTYMMMFRLWQNALL
EKPLCPKELWHFVHQCYGNELGLTSDDEDYVPPDD
DFNTMGYCEEIPVEENEVNDSSSKSSIETKPDASPQLPKKSITNSTLTSTGSSEAPVSFD
GLPLEEEALEGDGSLEKELAIDNIMGEKIEMIAPVNSPSLDFNDNEDIPTELSDSSDTHD
EGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFQRDFMEQRRFSDIIFHPWKKEE
NGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYT
INRYTLTRVARNKSRLRVSTELRYRKQPWGLVKTFIEKNFWSG
LEDYFRHLESELAKTES
TYLAEMHRQSPKEKASKTTTVRRRKRPHAHLRVPHLEEVMSPVTTPTDEDVGHRIKHVAG
STQTRHIPEDTPNGFHLQSVSKLLLVISCVICFSLVLLVILNMMLFYKLWMLEYTTQTLT
AWQGLRLQERLPQSQTEWAQLLESQQKYHDTELQKWREIIKSSVMLLDQMKDSLINLQNG
IRSRDYTSESEEKRNRYH
Sequence length 738
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Alzheimer disease Alzheimer's disease or family history of Alzheimer's disease N/A N/A GWAS
Breast Cancer Response to chemotherapy in breast cancer (hypertension) (bevacizumab), Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) N/A N/A GWAS
Follicular lymphoma Follicular lymphoma N/A N/A GWAS
Lymphocytic Leukemia Chronic lymphocytic leukemia N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 32132097
Breast Neoplasms Associate 29934528
Carcinoma Non Small Cell Lung Associate 36056349
Glioma Stimulate 35676651
Inflammation Associate 36553660
Intellectual Disability Associate 33604931
Leukemia B Cell Associate 20855867
Leukemia Lymphocytic Chronic B Cell Associate 20332261, 20639881, 20855867, 29547969
Leukemia Prolymphocytic T Cell Associate 20553269
Multiple Sclerosis Associate 36553660