Gene Gene information from NCBI Gene database.
Entrez ID 57474
Gene name Zinc finger protein 490
Gene symbol ZNF490
Synonyms (NCBI Gene)
-
Chromosome 19
Chromosome location 19p13.2-p13.13
miRNA miRNA information provided by mirtarbase database.
1322
miRTarBase ID miRNA Experiments Reference
MIRT021674 hsa-miR-140-3p Sequencing 20371350
MIRT022083 hsa-miR-128-3p Sequencing 20371350
MIRT025991 hsa-miR-148a-3p Sequencing 20371350
MIRT718754 hsa-miR-217 HITS-CLIP 19536157
MIRT718753 hsa-miR-6807-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
GO ID Ontology Definition Evidence Reference
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 21516116, 25416956, 31515488, 32296183
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
620118 23705 ENSG00000188033
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9ULM2
Protein name Zinc finger protein 490
Protein function May be involved in transcriptional regulation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01352 KRAB 56 97 KRAB box Family
PF13912 zf-C2H2_6 157 181 Domain
PF00096 zf-C2H2 194 216 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 222 244 Zinc finger, C2H2 type Domain
PF13912 zf-C2H2_6 250 275 Domain
PF13912 zf-C2H2_6 278 303 Domain
PF13894 zf-C2H2_4 306 329 Domain
PF00096 zf-C2H2 334 356 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 362 384 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 390 412 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 446 468 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 502 524 Zinc finger, C2H2 type Domain
Sequence
MRRNSSLSFQMERPLEEQVQSKWSSSQGRTGTGGSDVLQMQNSEHHGQSIKTQTDSISLE
DVAVNFTLEEWALLDPGQRNIYRDVMRATFKNLACIG
EKWKDQDIEDEHKNQGRNLRSPM
VEALCENKEDCPCGKSTSQIPDLNTNLETPTGLKPCDCSVCGEVFMHQVSLNRHMRSHTE
Q
KPNECHEYGEKPHKCKECGKTFTRSSSIRTHERIHTGEKPYECKECGKAFAFLFSFRNH
IRIH
TGETPYECKECGKAFRYLTALRRHEKNHTGEKPYKCKQCGKAFIYYQPFLTHERTH
TGE
KPYECKQCGKAFSCPTYLRSHEKTHTGEKPFVCRECGRAFFSHSSLRKHVKTHTGVQ
PYTCKKCGEAFKSSSSCEVHERTHFGEKPYECKQCGKAFNSSSYLQLHERVHTGEKTYEC
KECGKAFLYSTHFRIHERTHTREKPYECKQCGRVFIYFSHLRRHERSHTGVKPCECKQCG
KAFTCLNSLKVHKRIHTGERPFQCRQCGKAFSYSKSLHVHERTHSRQKP
Sequence length 529
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Generic Transcription Pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EMPHYSEMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MALE INFERTILITY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Colorectal Neoplasms Associate 24146633
★☆☆☆☆
Found in Text Mining only