Gene Gene information from NCBI Gene database.
Entrez ID 57460
Gene name Protein phosphatase, Mg2+/Mn2+ dependent 1H
Gene symbol PPM1H
Synonyms (NCBI Gene)
ARHCL1NERPP-2CURCC2
Chromosome 12
Chromosome location 12q14.1-q14.2
miRNA miRNA information provided by mirtarbase database.
836
miRTarBase ID miRNA Experiments Reference
MIRT017161 hsa-miR-335-5p Microarray 18185580
MIRT023606 hsa-miR-1-3p Microarray 18668037
MIRT048785 hsa-miR-93-5p CLASH 23622248
MIRT047932 hsa-miR-30c-5p CLASH 23622248
MIRT046778 hsa-miR-222-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
GO ID Ontology Definition Evidence Reference
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004721 Function Phosphoprotein phosphatase activity IMP 22586611
GO:0004722 Function Protein serine/threonine phosphatase activity IEA
GO:0004741 Function [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IBA
GO:0005515 Function Protein binding IPI 31663853
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616016 18583 ENSG00000111110
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9ULR3
Protein name Protein phosphatase 1H (EC 3.1.3.16)
Protein function Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.
PDB 7KPR , 7L4I , 7L4J , 7N0Z
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00481 PP2C 221 324 Protein phosphatase 2C Family
PF00481 PP2C 365 480 Protein phosphatase 2C Family
Sequence
MLTRVKSAVANFMGGIMAGSSGSEHGGGSCGGSDLPLRFPYGRPEFLGLSQDEVECSADH
IARPILILKETRRLPWATGYAEVINAGKSTHNEDQASCEVLTVKKKAGAVTSTPNRNSSK
RRSSLPNGEGLQLKENSESEGVSCHYWSLFDGHAGSGAAVVASRLLQHHITEQLQDIVDI
LKNSAVLPPTCLGEEPENTPANSRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECL
VIGALESAFKEMDLQIERERSSYNISGGCTALIVICLLGKLYVANAGDSRAIIIRNGEII
PMSSEFTPETERQRLQYLAFMQPH
LLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAY
KTIEDEDLKFPLIYGEGKKARVMATIGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRIYD
LSKYDHGSDDVLILATDGLWDVLSNEEVAEAITQFLPNCDPDDPHRYTLAAQDLVMRARG

VLKDRGWRISNDRLGSGDDISVYVIPLIHGNKLS
Sequence length 514
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Lung cancer Uncertain significance rs762157400 RCV005932707
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Attention Deficit Disorder with Hyperactivity Associate 20732627
Colonic Neoplasms Associate 18059182
Colorectal Neoplasms Associate 30988394
Death Stimulate 18059182
Lupus Erythematosus Systemic Associate 20659327, 30685201
Neoplasms Associate 18059182, 30988394