Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57448
Gene name Gene Name - the full gene name approved by the HGNC.	Baculoviral IAP repeat containing 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	BIRC6
Synonyms (NCBI Gene) Gene synonyms aliases	APOLLON, BRUCE
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p22.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubi

Show/Hide all(162)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005001	hsa-miR-218-5p	Luciferase reporter assay, qRT-PCR	19890957
MIRT004956	hsa-let-7b-5p	qRT-PCR	17942906
MIRT052603	hsa-let-7a-5p	CLASH	23622248
MIRT052603	hsa-let-7a-5p	CLASH	23622248
MIRT047374	hsa-miR-34a-5p	CLASH	23622248
MIRT039908	hsa-miR-615-3p	CLASH	23622248
MIRT039908	hsa-miR-615-3p	CLASH	23622248
MIRT437461	ebv-miR-BART15	Luciferase reporter assay	23678170
MIRT437461	ebv-miR-BART15	Luciferase reporter assay	23678170
MIRT437461	ebv-miR-BART15	Luciferase reporter assay	23678170
MIRT047374	hsa-miR-34a-5p	PCR array	28097098
MIRT821651	hsa-miR-1243	CLIP-seq
MIRT821652	hsa-miR-181a	CLIP-seq
MIRT821653	hsa-miR-181b	CLIP-seq
MIRT821654	hsa-miR-181c	CLIP-seq
MIRT821655	hsa-miR-181d	CLIP-seq
MIRT821656	hsa-miR-196a	CLIP-seq
MIRT821657	hsa-miR-196b	CLIP-seq
MIRT821658	hsa-miR-204	CLIP-seq
MIRT821659	hsa-miR-211	CLIP-seq
MIRT821660	hsa-miR-30a	CLIP-seq
MIRT821661	hsa-miR-30b	CLIP-seq
MIRT821662	hsa-miR-30c	CLIP-seq
MIRT821663	hsa-miR-30d	CLIP-seq
MIRT821664	hsa-miR-30e	CLIP-seq
MIRT821665	hsa-miR-3124-3p	CLIP-seq
MIRT821666	hsa-miR-3149	CLIP-seq
MIRT821667	hsa-miR-3685	CLIP-seq
MIRT821668	hsa-miR-384	CLIP-seq
MIRT821669	hsa-miR-3945	CLIP-seq
MIRT821670	hsa-miR-4262	CLIP-seq
MIRT821671	hsa-miR-4274	CLIP-seq
MIRT821672	hsa-miR-4328	CLIP-seq
MIRT821673	hsa-miR-4446-5p	CLIP-seq
MIRT821674	hsa-miR-4452	CLIP-seq
MIRT821675	hsa-miR-4519	CLIP-seq
MIRT821676	hsa-miR-4719	CLIP-seq
MIRT821677	hsa-miR-4731-3p	CLIP-seq
MIRT821678	hsa-miR-4755-5p	CLIP-seq
MIRT821679	hsa-miR-4761-3p	CLIP-seq
MIRT821680	hsa-miR-4789-5p	CLIP-seq
MIRT821681	hsa-miR-4801	CLIP-seq
MIRT821682	hsa-miR-543	CLIP-seq
MIRT821683	hsa-miR-548aa	CLIP-seq
MIRT821684	hsa-miR-548ag	CLIP-seq
MIRT821685	hsa-miR-548ai	CLIP-seq
MIRT821686	hsa-miR-548g	CLIP-seq
MIRT821687	hsa-miR-568	CLIP-seq
MIRT821688	hsa-miR-600	CLIP-seq
MIRT821689	hsa-miR-623	CLIP-seq
MIRT821690	hsa-miR-653	CLIP-seq
MIRT821651	hsa-miR-1243	CLIP-seq
MIRT1942887	hsa-miR-130a	CLIP-seq
MIRT1942888	hsa-miR-130b	CLIP-seq
MIRT1942889	hsa-miR-183	CLIP-seq
MIRT821656	hsa-miR-196a	CLIP-seq
MIRT821657	hsa-miR-196b	CLIP-seq
MIRT821658	hsa-miR-204	CLIP-seq
MIRT821659	hsa-miR-211	CLIP-seq
MIRT1942890	hsa-miR-300	CLIP-seq
MIRT1942891	hsa-miR-301a	CLIP-seq
MIRT1942892	hsa-miR-301b	CLIP-seq
MIRT821665	hsa-miR-3124-3p	CLIP-seq
MIRT821666	hsa-miR-3149	CLIP-seq
MIRT1942893	hsa-miR-3666	CLIP-seq
MIRT821667	hsa-miR-3685	CLIP-seq
MIRT1942894	hsa-miR-381	CLIP-seq
MIRT821668	hsa-miR-384	CLIP-seq
MIRT1942895	hsa-miR-3925-3p	CLIP-seq
MIRT821669	hsa-miR-3945	CLIP-seq
MIRT821671	hsa-miR-4274	CLIP-seq
MIRT1942896	hsa-miR-4295	CLIP-seq
MIRT821672	hsa-miR-4328	CLIP-seq
MIRT821673	hsa-miR-4446-5p	CLIP-seq
MIRT821674	hsa-miR-4452	CLIP-seq
MIRT821675	hsa-miR-4519	CLIP-seq
MIRT1942897	hsa-miR-454	CLIP-seq
MIRT821676	hsa-miR-4719	CLIP-seq
MIRT821677	hsa-miR-4731-3p	CLIP-seq
MIRT821678	hsa-miR-4755-5p	CLIP-seq
MIRT1942898	hsa-miR-4760-3p	CLIP-seq
MIRT821679	hsa-miR-4761-3p	CLIP-seq
MIRT821680	hsa-miR-4789-5p	CLIP-seq
MIRT1942899	hsa-miR-4795-3p	CLIP-seq
MIRT821681	hsa-miR-4801	CLIP-seq
MIRT1942900	hsa-miR-519a	CLIP-seq
MIRT1942901	hsa-miR-519b-3p	CLIP-seq
MIRT1942902	hsa-miR-519c-3p	CLIP-seq
MIRT821684	hsa-miR-548ag	CLIP-seq
MIRT821685	hsa-miR-548ai	CLIP-seq
MIRT821686	hsa-miR-548g	CLIP-seq
MIRT821687	hsa-miR-568	CLIP-seq
MIRT1942903	hsa-miR-586	CLIP-seq
MIRT821689	hsa-miR-623	CLIP-seq
MIRT1942904	hsa-miR-766	CLIP-seq
MIRT2181633	hsa-miR-1207-5p	CLIP-seq
MIRT1942889	hsa-miR-183	CLIP-seq
MIRT2181634	hsa-miR-194	CLIP-seq
MIRT821656	hsa-miR-196a	CLIP-seq
MIRT821657	hsa-miR-196b	CLIP-seq
MIRT821658	hsa-miR-204	CLIP-seq
MIRT2181635	hsa-miR-2053	CLIP-seq
MIRT821659	hsa-miR-211	CLIP-seq
MIRT2181636	hsa-miR-29a	CLIP-seq
MIRT2181637	hsa-miR-29b	CLIP-seq
MIRT2181638	hsa-miR-29c	CLIP-seq
MIRT2181639	hsa-miR-3065-3p	CLIP-seq
MIRT821669	hsa-miR-3945	CLIP-seq
MIRT821671	hsa-miR-4274	CLIP-seq
MIRT821672	hsa-miR-4328	CLIP-seq
MIRT821673	hsa-miR-4446-5p	CLIP-seq
MIRT821675	hsa-miR-4519	CLIP-seq
MIRT2181640	hsa-miR-4736	CLIP-seq
MIRT821678	hsa-miR-4755-5p	CLIP-seq
MIRT2181641	hsa-miR-4763-3p	CLIP-seq
MIRT821689	hsa-miR-623	CLIP-seq
MIRT2485188	hsa-miR-1233	CLIP-seq
MIRT2485189	hsa-miR-129-3p	CLIP-seq
MIRT2485190	hsa-miR-134	CLIP-seq
MIRT2485191	hsa-miR-139-5p	CLIP-seq
MIRT2181634	hsa-miR-194	CLIP-seq
MIRT2181636	hsa-miR-29a	CLIP-seq
MIRT2181637	hsa-miR-29b	CLIP-seq
MIRT2181638	hsa-miR-29c	CLIP-seq
MIRT2181639	hsa-miR-3065-3p	CLIP-seq
MIRT2485192	hsa-miR-3118	CLIP-seq
MIRT2485193	hsa-miR-3148	CLIP-seq
MIRT2485194	hsa-miR-3164	CLIP-seq
MIRT2485195	hsa-miR-3183	CLIP-seq
MIRT2485196	hsa-miR-3607-5p	CLIP-seq
MIRT2485197	hsa-miR-374c	CLIP-seq
MIRT2485198	hsa-miR-4279	CLIP-seq
MIRT2485199	hsa-miR-4501	CLIP-seq
MIRT2485200	hsa-miR-4666-5p	CLIP-seq
MIRT2485201	hsa-miR-4723-3p	CLIP-seq
MIRT2485202	hsa-miR-4797-5p	CLIP-seq
MIRT821683	hsa-miR-548aa	CLIP-seq
MIRT2485203	hsa-miR-655	CLIP-seq
MIRT2485204	hsa-miR-665	CLIP-seq
MIRT2485190	hsa-miR-134	CLIP-seq
MIRT2485191	hsa-miR-139-5p	CLIP-seq
MIRT2181634	hsa-miR-194	CLIP-seq
MIRT2181636	hsa-miR-29a	CLIP-seq
MIRT2181637	hsa-miR-29b	CLIP-seq
MIRT2181638	hsa-miR-29c	CLIP-seq
MIRT2181639	hsa-miR-3065-3p	CLIP-seq
MIRT2485192	hsa-miR-3118	CLIP-seq
MIRT2485193	hsa-miR-3148	CLIP-seq
MIRT2485194	hsa-miR-3164	CLIP-seq
MIRT2485195	hsa-miR-3183	CLIP-seq
MIRT2485196	hsa-miR-3607-5p	CLIP-seq
MIRT2485197	hsa-miR-374c	CLIP-seq
MIRT2485198	hsa-miR-4279	CLIP-seq
MIRT2675973	hsa-miR-4476	CLIP-seq
MIRT2485199	hsa-miR-4501	CLIP-seq
MIRT2485200	hsa-miR-4666-5p	CLIP-seq
MIRT2485201	hsa-miR-4723-3p	CLIP-seq
MIRT2485202	hsa-miR-4797-5p	CLIP-seq
MIRT821683	hsa-miR-548aa	CLIP-seq
MIRT2485203	hsa-miR-655	CLIP-seq
MIRT2485204	hsa-miR-665	CLIP-seq
MIRT2675974	hsa-miR-760	CLIP-seq

Show/Hide all(28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000922	Component	Spindle pole	IDA	18329369
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	15200957
GO:0004869	Function	Cysteine-type endopeptidase inhibitor activity	IBA	21873635
GO:0004869	Function	Cysteine-type endopeptidase inhibitor activity	IMP	15200957
GO:0005515	Function	Protein binding	IPI	14765125, 15200957, 18329369, 26496610
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005768	Component	Endosome	IDA	18329369
GO:0005802	Component	Trans-Golgi network	IDA	18329369
GO:0005815	Component	Microtubule organizing center	IDA	18329369
GO:0006468	Process	Protein phosphorylation	TAS	18329369
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA	21873635
GO:0006915	Process	Apoptotic process	IEA
GO:0007049	Process	Cell cycle	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0010951	Process	Negative regulation of endopeptidase activity	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016567	Process	Protein ubiquitination	TAS	18329369
GO:0030496	Component	Midbody	IDA	18329369
GO:0032465	Process	Regulation of cytokinesis	IMP	18329369
GO:0042127	Process	Regulation of cell population proliferation	TAS	18414036
GO:0043066	Process	Negative regulation of apoptotic process	IBA	21873635
GO:0043066	Process	Negative regulation of apoptotic process	IMP	15200957
GO:0043066	Process	Negative regulation of apoptotic process	TAS	10544019
GO:0051301	Process	Cell division	IEA
GO:0060711	Process	Labyrinthine layer development	IEA
GO:0061631	Function	Ubiquitin conjugating enzyme activity	IBA	21873635
GO:0090543	Component	Flemming body	IEA
GO:2001237	Process	Negative regulation of extrinsic apoptotic signaling pathway	IMP	14765125

MIM	HGNC	e!Ensembl
605638	13516	ENSG00000115760

Protein

UniProt ID

Q9NR09

Protein name

Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 (EC 2.3.2.24) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (Baculoviral IAP repeat-containing protein 6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON)

Protein function

Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not co

PDB

3CEG , 8ATM , 8ATO , 8ATU , 8ATX , 8AUK , 8AUW , 8E2D , 8E2E , 8E2F , 8E2G , 8E2H , 8E2I , 8E2K

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00653	BIR	289 → 359	Inhibitor of Apoptosis domain	Domain
PF12356	BIRC6	3463 → 3618	Baculoviral IAP repeat-containing protein 6	Family
PF00179	UQ_con	4577 → 4735	Ubiquitin-conjugating enzyme	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain cancer cells.

Sequence

MVTGGGAAPPGTVTEPLPSVIVLSAGRKMAAAAAAASGPGCSSAAGAGAAGVSEWLVLRD
GCMHCDADGLHSLSYHPALNAILAVTSRGTIKVIDGTSGATLQASALSAKPGGQVKCQYI
SAVDKVIFVDDYAVGCRKDLNGILLLDTALQTPVSKQDDVVQLELPVTEAQQLLSACLEK
VDISSTEGYDLFITQLKDGLKNTSHETAANHKVAKWATVTFHLPHHVLKSIASAIVNELK
KINQNVAALPVASSVMDRLSYLLPSARPELGVGPGRSVDRSLMYSEANRRETFTSWPHVG
YRWAQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEPTDEPWSEHERHSPNCPFVKG
EHTQNVPLSVTLATSPAQFPCTDGTDRISCFGSGSCPHFLAAATKRGKICIWDVSKLMKV
HLKFEINAYDPAIVQQLILSGDPSSGVDSRRPTLAWLEDSSSCSDIPKLEGDSDDLLEDS
DSEEHSRSDSVTGHTSQKEAMEVSLDITALSILQQPEKLQWEIVANVLEDTVKDLEELGA
NPCLTNSKSEKTKEKHQEQHNIPFPCLLAGGLLTYKSPATSPISSNSHRSLDGLSRTQGE
SISEQGSTDNESCTNSELNSPLVRRTLPVLLLYSIKESDEKAGKIFSQMNNIMSKSLHDD
GFTVPQIIEMELDSQEQLLLQDPPVTYIQQFADAAANLTSPDSEKWNSVFPKPGTLVQCL
RLPKFAEEENLCIDSITPCADGIHLLVGLRTCPVESLSAINQVEALNNLNKLNSALCNRR
KGELESNLAVVNGANISVIQHESPADVQTPLIIQPEQRNVSGGYLVLYKMNYATRIVTLE
EEPIKIQHIKDPQDTITSLILLPPDILDNREDDCEEPIEDMQLTSKNGFEREKTSDISTL
GHLVITTQGGYVKILDLSNFEILAKVEPPKKEGTEEQDTFVSVIYCSGTDRLCACTKGGE
LHFLQIGGTCDDIDEADILVDGSLSKGIEPSSEGSKPLSNPSSPGISGVDLLVDQPFTLE
ILTSLVELTRFETLTPRFSATVPPCWVEVQQEQQQRRHPQHLHQQHHGDAAQHTRTWKLQ
TDSNSWDEHVFELVLPKACMVGHVDFKFVLNSNITNIPQIQVTLLKNKAPGLGKVNALNI
EVEQNGKPSLVDLNEEMQHMDVEESQCLRLCPFLEDHKEDILCGPVWLASGLDLSGHAGM
LTLTSPKLVKGMAGGKYRSFLIHVKAVNERGTEEICNGGMRPVVRLPSLKHQSNKGYSLA
SLLAKVAAGKEKSSNVKNENTSGTRKSENLRGCDLLQEVSVTIRRFKKTSISKERVQRCA
MLQFSEFHEKLVNTLCRKTDDGQITEHAQSLVLDTLCWLAGVHSNGPGSSKEGNENLLSK
TRKFLSDIVRVCFFEAGRSIAHKCARFLALCISNGKCDPCQPAFGPVLLKALLDNMSFLP
AATTGGSVYWYFVLLNYVKDEDLAGCSTACASLLTAVSRQLQDRLTPMEALLQTRYGLYS
SPFDPVLFDLEMSGSSCKNVYNSSIGVQSDEIDLSDVLSGNGKVSSCTAAEGSFTSLTGL
LEVEPLHFTCVSTSDGTRIERDDAMSSFGVTPAVGGLSSGTVGEASTALSSAAQVALQSL
SHAMASAEQQLQVLQEKQQQLLKLQQQKAKLEAKLHQTTAAAAAAASAVGPVHNSVPSNP
VAAPGFFIHPSDVIPPTPKTTPLFMTPPLTPPNEAVSVVINAELAQLFPGSVIDPPAVNL
AAHNKNSNKSRMNPLGSGLALAISHASHFLQPPPHQSIIIERMHSGARRFVTLDFGRPIL
LTDVLIPTCGDLASLSIDIWTLGEEVDGRRLVVATDISTHSLILHDLIPPPVCRFMKITV
IGRYGSTNARAKIPLGFYYGHTYILPWESELKLMHDPLKGEGESANQPEIDQHLAMMVAL
QEDIQCRYNLACHRLETLLQSIDLPPLNSANNAQYFLRKPDKAVEEDSRVFSAYQDCIQL
QLQLNLAHNAVQRLKVALGASRKMLSETSNPEDLIQTSSTEQLRTIIRYLLDTLLSLLHA
SNGHSVPAVLQSTFHAQACEELFKHLCISGTPKIRLHTGLLLVQLCGGERWWGQFLSNVL
QELYNSEQLLIFPQDRVFMLLSCIGQRSLSNSGVLESLLNLLDNLLSPLQPQLPMHRRTE
GVLDIPMISWVVMLVSRLLDYVATVEDEAAAAKKPLNGNQWSFINNNLHTQSLNRSSKGS
SSLDRLYSRKIRKQLVHHKQQLNLLKAKQKALVEQMEKEKIQSNKGSSYKLLVEQAKLKQ
ATSKHFKDLIRLRRTAEWSRSNLDTEVTTAKESPEIEPLPFTLAHERCISVVQKLVLFLL
SMDFTCHADLLLFVCKVLARIANATRPTIHLCEIVNEPQLERLLLLLVGTDFNRGDISWG
GAWAQYSLTCMLQDILAGELLAPVAAEAMEEGTVGDDVGATAGDSDDSLQQSSVQLLETI
DEPLTHDITGAPPLSSLEKDKEIDLELLQDLMEVDIDPLDIDLEKDPLAAKVFKPISSTW
YDYWGADYGTYNYNPYIGGLGIPVAKPPANTEKNGSQTVSVSVSQALDARLEVGLEQQAE
LMLKMMSTLEADSILQALTNTSPTLSQSPTGTDDSLLGGLQAANQTSQLIIQLSSVPMLN
VCFNKLFSMLQVHHVQLESLLQLWLTLSLNSSSTGNKENGADIFLYNANRIPVISLNQAS
ITSFLTVLAWYPNTLLRTWCLVLHSLTLMTNMQLNSGSSSAIGTQESTAHLLVSDPNLIH
VLVKFLSGTSPHGTNQHSPQVGPTATQAMQEFLTRLQVHLSSTCPQIFSEFLLKLIHILS
TERGAFQTGQGPLDAQVKLLEFTLEQNFEVVSVSTISAVIESVTFLVHHYITCSDKVMSR
SGSDSSVGARACFGGLFANLIRPGDAKAVCGEMTRDQLMFDLLKLVNILVQLPLSGNREY
SARVSVTTNTTDSVSDEEKVSGGKDGNGSSTSVQGSPAYVADLVLANQQIMSQILSALGL
CNSSAMAMIIGASGLHLTKHENFHGGLDAISVGDGLFTILTTLSKKASTVHMMLQPILTY
MACGYMGRQGSLATCQLSEPLLWFILRVLDTSDALKAFHDMGGVQLICNNMVTSTRAIVN
TARSMVSTIMKFLDSGPNKAVDSTLKTRILASEPDNAEGIHNFAPLGTITSSSPTAQPAE
VLLQATPPHRRARSAAWSYIFLPEEAWCDLTIHLPAAVLLKEIHIQPHLASLATCPSSVS
VEVSADGVNMLPLSTPVVTSGLTYIKIQLVKAEVASAVCLRLHRPRDASTLGLSQIKLLG
LTAFGTTSSATVNNPFLPSEDQVSKTSIGWLRLLHHCLTHISDLEGMMASAAAPTANLLQ
TCAALLMSPYCGMHSPNIEVVLVKIGLQSTRIGLKLIDILLRNCAASGSDPTDLNSPLLF
GRLNGLSSDSTIDILYQLGTTQDPGTKDRIQALLKWVSDSARVAAMKRSGRMNYMCPNSS
TVEYGLLMPSPSHLHCVAAILWHSYELLVEYDLPALLDQELFELLFNWSMSLPCNMVLKK
AVDSLLCSMCHVHPNYFSLLMGWMGITPPPVQCHHRLSMTDDSKKQDLSSSLTDDSKNAQ
APLALTESHLATLASSSQSPEAIKQLLDSGLPSLLVRSLASFCFSHISSSESIAQSIDIS
QDKLRRHHVPQQCNKMPITADLVAPILRFLTEVGNSHIMKDWLGGSEVNPLWTALLFLLC
HSGSTSGSHNLGAQQTSARSASLSSAATTGLTTQQRTAIENATVAFFLQCISCHPNNQKL
MAQVLCELFQTSPQRGNLPTSGNISGFIRRLFLQLMLEDEKVTMFLQSPCPLYKGRINAT
SHVIQHPMYGAGHKFRTLHLPVSTTLSDVLDRVSDTPSITAKLISEQKDDKEKKNHEEKE
KVKAENGFQDNYSVVVASGLKSQSKRAVSATPPRPPSRRGRTIPDKIGSTSGAEAANKII
TVPVFHLFHKLLAGQPLPAEMTLAQLLTLLYDRKLPQGYRSIDLTVKLGSRVITDPSLSK
TDSYKRLHPEKDHGDLLASCPEDEALTPGDECMDGILDESLLETCPIQSPLQVFAGMGGL
ALIAERLPMLYPEVIQQVSAPVVTSTTQEKPKDSDQFEWVTIEQSGELVYEAPETVAAEP
PPIKSAVQTMSPIPAHSLAAFGLFLRLPGYAEVLLKERKHAQCLLRLVLGVTDDGEGSHI
LQSPSANVLPTLPFHVLRSLFSTTPLTTDDGVLLRRMALEIGALHLILVCLSALSHHSPR
VPNSSVNQTEPQVSSSHNPTSTEEQQLYWAKGTGFGTGSTASGWDVEQALTKQRLEEEHV
TCLLQVLASYINPVSSAVNGEAQSSHETRGQNSNALPSVLLELLSQSCLIPAMSSYLRND
SVLDMARHVPLYRALLELLRAIASCAAMVPLLLPLSTENGEEEEEQSECQTSVGTLLAKM
KTCVDTYTNRLRSKRENVKTGVKPDASDQEPEGLTLLVPDIQKTAEIVYAATTSLRQANQ
EKKLGEYSKKAAMKPKPLSVLKSLEEKYVAVMKKLQFDTFEMVSEDEDGKLGFKVNYHYM
SQVKNANDANSAARARRLAQEAVTLSTSLPLSSSSSVFVRCDEERLDIMKVLITGPADTP
YANGCFEFDVYFPQDYPSSPPLVNLETTGGHSVRFNPNLYNDGKVCLSILNTWHGRPEEK
WNPQTSSFLQVLVSVQSLILVAEPYFNEPGYERSRGTPSGTQSSREYDGNIRQATVKWAM
LEQIRNPSPCFKEVIHKHFYLKRVEIMAQCEEWIADIQQYSSDKRVGRTMSHHAAALKRH
TAQLREELLKLPCPEGLDPDTDDAPEVCRATTGAEETLMHDQVKPSSSKELPSDFQL

Sequence length

4857

Interactions

View interactions

	KEGG
	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Evidence	Source
Unknown
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587	GWAS, CBGDA
Hypogonadism	Hypogonadism		GWAS

Show/Hide Text Mining Associations (37)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenoma	Associate	23301059
Aneuploidy	Associate	36576405
Atherosclerosis	Associate	33317170
Autism Spectrum Disorder	Associate	31674007
Breast Neoplasms	Associate	19223905, 30987626
Burkitt Lymphoma	Associate	19759907
Carcinogenesis	Associate	23301059, 24453032
Carcinoma	Associate	36576405
Carcinoma Ovarian Epithelial	Associate	24453032
Carotid Stenosis	Associate	33317170
Colorectal Neoplasms	Associate	21788403, 25933218, 29575536
Esophageal Squamous Cell Carcinoma	Associate	27432467
Exfoliation Syndrome	Associate	25118708
Glaucoma Open Angle	Stimulate	21655191
Glioblastoma	Associate	27388765
Inflammation	Associate	35964136
Leukemia Lymphocytic Chronic B Cell	Associate	21091633
Leukemia Myeloid Acute	Associate	29764561, 30982490
Lymphoma Mantle Cell	Associate	32961552
Melanoma	Associate	22553342
Mitochondrial Diseases	Associate	22553342
Neoplasm Metastasis	Associate	27432467
Neoplasms	Associate	19223905, 19759907, 21788403, 22788920, 24453032, 29575536, 36576405
Neoplasms	Stimulate	27432467
Neuroblastoma	Associate	22788920
Neurodegenerative Diseases	Associate	31692446
Obstetric Labor Premature	Associate	36768802
Ovarian Neoplasms	Associate	29123378, 31091257
Paget's Disease Mammary	Associate	30905357
Pancreatic Neoplasms	Stimulate	17912030
Parathyroid Neoplasms	Associate	22198862
Prostate Cancer Hereditary 6	Stimulate	23409057
Prostatic Neoplasms	Associate	23409057, 29429983
Prostatic Neoplasms Castration Resistant	Stimulate	23409057
Stomach Neoplasms	Associate	38438090
Stroke	Associate	33317170
Tertiary Lymphoid Structures	Associate	27432467

BIRC6 (baculoviral IAP repeat containing 6)