SPC25 (SPC25 component of NDC80 kinetochore complex)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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57405 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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SPC25 component of NDC80 kinetochore complex |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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SPC25 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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AD024, SPBC25, hSpc25 |
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Chromosome
Chromosome number
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2 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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2q24.3 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity. [provided by RefSeq, Jul 2008] |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | Q9HBM1 | ||||||||||
| Protein name | Kinetochore protein Spc25 (hSpc25) | ||||||||||
| Protein function | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization o | ||||||||||
| PDB | 2VE7 , 3IZ0 , 8PPR , 8Q5H | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 224 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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