PTGIS (prostaglandin I2 synthase)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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5740 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Prostaglandin I2 synthase |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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PTGIS |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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CYP8, CYP8A1, PGIS, PTGI |
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Chromosome
Chromosome number
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20 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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20q13.13 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this prot |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | Q16647 | ||||||||||
| Protein name | Prostacyclin synthase (EC 5.3.99.4) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) (Prostaglandin I2 synthase) | ||||||||||
| Protein function | Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation (PubMed:12372404, PubMed:1511 | ||||||||||
| PDB | 2IAG , 3B6H | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate. {ECO:0000269|PubMed:8185632}. | ||||||||||
| Sequence |
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| Sequence length | 500 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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