Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5739
Gene name Gene Name - the full gene name approved by the HGNC.	Prostaglandin I2 receptor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PTGIR
Synonyms (NCBI Gene) Gene synonyms aliases	IP, PRIPR
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.32
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and

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miRTarBase ID	miRNA	Experiments
MIRT1273090	hsa-miR-1	CLIP-seq
MIRT1273091	hsa-miR-1207-5p	CLIP-seq
MIRT1273092	hsa-miR-122	CLIP-seq
MIRT1273093	hsa-miR-1266	CLIP-seq
MIRT1273094	hsa-miR-1273g	CLIP-seq
MIRT1273095	hsa-miR-149	CLIP-seq
MIRT1273096	hsa-miR-1972	CLIP-seq
MIRT1273097	hsa-miR-206	CLIP-seq
MIRT1273098	hsa-miR-2113	CLIP-seq
MIRT1273099	hsa-miR-3198	CLIP-seq
MIRT1273100	hsa-miR-323b-3p	CLIP-seq
MIRT1273101	hsa-miR-3664-3p	CLIP-seq
MIRT1273102	hsa-miR-3673	CLIP-seq
MIRT1273103	hsa-miR-4270	CLIP-seq
MIRT1273104	hsa-miR-4300	CLIP-seq
MIRT1273105	hsa-miR-4309	CLIP-seq
MIRT1273106	hsa-miR-4318	CLIP-seq
MIRT1273107	hsa-miR-432	CLIP-seq
MIRT1273108	hsa-miR-4436b-3p	CLIP-seq
MIRT1273109	hsa-miR-4441	CLIP-seq
MIRT1273110	hsa-miR-4468	CLIP-seq
MIRT1273111	hsa-miR-4492	CLIP-seq
MIRT1273112	hsa-miR-4498	CLIP-seq
MIRT1273113	hsa-miR-4518	CLIP-seq
MIRT1273114	hsa-miR-4650-5p	CLIP-seq
MIRT1273115	hsa-miR-4671-5p	CLIP-seq
MIRT1273116	hsa-miR-4752	CLIP-seq
MIRT1273117	hsa-miR-4756-3p	CLIP-seq
MIRT1273118	hsa-miR-4763-3p	CLIP-seq
MIRT1273119	hsa-miR-613	CLIP-seq
MIRT1273120	hsa-miR-760	CLIP-seq
MIRT1273121	hsa-miR-762	CLIP-seq
MIRT1273122	hsa-miR-920	CLIP-seq
MIRT1273123	hsa-miR-940	CLIP-seq

Transcription factors

Show/Hide all(3)

Transcription factor	Regulation	Reference
POU2F1	Activation	19118563
SP1	Activation	19118563
SPI1	Activation	19118563

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005829	Component	Cytosol	IDA	20622039
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	20622039
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7512962
GO:0006954	Process	Inflammatory response	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	7512962
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	20622039
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA
GO:0007267	Process	Cell-cell signaling	TAS	7512962
GO:0010642	Process	Negative regulation of platelet-derived growth factor receptor signaling pathway	IEA
GO:0010642	Process	Negative regulation of platelet-derived growth factor receptor signaling pathway	ISS	20622039
GO:0016020	Component	Membrane	IEA
GO:0016501	Function	Prostacyclin receptor activity	IBA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	IBA
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	IDA	20622039
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	IEA

MIM	HGNC	e!Ensembl
600022	9602	ENSG00000160013

Protein

UniProt ID

P43119

Protein name

Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor)

Protein function

Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

PDB

8X79 , 8X7A

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	30 → 292	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC

Sequence length

386

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction Vascular smooth muscle contraction Platelet activation		Prostanoid ligand receptors Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Inflammatory Bowel Disease	Inflammatory bowel disease	N/A	N/A	GWAS
Ulcerative colitis	Ulcerative colitis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (17)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Atherosclerosis	Associate	18323528, 24886841
Blood Platelet Disorders	Associate	18323528, 24886841
Cardiovascular Diseases	Associate	18323528
Coronary Artery Dissection Spontaneous	Associate	32531060
Dementia Vascular	Associate	16763535
Endometriosis	Associate	35781537
Fibromuscular Dysplasia	Associate	32531060
Immunologic Deficiency Syndromes	Associate	18323528
Inflammation	Inhibit	19880449
Inflammatory Bowel Diseases	Associate	36155972
Myocardial Infarction	Associate	7543911
Oropharyngeal Neoplasms	Associate	31969157
Pulmonary Arterial Hypertension	Associate	29720235
Pulmonary Disease Chronic Obstructive	Associate	19880449
Squamous Cell Carcinoma of Head and Neck	Associate	31969157
Thrombosis	Associate	7543911
Vascular Remodeling	Associate	32531060

PTGIR (prostaglandin I2 receptor)