PTGIR (prostaglandin I2 receptor)

Gene

• Entrez ID: 5739
• Gene name: Prostaglandin I2 receptor
• Gene symbol: PTGIR
• Synonyms (NCBI Gene): IP, PRIPR
• Chromosome: 19
• Chromosome location: 19q13.32
• Summary: The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1273090	hsa-miR-1	CLIP-seq
MIRT1273091	hsa-miR-1207-5p	CLIP-seq
MIRT1273092	hsa-miR-122	CLIP-seq
MIRT1273093	hsa-miR-1266	CLIP-seq
MIRT1273094	hsa-miR-1273g	CLIP-seq
MIRT1273095	hsa-miR-149	CLIP-seq
MIRT1273096	hsa-miR-1972	CLIP-seq
MIRT1273097	hsa-miR-206	CLIP-seq
MIRT1273098	hsa-miR-2113	CLIP-seq
MIRT1273099	hsa-miR-3198	CLIP-seq
MIRT1273100	hsa-miR-323b-3p	CLIP-seq
MIRT1273101	hsa-miR-3664-3p	CLIP-seq
MIRT1273102	hsa-miR-3673	CLIP-seq
MIRT1273103	hsa-miR-4270	CLIP-seq
MIRT1273104	hsa-miR-4300	CLIP-seq
MIRT1273105	hsa-miR-4309	CLIP-seq
MIRT1273106	hsa-miR-4318	CLIP-seq
MIRT1273107	hsa-miR-432	CLIP-seq
MIRT1273108	hsa-miR-4436b-3p	CLIP-seq
MIRT1273109	hsa-miR-4441	CLIP-seq
MIRT1273110	hsa-miR-4468	CLIP-seq
MIRT1273111	hsa-miR-4492	CLIP-seq
MIRT1273112	hsa-miR-4498	CLIP-seq
MIRT1273113	hsa-miR-4518	CLIP-seq
MIRT1273114	hsa-miR-4650-5p	CLIP-seq
MIRT1273115	hsa-miR-4671-5p	CLIP-seq
MIRT1273116	hsa-miR-4752	CLIP-seq
MIRT1273117	hsa-miR-4756-3p	CLIP-seq
MIRT1273118	hsa-miR-4763-3p	CLIP-seq
MIRT1273119	hsa-miR-613	CLIP-seq
MIRT1273120	hsa-miR-760	CLIP-seq
MIRT1273121	hsa-miR-762	CLIP-seq
MIRT1273122	hsa-miR-920	CLIP-seq
MIRT1273123	hsa-miR-940	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
POU2F1	Activation	19118563
SP1	Activation	19118563
SPI1	Activation	19118563

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005829	Component	Cytosol	IDA	20622039
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	20622039
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7512962
GO:0006954	Process	Inflammatory response	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	7512962
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	20622039
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA
GO:0007267	Process	Cell-cell signaling	TAS	7512962
GO:0010642	Process	Negative regulation of platelet-derived growth factor receptor signaling pathway	IEA
GO:0010642	Process	Negative regulation of platelet-derived growth factor receptor signaling pathway	ISS	20622039
GO:0016020	Component	Membrane	IEA
GO:0016501	Function	Prostacyclin receptor activity	IBA
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	IBA
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	IDA	20622039
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	IEA

Other IDs

• MIM: 600022
• HGNC: 9602
• e!Ensembl: ENSG00000160013

Protein

• UniProt ID: P43119
• Protein name: Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor)
• Protein function: Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
• PDB: 8X79, 8X7A
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	30 → 292	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
  LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
  LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
  GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
  LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
  QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
  PPTQQSSGSAVGTSSKAEASVACSLC

• Sequence length: 386

Pathways

KEGG:

Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activation

Reactome:

Prostanoid ligand receptors
Prostacyclin signalling through prostacyclin receptor
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Colorectal cancer	Uncertain significance	rs200973220	RCV005932596
Sarcoma	Uncertain significance	rs200973220	RCV005932597

Associations from Text Mining
Disease Name	Relationship Type	References
Atherosclerosis	Associate	18323528, 24886841
Blood Platelet Disorders	Associate	18323528, 24886841
Cardiovascular Diseases	Associate	18323528
Coronary Artery Dissection Spontaneous	Associate	32531060
Dementia Vascular	Associate	16763535
Endometriosis	Associate	35781537
Fibromuscular Dysplasia	Associate	32531060
Immunologic Deficiency Syndromes	Associate	18323528
Inflammation	Inhibit	19880449
Inflammatory Bowel Diseases	Associate	36155972
Myocardial Infarction	Associate	7543911
Oropharyngeal Neoplasms	Associate	31969157
Pulmonary Arterial Hypertension	Associate	29720235
Pulmonary Disease Chronic Obstructive	Associate	19880449
Squamous Cell Carcinoma of Head and Neck	Associate	31969157
Thrombosis	Associate	7543911
Vascular Remodeling	Associate	32531060