Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	57379
Gene name	Activation induced cytidine deaminase
Gene symbol	AICDA
Synonyms (NCBI Gene)	AIDARP2CDA2HEL-S-284HIGM2
Chromosome	12
Chromosome location	12p13.31
Summary	This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. AICDA is specifically expressed and active in germinal center-like B cells. In the germinal center, AICDA is involved in somatic hypermutation, gene conversion, a

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SNP ID	Visualize variation	Clinical significance	Consequence
rs104894320	A>G	Pathogenic	Coding sequence variant, missense variant
rs104894321	A>G	Pathogenic	Coding sequence variant, missense variant
rs104894322	T>C	Pathogenic	Coding sequence variant, missense variant
rs104894323	G>T	Pathogenic	Coding sequence variant, intron variant, stop gained
rs104894324	G>A	Pathogenic	Coding sequence variant, missense variant
rs104894325	C>T	Pathogenic	Coding sequence variant, stop gained
rs104894327	A>G	Pathogenic	Coding sequence variant, intron variant, missense variant
rs186739900	T>C	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs193922703	C>T	Pathogenic, likely-pathogenic	Stop gained, coding sequence variant
rs193922704	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs200858797	A>G	Pathogenic	Missense variant, coding sequence variant
rs387906328	GTAAAGAAACTTCCTCCGG>-	Pathogenic	Frameshift variant, coding sequence variant
rs387906329	GGAAGAGCA>-	Pathogenic	Inframe indel, coding sequence variant
rs762590894	A>G	Pathogenic	Coding sequence variant, missense variant
rs766361035	C>A,T	Likely-pathogenic	Intron variant, splice acceptor variant
rs769399833	G>A,C,T	Likely-pathogenic	Missense variant, stop gained, coding sequence variant, synonymous variant, 3 prime UTR variant
rs786205474	C>T	Likely-pathogenic	Missense variant, coding sequence variant
rs1057519097	T>C	Likely-pathogenic	Missense variant, coding sequence variant
rs1057520542	G>A	Pathogenic	Missense variant, coding sequence variant
rs1227905250	G>A,T	Likely-pathogenic	Stop gained, synonymous variant, coding sequence variant
rs1591744217	C>A	Likely-pathogenic	Missense variant, coding sequence variant

224

Show/Hide all (224)

miRTarBase ID	miRNA	Experiments	Reference
MIRT628943	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT628942	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT628941	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT628940	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT628939	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT628938	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT628937	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT628943	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT628942	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT628941	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT628940	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT628939	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT628938	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT628937	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT774045	hsa-miR-105	CLIP-seq
MIRT774046	hsa-miR-122	CLIP-seq
MIRT774047	hsa-miR-1234	CLIP-seq
MIRT774048	hsa-miR-129-5p	CLIP-seq
MIRT774049	hsa-miR-130a	CLIP-seq
MIRT774050	hsa-miR-130b	CLIP-seq
MIRT774051	hsa-miR-1343	CLIP-seq
MIRT774052	hsa-miR-150	CLIP-seq
MIRT774053	hsa-miR-1976	CLIP-seq
MIRT774054	hsa-miR-2117	CLIP-seq
MIRT774055	hsa-miR-219-1-3p	CLIP-seq
MIRT774056	hsa-miR-301a	CLIP-seq
MIRT774057	hsa-miR-301b	CLIP-seq
MIRT774058	hsa-miR-3122	CLIP-seq
MIRT774059	hsa-miR-3135b	CLIP-seq
MIRT774060	hsa-miR-3144-3p	CLIP-seq
MIRT774061	hsa-miR-3185	CLIP-seq
MIRT774062	hsa-miR-3187-3p	CLIP-seq
MIRT774063	hsa-miR-3609	CLIP-seq
MIRT774064	hsa-miR-3646	CLIP-seq
MIRT774065	hsa-miR-3652	CLIP-seq
MIRT774066	hsa-miR-3655	CLIP-seq
MIRT774067	hsa-miR-3663-5p	CLIP-seq
MIRT774068	hsa-miR-3666	CLIP-seq
MIRT774069	hsa-miR-3671	CLIP-seq
MIRT774070	hsa-miR-3689a-3p	CLIP-seq
MIRT774071	hsa-miR-3689c	CLIP-seq
MIRT774072	hsa-miR-371-5p	CLIP-seq
MIRT774073	hsa-miR-371b-5p	CLIP-seq
MIRT774074	hsa-miR-377	CLIP-seq
MIRT774075	hsa-miR-3913-5p	CLIP-seq
MIRT774076	hsa-miR-4273	CLIP-seq
MIRT774077	hsa-miR-4279	CLIP-seq
MIRT774078	hsa-miR-4295	CLIP-seq
MIRT774079	hsa-miR-431	CLIP-seq
MIRT774080	hsa-miR-4430	CLIP-seq
MIRT774081	hsa-miR-4434	CLIP-seq
MIRT774082	hsa-miR-4435	CLIP-seq
MIRT774083	hsa-miR-4454	CLIP-seq
MIRT774084	hsa-miR-4516	CLIP-seq
MIRT774085	hsa-miR-454	CLIP-seq
MIRT774086	hsa-miR-4659a-5p	CLIP-seq
MIRT774087	hsa-miR-4659b-5p	CLIP-seq
MIRT774088	hsa-miR-4677-5p	CLIP-seq
MIRT774089	hsa-miR-4693-3p	CLIP-seq
MIRT774090	hsa-miR-4701-5p	CLIP-seq
MIRT774091	hsa-miR-4709-3p	CLIP-seq
MIRT774092	hsa-miR-4716-5p	CLIP-seq
MIRT774093	hsa-miR-4722-3p	CLIP-seq
MIRT774094	hsa-miR-4755-3p	CLIP-seq
MIRT774095	hsa-miR-4764-3p	CLIP-seq
MIRT774096	hsa-miR-4776-3p	CLIP-seq
MIRT774097	hsa-miR-4778-3p	CLIP-seq
MIRT774098	hsa-miR-4781-3p	CLIP-seq
MIRT774099	hsa-miR-4803	CLIP-seq
MIRT774100	hsa-miR-498	CLIP-seq
MIRT774101	hsa-miR-5095	CLIP-seq
MIRT774102	hsa-miR-548ac	CLIP-seq
MIRT774103	hsa-miR-548ae	CLIP-seq
MIRT774104	hsa-miR-548ah	CLIP-seq
MIRT774105	hsa-miR-548aj	CLIP-seq
MIRT774106	hsa-miR-548am	CLIP-seq
MIRT774107	hsa-miR-548d-3p	CLIP-seq
MIRT774108	hsa-miR-548s	CLIP-seq
MIRT774109	hsa-miR-548x	CLIP-seq
MIRT774110	hsa-miR-548z	CLIP-seq
MIRT774111	hsa-miR-552	CLIP-seq
MIRT774112	hsa-miR-562	CLIP-seq
MIRT774113	hsa-miR-588	CLIP-seq
MIRT774114	hsa-miR-618	CLIP-seq
MIRT774115	hsa-miR-764	CLIP-seq
MIRT774116	hsa-miR-875-5p	CLIP-seq
MIRT774117	hsa-miR-888	CLIP-seq
MIRT774118	hsa-miR-891a	CLIP-seq
MIRT774119	hsa-miR-924	CLIP-seq
MIRT774048	hsa-miR-129-5p	CLIP-seq
MIRT774051	hsa-miR-1343	CLIP-seq
MIRT774052	hsa-miR-150	CLIP-seq
MIRT774053	hsa-miR-1976	CLIP-seq
MIRT1928447	hsa-miR-217	CLIP-seq
MIRT774062	hsa-miR-3187-3p	CLIP-seq
MIRT774067	hsa-miR-3663-5p	CLIP-seq
MIRT774072	hsa-miR-371-5p	CLIP-seq
MIRT774073	hsa-miR-371b-5p	CLIP-seq
MIRT774077	hsa-miR-4279	CLIP-seq
MIRT1928448	hsa-miR-4418	CLIP-seq
MIRT774082	hsa-miR-4435	CLIP-seq
MIRT774086	hsa-miR-4659a-5p	CLIP-seq
MIRT774087	hsa-miR-4659b-5p	CLIP-seq
MIRT774090	hsa-miR-4701-5p	CLIP-seq
MIRT774092	hsa-miR-4716-5p	CLIP-seq
MIRT774093	hsa-miR-4722-3p	CLIP-seq
MIRT774094	hsa-miR-4755-3p	CLIP-seq
MIRT1928449	hsa-miR-4772-3p	CLIP-seq
MIRT774096	hsa-miR-4776-3p	CLIP-seq
MIRT774098	hsa-miR-4781-3p	CLIP-seq
MIRT774100	hsa-miR-498	CLIP-seq
MIRT1928450	hsa-miR-509-3-5p	CLIP-seq
MIRT774101	hsa-miR-5095	CLIP-seq
MIRT1928451	hsa-miR-509-5p	CLIP-seq
MIRT774108	hsa-miR-548s	CLIP-seq
MIRT774111	hsa-miR-552	CLIP-seq
MIRT774112	hsa-miR-562	CLIP-seq
MIRT774113	hsa-miR-588	CLIP-seq
MIRT774046	hsa-miR-122	CLIP-seq
MIRT2169232	hsa-miR-1237	CLIP-seq
MIRT2169233	hsa-miR-1248	CLIP-seq
MIRT774049	hsa-miR-130a	CLIP-seq
MIRT774050	hsa-miR-130b	CLIP-seq
MIRT774051	hsa-miR-1343	CLIP-seq
MIRT774052	hsa-miR-150	CLIP-seq
MIRT774053	hsa-miR-1976	CLIP-seq
MIRT1928447	hsa-miR-217	CLIP-seq
MIRT774056	hsa-miR-301a	CLIP-seq
MIRT774057	hsa-miR-301b	CLIP-seq
MIRT774059	hsa-miR-3135b	CLIP-seq
MIRT774065	hsa-miR-3652	CLIP-seq
MIRT774066	hsa-miR-3655	CLIP-seq
MIRT774068	hsa-miR-3666	CLIP-seq
MIRT774077	hsa-miR-4279	CLIP-seq
MIRT774078	hsa-miR-4295	CLIP-seq
MIRT1928448	hsa-miR-4418	CLIP-seq
MIRT774080	hsa-miR-4430	CLIP-seq
MIRT774085	hsa-miR-454	CLIP-seq
MIRT2169234	hsa-miR-4695-3p	CLIP-seq
MIRT2169235	hsa-miR-4713-5p	CLIP-seq
MIRT774093	hsa-miR-4722-3p	CLIP-seq
MIRT2169236	hsa-miR-4763-5p	CLIP-seq
MIRT1928449	hsa-miR-4772-3p	CLIP-seq
MIRT774100	hsa-miR-498	CLIP-seq
MIRT1928450	hsa-miR-509-3-5p	CLIP-seq
MIRT774101	hsa-miR-5095	CLIP-seq
MIRT1928451	hsa-miR-509-5p	CLIP-seq
MIRT2169237	hsa-miR-532-3p	CLIP-seq
MIRT2169238	hsa-miR-550a	CLIP-seq
MIRT774111	hsa-miR-552	CLIP-seq
MIRT774112	hsa-miR-562	CLIP-seq
MIRT774115	hsa-miR-764	CLIP-seq
MIRT774118	hsa-miR-891a	CLIP-seq
MIRT2169239	hsa-miR-942	CLIP-seq
MIRT774052	hsa-miR-150	CLIP-seq
MIRT774051	hsa-miR-1343	CLIP-seq
MIRT774052	hsa-miR-150	CLIP-seq
MIRT774053	hsa-miR-1976	CLIP-seq
MIRT774059	hsa-miR-3135b	CLIP-seq
MIRT774065	hsa-miR-3652	CLIP-seq
MIRT774066	hsa-miR-3655	CLIP-seq
MIRT774077	hsa-miR-4279	CLIP-seq
MIRT774079	hsa-miR-431	CLIP-seq
MIRT774080	hsa-miR-4430	CLIP-seq
MIRT774093	hsa-miR-4722-3p	CLIP-seq
MIRT2443378	hsa-miR-4797-5p	CLIP-seq
MIRT774100	hsa-miR-498	CLIP-seq
MIRT774112	hsa-miR-562	CLIP-seq
MIRT774119	hsa-miR-924	CLIP-seq
MIRT2169232	hsa-miR-1237	CLIP-seq
MIRT2169233	hsa-miR-1248	CLIP-seq
MIRT774051	hsa-miR-1343	CLIP-seq
MIRT774052	hsa-miR-150	CLIP-seq
MIRT774053	hsa-miR-1976	CLIP-seq
MIRT774077	hsa-miR-4279	CLIP-seq
MIRT2464837	hsa-miR-4326	CLIP-seq
MIRT774082	hsa-miR-4435	CLIP-seq
MIRT2464838	hsa-miR-4684-5p	CLIP-seq
MIRT774093	hsa-miR-4722-3p	CLIP-seq
MIRT774100	hsa-miR-498	CLIP-seq
MIRT2169239	hsa-miR-942	CLIP-seq
MIRT774046	hsa-miR-122	CLIP-seq
MIRT774048	hsa-miR-129-5p	CLIP-seq
MIRT774051	hsa-miR-1343	CLIP-seq
MIRT774052	hsa-miR-150	CLIP-seq
MIRT774053	hsa-miR-1976	CLIP-seq
MIRT774059	hsa-miR-3135b	CLIP-seq
MIRT774065	hsa-miR-3652	CLIP-seq
MIRT774066	hsa-miR-3655	CLIP-seq
MIRT774077	hsa-miR-4279	CLIP-seq
MIRT774079	hsa-miR-431	CLIP-seq
MIRT774080	hsa-miR-4430	CLIP-seq
MIRT774093	hsa-miR-4722-3p	CLIP-seq
MIRT2471810	hsa-miR-4735-5p	CLIP-seq
MIRT2169236	hsa-miR-4763-5p	CLIP-seq
MIRT2471811	hsa-miR-4775	CLIP-seq
MIRT2471812	hsa-miR-4794	CLIP-seq
MIRT774100	hsa-miR-498	CLIP-seq
MIRT774101	hsa-miR-5095	CLIP-seq
MIRT2169238	hsa-miR-550a	CLIP-seq
MIRT774111	hsa-miR-552	CLIP-seq
MIRT774112	hsa-miR-562	CLIP-seq
MIRT2471813	hsa-miR-590-3p	CLIP-seq
MIRT774119	hsa-miR-924	CLIP-seq
MIRT2169232	hsa-miR-1237	CLIP-seq
MIRT2169233	hsa-miR-1248	CLIP-seq
MIRT774051	hsa-miR-1343	CLIP-seq
MIRT774052	hsa-miR-150	CLIP-seq
MIRT774053	hsa-miR-1976	CLIP-seq
MIRT774066	hsa-miR-3655	CLIP-seq
MIRT774077	hsa-miR-4279	CLIP-seq
MIRT774079	hsa-miR-431	CLIP-seq
MIRT2464837	hsa-miR-4326	CLIP-seq
MIRT774082	hsa-miR-4435	CLIP-seq
MIRT2464838	hsa-miR-4684-5p	CLIP-seq
MIRT774093	hsa-miR-4722-3p	CLIP-seq
MIRT2443378	hsa-miR-4797-5p	CLIP-seq
MIRT774100	hsa-miR-498	CLIP-seq
MIRT774101	hsa-miR-5095	CLIP-seq
MIRT774111	hsa-miR-552	CLIP-seq
MIRT774112	hsa-miR-562	CLIP-seq
MIRT774115	hsa-miR-764	CLIP-seq
MIRT774119	hsa-miR-924	CLIP-seq
MIRT2169239	hsa-miR-942	CLIP-seq

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Transcription factor	Regulation	Reference
TCF3	Unknown	18203819

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000932	Component	P-body	IBA
GO:0003723	Function	RNA binding	IBA
GO:0003824	Function	Catalytic activity	IEA
GO:0004126	Function	Cytidine deaminase activity	IBA
GO:0004126	Function	Cytidine deaminase activity	IDA	18722174
GO:0004126	Function	Cytidine deaminase activity	IEA
GO:0004126	Function	Cytidine deaminase activity	NAS	10950930
GO:0005515	Function	Protein binding	IPI	16387847, 18722174, 19412186, 21385873, 21518874, 21722948, 22085931, 26867650
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	14769937
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	14769937, 18722174
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010556	Process	Regulation of macromolecule biosynthetic process	IEA
GO:0016445	Process	Somatic diversification of immunoglobulins	IDA	18722174
GO:0016445	Process	Somatic diversification of immunoglobulins	IEA
GO:0016446	Process	Somatic hypermutation of immunoglobulin genes	IMP	21518874
GO:0016554	Process	Cytidine to uridine editing	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016814	Function	Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	IEA
GO:0030183	Process	B cell differentiation	NAS	11007475
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	23277564
GO:0032991	Component	Protein-containing complex	IPI	21255825
GO:0033262	Process	Regulation of nuclear cell cycle DNA replication	IMP	19734146
GO:0042742	Process	Defense response to bacterium	IEA
GO:0042802	Function	Identical protein binding	IPI	19412186
GO:0044029	Process	Positive regulation of gene expression via chromosomal CpG island demethylation	IDA	21496894
GO:0045190	Process	Isotype switching	IEA
GO:0045869	Process	Negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051607	Process	Defense response to virus	IBA
GO:0070383	Process	DNA cytosine deamination	IBA
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA

MIM	HGNC	e!Ensembl
605257	13203	ENSG00000111732

Q9GZX7

Protein name

Single-stranded DNA cytosine deaminase (EC 3.5.4.38) (Activation-induced cytidine deaminase) (AID) (Cytidine aminohydrolase)

Protein function

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) regi

PDB

5JJ4 , 5W0R , 5W0U , 5W0Z , 5W1C

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18772	APOBEC2	6 → 181		Family

Tissue specificity

TISSUE SPECIFICITY: Strongly expressed in lymph nodes and tonsils. {ECO:0000269|PubMed:23166356}.

Sequence

MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSLDFGYLRNKNGCHVELL
FLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTARLYFCEDRK
AEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFKAWEGLHENSVRLSRQLRRIL
LPLYEVDDLRDAFRTLGL

Sequence length

198

Interactions

View interactions

	KEGG
	Intestinal immune network for IgA production Primary immunodeficiency

245

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
AICDA-related disorder	Pathogenic; Likely pathogenic	rs1057520542, rs1260264247	RCV003912638 RCV003405393
Hyper-IgM syndrome type 2	Likely pathogenic; Pathogenic	rs772388034, rs2136431608, rs2136433359, rs2540251593, rs777729620, rs786205474, rs773521793, rs104894324, rs104894325, rs104894321, rs104894322, rs104894323, rs104894327, rs387906328, rs387906329 View all (12 more)	RCV001969612 RCV003232560 RCV002244226 RCV003037443 RCV003037444 RCV003987400 RCV002631527 RCV000005429 RCV000005430 RCV000005432 RCV000005433 RCV000005434 RCV000005435 RCV000005436 RCV000005437 RCV003486494 RCV003613946 RCV000808983 RCV000029303 RCV001043961 RCV001385304 RCV000988783 RCV000991445 RCV001869384 RCV001070577 RCV001222115 RCV001208331

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Hyperimmunoglobulin M syndrome	Benign; Uncertain significance; Conflicting classifications of pathogenicity	rs5796316, rs201738977, rs755095913, rs1345004	RCV001844123 RCV001844121 RCV001844122 RCV001844124 RCV001844156
Lung cancer	Likely benign	rs77429608	RCV005911422
Malignant tumor of esophagus	Likely benign	rs77429608	RCV005911419
Sarcoma	Likely benign	rs77429608	RCV005911420
Uterine carcinosarcoma	Likely benign	rs77429608	RCV005911421

Show/Hide Text Mining Associations (108)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	11724784, 12563035, 35246784
Arthritis Juvenile	Associate	19703021
Arthritis Rheumatoid	Associate	19703021, 20491788
Autoimmune Diseases	Associate	21700883, 21984922, 27527602, 28333576
Barrett Esophagus	Associate	21890457
Brain Neoplasms	Associate	23408445
Breast Neoplasms	Associate	16618718, 21831295
Bruton type agammaglobulinemia	Associate	33377626
Burkitt Lymphoma	Associate	15304391, 15593119, 19734146, 21831295, 25099163, 27217538, 32843697, 35503749
Burkitt Lymphoma	Stimulate	40085439
Carcinogenesis	Associate	21831295, 21890457, 23150777, 24351917, 26936395, 27485054, 27924834
Chromosome 14 trisomy	Associate	23263985
Colitis Associated Neoplasms	Associate	20878190
Colitis Ulcerative	Stimulate	20878190
Colorectal Neoplasms	Associate	29875879
Common Variable Immunodeficiency	Associate	20652909, 27484504, 32961586
COVID 19	Associate	34276680
Cytokine Release Syndrome	Stimulate	20878190
Diarrhea 5 With Tufting Enteropathy Congenital	Associate	24351917
Down Syndrome	Associate	30515165
Drug Hypersensitivity	Associate	21984922
Dysgammaglobulinemia	Associate	19903677
Epstein Barr Virus Infections	Associate	19193789
Esophageal Squamous Cell Carcinoma	Associate	19528036
Familial Cold Autoinflammatory Syndrome 2	Stimulate	37877365
Fibrosis	Associate	22824292
Graves Disease	Associate	28333576
Hearing Loss	Associate	35720340
Hepatitis B	Associate	24025329
Hepatitis C	Associate	20523896, 26219420
Hepatitis C	Stimulate	20878190
Hereditary Autoinflammatory Diseases	Associate	37877365
HIV Infections	Stimulate	19412542
HIV Infections	Associate	30219203, 32773475
Hodgkin Disease	Associate	16126891, 31816062, 36723991
Hyper IgM Immunodeficiency Syndrome	Associate	11007475, 12840068, 14564357, 19266080, 20652909, 21700883, 22715099, 23803409, 26551569, 27142677, 27716525, 33377626, 33950194, 35246784, 36931691
Hyper IgM Immunodeficiency Syndrome Type 1	Associate	15358621
IgA Vasculitis	Associate	21798884
IgG Deficiency	Associate	19903677
Immunoglobulin G4 Related Disease	Associate	22824292, 30679751, 33920932
Immunologic Deficiency Syndromes	Associate	18575580, 20652909, 35471583
Inflammation	Associate	20878190, 20921530, 21984922, 23820005, 24351917, 26219420, 26936395, 30679751
Inflammation	Stimulate	22466889, 23634222, 33920932
Inflammatory Bowel Diseases	Associate	20878190
Leukemia	Associate	12855567, 17485517, 30571766, 35524550
Leukemia Biphenotypic Acute	Associate	21623761
Leukemia Hairy Cell	Associate	15284115
Leukemia Lymphocytic Chronic B Cell	Associate	12444172, 12511417, 12521993, 12586616, 12855567, 15198729, 15561888, 19898425, 20233972, 23071276, 25179679, 25486549, 28125682, 30571766, 30814061, 34884820 View all (1 more)
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	19732715
Leukemia Myeloid Chronic Phase	Associate	32782381
Leukemia Prolymphocytic T Cell	Associate	26638776
Light Fixation Seizure Syndrome	Associate	15358621, 26551569
Lung Neoplasms	Associate	30333118
Lupus Erythematosus Systemic	Stimulate	36748375
Lymphoma	Associate	19734146, 22899287, 25486549, 27217538, 28421278, 32633086, 32843697, 34884820, 35524550, 36595774
Lymphoma AIDS Related	Associate	20625427, 32773475, 39324141
Lymphoma AIDS Related	Stimulate	23722608
Lymphoma B Cell	Associate	12511417, 15593119, 15842661, 16269615, 16507780, 16882707, 21990614, 22168746, 25179679, 25486549, 26077666, 28125682, 32633086, 32773475, 34260910
Lymphoma B Cell Marginal Zone	Associate	17878393, 33920932
Lymphoma Follicular	Associate	18945749, 22168746, 25311808, 26077666, 27924834, 29070849, 34884820
Lymphoma Large B Cell Diffuse	Associate	12511417, 15304391, 20196672, 22808135, 26077666, 32773475
Lymphoma Mantle Cell	Associate	14551145, 25843681
Lymphoma Non Hodgkin	Associate	23722608
Lymphoma T Cell	Associate	17672882, 34581268
Lymphoma T Cell Peripheral	Associate	34581268
Lymphoproliferative Disorders	Associate	15956553, 16882707
Macular Degeneration	Associate	30996586
Malaria	Stimulate	25099163, 35503749, 40085439
Malaria Falciparum	Stimulate	40085439
Malocclusion Angle Class I	Associate	19008192
Melanoma	Associate	27411958
Mouth Neoplasms	Associate	23634222, 24351917
Multiple Myeloma	Associate	28544233, 32317634, 33057009, 34625538, 36595774
Muscular Dystrophy Duchenne	Associate	33111067
Myelodysplastic Syndromes	Associate	34022778
Myotonic Dystrophy	Associate	21414848
Nasal Polyps	Associate	21984922
Neoplasms	Associate	15593119, 15920162, 17485517, 20233972, 20491788, 20878190, 21831295, 21890457, 21984922, 22308462, 22466889, 23820005, 24351917, 24853685, 25486549 View all (11 more)
Nephrotic Syndrome	Inhibit	31352232
Ovarian Diseases	Associate	26936395
Ovarian Neoplasms	Associate	27485054, 27527602
Paraproteinemias	Associate	36595774
Philadelphia Chromosome	Associate	17485517
Pneumonia	Associate	28302172
Polyps	Associate	21984922
Polyradiculoneuropathy Chronic Inflammatory Demyelinating	Associate	20523896
Precursor B Cell Lymphoblastic Leukemia Lymphoma	Associate	33507341
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	17485517, 27431763
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	21623761
Primary Immunodeficiency Diseases	Associate	33950194
Pyruvate Carboxylase Deficiency Disease	Associate	19846886
Recombinant chromosome 8 syndrome	Associate	19008192
Severe combined immunodeficiency due to adenosine deaminase deficiency	Inhibit	11007475
Severe combined immunodeficiency due to adenosine deaminase deficiency	Associate	21700883, 27142677, 33377626
Sialadenitis	Associate	17878393, 30679751
Sjogren's Syndrome	Associate	17878393, 36541240
Somatoform Disorders	Associate	25311808
Spondylitis Ankylosing	Associate	28959900
Squamous Cell Carcinoma of Head and Neck	Associate	22466889, 23634222, 24351917, 32775421, 37080394
Stomach Neoplasms	Associate	18391550
Tetra amelia with ectodermal dysplasia and lacrimal duct abnormalities	Associate	17485517
Thyroid Cancer Papillary	Associate	21909078
Thyroid Carcinoma Anaplastic	Associate	31991166
Tuberculosis	Associate	26551569
Tuberculosis Lymph Node	Associate	26551569
Uterine Cervicitis	Associate	26551569
Vasculitis	Associate	26219420
Waldenstrom Macroglobulinemia	Associate	36332058

AICDA (activation induced cytidine deaminase)