Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5737
Gene name Gene Name - the full gene name approved by the HGNC.
Prostaglandin F receptor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PTGFR
Synonyms (NCBI Gene) Gene synonyms aliases
FP
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p31.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pre
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs3753380 T>A,C Drug-response Upstream transcript variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT031037 hsa-miR-21-5p Microarray 18591254
MIRT654626 hsa-miR-570-3p HITS-CLIP 23824327
MIRT654626 hsa-miR-570-3p HITS-CLIP 23824327
MIRT1272860 hsa-miR-1270 CLIP-seq
MIRT1272861 hsa-miR-1284 CLIP-seq
Transcription factors
Transcription factor Regulation Reference
GATA1 Repression 14746914
NFKB1 Unknown 16855208
RELA Unknown 16855208
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004958 Function Prostaglandin F receptor activity IBA 21873635
GO:0004958 Function Prostaglandin F receptor activity IDA 18587449
GO:0005576 Component Extracellular region IDA 10575000
GO:0005737 Component Cytoplasm IDA 18508192
GO:0005886 Component Plasma membrane IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600563 9600 ENSG00000122420
Protein
UniProt ID P43088
Protein name Prostaglandin F2-alpha receptor (PGF receptor) (PGF2-alpha receptor) (Prostanoid FP receptor)
Protein function Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms
PDB 8IQ4 , 8IQ6 , 8IUK , 8IUL , 8IUM , 8XJK , 8XJL , 8XJM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 43 304 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Eye. {ECO:0000269|PubMed:18587449}.
Sequence
Sequence length 359
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Calcium signaling pathway
Phospholipase D signaling pathway
Neuroactive ligand-receptor interaction
  Prostanoid ligand receptors
G alpha (q) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
27207532
Unknown
Disease term Disease name Evidence References Source
Endometriosis Endometriosis 25446850 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Aniridia Associate 40570009
Carcinoma Hepatocellular Associate 31514484, 38188684
Dermatitis Herpetiformis Associate 22991566
Developmental Dysplasia of the Hip Associate 34174923
Gestational Weight Gain Associate 32321883
Glaucoma Associate 17582204
Inflammation Associate 22991566
Ocular Hypertension Associate 36768422
Ovarian Neoplasms Associate 25365139
Squamous Cell Carcinoma of Head and Neck Associate 31969157