Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	57336
Gene name	Zinc finger protein 287
Gene symbol	ZNF287
Synonyms (NCBI Gene)	ZKSCAN13ZSCAN45
Chromosome	17
Chromosome location	17p11.2
Summary	This gene encodes a member of the krueppel family of zinc finger proteins, suggesting a role as a transcription factor. Its specific function has not been determined. This gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided

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miRTarBase ID	miRNA	Experiments
MIRT1521312	hsa-miR-1184	CLIP-seq
MIRT1521313	hsa-miR-1205	CLIP-seq
MIRT1521314	hsa-miR-1323	CLIP-seq
MIRT1521315	hsa-miR-153	CLIP-seq
MIRT1521316	hsa-miR-1973	CLIP-seq
MIRT1521317	hsa-miR-3119	CLIP-seq
MIRT1521318	hsa-miR-3158-3p	CLIP-seq
MIRT1521319	hsa-miR-3158-5p	CLIP-seq
MIRT1521320	hsa-miR-34c-3p	CLIP-seq
MIRT1521321	hsa-miR-3606	CLIP-seq
MIRT1521322	hsa-miR-3660	CLIP-seq
MIRT1521323	hsa-miR-376c	CLIP-seq
MIRT1521324	hsa-miR-3929	CLIP-seq
MIRT1521325	hsa-miR-3942-3p	CLIP-seq
MIRT1521326	hsa-miR-4256	CLIP-seq
MIRT1521327	hsa-miR-4419b	CLIP-seq
MIRT1521328	hsa-miR-4427	CLIP-seq
MIRT1521329	hsa-miR-4436b-5p	CLIP-seq
MIRT1521330	hsa-miR-4446-3p	CLIP-seq
MIRT1521331	hsa-miR-4452	CLIP-seq
MIRT1521332	hsa-miR-4478	CLIP-seq
MIRT1521333	hsa-miR-4526	CLIP-seq
MIRT1521334	hsa-miR-4672	CLIP-seq
MIRT1521335	hsa-miR-4680-3p	CLIP-seq
MIRT1521336	hsa-miR-4704-5p	CLIP-seq
MIRT1521337	hsa-miR-4733-3p	CLIP-seq
MIRT1521338	hsa-miR-4789-3p	CLIP-seq
MIRT1521339	hsa-miR-4789-5p	CLIP-seq
MIRT1521340	hsa-miR-4803	CLIP-seq
MIRT1521341	hsa-miR-544	CLIP-seq
MIRT1521342	hsa-miR-548o	CLIP-seq
MIRT1521343	hsa-miR-576-3p	CLIP-seq
MIRT1521344	hsa-miR-642b	CLIP-seq
MIRT1521345	hsa-miR-891b	CLIP-seq
MIRT2157418	hsa-miR-23a	CLIP-seq
MIRT2157419	hsa-miR-23b	CLIP-seq
MIRT2157420	hsa-miR-23c	CLIP-seq
MIRT2157421	hsa-miR-411	CLIP-seq
MIRT2157422	hsa-miR-4725-5p	CLIP-seq
MIRT2157423	hsa-miR-4780	CLIP-seq
MIRT1521338	hsa-miR-4789-3p	CLIP-seq
MIRT1521339	hsa-miR-4789-5p	CLIP-seq
MIRT2157424	hsa-miR-504	CLIP-seq
MIRT2157425	hsa-miR-513a-3p	CLIP-seq
MIRT2157426	hsa-miR-582-5p	CLIP-seq
MIRT2157421	hsa-miR-411	CLIP-seq
MIRT1521338	hsa-miR-4789-3p	CLIP-seq
MIRT1521339	hsa-miR-4789-5p	CLIP-seq
MIRT2157421	hsa-miR-411	CLIP-seq

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GO ID	Ontology	Definition	Evidence
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0001817	Process	Regulation of cytokine production	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q9HBT7

Protein name

Zinc finger protein 287 (Zinc finger protein with KRAB and SCAN domains 13)

Protein function

May be involved in transcriptional regulation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02023	SCAN	38 → 127	SCAN domain	Domain
PF01352	KRAB	162 → 203	KRAB box	Family
PF00096	zf-C2H2	361 → 383	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	389 → 411	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	417 → 439	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	445 → 467	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	473 → 495	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	501 → 523	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	529 → 551	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	557 → 579	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	585 → 607	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	613 → 635	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	641 → 663	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	669 → 691	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	697 → 719	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	725 → 747	Zinc finger, C2H2 type	Domain

Sequence

MLASSKRMNSSSRSQILLRWKSDKAQSGPYNVEKEILTSRFLRDTETCRQNFRNFPYPDL
AGPRKALSQLRELCLKWLRPEIHSKEQILELLVLEQFLTILPGEVRTWVKSQYPESSEEA
VTLVEDLTQILEEEAPQNSTLSQDTPEEDPRGKHAFQTGWLNDLVTKESMTFKDVAVDIT
QEDWELMRPVQKELYKTVTLQNYWNMVSLGLTVYRPTVIPILEEPWMVIKEILEGPSPEW
ETKAQACTPVEDMSKLTKEETHTIKLEDSYDYDDRLERRGKGGFWKIHTDERGFSLKSVL
SQEYDPTEECLSKYDIYRNNFEKHSNLIVQFDTQLDNKTSVYNEGRATFNHVSYGIVHRK
ILPGEKPYKCNVCGKKFRKYPSLLKHQSTHAKEKSYECEECGKEFRHISSLIAHQRMHTG
EKPYECHQCGKAFSQRAHLTIHQRIHTGEKPYKCDDCGKDFSQRAHLTIHQRTHTGEKPY
KCLECGKTFSHSSSLINHQRVHTGEKPYICNECGKTFSQSTHLLQHQKIHTGKKPYKCNE
CWKVFSQSTYLIRHQRIHSGEKCYKCNECGKAFAHSSTLIQHQTTHTGEKSYICNICGKA
FSQSANLTQHHRTHTGEKPYKCSVCGKAFSQSVHLTQHQRIHNGEKPFKCNICGKAYRQG
ANLTQHQRIHTGEKPYKCNECGKAFIYSSSLNQHQRTHTGERPYKCNECDKDFSQRTCLI
QHQRIHTGEKPYACRICGKTFTQSTNLIQHQRVHTGAKHRN

Sequence length

761

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PENILE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
URINARY SYSTEM DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ZNF287 (zinc finger protein 287)