RCN3 (reticulocalbin 3)

Gene

• Entrez ID: 57333
• Gene name: Reticulocalbin 3
• Gene symbol: RCN3
• Synonyms (NCBI Gene): RLP49
• Chromosome: 19
• Chromosome location: 19q13.33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049606	hsa-miR-92a-3p	CLASH	23622248
MIRT1298436	hsa-miR-1207-5p	CLIP-seq
MIRT1298437	hsa-miR-1254	CLIP-seq
MIRT1298438	hsa-miR-1321	CLIP-seq
MIRT1298439	hsa-miR-1539	CLIP-seq
MIRT1298440	hsa-miR-1972	CLIP-seq
MIRT1298441	hsa-miR-2277-5p	CLIP-seq
MIRT1298442	hsa-miR-2467-5p	CLIP-seq
MIRT1298443	hsa-miR-2861	CLIP-seq
MIRT1298444	hsa-miR-3116	CLIP-seq
MIRT1298445	hsa-miR-3188	CLIP-seq
MIRT1298446	hsa-miR-3193	CLIP-seq
MIRT1298447	hsa-miR-3665	CLIP-seq
MIRT1298448	hsa-miR-3688-5p	CLIP-seq
MIRT1298449	hsa-miR-3690	CLIP-seq
MIRT1298450	hsa-miR-3921	CLIP-seq
MIRT1298451	hsa-miR-3975	CLIP-seq
MIRT1298452	hsa-miR-4270	CLIP-seq
MIRT1298453	hsa-miR-4441	CLIP-seq
MIRT1298454	hsa-miR-4446-3p	CLIP-seq
MIRT1298455	hsa-miR-4479	CLIP-seq
MIRT1298456	hsa-miR-4514	CLIP-seq
MIRT1298457	hsa-miR-4520a-3p	CLIP-seq
MIRT1298458	hsa-miR-4638-3p	CLIP-seq
MIRT1298459	hsa-miR-4645-5p	CLIP-seq
MIRT1298460	hsa-miR-4649-3p	CLIP-seq
MIRT1298461	hsa-miR-4653-5p	CLIP-seq
MIRT1298462	hsa-miR-4673	CLIP-seq
MIRT1298463	hsa-miR-4692	CLIP-seq
MIRT1298464	hsa-miR-4706	CLIP-seq
MIRT1298465	hsa-miR-4721	CLIP-seq
MIRT1298466	hsa-miR-4722-5p	CLIP-seq
MIRT1298467	hsa-miR-4728-5p	CLIP-seq
MIRT1298468	hsa-miR-4734	CLIP-seq
MIRT1298469	hsa-miR-4736	CLIP-seq
MIRT1298470	hsa-miR-4739	CLIP-seq
MIRT1298471	hsa-miR-4749-5p	CLIP-seq
MIRT1298472	hsa-miR-4755-3p	CLIP-seq
MIRT1298473	hsa-miR-4756-5p	CLIP-seq
MIRT1298474	hsa-miR-4763-3p	CLIP-seq
MIRT1298475	hsa-miR-4768-3p	CLIP-seq
MIRT1298476	hsa-miR-485-5p	CLIP-seq
MIRT1298477	hsa-miR-744	CLIP-seq
MIRT1298478	hsa-miR-764	CLIP-seq
MIRT1298479	hsa-miR-940	CLIP-seq
MIRT1298437	hsa-miR-1254	CLIP-seq
MIRT1298438	hsa-miR-1321	CLIP-seq
MIRT1298439	hsa-miR-1539	CLIP-seq
MIRT2088768	hsa-miR-2116	CLIP-seq
MIRT1298443	hsa-miR-2861	CLIP-seq
MIRT1298444	hsa-miR-3116	CLIP-seq
MIRT1298446	hsa-miR-3193	CLIP-seq
MIRT1298449	hsa-miR-3690	CLIP-seq
MIRT2088769	hsa-miR-4260	CLIP-seq
MIRT1298452	hsa-miR-4270	CLIP-seq
MIRT1298453	hsa-miR-4441	CLIP-seq
MIRT1298457	hsa-miR-4520a-3p	CLIP-seq
MIRT1298458	hsa-miR-4638-3p	CLIP-seq
MIRT1298464	hsa-miR-4706	CLIP-seq
MIRT1298467	hsa-miR-4728-5p	CLIP-seq
MIRT1298468	hsa-miR-4734	CLIP-seq
MIRT1298470	hsa-miR-4739	CLIP-seq
MIRT1298471	hsa-miR-4749-5p	CLIP-seq
MIRT1298473	hsa-miR-4756-5p	CLIP-seq
MIRT1298477	hsa-miR-744	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IBA
GO:0005509	Function	Calcium ion binding	IDA	16433634
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 16433634, 25416956, 32296183
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	16433634
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	IEA
GO:0009306	Process	Protein secretion	IMP	16433634
GO:0010952	Process	Positive regulation of peptidase activity	IMP	28939891
GO:0015031	Process	Protein transport	IEA
GO:0015031	Process	Protein transport	ISS
GO:0032964	Process	Collagen biosynthetic process	IMP	28939891
GO:0036503	Process	ERAD pathway	IEA
GO:0036503	Process	ERAD pathway	ISS
GO:0043129	Process	Surfactant homeostasis	IEA
GO:0043129	Process	Surfactant homeostasis	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0051896	Process	Regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP	28939891
GO:0055091	Process	Phospholipid homeostasis	IEA
GO:0055091	Process	Phospholipid homeostasis	ISS
GO:0060428	Process	Lung epithelium development	IEA
GO:0060428	Process	Lung epithelium development	ISS

Other IDs

• MIM: 619032
• HGNC: 21145
• e!Ensembl: ENSG00000142552

Protein

• UniProt ID: Q96D15
• Protein name: Reticulocalbin-3 (EF-hand calcium-binding protein RLP49)
• Protein function: Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:16433634, PubMed:28939891). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulm
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13202	EF-hand_5	123 → 141	EF hand	Domain
  PF13202	EF-hand_5	205 → 230	EF hand	Domain
  PF13833	EF-hand_8	280 → 308	EF-hand domain pair	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:16433634}.
• Sequence:

  MMWRPSVLLLLLLLRHGAQGKPSPDAGPHGQGRVHQAAPLSDAPHDDAHGNFQYDHEAFL
  GREVAKEFDQLTPEESQARLGRIVDRMDRAGDGDGWVSLAELRAWIAHTQQRHIRDSVSA
  AWDTYDTDRDGRVGWEELRNATYGHYAPGEEFHDVEDAETYKKMLARDERRFRVADQDGD
  SMATREELTAFLHPEEFPHMRDIVIAETLEDLDRNKDGYVQVEEYIADLYSAEPGEEEPA
  WVQTERQQFRDFRDLNKDGHLDGSEVGHWVLPPAQDQPLVEANHLLHESDTDKDGRLSKA
  EILGNWNMFVGSQATNYGEDLTRHHDEL

• Sequence length: 328