Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	57333
Gene name Gene Name - the full gene name approved by the HGNC.	Reticulocalbin 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RCN3
Synonyms (NCBI Gene) Gene synonyms aliases	RLP49
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.33

Show/Hide all(65)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049606	hsa-miR-92a-3p	CLASH	23622248
MIRT1298436	hsa-miR-1207-5p	CLIP-seq
MIRT1298437	hsa-miR-1254	CLIP-seq
MIRT1298438	hsa-miR-1321	CLIP-seq
MIRT1298439	hsa-miR-1539	CLIP-seq
MIRT1298440	hsa-miR-1972	CLIP-seq
MIRT1298441	hsa-miR-2277-5p	CLIP-seq
MIRT1298442	hsa-miR-2467-5p	CLIP-seq
MIRT1298443	hsa-miR-2861	CLIP-seq
MIRT1298444	hsa-miR-3116	CLIP-seq
MIRT1298445	hsa-miR-3188	CLIP-seq
MIRT1298446	hsa-miR-3193	CLIP-seq
MIRT1298447	hsa-miR-3665	CLIP-seq
MIRT1298448	hsa-miR-3688-5p	CLIP-seq
MIRT1298449	hsa-miR-3690	CLIP-seq
MIRT1298450	hsa-miR-3921	CLIP-seq
MIRT1298451	hsa-miR-3975	CLIP-seq
MIRT1298452	hsa-miR-4270	CLIP-seq
MIRT1298453	hsa-miR-4441	CLIP-seq
MIRT1298454	hsa-miR-4446-3p	CLIP-seq
MIRT1298455	hsa-miR-4479	CLIP-seq
MIRT1298456	hsa-miR-4514	CLIP-seq
MIRT1298457	hsa-miR-4520a-3p	CLIP-seq
MIRT1298458	hsa-miR-4638-3p	CLIP-seq
MIRT1298459	hsa-miR-4645-5p	CLIP-seq
MIRT1298460	hsa-miR-4649-3p	CLIP-seq
MIRT1298461	hsa-miR-4653-5p	CLIP-seq
MIRT1298462	hsa-miR-4673	CLIP-seq
MIRT1298463	hsa-miR-4692	CLIP-seq
MIRT1298464	hsa-miR-4706	CLIP-seq
MIRT1298465	hsa-miR-4721	CLIP-seq
MIRT1298466	hsa-miR-4722-5p	CLIP-seq
MIRT1298467	hsa-miR-4728-5p	CLIP-seq
MIRT1298468	hsa-miR-4734	CLIP-seq
MIRT1298469	hsa-miR-4736	CLIP-seq
MIRT1298470	hsa-miR-4739	CLIP-seq
MIRT1298471	hsa-miR-4749-5p	CLIP-seq
MIRT1298472	hsa-miR-4755-3p	CLIP-seq
MIRT1298473	hsa-miR-4756-5p	CLIP-seq
MIRT1298474	hsa-miR-4763-3p	CLIP-seq
MIRT1298475	hsa-miR-4768-3p	CLIP-seq
MIRT1298476	hsa-miR-485-5p	CLIP-seq
MIRT1298477	hsa-miR-744	CLIP-seq
MIRT1298478	hsa-miR-764	CLIP-seq
MIRT1298479	hsa-miR-940	CLIP-seq
MIRT1298437	hsa-miR-1254	CLIP-seq
MIRT1298438	hsa-miR-1321	CLIP-seq
MIRT1298439	hsa-miR-1539	CLIP-seq
MIRT2088768	hsa-miR-2116	CLIP-seq
MIRT1298443	hsa-miR-2861	CLIP-seq
MIRT1298444	hsa-miR-3116	CLIP-seq
MIRT1298446	hsa-miR-3193	CLIP-seq
MIRT1298449	hsa-miR-3690	CLIP-seq
MIRT2088769	hsa-miR-4260	CLIP-seq
MIRT1298452	hsa-miR-4270	CLIP-seq
MIRT1298453	hsa-miR-4441	CLIP-seq
MIRT1298457	hsa-miR-4520a-3p	CLIP-seq
MIRT1298458	hsa-miR-4638-3p	CLIP-seq
MIRT1298464	hsa-miR-4706	CLIP-seq
MIRT1298467	hsa-miR-4728-5p	CLIP-seq
MIRT1298468	hsa-miR-4734	CLIP-seq
MIRT1298470	hsa-miR-4739	CLIP-seq
MIRT1298471	hsa-miR-4749-5p	CLIP-seq
MIRT1298473	hsa-miR-4756-5p	CLIP-seq
MIRT1298477	hsa-miR-744	CLIP-seq

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IBA
GO:0005509	Function	Calcium ion binding	IDA	16433634
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 16433634, 25416956, 32296183
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	16433634
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	IEA
GO:0009306	Process	Protein secretion	IMP	16433634
GO:0010952	Process	Positive regulation of peptidase activity	IMP	28939891
GO:0015031	Process	Protein transport	IEA
GO:0015031	Process	Protein transport	ISS
GO:0032964	Process	Collagen biosynthetic process	IMP	28939891
GO:0036503	Process	ERAD pathway	IEA
GO:0036503	Process	ERAD pathway	ISS
GO:0043129	Process	Surfactant homeostasis	IEA
GO:0043129	Process	Surfactant homeostasis	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0051896	Process	Regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP	28939891
GO:0055091	Process	Phospholipid homeostasis	IEA
GO:0055091	Process	Phospholipid homeostasis	ISS
GO:0060428	Process	Lung epithelium development	IEA
GO:0060428	Process	Lung epithelium development	ISS

MIM	HGNC	e!Ensembl
619032	21145	ENSG00000142552

Protein

UniProt ID

Q96D15

Protein name

Reticulocalbin-3 (EF-hand calcium-binding protein RLP49)

Protein function

Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:16433634, PubMed:28939891). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulm

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13202	EF-hand_5	123 → 141	EF hand	Domain
PF13202	EF-hand_5	205 → 230	EF hand	Domain
PF13833	EF-hand_8	280 → 308	EF-hand domain pair	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:16433634}.

Sequence

MMWRPSVLLLLLLLRHGAQGKPSPDAGPHGQGRVHQAAPLSDAPHDDAHGNFQYDHEAFL
GREVAKEFDQLTPEESQARLGRIVDRMDRAGDGDGWVSLAELRAWIAHTQQRHIRDSVSA
AWDTYDTDRDGRVGWEELRNATYGHYAPGEEFHDVEDAETYKKMLARDERRFRVADQDGD
SMATREELTAFLHPEEFPHMRDIVIAETLEDLDRNKDGYVQVEEYIADLYSAEPGEEEPA
WVQTERQQFRDFRDLNKDGHLDGSEVGHWVLPPAQDQPLVEANHLLHESDTDKDGRLSKA
EILGNWNMFVGSQATNYGEDLTRHHDEL

Sequence length

328

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes	N/A	N/A	GWAS

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Colorectal Neoplasms	Associate	33096021
Esophageal Squamous Cell Carcinoma	Stimulate	35839283
Feeding and Eating Disorders	Associate	35057575
Glioma	Associate	19544381
Lymphatic Metastasis	Stimulate	35839283
Neoplasms	Associate	19544381, 39206893
Neoplasms	Stimulate	35839283
Stomach Neoplasms	Stimulate	39206893
Uterine Cervical Neoplasms	Stimulate	35181591

RCN3 (reticulocalbin 3)