Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	57332
Gene name	Chromobox 8
Gene symbol	CBX8
Synonyms (NCBI Gene)	PC3RC1
Chromosome	17
Chromosome location	17q25.3

Show/Hide all (91)

miRTarBase ID	miRNA	Experiments	Reference
MIRT669210	hsa-miR-509-3p	HITS-CLIP	23824327
MIRT669209	hsa-miR-5189-3p	HITS-CLIP	23824327
MIRT669208	hsa-miR-505-5p	HITS-CLIP	23824327
MIRT669207	hsa-miR-6827-5p	HITS-CLIP	23824327
MIRT669206	hsa-miR-1343-5p	HITS-CLIP	23824327
MIRT669205	hsa-miR-939-5p	HITS-CLIP	23824327
MIRT669204	hsa-miR-6825-5p	HITS-CLIP	23824327
MIRT669203	hsa-miR-2110	HITS-CLIP	23824327
MIRT669202	hsa-miR-6810-5p	HITS-CLIP	23824327
MIRT669200	hsa-miR-6857-5p	HITS-CLIP	23824327
MIRT669201	hsa-miR-450a-2-3p	HITS-CLIP	23824327
MIRT624434	hsa-miR-526b-3p	HITS-CLIP	23824327
MIRT624433	hsa-miR-93-5p	HITS-CLIP	23824327
MIRT624432	hsa-miR-106a-5p	HITS-CLIP	23824327
MIRT624431	hsa-miR-17-5p	HITS-CLIP	23824327
MIRT624430	hsa-miR-519d-3p	HITS-CLIP	23824327
MIRT624429	hsa-miR-20b-5p	HITS-CLIP	23824327
MIRT624428	hsa-miR-20a-5p	HITS-CLIP	23824327
MIRT624427	hsa-miR-106b-5p	HITS-CLIP	23824327
MIRT624426	hsa-miR-3609	HITS-CLIP	23824327
MIRT624425	hsa-miR-548ah-5p	HITS-CLIP	23824327
MIRT624424	hsa-miR-4796-3p	HITS-CLIP	23824327
MIRT624420	hsa-miR-8485	HITS-CLIP	23824327
MIRT624419	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT624418	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT624417	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT624434	hsa-miR-526b-3p	HITS-CLIP	23824327
MIRT624433	hsa-miR-93-5p	HITS-CLIP	23824327
MIRT624432	hsa-miR-106a-5p	HITS-CLIP	23824327
MIRT624431	hsa-miR-17-5p	HITS-CLIP	23824327
MIRT624430	hsa-miR-519d-3p	HITS-CLIP	23824327
MIRT624429	hsa-miR-20b-5p	HITS-CLIP	23824327
MIRT624428	hsa-miR-20a-5p	HITS-CLIP	23824327
MIRT624427	hsa-miR-106b-5p	HITS-CLIP	23824327
MIRT624426	hsa-miR-3609	HITS-CLIP	23824327
MIRT624425	hsa-miR-548ah-5p	HITS-CLIP	23824327
MIRT624424	hsa-miR-4796-3p	HITS-CLIP	23824327
MIRT624423	hsa-miR-519a-3p	HITS-CLIP	23824327
MIRT624422	hsa-miR-519b-3p	HITS-CLIP	23824327
MIRT624421	hsa-miR-519c-3p	HITS-CLIP	23824327
MIRT624420	hsa-miR-8485	HITS-CLIP	23824327
MIRT624419	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT624418	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT624417	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT440996	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440996	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT669210	hsa-miR-509-3p	HITS-CLIP	23824327
MIRT669209	hsa-miR-5189-3p	HITS-CLIP	23824327
MIRT669208	hsa-miR-505-5p	HITS-CLIP	23824327
MIRT669207	hsa-miR-6827-5p	HITS-CLIP	23824327
MIRT669206	hsa-miR-1343-5p	HITS-CLIP	23824327
MIRT669205	hsa-miR-939-5p	HITS-CLIP	23824327
MIRT669204	hsa-miR-6825-5p	HITS-CLIP	23824327
MIRT669203	hsa-miR-2110	HITS-CLIP	23824327
MIRT669202	hsa-miR-6810-5p	HITS-CLIP	23824327
MIRT669200	hsa-miR-6857-5p	HITS-CLIP	23824327
MIRT669201	hsa-miR-450a-2-3p	HITS-CLIP	23824327
MIRT624434	hsa-miR-526b-3p	HITS-CLIP	23824327
MIRT624433	hsa-miR-93-5p	HITS-CLIP	23824327
MIRT624432	hsa-miR-106a-5p	HITS-CLIP	23824327
MIRT624431	hsa-miR-17-5p	HITS-CLIP	23824327
MIRT624430	hsa-miR-519d-3p	HITS-CLIP	23824327
MIRT624429	hsa-miR-20b-5p	HITS-CLIP	23824327
MIRT624428	hsa-miR-20a-5p	HITS-CLIP	23824327
MIRT624427	hsa-miR-106b-5p	HITS-CLIP	23824327
MIRT624426	hsa-miR-3609	HITS-CLIP	23824327
MIRT624425	hsa-miR-548ah-5p	HITS-CLIP	23824327
MIRT624424	hsa-miR-4796-3p	HITS-CLIP	23824327
MIRT624420	hsa-miR-8485	HITS-CLIP	23824327
MIRT624419	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT624418	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT624417	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT624434	hsa-miR-526b-3p	HITS-CLIP	23824327
MIRT624433	hsa-miR-93-5p	HITS-CLIP	23824327
MIRT624432	hsa-miR-106a-5p	HITS-CLIP	23824327
MIRT624431	hsa-miR-17-5p	HITS-CLIP	23824327
MIRT624430	hsa-miR-519d-3p	HITS-CLIP	23824327
MIRT624429	hsa-miR-20b-5p	HITS-CLIP	23824327
MIRT624428	hsa-miR-20a-5p	HITS-CLIP	23824327
MIRT624427	hsa-miR-106b-5p	HITS-CLIP	23824327
MIRT624426	hsa-miR-3609	HITS-CLIP	23824327
MIRT624425	hsa-miR-548ah-5p	HITS-CLIP	23824327
MIRT624424	hsa-miR-4796-3p	HITS-CLIP	23824327
MIRT624423	hsa-miR-519a-3p	HITS-CLIP	23824327
MIRT624422	hsa-miR-519b-3p	HITS-CLIP	23824327
MIRT624421	hsa-miR-519c-3p	HITS-CLIP	23824327
MIRT624420	hsa-miR-8485	HITS-CLIP	23824327
MIRT624419	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT624418	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT624417	hsa-miR-140-3p	HITS-CLIP	23824327
MIRT1957284	hsa-miR-4279	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	19636380, 21282530
GO:0000785	Component	Chromatin	IBA
GO:0000785	Component	Chromatin	IDA	19636380
GO:0000792	Component	Heterochromatin	IEA
GO:0003682	Function	Chromatin binding	IBA
GO:0003727	Function	Single-stranded RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	16169070, 17332741, 18927235, 19636380, 20543829, 20601937, 21282530, 22094252, 23260655, 24981860, 25416956, 26496610, 27505670, 27705803, 28514442, 30021884, 32296183, 33961781, 34316702
GO:0005634	Component	Nucleus	IDA	21282530
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006325	Process	Chromatin organization	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0031519	Component	PcG protein complex	IDA	21282530
GO:0031519	Component	PcG protein complex	IEA
GO:0032967	Process	Positive regulation of collagen biosynthetic process	IEA
GO:0035102	Component	PRC1 complex	IBA
GO:0035102	Component	PRC1 complex	IDA	12167701, 19636380
GO:0035102	Component	PRC1 complex	IEA
GO:0045739	Process	Positive regulation of DNA repair	IEA
GO:0061628	Function	Histone H3K27me3 reader activity	IDA	21029866
GO:0070301	Process	Cellular response to hydrogen peroxide	IEA
GO:0097027	Function	Ubiquitin-protein transferase activator activity	IEA

MIM	HGNC	e!Ensembl
617354	15962	ENSG00000141570

Q9HC52

Protein name

Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1)

Protein function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remod

PDB

2N4Q , 3I91 , 5EQ0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00385	Chromo	11 → 60	Chromo (CHRromatin Organisation MOdifier) domain	Domain
PF17218	CBX7_C	349 → 381	CBX family C-terminal motif	Motif

Sequence

MELSAVGERVFAAEALLKRRIRKGRMEYLVKWKGWSQKYSTWEPEENILDARLLAAFEER
EREMELYGPKKRGPKPKTFLLKAQAKAKAKTYEFRSDSARGIRIPYPGRSPQDLASTSRA
REGLRNMGLSPPASSTSTSSTCRAEAPRDRDRDRDRDRERDRERERERERERERERERER
GTSRVDDKPSSPGDSSKKRGPKPRKELPDPSQRPLGEPSAGLGEYLKGRKLDDTPSGAGK
FPAGHSVIQLARRQDSDLVQCGVTSPSSAEATGKLAVDTFPARVIKHRAAFLEAKGQGAL
DPNGTRVRHGSGPPSSGGGLYRDMGAQGGRPSLIARIPVARILGDPEEESWSPSLTNLEK
VVVTDVTSNFLTVTIKESNTDQGFFKEKR

Sequence length

389

Interactions

View interactions

	KEGG		Reactome
	Polycomb repressive complex		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription

CBX8 (chromobox 8)